DK728588D0 - Gaercelle omfattende en dna-konstruktion, der tilvejebringer ekspression og secernering af et ikke-gaerprotein, samt dobbeltstrenget dna-molekyle - Google Patents

Gaercelle omfattende en dna-konstruktion, der tilvejebringer ekspression og secernering af et ikke-gaerprotein, samt dobbeltstrenget dna-molekyle

Info

Publication number: DK728588D0
Authority: DK; Denmark
Prior art keywords: yeast; protein; encodes; precursor polypeptide; precursor
Prior art date: 1987-12-30

Application number

DK728588A

Other languages

English (en)

Other versions

DK175910B1 (da

DK728588A (da

Inventor

Patricia Tekamp-Olson

Original Assignee

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-30

Filing date

1988-12-29

Publication date

1988-12-29

1988-12-29 Application filed by Chiron Corp filed Critical Chiron Corp

1988-12-29 Publication of DK728588D0 publication Critical patent/DK728588D0/da

1989-07-01 Publication of DK728588A publication Critical patent/DK728588A/da

2005-01-27 Priority to DK200500130A priority Critical patent/DK176075B1/da

2005-06-13 Application granted granted Critical

2005-06-13 Publication of DK175910B1 publication Critical patent/DK175910B1/da

Links

108020004414 DNA Proteins 0.000 title abstract 5
108090000623 proteins and genes Proteins 0.000 title abstract 3
102000053602 DNA Human genes 0.000 title abstract 2
102000004169 proteins and genes Human genes 0.000 title abstract 2
238000010276 construction Methods 0.000 title 1
239000002243 precursor Substances 0.000 abstract 8
229920001184 polypeptide Polymers 0.000 abstract 7
108090000765 processed proteins & peptides Proteins 0.000 abstract 7
102000004196 processed proteins & peptides Human genes 0.000 abstract 7
108010058643 Fungal Proteins Proteins 0.000 abstract 5
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 4
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
238000003776 cleavage reaction Methods 0.000 abstract 3
230000013595 glycosylation Effects 0.000 abstract 3
238000006206 glycosylation reaction Methods 0.000 abstract 3
230000007017 scission Effects 0.000 abstract 3
108091026890 Coding region Proteins 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
101150045458 KEX2 gene Proteins 0.000 abstract 2
238000001727 in vivo Methods 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
108010016626 Dipeptides Proteins 0.000 abstract 1
102000005593 Endopeptidases Human genes 0.000 abstract 1
108010059378 Endopeptidases Proteins 0.000 abstract 1
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
102100037852 Insulin-like growth factor I Human genes 0.000 abstract 1
125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
108010076181 Proinsulin Proteins 0.000 abstract 1
108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
241000235070 Saccharomyces Species 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
230000005026 transcription initiation Effects 0.000 abstract 1
230000005030 transcription termination Effects 0.000 abstract 1
210000005253 yeast cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Mycology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
General Engineering & Computer Science (AREA)
Endocrinology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

DK198807285A 1987-12-30 1988-12-29 Gærcelle omfattende en DNA-konstruktion, der tilvejebringer ekspression og secernering af et ikke-gærprotein, samt dobbeltstrenget DNA-molekyle DK175910B1 (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK200500130A DK176075B1 (da)	1987-12-30	2005-01-27	Gærcelle opfattende en DNA-konstruktion, der tilvejbringer ekspression og secernering af et ikke-gærprotein, samt dobbeltstrenget DNA-molekyle

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13968287A	1987-12-30	1987-12-30
US13968287		1987-12-30

Publications (3)

Publication Number	Publication Date
DK728588D0 true DK728588D0 (da)	1988-12-29
DK728588A DK728588A (da)	1989-07-01
DK175910B1 DK175910B1 (da)	2005-06-13

Family

ID=22487825

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK198807285A DK175910B1 (da)	1987-12-30	1988-12-29	Gærcelle omfattende en DNA-konstruktion, der tilvejebringer ekspression og secernering af et ikke-gærprotein, samt dobbeltstrenget DNA-molekyle
DK200500130A DK176075B1 (da)	1987-12-30	2005-01-27	Gærcelle opfattende en DNA-konstruktion, der tilvejbringer ekspression og secernering af et ikke-gærprotein, samt dobbeltstrenget DNA-molekyle

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK200500130A DK176075B1 (da)	1987-12-30	2005-01-27	Gærcelle opfattende en DNA-konstruktion, der tilvejbringer ekspression og secernering af et ikke-gærprotein, samt dobbeltstrenget DNA-molekyle

Country Status (15)

Country	Link
US (2)	US5602034A (da)
EP (1)	EP0324274B1 (da)
JP (1)	JP2793215B2 (da)
AT (1)	ATE97441T1 (da)
AU (1)	AU616228B2 (da)
CA (1)	CA1340772C (da)
DE (1)	DE3885728T2 (da)
DK (2)	DK175910B1 (da)
ES (1)	ES2059547T3 (da)
FI (1)	FI100995B (da)
HK (1)	HK139994A (da)
IE (1)	IE62087B1 (da)
IL (1)	IL88802A0 (da)
NO (1)	NO178829C (da)
PT (1)	PT89367B (da)

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- 1988-12-23 EP EP88312306A patent/EP0324274B1/en not_active Expired - Lifetime
- 1988-12-23 ES ES88312306T patent/ES2059547T3/es not_active Expired - Lifetime
- 1988-12-23 DE DE88312306T patent/DE3885728T2/de not_active Expired - Lifetime
- 1988-12-23 AT AT88312306T patent/ATE97441T1/de not_active IP Right Cessation
- 1988-12-26 IL IL88802A patent/IL88802A0/xx unknown
- 1988-12-28 FI FI886008A patent/FI100995B/fi not_active IP Right Cessation
- 1988-12-28 NO NO885786A patent/NO178829C/no unknown
- 1988-12-29 DK DK198807285A patent/DK175910B1/da not_active IP Right Cessation
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1994
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1998
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DK200500130A (da)	2005-01-27
EP0324274B1 (en)	1993-11-18
NO885786D0 (no)	1988-12-28
DK175910B1 (da)	2005-06-13
US5602034A (en)	1997-02-11
NO178829C (no)	1996-06-12
ATE97441T1 (de)	1993-12-15
JP2793215B2 (ja)	1998-09-03
DE3885728T2 (de)	1994-03-10
ES2059547T3 (es)	1994-11-16
AU616228B2 (en)	1991-10-24
DK176075B1 (da)	2006-04-10
NO178829B (no)	1996-03-04
IE883896L (en)	1989-06-30
HK139994A (en)	1994-12-16
DE3885728D1 (de)	1993-12-23
EP0324274A1 (en)	1989-07-19
JPH022339A (ja)	1990-01-08
IL88802A0 (en)	1989-07-31
NO885786L (no)	1989-07-03
IE62087B1 (en)	1994-12-14
USRE37343E1 (en)	2001-08-28
FI886008L (fi)	1989-07-01
DK728588A (da)	1989-07-01
FI100995B (fi)	1998-03-31
AU2765088A (en)	1989-07-06
CA1340772C (en)	1999-09-28
PT89367B (pt)	1993-09-30
PT89367A (pt)	1989-12-29

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2009-01-19	PUP	Patent expired

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