ZA838065B - Derivatives of piperidenedione,process for preparing them and drugs containing said derivatives - Google Patents

Derivatives of piperidenedione,process for preparing them and drugs containing said derivatives

Info

Publication number: ZA838065B
Authority: ZA; South Africa
Prior art keywords: derivatives; drugs containing; piperidenedione; preparing; represent
Prior art date: 1982-11-08

Application number

ZA838065A

Other languages

English (en)

Inventor

Claude Bernhart

Werner Cautreels

Patrick Gautier

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-08

Filing date

1983-10-28

Publication date

1984-06-27

1983-10-28 Application filed by Sanofi Sa filed Critical Sanofi Sa

1984-06-27 Publication of ZA838065B publication Critical patent/ZA838065B/xx

Links

239000003814 drug Substances 0.000 title abstract 2
229940079593 drug Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 4
238000000034 method Methods 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000005458 piperidinediones Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA838065A 1982-11-08 1983-10-28 Derivatives of piperidenedione,process for preparing them and drugs containing said derivatives ZA838065B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8218706A FR2535721A1 (fr)	1982-11-08	1982-11-08	Derives de la piperidinedione protecteurs du myocarde presentant une acticite antiarythmique, leur procede de preparation et les medicaments qui contiennent lesdits derives

Publications (1)

Publication Number	Publication Date
ZA838065B true ZA838065B (en)	1984-06-27

Family

ID=9279000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA838065A ZA838065B (en)	1982-11-08	1983-10-28	Derivatives of piperidenedione,process for preparing them and drugs containing said derivatives

Country Status (29)

Country	Link
US (1)	US4721710A (da)
EP (1)	EP0110755B1 (da)
JP (1)	JPS59161377A (da)
KR (1)	KR900006721B1 (da)
AT (1)	ATE22561T1 (da)
AU (1)	AU565519B2 (da)
CA (1)	CA1221967A (da)
CS (1)	CS244681B2 (da)
DD (3)	DD229407A5 (da)
DE (1)	DE3366623D1 (da)
DK (1)	DK511383A (da)
ES (1)	ES527091A0 (da)
FI (1)	FI79536C (da)
FR (1)	FR2535721A1 (da)
GR (1)	GR78747B (da)
HU (1)	HU191494B (da)
IE (1)	IE56209B1 (da)
IL (1)	IL70099A (da)
MA (1)	MA19948A1 (da)
NO (1)	NO159852C (da)
NZ (1)	NZ206177A (da)
OA (1)	OA07582A (da)
PH (1)	PH20421A (da)
PL (3)	PL139946B1 (da)
PT (1)	PT77607B (da)
SG (1)	SG1989G (da)
SU (3)	SU1333237A3 (da)
YU (3)	YU221183A (da)
ZA (1)	ZA838065B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4668689A (en) *	1984-07-19	1987-05-26	National Research Development Corporation	Glutarimide derivatives for treating oestrogen-dependent tumors
US5238947A (en) *	1990-04-12	1993-08-24	University Of Georgia Research Foundation, Inc.	Synthetic piperidinediones with cytostatic activity
US5463063A (en) *	1993-07-02	1995-10-31	Celgene Corporation	Ring closure of N-phthaloylglutamines
DE19703763C1 (de) *	1997-02-01	1998-10-01	Gruenenthal Gmbh	Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione
WO2012158795A1 (en)	2011-05-17	2012-11-22	Principia Biopharma Inc.	Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
EA025496B1 (ru)	2011-05-17	2016-12-30	Принсипиа Биофарма Инк.	Ингибиторы тирозинкиназы
HUE048834T2 (hu)	2011-05-17	2020-08-28	Univ California	Kináz inhibitorok
US9266895B2 (en)	2012-09-10	2016-02-23	Principia Biopharma Inc.	Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
US8957080B2 (en)	2013-04-09	2015-02-17	Principia Biopharma Inc.	Tyrosine kinase inhibitors
EP4681737A3 (en)	2014-02-21	2026-03-11	Principia Biopharma Inc.	Salts and solid form of a btk inhibitor
US10485797B2 (en)	2014-12-18	2019-11-26	Principia Biopharma Inc.	Treatment of pemphigus
TW201718572A (zh)	2015-06-24	2017-06-01	普林斯匹亞生物製藥公司	酪胺酸激酶抑制劑
IL293621B2 (en)	2016-06-29	2023-09-01	Principia Biopharma Inc	Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(oxane-3-yl)piperazine-1-yl)penta-2-ananitrile
JP7795454B2 (ja)	2019-10-14	2026-01-07	プリンシピアバイオファーマインコーポレイテッド	（ｒ）－２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペンタ－２－エンニトリルを投与することにより免疫性血小板減少症を治療する方法
AU2021209884A1 (en)	2020-01-22	2022-09-15	Principia Biopharma Inc.	Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2664424A (en) *		1953-12-29		Dioxo-piperidines
GB1455687A (en) *	1972-12-28	1976-11-17	Aspro Nicholas Ltd	Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
FR2467200A1 (fr) *	1979-10-11	1981-04-17	Clin Midy	Derives du pyrrole actifs sur les troubles du rythme cardiovasculaire

1982
- 1982-11-08 FR FR8218706A patent/FR2535721A1/fr active Granted
1983
- 1983-10-28 ZA ZA838065A patent/ZA838065B/xx unknown
- 1983-10-31 IL IL70099A patent/IL70099A/xx unknown
- 1983-11-02 AU AU20898/83A patent/AU565519B2/en not_active Ceased
- 1983-11-04 IE IE2581/83A patent/IE56209B1/xx unknown
- 1983-11-04 AT AT83402142T patent/ATE22561T1/de not_active IP Right Cessation
- 1983-11-04 DE DE8383402142T patent/DE3366623D1/de not_active Expired
- 1983-11-04 PT PT77607A patent/PT77607B/pt not_active IP Right Cessation
- 1983-11-04 EP EP83402142A patent/EP0110755B1/fr not_active Expired
- 1983-11-04 GR GR72874A patent/GR78747B/el unknown
- 1983-11-05 SU SU833661804A patent/SU1333237A3/ru active
- 1983-11-07 NZ NZ206177A patent/NZ206177A/en unknown
- 1983-11-07 NO NO834057A patent/NO159852C/no unknown
- 1983-11-07 MA MA20168A patent/MA19948A1/fr unknown
- 1983-11-07 DD DD83270120A patent/DD229407A5/de not_active IP Right Cessation
- 1983-11-07 DD DD83256411A patent/DD219770A5/de not_active IP Right Cessation
- 1983-11-07 DD DD83270121A patent/DD229402A5/de not_active IP Right Cessation
- 1983-11-08 CA CA000440675A patent/CA1221967A/en not_active Expired
- 1983-11-08 JP JP58209772A patent/JPS59161377A/ja active Pending
- 1983-11-08 PL PL1983244462A patent/PL139946B1/pl unknown
- 1983-11-08 FI FI834087A patent/FI79536C/fi not_active IP Right Cessation
- 1983-11-08 PH PH29800A patent/PH20421A/en unknown
- 1983-11-08 PL PL1983249749A patent/PL140992B1/pl unknown
- 1983-11-08 DK DK511383A patent/DK511383A/da not_active Application Discontinuation
- 1983-11-08 CS CS838220A patent/CS244681B2/cs unknown
- 1983-11-08 YU YU02211/83A patent/YU221183A/xx unknown
- 1983-11-08 KR KR1019830005288A patent/KR900006721B1/ko not_active Expired
- 1983-11-08 ES ES527091A patent/ES527091A0/es active Granted
- 1983-11-08 PL PL1983249750A patent/PL140021B1/pl unknown
- 1983-11-08 OA OA58153A patent/OA07582A/xx unknown
- 1983-11-08 HU HU833827A patent/HU191494B/hu not_active IP Right Cessation
1984
- 1984-09-06 SU SU843786907A patent/SU1316558A3/ru active
- 1984-09-06 SU SU843786916A patent/SU1333238A3/ru active
1985
- 1985-11-26 YU YU01842/85A patent/YU184285A/xx unknown
- 1985-11-26 YU YU01841/85A patent/YU184185A/xx unknown
1986
- 1986-03-10 US US06/838,255 patent/US4721710A/en not_active Expired - Fee Related
1989
- 1989-01-11 SG SG19/89A patent/SG1989G/en unknown

Also Published As

Publication number	Publication date
PL249750A1 (en)	1985-03-12
GR78747B (da)	1984-10-02
IL70099A0 (en)	1984-01-31
PT77607B (fr)	1986-03-18
EP0110755A1 (fr)	1984-06-13
OA07582A (fr)	1985-03-31
SG1989G (en)	1989-06-02
ES8406070A1 (es)	1984-07-01
PL140021B1 (en)	1987-03-31
US4721710A (en)	1988-01-26
JPS59161377A (ja)	1984-09-12
IE56209B1 (en)	1991-05-22
IE832581L (en)	1984-05-08
FR2535721B1 (da)	1985-05-17
FI79536C (fi)	1990-01-10
CA1221967A (en)	1987-05-19
CS244681B2 (en)	1986-08-14
SU1333237A3 (ru)	1987-08-23
FI79536B (fi)	1989-09-29
KR840006641A (ko)	1984-12-01
ES527091A0 (es)	1984-07-01
YU184285A (en)	1986-06-30
MA19948A1 (fr)	1984-07-01
PL244462A1 (en)	1985-02-13
ATE22561T1 (de)	1986-10-15
NO159852C (no)	1989-02-15
DE3366623D1 (en)	1986-11-06
FR2535721A1 (fr)	1984-05-11
YU221183A (en)	1986-06-30
YU184185A (en)	1986-06-30
DK511383A (da)	1984-05-09
NZ206177A (en)	1985-11-08
PH20421A (en)	1987-01-05
AU565519B2 (en)	1987-09-17
KR900006721B1 (ko)	1990-09-20
FI834087A0 (fi)	1983-11-08
PL139946B1 (en)	1987-03-31
IL70099A (en)	1987-10-20
HU191494B (en)	1987-02-27
PL249749A1 (en)	1985-03-12
AU2089883A (en)	1984-05-17
DD219770A5 (de)	1985-03-13
SU1333238A3 (ru)	1987-08-23
NO159852B (no)	1988-11-07
PT77607A (fr)	1983-12-01
FI834087L (fi)	1984-05-09
EP0110755B1 (fr)	1986-10-01
PL140992B1 (en)	1987-06-30
NO834057L (no)	1984-05-09
DD229407A5 (de)	1985-11-06
SU1316558A3 (ru)	1987-06-07
DK511383D0 (da)	1983-11-08
DD229402A5 (de)	1985-11-06

Publication	Publication Date	Title
PL249749A1 (en)	1985-03-12	Process for preparing novel derivatives of piperidinedione
HUT60734A (en)	1992-10-28	Process for producing substituted azoles and pharmaceutical compositions comprising such compounds
HUT68166A (en)	1995-05-29	Process for preparing substituted piperidines
PL293392A1 (en)	1992-07-13	Method of obtaining novel derivatives of 3-aminopiperidine
DK357482A (da)	1983-02-11	Fremgangsmaade til fremstilling af 4-methyl-6-phenyl-pyridazinderivater
EP0280946A3 (en)	1990-05-09	Organosilanes containing benzoylthiourea; process for their preparation
DE3160360D1 (en)	1983-07-07	5-subsituted 5,10-dihydro-11h-dibenzo(b,e)(1,4)diazepin-11-ones, process for preparing them and medicaments containing them
ES8501771A1 (es)	1984-12-01	Procedimiento para la preparacion de un nuevo compuesto heterociclico
HUT50142A (en)	1989-12-28	Process for producing allyl-mercapto-acetyl-sidnonimine derivatives and pharmaceutical compositions containing them
CS859582A2 (en)	1984-02-13	Zpusob pripravy cefalosporinu
FI830338L (fi)	1983-08-09	Foerfarande foer framstaellning av piperazinyl-4 fenyl-4 kinatsolin derivat
HUT48891A (en)	1989-07-28	Process for producing substituted vinyl-cephalosporines and pharmaceutical compositions containing t them
DE3564426D1 (en)	1988-09-22	Polyprenyl compound, process of producing it and pharmaceutical use
ZA828491B (en)	1983-09-28	Alkylcycloalkyl imidazolylmethyl ketones and a process for their preparation
AT383811B (de)	1987-08-25	Verfahren zur herstellung von monoalkalisalzen von 7-amino-3-cephem-4-carbonsaeurederivaten
CS821983A2 (en)	1985-10-16	Zpusob pripravy derivatu gama-butyrolaktonu