DK56086A - 11beta-phenylgonaner, deres fremstilling og farmaceutiske indeholdende dem - Google Patents

11beta-phenylgonaner, deres fremstilling og farmaceutiske indeholdende dem Download PDF

Info

Publication number
DK56086A
DK56086A DK56086A DK56086A DK56086A DK 56086 A DK56086 A DK 56086A DK 56086 A DK56086 A DK 56086A DK 56086 A DK56086 A DK 56086A DK 56086 A DK56086 A DK 56086A
Authority
DK
Denmark
Prior art keywords
phenylgonanes
11beta
preparation
pharmaceutical contents
pharmaceutical
Prior art date
Application number
DK56086A
Other languages
English (en)
Other versions
DK161709C (da
DK56086D0 (da
DK161709B (da
Inventor
Guenter Neef
Sybille Beier
Walter Elger
David Henderson
Eckard Ottow
Ralph Rohde
Rudolf Wiechert
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853504421 external-priority patent/DE3504421A1/de
Priority claimed from DE19853527517 external-priority patent/DE3527517A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK56086D0 publication Critical patent/DK56086D0/da
Publication of DK56086A publication Critical patent/DK56086A/da
Publication of DK161709B publication Critical patent/DK161709B/da
Application granted granted Critical
Publication of DK161709C publication Critical patent/DK161709C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK056086A 1985-02-07 1986-02-05 13-alkyl-11beta-phenylgonaner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende dem samt deres anvendelse til fremstilling af laegemidler DK161709C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19853504421 DE3504421A1 (de) 1985-02-07 1985-02-07 Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3504421 1985-02-07
DE3527517 1985-07-29
DE19853527517 DE3527517A1 (de) 1985-07-29 1985-07-29 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate

Publications (4)

Publication Number Publication Date
DK56086D0 DK56086D0 (da) 1986-02-05
DK56086A true DK56086A (da) 1986-08-08
DK161709B DK161709B (da) 1991-08-05
DK161709C DK161709C (da) 1992-01-13

Family

ID=25829248

Family Applications (1)

Application Number Title Priority Date Filing Date
DK056086A DK161709C (da) 1985-02-07 1986-02-05 13-alkyl-11beta-phenylgonaner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende dem samt deres anvendelse til fremstilling af laegemidler

Country Status (16)

Country Link
US (1) US5089635A (da)
EP (1) EP0190759B1 (da)
CN (1) CN1033753C (da)
AU (1) AU580843B2 (da)
CA (1) CA1310630C (da)
DE (1) DE3665307D1 (da)
DK (1) DK161709C (da)
ES (1) ES8701778A1 (da)
FI (1) FI85377C (da)
GR (1) GR860342B (da)
HU (1) HU194904B (da)
IE (1) IE58149B1 (da)
IL (1) IL77762A (da)
NO (1) NO171994C (da)
NZ (1) NZ214998A (da)
PT (1) PT81969B (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
GB8513723D0 (en) * 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids
DE3866410D1 (de) * 1987-04-24 1992-01-09 Akzo Nv 11-arylestranderivate und 11-arylpregnanderivate.
DE3723788A1 (de) * 1987-07-16 1989-01-26 Schering Ag 11(beta)-phenyl-4,9,15-estratriene, deren herstellung und diese enthaltende pharmazeutische praeparate
AU625450B2 (en) * 1987-07-16 1992-07-09 Schering Aktiengesellschaft Berlin Und Bergkamen 11beta-phenyl-4,9,15-estratrienes, their manufacture, and pharmaceutical preparations containing them
ES2053714T3 (es) * 1987-12-12 1994-08-01 Akzo Nv Proceso para la preparacion de 11-arilesteroides.
DE3822770A1 (de) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
FR2665901B2 (fr) * 1989-02-24 1994-07-29 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments.
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
JP2959839B2 (ja) * 1989-07-07 1999-10-06 アンドルシェルシュ・インコーポレイテッド 性ステロイド活性の抑制における使用のためのアンドロゲン誘導体
DK0595796T3 (da) * 1989-07-07 2003-05-05 Endorech Inc Fremgangsmåde til behandling af androgen-relaterede sygdomme
DK0411733T3 (da) * 1989-08-04 1999-06-28 Schering Ag 11-beta-aryl-gona-4,9-dien-3-oner
DE4042007A1 (de) * 1990-12-22 1992-06-25 Schering Ag 6,7-modifizierte-11(beta)-aryl-4-estrene
DE69128820T2 (de) * 1990-08-14 1998-06-10 Hoechst Marion Roussel Inc Neue 19-Nor Steroide, die eine Amid tragende Gruppe in der 11-Beta-Stelle haben, ihre Herstellung, ihre Verwendung als Medikamente und pharmazeutische Präparate davon
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
FR2688004A1 (fr) * 1992-02-27 1993-09-03 Roussel Uclaf Nouveaux sterouides comportant en position 17 un radical methylene lactone, leur procede et des intermediaires de preparation, leur application comme medicaments.
KR950701527A (ko) * 1992-05-21 1995-04-28 라브리 페르낭 테스토스테론 5α 환원효소 활성 저해제(INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY)
DE4332284C2 (de) * 1993-09-20 1997-05-28 Jenapharm Gmbh 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
US5521166A (en) * 1994-12-19 1996-05-28 Ortho Pharmaceitical Corporation Antiprogestin cyclophasic hormonal regimen
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
ES2152671T3 (es) 1996-05-01 2001-02-01 Us Gov Health & Human Serv Derivados de progesterona sustituidos en posicion 21 como nuevos agentes antiprogestacionales.
IL122740A (en) * 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
US6090798A (en) * 1997-12-19 2000-07-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with glucocorticoid antagonists
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
EP1285927A3 (de) * 2001-08-16 2005-06-29 Schering Aktiengesellschaft Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
DE10236405A1 (de) * 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
DE102009034367A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
WO2011150209A1 (en) 2010-05-26 2011-12-01 Corcept Therapeutics, Inc. Treatment of muscular dystrophy
JP6821582B2 (ja) 2015-03-02 2021-01-27 コーセプト セラピューティクス， インコーポレイテッド Ａｃｔｈ分泌腫瘍を処置するための糖質コルチコイドレセプターアンタゴニストおよびソマトスタチンアナログの使用
JP6754533B2 (ja) 2015-03-30 2020-09-16 コーセプト セラピューティクス， インコーポレイテッド 副腎機能不全を処置するための糖質コルチコイドと組み合わせた糖質コルチコイドレセプターアンタゴニストの使用
MX383318B (es) 2015-08-13 2025-03-13 Corcept Therapeutics Inc Metodo para diagnosticar de manera diferencial el sindrome de cushing dependiente de la corticotropina.
JP6765443B2 (ja) 2016-01-19 2020-10-07 コーセプト セラピューティクス， インコーポレイテッド 異所性クッシング症候群の鑑別診断
US9943505B2 (en) 2016-09-09 2018-04-17 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat pancreatic cancer
AU2018244928B2 (en) 2017-03-31 2023-10-19 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat cervical cancer
WO2018236749A2 (en) 2017-06-20 2018-12-27 Corcept Therapeutics, Inc. Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
EP4263807A2 (en) 2020-12-18 2023-10-25 Instil Bio (Uk) Limited Processing of tumor infiltrating lymphocytes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
DE3231827A1 (de) * 1982-08-24 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2573657B1 (fr) * 1984-11-29 1989-05-12 Roussel Uclaf Produit comprenant une substance antiprogestomimetique et une substance uterotonique
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
FI860559L (fi) 1986-08-08
HU194904B (en) 1988-03-28
NO171994C (no) 1993-05-26
DK161709C (da) 1992-01-13
EP0190759A2 (de) 1986-08-13
FI85377C (fi) 1992-04-10
DK56086D0 (da) 1986-02-05
PT81969B (pt) 1988-03-03
FI860559A0 (fi) 1986-02-07
NO860425L (no) 1986-08-08
GR860342B (en) 1986-06-03
IE58149B1 (en) 1993-07-14
FI85377B (fi) 1991-12-31
ES551625A0 (es) 1986-12-16
DK161709B (da) 1991-08-05
IL77762A (en) 1992-08-18
EP0190759B1 (de) 1989-08-30
CN86100994A (zh) 1986-10-08
NZ214998A (en) 1989-06-28
CN1033753C (zh) 1997-01-08
IE860334L (en) 1986-08-07
ES8701778A1 (es) 1986-12-16
NO171994B (no) 1993-02-15
PT81969A (de) 1986-03-01
AU580843B2 (en) 1989-02-02
EP0190759A3 (en) 1986-11-20
DE3665307D1 (en) 1989-10-05
HUT40453A (en) 1986-12-28
CA1310630C (en) 1992-11-24
US5089635A (en) 1992-02-18
AU5291386A (en) 1986-08-14

Similar Documents

Publication Publication Date Title
DK56086D0 (da) 11beta-phenylgonaner, deres fremstilling og farmaceutiske praeparaterindeholdende dem
DK139287D0 (da) Tertiaere hydroxyalkylxanthiner, deres fremstilling og anvendelse som laegemidler
DK163923C (da) 2-phenyl-3-aminomethyl-imidazooe1,2-aaapyridinderivater og farmaceutisk praeparat indeholdende saadanne forbindelser
DK143588A (da) Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler
DK518687D0 (da) Imidazo-benzoxazinoner, deres fremstilling og laegemidler indholdende forbindelserne
DK164907C (da) Piperazinderivater, deres fremstilling og farmaceutiske praeparater indeholdende dem
DK129386A (da) Iodpropargylethere, deres fremstilling og anvendelse
DK590185D0 (da) Imidazoderivater, deres fremstilling og laegemiddel indeholdende saadanne forbindelser
DK272486A (da) Tienopyridoner og farmaceutiske praeparater indeholdende dem
DK592685A (da) Imidazoderivater, deres fremstilling og laegemiddel indeholdende saadanne forbindelser
DK519586A (da) 1-aryl-4-nitro-pyrazoler, deres fremstilling og anvendelse
DK272386A (da) Quinoloner og farmaceutiske praeparater indeholdende dem
DK504986D0 (da) 7-acylbenzoxazinoner og deres derivater, fremgangsmaade til deres fremstilling og farmaceutiske midler indeholdende dem
DK366888A (da) Castanosperminestre og -glykosider, deres fremstilling og anvendelse som laegemidler
DK307385A (da) Morpholinolforbindelser, deres fremstilling og farmaceutiske anvendelse
DK488385A (da) N6-bicycloadenosinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende saadanne forbindelser
DK420986A (da) Dihydropyridin-2-hydroxyaminer, fremgangsmaade til deres fremstilling og deres anvendelse i laege-midler
DK183585D0 (da) Iminothiazolidinderivater, deres fremstilling og farmaceutiske praeparater deraf
DK380286A (da) Sulfonamider, deres fremstilling og anvendelse
DK548586D0 (da) Thienylsulfonylguanidin-derivater, deres fremstilling og anvendelse
DK396886A (da) Gem-dihalogen-1,8-diamino-4-azaoctaner, deres fremstilling og anvendelse
DK377786D0 (da) 1-aryl-5-hydrazino-pyrazoler, deres fremstilling og anvendelse
DK393986A (da) Lactamamider, deres fremstilling og anvendelse
DK161022C (da) Imidazoquinoxalinforbindelser, deres fremstilling og farmaceutiske praeparater, der indeholder forbindelserne
DK14885D0 (da) 1,4-dihydropyrazin, deres fremstilling og anvendelse som laegemidler

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK