DK511383A - Fremgangsmaade til fremstilling af piperidindionderivater, der beskytter hjertemuskulaturen med en antiarythmisk aktivitet - Google Patents

Fremgangsmaade til fremstilling af piperidindionderivater, der beskytter hjertemuskulaturen med en antiarythmisk aktivitet Download PDF

Info

Publication number: DK511383A
Authority: DK; Denmark
Prior art keywords: derivatives; antiarythmic; indion; piperidine; protecting
Prior art date: 1982-11-08

Application number

DK511383A

Other languages

English (en)

Other versions

DK511383D0 (da

Inventor

Claude Bernhart

Werner Cautreels

Patrick Gautier

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-08

Filing date

1983-11-08

Publication date

1984-05-09

1983-11-08 Application filed by Sanofi Sa filed Critical Sanofi Sa

1983-11-08 Publication of DK511383D0 publication Critical patent/DK511383D0/da

1984-05-09 Publication of DK511383A publication Critical patent/DK511383A/da

Links

238000000034 method Methods 0.000 title abstract 2
-1 PIPERIDINE INDION DERIVATIVES Chemical class 0.000 title 1
230000000694 effects Effects 0.000 title 1
230000003387 muscular Effects 0.000 title 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000005458 piperidinediones Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK511383A 1982-11-08 1983-11-08 Fremgangsmaade til fremstilling af piperidindionderivater, der beskytter hjertemuskulaturen med en antiarythmisk aktivitet DK511383A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8218706A FR2535721A1 (fr)	1982-11-08	1982-11-08	Derives de la piperidinedione protecteurs du myocarde presentant une acticite antiarythmique, leur procede de preparation et les medicaments qui contiennent lesdits derives

Publications (2)

Publication Number	Publication Date
DK511383D0 DK511383D0 (da)	1983-11-08
DK511383A true DK511383A (da)	1984-05-09

Family

ID=9279000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK511383A DK511383A (da)	1982-11-08	1983-11-08	Fremgangsmaade til fremstilling af piperidindionderivater, der beskytter hjertemuskulaturen med en antiarythmisk aktivitet

Country Status (29)

Country	Link
US (1)	US4721710A (da)
EP (1)	EP0110755B1 (da)
JP (1)	JPS59161377A (da)
KR (1)	KR900006721B1 (da)
AT (1)	ATE22561T1 (da)
AU (1)	AU565519B2 (da)
CA (1)	CA1221967A (da)
CS (1)	CS244681B2 (da)
DD (3)	DD229402A5 (da)
DE (1)	DE3366623D1 (da)
DK (1)	DK511383A (da)
ES (1)	ES8406070A1 (da)
FI (1)	FI79536C (da)
FR (1)	FR2535721A1 (da)
GR (1)	GR78747B (da)
HU (1)	HU191494B (da)
IE (1)	IE56209B1 (da)
IL (1)	IL70099A (da)
MA (1)	MA19948A1 (da)
NO (1)	NO159852C (da)
NZ (1)	NZ206177A (da)
OA (1)	OA07582A (da)
PH (1)	PH20421A (da)
PL (3)	PL139946B1 (da)
PT (1)	PT77607B (da)
SG (1)	SG1989G (da)
SU (3)	SU1333237A3 (da)
YU (3)	YU221183A (da)
ZA (1)	ZA838065B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4668689A (en) *	1984-07-19	1987-05-26	National Research Development Corporation	Glutarimide derivatives for treating oestrogen-dependent tumors
US5238947A (en) *	1990-04-12	1993-08-24	University Of Georgia Research Foundation, Inc.	Synthetic piperidinediones with cytostatic activity
US5463063A (en) *	1993-07-02	1995-10-31	Celgene Corporation	Ring closure of N-phthaloylglutamines
DE19703763C1 (de) *	1997-02-01	1998-10-01	Gruenenthal Gmbh	Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione
DK2710007T3 (da)	2011-05-17	2020-01-27	Principia Biopharma Inc	Kinasehæmmere
AU2012255860C1 (en)	2011-05-17	2015-12-10	Principia Biopharma Inc.	Tyrosine kinase inhibitors
WO2012158795A1 (en)	2011-05-17	2012-11-22	Principia Biopharma Inc.	Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
SMT201900344T1 (it)	2012-09-10	2019-07-11	Principia Biopharma Inc	Composti di pirazolopirimidina come inibitori di chinasi
US8957080B2 (en)	2013-04-09	2015-02-17	Principia Biopharma Inc.	Tyrosine kinase inhibitors
CN112353806A (zh)	2014-02-21	2021-02-12	普林斯匹亚生物制药公司	Btk抑制剂的盐和固体形式
SG11201704808VA (en)	2014-12-18	2017-07-28	Principia Biopharma Inc	Treatment of pemphigus
US20180305350A1 (en)	2015-06-24	2018-10-25	Principia Biopharma Inc.	Tyrosine kinase inhibitors
IL263815B (en)	2016-06-29	2022-07-01	Principia Biopharma Inc	Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(Oxtan-3-yl)piperazin-1-yl)pent-2-ananitrile
AU2020365951B2 (en)	2019-10-14	2026-07-16	Principia Biopharma Inc.	Methods for treating immune thrombocytopenia by administering (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
KR102993352B1 (ko)	2019-12-20	2026-07-22	프린시피아 바이오파마, 인코퍼레이티드	2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-에네니트릴의 고체 형태
WO2021150723A1 (en)	2020-01-22	2021-07-29	Principia Biopharma Inc.	Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2664424A (en) *		1953-12-29		Dioxo-piperidines
GB1455687A (en) *	1972-12-28	1976-11-17	Aspro Nicholas Ltd	Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
FR2467200A1 (fr) *	1979-10-11	1981-04-17	Clin Midy	Derives du pyrrole actifs sur les troubles du rythme cardiovasculaire

1982
- 1982-11-08 FR FR8218706A patent/FR2535721A1/fr active Granted
1983
- 1983-10-28 ZA ZA838065A patent/ZA838065B/xx unknown
- 1983-10-31 IL IL70099A patent/IL70099A/xx unknown
- 1983-11-02 AU AU20898/83A patent/AU565519B2/en not_active Ceased
- 1983-11-04 GR GR72874A patent/GR78747B/el unknown
- 1983-11-04 PT PT77607A patent/PT77607B/pt not_active IP Right Cessation
- 1983-11-04 DE DE8383402142T patent/DE3366623D1/de not_active Expired
- 1983-11-04 EP EP83402142A patent/EP0110755B1/fr not_active Expired
- 1983-11-04 AT AT83402142T patent/ATE22561T1/de not_active IP Right Cessation
- 1983-11-04 IE IE2581/83A patent/IE56209B1/xx unknown
- 1983-11-05 SU SU833661804A patent/SU1333237A3/ru active
- 1983-11-07 MA MA20168A patent/MA19948A1/fr unknown
- 1983-11-07 NZ NZ206177A patent/NZ206177A/en unknown
- 1983-11-07 DD DD83270121A patent/DD229402A5/de not_active IP Right Cessation
- 1983-11-07 NO NO834057A patent/NO159852C/no unknown
- 1983-11-07 DD DD83270120A patent/DD229407A5/de not_active IP Right Cessation
- 1983-11-07 DD DD83256411A patent/DD219770A5/de not_active IP Right Cessation
- 1983-11-08 CS CS838220A patent/CS244681B2/cs unknown
- 1983-11-08 PH PH29800A patent/PH20421A/en unknown
- 1983-11-08 ES ES527091A patent/ES8406070A1/es not_active Expired
- 1983-11-08 YU YU02211/83A patent/YU221183A/xx unknown
- 1983-11-08 CA CA000440675A patent/CA1221967A/en not_active Expired
- 1983-11-08 FI FI834087A patent/FI79536C/fi not_active IP Right Cessation
- 1983-11-08 JP JP58209772A patent/JPS59161377A/ja active Pending
- 1983-11-08 PL PL1983244462A patent/PL139946B1/pl unknown
- 1983-11-08 KR KR1019830005288A patent/KR900006721B1/ko not_active Expired
- 1983-11-08 OA OA58153A patent/OA07582A/xx unknown
- 1983-11-08 PL PL1983249749A patent/PL140992B1/pl unknown
- 1983-11-08 DK DK511383A patent/DK511383A/da not_active Application Discontinuation
- 1983-11-08 PL PL1983249750A patent/PL140021B1/pl unknown
- 1983-11-08 HU HU833827A patent/HU191494B/hu not_active IP Right Cessation
1984
- 1984-09-06 SU SU843786907A patent/SU1316558A3/ru active
- 1984-09-06 SU SU843786916A patent/SU1333238A3/ru active
1985
- 1985-11-26 YU YU01841/85A patent/YU184185A/xx unknown
- 1985-11-26 YU YU01842/85A patent/YU184285A/xx unknown
1986
- 1986-03-10 US US06/838,255 patent/US4721710A/en not_active Expired - Fee Related
1989
- 1989-01-11 SG SG19/89A patent/SG1989G/en unknown

Also Published As

Publication number	Publication date
CA1221967A (en)	1987-05-19
ES527091A0 (es)	1984-07-01
EP0110755A1 (fr)	1984-06-13
FI79536C (fi)	1990-01-10
GR78747B (da)	1984-10-02
NO159852C (no)	1989-02-15
PT77607B (fr)	1986-03-18
ES8406070A1 (es)	1984-07-01
CS244681B2 (en)	1986-08-14
IE56209B1 (en)	1991-05-22
AU565519B2 (en)	1987-09-17
KR840006641A (ko)	1984-12-01
US4721710A (en)	1988-01-26
OA07582A (fr)	1985-03-31
PH20421A (en)	1987-01-05
ZA838065B (en)	1984-06-27
DD219770A5 (de)	1985-03-13
YU221183A (en)	1986-06-30
SU1333238A3 (ru)	1987-08-23
ATE22561T1 (de)	1986-10-15
PL140992B1 (en)	1987-06-30
AU2089883A (en)	1984-05-17
FR2535721A1 (fr)	1984-05-11
FI834087L (fi)	1984-05-09
YU184185A (en)	1986-06-30
PT77607A (fr)	1983-12-01
HU191494B (en)	1987-02-27
NO159852B (no)	1988-11-07
PL249749A1 (en)	1985-03-12
FI834087A0 (fi)	1983-11-08
NO834057L (no)	1984-05-09
FR2535721B1 (da)	1985-05-17
IL70099A0 (en)	1984-01-31
JPS59161377A (ja)	1984-09-12
SG1989G (en)	1989-06-02
KR900006721B1 (ko)	1990-09-20
DK511383D0 (da)	1983-11-08
SU1333237A3 (ru)	1987-08-23
PL140021B1 (en)	1987-03-31
IL70099A (en)	1987-10-20
YU184285A (en)	1986-06-30
EP0110755B1 (fr)	1986-10-01
PL249750A1 (en)	1985-03-12
PL139946B1 (en)	1987-03-31
IE832581L (en)	1984-05-08
PL244462A1 (en)	1985-02-13
NZ206177A (en)	1985-11-08
SU1316558A3 (ru)	1987-06-07
FI79536B (fi)	1989-09-29
DE3366623D1 (en)	1986-11-06
DD229407A5 (de)	1985-11-06
MA19948A1 (fr)	1984-07-01
DD229402A5 (de)	1985-11-06

Legal Events

Date	Code	Title	Description
1991-07-29	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK511383D0 (da)	1983-11-08	Fremgangsmade til fremstilling af piperidindionderivater,der beskytter hjertemuskulaturen med en antiarythmisk aktivitet
DK26289D0 (da)	1989-01-20	Anvendelse af 1,4-disubstitueret piperidinyl til fremstilling af et farmaceutisk praeparat til behandling af insomnia
AU576888B2 (en)	1988-09-08	Benzodisultams
DE3674117D1 (de)	1990-10-18	Verfahren zur herstellung von 1,4-dihydropyridinderivaten ueber neue zwischenprodukte.
GR76976B (da)	1984-09-04
DE3270999D1 (de)	1986-06-12	N-substituted-tetrahydroisophthalimide derivatives
JPS53124277A (en)	1978-10-30	1-substed-(1,2-diphenylpropyl)piperazines