DK494689A - Peptidaseinhibitorer - Google Patents

Peptidaseinhibitorer Download PDF

Info

Publication number: DK494689A
Authority: DK; Denmark
Prior art keywords: alpha; amino acid; group; peptidase; alkyl
Prior art date: 1988-10-07

Application number

DK494689A

Other languages

English (en)

Other versions

DK494689D0 (da

Inventor

Philippe Bey

Michael Angelastro

Shujaath Mehdi

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-07

Filing date

1989-10-06

Publication date

1990-04-08

1989-10-06 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-10-06 Publication of DK494689D0 publication Critical patent/DK494689D0/da

1990-04-08 Publication of DK494689A publication Critical patent/DK494689A/da

Links

102000035195 Peptidases Human genes 0.000 title abstract 5
108091005804 Peptidases Proteins 0.000 title abstract 5
235000019833 protease Nutrition 0.000 title abstract 4
235000008206 alpha-amino acids Nutrition 0.000 abstract 7
150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 5
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
239000000758 substrate Substances 0.000 abstract 4
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
150000001371 alpha-amino acids Chemical class 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000002532 enzyme inhibitor Substances 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
125000000346 malonyl group Chemical group C(CC(=O)*)(=O)* 0.000 abstract 1
239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Crystallography & Structural Chemistry (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Detergent Compositions (AREA)

DK494689A 1988-10-07 1989-10-06 Peptidaseinhibitorer DK494689A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25476288A	1988-10-07	1988-10-07

Publications (2)

Publication Number	Publication Date
DK494689D0 DK494689D0 (da)	1989-10-06
DK494689A true DK494689A (da)	1990-04-08

Family

ID=22965502

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK494789A DK494789A (da)	1988-10-07	1989-10-06	Peptidaseinhibitorer
DK494689A DK494689A (da)	1988-10-07	1989-10-06	Peptidaseinhibitorer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK494789A DK494789A (da)	1988-10-07	1989-10-06	Peptidaseinhibitorer

Country Status (18)

Country	Link
EP (2)	EP0364344B1 (da)
JP (2)	JP3203579B2 (da)
KR (2)	KR900006363A (da)
CN (2)	CN1041950A (da)
AT (2)	ATE165835T1 (da)
AU (1)	AU617875B2 (da)
CA (2)	CA2000342C (da)
DE (2)	DE68928042T2 (da)
DK (2)	DK494789A (da)
ES (2)	ES2118710T3 (da)
FI (2)	FI894747L (da)
GR (1)	GR3024158T3 (da)
HU (2)	HU895246D0 (da)
IL (2)	IL91896A0 (da)
NO (2)	NO894013L (da)
NZ (2)	NZ230893A (da)
PT (2)	PT91927B (da)
ZA (2)	ZA897515B (da)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
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DE4421052A1 (de)	1994-06-17	1995-12-21	Basf Ag	Neue Thrombininhibitoren, ihre Herstellung und Verwendung
DE4421884A1 (de)	1994-06-23	1996-01-04	Hoechst Ag	Verfahren zur Herstellung von Hydroxycarbonsäureaniliden
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DE4427837A1 (de)	1994-08-05	1996-02-08	Hoechst Ag	Verfahren zur Herstellung von O-Acylglykolsäureaniliden
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SE9404196D0 (sv) *	1994-12-02	1994-12-02	Astra Ab	New antithrombotic formulation
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FI119756B (fi)	1995-01-18	2009-03-13	Alteon Inc	Tiatsoliumyhdisteiden käyttö pitkälle edenneen glykosylaation lopputuotteiden muodostumisen estossa ja suunnan muutoksessa
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SA96170106A (ar)	1995-07-06	2005-12-03	أسترا أكتيبولاج	مشتقات حامض أميني جديدة
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EP1136498A1 (en) *	1996-10-18	2001-09-26	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases, particularly hepatitis c virus NS3 protease
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- 1989-10-03 ZA ZA897515A patent/ZA897515B/xx unknown
- 1989-10-03 ZA ZA897514A patent/ZA897514B/xx unknown
- 1989-10-04 NZ NZ230893A patent/NZ230893A/en unknown
- 1989-10-04 AU AU42491/89A patent/AU617875B2/en not_active Ceased
- 1989-10-05 IL IL91896A patent/IL91896A0/xx unknown
- 1989-10-05 IL IL91895A patent/IL91895A0/xx unknown
- 1989-10-05 NZ NZ230916A patent/NZ230916A/en unknown
- 1989-10-06 KR KR1019890014375A patent/KR900006363A/ko not_active Withdrawn
- 1989-10-06 DE DE68928042T patent/DE68928042T2/de not_active Expired - Fee Related
- 1989-10-06 DE DE68928662T patent/DE68928662T2/de not_active Expired - Fee Related
- 1989-10-06 ES ES89402763T patent/ES2118710T3/es not_active Expired - Lifetime
- 1989-10-06 HU HU895246A patent/HU895246D0/hu unknown
- 1989-10-06 AT AT89402763T patent/ATE165835T1/de not_active IP Right Cessation
- 1989-10-06 PT PT91927A patent/PT91927B/pt not_active IP Right Cessation
- 1989-10-06 HU HU895247A patent/HUT54105A/hu unknown
- 1989-10-06 NO NO89894013A patent/NO894013L/no unknown
- 1989-10-06 KR KR1019890014374A patent/KR900006362A/ko not_active Withdrawn
- 1989-10-06 ES ES89402762T patent/ES2103709T3/es not_active Expired - Lifetime
- 1989-10-06 EP EP89402763A patent/EP0364344B1/en not_active Expired - Lifetime
- 1989-10-06 FI FI894747A patent/FI894747L/fi not_active IP Right Cessation
- 1989-10-06 DK DK494789A patent/DK494789A/da not_active Application Discontinuation
- 1989-10-06 EP EP89402762A patent/EP0363284B1/en not_active Expired - Lifetime
- 1989-10-06 PT PT91926A patent/PT91926B/pt not_active IP Right Cessation
- 1989-10-06 FI FI894748A patent/FI894748A7/fi not_active IP Right Cessation
- 1989-10-06 JP JP26036089A patent/JP3203579B2/ja not_active Expired - Fee Related
- 1989-10-06 AT AT89402762T patent/ATE153029T1/de not_active IP Right Cessation
- 1989-10-06 JP JP1260361A patent/JPH02134398A/ja active Pending
- 1989-10-06 NO NO89894014A patent/NO894014L/no unknown
- 1989-10-06 DK DK494689A patent/DK494689A/da not_active Application Discontinuation
- 1989-10-07 CN CN89107699A patent/CN1041950A/zh active Pending
- 1989-10-07 CN CN89107700A patent/CN1041951A/zh active Pending
- 1989-10-10 CA CA002000342A patent/CA2000342C/en not_active Expired - Fee Related
- 1989-10-10 CA CA002000340A patent/CA2000340A1/en not_active Abandoned
1997
- 1997-07-18 GR GR970401803T patent/GR3024158T3/el unknown

Also Published As

Publication number	Publication date
CA2000340A1 (en)	1990-04-07
DE68928042D1 (de)	1997-06-19
ZA897515B (en)	1990-06-27
JPH02256654A (ja)	1990-10-17
DK494789D0 (da)	1989-10-06
EP0364344A2 (en)	1990-04-18
AU626918B2 (en)	1992-08-13
HUT54105A (en)	1991-01-28
JP3203579B2 (ja)	2001-08-27
FI894748L (fi)	1990-04-08
DE68928662D1 (de)	1998-06-10
FI894747A7 (fi)	1990-04-08
ES2118710T3 (es)	1998-10-01
DE68928042T2 (de)	1997-08-28
AU617875B2 (en)	1991-12-05
FI894747A0 (fi)	1989-10-06
CN1041950A (zh)	1990-05-09
JPH02134398A (ja)	1990-05-23
PT91926B (pt)	1995-07-03
GR3024158T3 (en)	1997-10-31
ATE165835T1 (de)	1998-05-15
PT91926A (pt)	1990-04-30
DK494689D0 (da)	1989-10-06
NZ230893A (en)	1992-01-29
DK494789A (da)	1990-04-08
EP0363284B1 (en)	1997-05-14
AU4249189A (en)	1990-06-28
KR900006362A (ko)	1990-05-08
FI894748A0 (fi)	1989-10-06
EP0363284A2 (en)	1990-04-11
PT91927B (pt)	1995-07-03
NO894014D0 (no)	1989-10-06
ATE153029T1 (de)	1997-05-15
PT91927A (pt)	1990-04-30
AU4262589A (en)	1990-04-12
NZ230916A (en)	1992-02-25
CA2000342C (en)	2000-10-03
FI894747L (fi)	1990-04-08
HU895247D0 (da)	1990-01-28
CN1041951A (zh)	1990-05-09
DE68928662T2 (de)	1998-11-26
ZA897514B (en)	1990-06-27
CA2000342A1 (en)	1990-04-07
EP0363284A3 (en)	1992-07-01
ES2103709T3 (es)	1997-10-01
NO894013L (no)	1990-04-09
NO894013D0 (no)	1989-10-06
IL91896A0 (en)	1990-06-10
EP0364344B1 (en)	1998-05-06
IL91895A0 (en)	1990-06-10
HU895246D0 (en)	1990-01-28
NO894014L (no)	1990-04-09
KR900006363A (ko)	1990-05-08
FI894748A7 (fi)	1990-04-08
EP0364344A3 (en)	1991-09-11

Legal Events

Date	Code	Title	Description
1993-09-13	ATS	Application withdrawn

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ATE165835T1 (de)	1998-05-15	Peptidase-hemmer
MY137301A (en)	2009-01-30	Peptide analogs as irreversible interleukin-1b protease inhibitors
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ATE257517T1 (de)	2004-01-15	Interleukin 1-beta protease und ihre inhibitoren
DK0615978T3 (da)	1999-11-15	Peptidderivater af borsyre med proteaseinhiberende virkning, fremgangsmåde til fremstilling heraf samt farmaceutiske sammen
NO982907L (no)	1998-06-22	Tyrosinderivater som <alfa>-v-integrininhibitorer
DE69630160D1 (de)	2003-11-06	Selektive Thrombin-Hemmer
ES2053525T3 (es)	1994-08-01	Acidos hidroxamicos.
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ES2187063T3 (es)	2003-05-16	Derivados de azetidinona para el tratamiento de infecciones por hcmv.
NO921852L (no)	1992-05-11	N-substituerte azaheterosykliske karboksylsyrer og en farmasoeytisk sammensetning
TH14443A (th)	1994-07-29	(สูตร) - อะมิโนแอลคิลและ (สูตร)-n- เพปทิดิลอะมิโนแอลคิลปอ?โรนิคแอซิด
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