DK479688A - Substituerede 3-aminosydnoniminer og farmakologisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelse - Google Patents
Substituerede 3-aminosydnoniminer og farmakologisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelseInfo
- Publication number
- DK479688A DK479688A DK479688A DK479688A DK479688A DK 479688 A DK479688 A DK 479688A DK 479688 A DK479688 A DK 479688A DK 479688 A DK479688 A DK 479688A DK 479688 A DK479688 A DK 479688A
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- acid addition
- addition salts
- acceptable acid
- sydnonimines
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 230000000144 pharmacologic effect Effects 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- QVZILVCJQMNOLN-UHFFFAOYSA-N 5-imino-1-oxa-3-azonia-2-azanidacyclopent-3-en-3-amine Chemical class N[N+]1=CC(=N)O[N-]1 QVZILVCJQMNOLN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Detergent Compositions (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873732174 DE3732174A1 (de) | 1987-09-24 | 1987-09-24 | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK479688D0 DK479688D0 (da) | 1988-08-26 |
| DK479688A true DK479688A (da) | 1989-03-25 |
Family
ID=6336771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK479688A DK479688A (da) | 1987-09-24 | 1988-08-26 | Substituerede 3-aminosydnoniminer og farmakologisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelse |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4937244A (da) |
| EP (1) | EP0312773B1 (da) |
| JP (1) | JPH01106881A (da) |
| KR (1) | KR890005094A (da) |
| AT (1) | ATE70838T1 (da) |
| DE (2) | DE3732174A1 (da) |
| DK (1) | DK479688A (da) |
| ES (1) | ES2037783T3 (da) |
| HU (1) | HU203749B (da) |
| IL (1) | IL87796A0 (da) |
| PT (1) | PT88569B (da) |
| ZA (1) | ZA887086B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5221680A (en) * | 1988-01-14 | 1993-06-22 | Cassella Aktiengesellschaft | Substituted 3-aminosydnonimines |
| DE4015236A1 (de) * | 1990-05-13 | 1991-11-14 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| DE3921460A1 (de) * | 1989-06-30 | 1991-01-03 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| DE3921796A1 (de) * | 1989-07-03 | 1991-01-17 | Cassella Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| ATE90677T1 (de) * | 1989-11-30 | 1993-07-15 | Cassella Farbwerke Mainkur Ag | Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung. |
| DE4031373A1 (de) * | 1990-10-04 | 1992-04-09 | Cassella Ag | 3-piperazino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1695897C3 (de) * | 1966-07-04 | 1979-02-15 | Takeda Chemical Industries Ltd | N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US3833580A (en) * | 1966-08-09 | 1974-09-03 | Boehringer Sohn Ingelheim | 3-morpholino-n6-cyclohexylcarbonyl sydnonimine |
| CH507276A (de) * | 1966-09-29 | 1971-05-15 | Takeda Chemical Industries Ltd | Verfahren zur Herstellung von Sydnoniminderivaten |
| US3833589A (en) * | 1972-07-31 | 1974-09-03 | Sandoz Ag | Substituted sydnonimine nitrate esters |
| US4245100A (en) * | 1977-11-28 | 1981-01-13 | Vsesojuzny Nauchno-Issledovatelsky Khimikofarmatsevtichesky Institut Imeni S. Ordzhonikidze | Sydnonimine N-acyl derivatives and method for preparing same |
| DE2930736A1 (de) * | 1979-07-28 | 1981-02-12 | Cassella Ag | Pharmakologisch wirksame, substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| US4277609A (en) * | 1979-08-31 | 1981-07-07 | American Home Products Corporation | Sydnone imines |
| US4446322A (en) * | 1980-07-29 | 1984-05-01 | American Home Products Corporation | Hydroxyl protected 3-(2-hydroxy-2-phenylethyl)-N-[(phenylamino)carbonyl]sydnone imine intermediates |
| US4324897A (en) * | 1980-10-02 | 1982-04-13 | American Home Products Corporation | 1,2,3 Oxadiazolium salts |
| US4301285A (en) * | 1980-10-02 | 1981-11-17 | American Home Products Corporation | Sydnonimine CNS stimulants |
| US4289885A (en) * | 1980-10-02 | 1981-09-15 | American Home Products Corporation | 3-[2-(Dimethylamino)-2-phenylethyl]N-[phenylamino)carbonyl]sydnone imine, a new central nervous system stimulant |
| US4371697A (en) * | 1980-10-06 | 1983-02-01 | American Home Products Corporation | 3-[1-(Hydroxymethyl)-2-phenylethyl]-N-[(phenylamino)-carbonyl]sydnone imine |
| DE3107933A1 (de) * | 1981-03-02 | 1982-09-16 | Cassella Ag, 6000 Frankfurt | Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung |
| US4371539A (en) * | 1981-04-27 | 1983-02-01 | American Home Products Corporation | CNS Stimulants |
| JPS5832870A (ja) * | 1981-08-24 | 1983-02-25 | Hiroyoshi Hidaka | 新規なシドノンイミン誘導体及びその製法 |
| JPS5859977A (ja) * | 1981-10-06 | 1983-04-09 | Banyu Pharmaceut Co Ltd | 新規なｎ−アシルシドノンイミン誘導体およびその製法 |
-
1987
- 1987-09-24 DE DE19873732174 patent/DE3732174A1/de not_active Withdrawn
-
1988
- 1988-08-03 US US07/238,456 patent/US4937244A/en not_active Expired - Fee Related
- 1988-08-26 DK DK479688A patent/DK479688A/da not_active Application Discontinuation
- 1988-09-16 EP EP88115165A patent/EP0312773B1/de not_active Expired - Lifetime
- 1988-09-16 AT AT88115165T patent/ATE70838T1/de not_active IP Right Cessation
- 1988-09-16 ES ES198888115165T patent/ES2037783T3/es not_active Expired - Lifetime
- 1988-09-16 DE DE8888115165T patent/DE3867205D1/de not_active Expired - Fee Related
- 1988-09-19 IL IL87796A patent/IL87796A0/xx unknown
- 1988-09-22 ZA ZA887086A patent/ZA887086B/xx unknown
- 1988-09-22 PT PT88569A patent/PT88569B/pt not_active IP Right Cessation
- 1988-09-22 JP JP63236665A patent/JPH01106881A/ja active Pending
- 1988-09-23 HU HU884988A patent/HU203749B/hu not_active IP Right Cessation
- 1988-09-23 KR KR1019880012291A patent/KR890005094A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ZA887086B (en) | 1989-06-28 |
| KR890005094A (ko) | 1989-05-11 |
| JPH01106881A (ja) | 1989-04-24 |
| EP0312773A2 (de) | 1989-04-26 |
| PT88569A (pt) | 1988-10-01 |
| DE3732174A1 (de) | 1989-04-06 |
| US4937244A (en) | 1990-06-26 |
| HU203749B (en) | 1991-09-30 |
| ATE70838T1 (de) | 1992-01-15 |
| EP0312773B1 (de) | 1991-12-27 |
| HUT51618A (en) | 1990-05-28 |
| EP0312773A3 (en) | 1990-05-09 |
| IL87796A0 (en) | 1989-03-31 |
| DE3867205D1 (de) | 1992-02-06 |
| PT88569B (pt) | 1992-11-30 |
| ES2037783T3 (es) | 1993-07-01 |
| DK479688D0 (da) | 1988-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |