DZ1634A1 - Indolpyrrolcarbazole dérivatives les dérives de l0indolopyrolocarbazole. - Google Patents

Indolpyrrolcarbazole dérivatives les dérives de l0indolopyrolocarbazole.

Info

Publication number: DZ1634A1
Authority: DZ; Algeria
Prior art keywords: substd; opt; carboxyl; alkyl; carbamoyl
Prior art date: 1991-11-29

Application number

DZ920145A

Other languages

English (en)

Inventor

Katsuhisa Kojzir

Hisao Kondo

Hiroharu Arakwa

Mitsuru Ohkudo

Biroyuki Suda

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-29

Filing date

1992-11-22

Publication date

2002-02-17

1992-11-22 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

2002-02-17 Application granted granted Critical

2002-02-17 Publication of DZ1634A1 publication Critical patent/DZ1634A1/fr

Links

125000000217 alkyl group Chemical group 0.000 abstract 5
-1 alkenyl alkynyl Chemical group 0.000 abstract 4
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 4
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
125000004663 dialkyl amino group Chemical group 0.000 abstract 3
RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002402 hexoses Chemical class 0.000 abstract 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
150000002972 pentoses Chemical class 0.000 abstract 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Silicon Polymers (AREA)

DZ920145A 1991-11-29 1992-11-22 Indolpyrrolcarbazole dérivatives les dérives de l0indolopyrolocarbazole. DZ1634A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP34191691		1991-11-29
JP6926992		1992-02-18
JP25730692		1992-09-01

Publications (1)

Publication Number	Publication Date
DZ1634A1 true DZ1634A1 (fr)	2002-02-17

Family

ID=27300000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DZ920145A DZ1634A1 (fr)	1991-11-29	1992-11-22	Indolpyrrolcarbazole dérivatives les dérives de l0indolopyrolocarbazole.

Country Status (27)

Country	Link
EP (1)	EP0545195B1 (fr)
JP (1)	JP2629542B2 (fr)
KR (1)	KR100275976B1 (fr)
AT (1)	ATE130617T1 (fr)
AU (1)	AU650376B2 (fr)
BG (1)	BG61036B1 (fr)
CA (1)	CA2083534C (fr)
CZ (1)	CZ287304B6 (fr)
DE (1)	DE69206242T2 (fr)
DK (1)	DK0545195T3 (fr)
DZ (1)	DZ1634A1 (fr)
ES (1)	ES2079774T3 (fr)
FI (1)	FI106864B (fr)
GR (1)	GR3018527T3 (fr)
HU (3)	HU9203754D0 (fr)
IL (1)	IL103844A (fr)
MX (1)	MX9206847A (fr)
MY (1)	MY114655A (fr)
NO (1)	NO178929C (fr)
NZ (1)	NZ245203A (fr)
PL (1)	PL171468B1 (fr)
RO (1)	RO113469B1 (fr)
RU (1)	RU2117671C1 (fr)
SA (1)	SA93130351B1 (fr)
TW (1)	TW224469B (fr)
WO (1)	WO1993011145A1 (fr)
YU (1)	YU48963B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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WO1995030682A1 (fr) *	1994-05-09	1995-11-16	Banyu Pharmaceutical Co., Ltd.	Derive d'indolopyrolocarbazole antitumoral
EP0760375B1 (fr) *	1994-05-09	2003-11-26	Banyu Pharmaceutical Co., Ltd.	Derive d'indolopyrolocarbazole antitumoral
JP3707075B2 (ja) *	1994-06-13	2005-10-19	萬有製薬株式会社	グリコシルトランスフェラーゼをコードする遺伝子及びその用途
AU3086495A (en) *	1994-08-02	1996-03-04	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazoles
US5705511A (en) *	1994-10-14	1998-01-06	Cephalon, Inc.	Fused pyrrolocarbazoles
US5591855A (en) *	1994-10-14	1997-01-07	Cephalon, Inc.	Fused pyrrolocarbazoles
US5594009A (en) *	1994-10-14	1997-01-14	Cephalon, Inc.	Fused pyrrolocarbazoles
US5475110A (en) *	1994-10-14	1995-12-12	Cephalon, Inc.	Fused Pyrrolocarbazoles
AU6836696A (en) *	1995-09-05	1997-03-27	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
US5616724A (en) *	1996-02-21	1997-04-01	Cephalon, Inc.	Fused pyrrolo[2,3-c]carbazole-6-ones
JP2000516250A (ja) *	1996-08-22	2000-12-05	ブリストルーマイヤーズスクイブカンパニー	インドロピロロカルバゾールの細胞毒性アミノ糖および関連する糖誘導体
GB9811624D0 (en) *	1998-05-29	1998-07-29	Merck Sharp & Dohme	Therapeutic use
US6013646A (en) *	1998-07-02	2000-01-11	Bayer Corporation	Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6703373B1 (en)	1999-09-10	2004-03-09	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives and antitumor agents
FR2801054B1 (fr) *	1999-11-17	2003-06-13	Adir	Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2001062769A1 (fr)	2000-02-24	2001-08-30	Banyu Pharmaceutical Co., Ltd.	Procede de preparation de derives d'indolopyrrolocarbazole, leurs intermediaires, et procede de preparation des intermediaires
US6610727B2 (en)	2000-10-06	2003-08-26	Bristol-Myers Squibb Company	Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en)	2000-10-06	2003-11-25	Bristol-Myers Squibb Company	Tumor proliferation inhibitors
US6677450B2 (en)	2000-10-06	2004-01-13	Bristol-Myers Squibb Company	Topoisomerase inhibitors
US6555677B2 (en)	2000-10-31	2003-04-29	Merck & Co., Inc.	Phase transfer catalyzed glycosidation of an indolocarbazole
JP2004534006A (ja)	2001-03-22	2004-11-11	ブリストル−マイヤーズ　スクイブ　カンパニー	インドロピロロカルバゾール化合物のトポイソメラーゼｉ選択的細胞毒シュガー誘導体
US6559299B2 (en)	2001-03-29	2003-05-06	Merck & Co., Inc.	Preparation and isolation of indolocarbazole glycosides
KR20040097237A (ko) *	2002-03-26	2004-11-17	반유 세이야꾸 가부시끼가이샤	항종양성 인돌로피롤로카바졸 유도체와 기타 항암제의 병용
CA2398828A1 (fr)	2002-08-09	2004-02-09	Merck & Co., Inc.	Une composition pharmaceutique contenant un derive de l'indolopyrrolocarbazole
KR20050058444A (ko) *	2002-08-23	2005-06-16	반유 세이야꾸 가부시끼가이샤	인돌로피롤로카르바졸 유도체의 제조법
AU2003248103A1 (en) *	2003-07-24	2005-02-14	Banyu Pharmaceutical Co., Ltd	Indolopyrrolocarbazole derivative and antitumor agent
EP1666485A1 (fr) *	2003-09-16	2006-06-07	Banyu Pharmaceutical Co., Ltd.	Nouveau derive d'indolopyrrolocarbazole a active anti-tumeur
US7241779B2 (en)	2003-12-23	2007-07-10	Cephalon, Inc.	Fused pyrrolocarbazoles
US7169802B2 (en)	2003-12-23	2007-01-30	Cephalon, Inc.	Fused pyrrolocarbazoles
RU2255089C1 (ru) *	2003-12-26	2005-06-27	Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории"	Производные гликозидов индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-дионов, обладающие цитотоксической и противоопухолевой активностью
ES2326459B1 (es)	2008-04-08	2010-05-28	Universidad De Oviedo	Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
WO2010059795A1 (fr)	2008-11-19	2010-05-27	Cephalon, Inc.	Nouvelles formes d'un composé indazolo [5,4-a] pyrrolo [3,4-c] carbazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4785085A (en) *	1986-11-21	1988-11-15	Bristol-Myers Company	Rebeccamycin analogs
DE4005969A1 (de) *	1990-02-26	1991-08-29	Boehringer Mannheim Gmbh	Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
IL97233A (en) *	1990-03-06	1995-03-30	Bristol Myers Squibb Co	Rebeccamycin analogs, their production and pharmaceutical compositions containing them
JPH0725787B2 (ja) *	1990-03-06	1995-03-22	ブリストル−マイヤーズスクイブカンパニー	臭化物前駆物質物質供給によるレベカマイシン類似体
SK108293A3 (en) *	1991-04-11	1994-09-07	Schering Corp	Anti-tumor and anti-psoriatic agents

1992
- 1992-11-20 NZ NZ245203A patent/NZ245203A/en not_active IP Right Cessation
- 1992-11-22 DZ DZ920145A patent/DZ1634A1/fr active
- 1992-11-23 AT AT92119904T patent/ATE130617T1/de not_active IP Right Cessation
- 1992-11-23 DK DK92119904.8T patent/DK0545195T3/da active
- 1992-11-23 DE DE69206242T patent/DE69206242T2/de not_active Expired - Fee Related
- 1992-11-23 IL IL103844A patent/IL103844A/xx not_active IP Right Cessation
- 1992-11-23 EP EP92119904A patent/EP0545195B1/fr not_active Expired - Lifetime
- 1992-11-23 ES ES92119904T patent/ES2079774T3/es not_active Expired - Lifetime
- 1992-11-23 CA CA002083534A patent/CA2083534C/fr not_active Expired - Fee Related
- 1992-11-24 JP JP4336560A patent/JP2629542B2/ja not_active Expired - Fee Related
- 1992-11-25 TW TW081109448A patent/TW224469B/zh active
- 1992-11-25 MY MYPI92002167A patent/MY114655A/en unknown
- 1992-11-26 AU AU29637/92A patent/AU650376B2/en not_active Ceased
- 1992-11-27 RU RU93050130A patent/RU2117671C1/ru not_active IP Right Cessation
- 1992-11-27 HU HU9203754A patent/HU9203754D0/hu unknown
- 1992-11-27 NO NO924593A patent/NO178929C/no not_active IP Right Cessation
- 1992-11-27 MX MX9206847A patent/MX9206847A/es unknown
- 1992-11-27 FI FI925422A patent/FI106864B/fi active
- 1992-11-27 PL PL92304729A patent/PL171468B1/pl not_active IP Right Cessation
- 1992-11-27 YU YU102692A patent/YU48963B/sh unknown
- 1992-11-27 WO PCT/JP1992/001549 patent/WO1993011145A1/fr not_active Ceased
- 1992-11-27 RO RO93-01067A patent/RO113469B1/ro unknown
- 1992-11-27 CZ CS19923508A patent/CZ287304B6/cs not_active IP Right Cessation
- 1992-11-27 HU HU9203754A patent/HU217611B/hu not_active IP Right Cessation
- 1992-11-28 KR KR1019920022729A patent/KR100275976B1/ko not_active Expired - Fee Related
1993
- 1993-01-30 SA SA93130351A patent/SA93130351B1/ar unknown
- 1993-07-20 BG BG97970A patent/BG61036B1/bg unknown
1995
- 1995-06-08 HU HU95P/P00172P patent/HU211254A9/hu unknown
- 1995-12-22 GR GR950403667T patent/GR3018527T3/el unknown

Also Published As

Publication number	Publication date
IL103844A (en)	1997-09-30
HUT65699A (en)	1994-07-28
WO1993011145A1 (fr)	1993-06-10
AU2963792A (en)	1993-06-03
JPH06128283A (ja)	1994-05-10
YU48963B (sh)	2003-01-31
CZ350892A3 (en)	1993-10-13
KR930010039A (ko)	1993-06-21
NZ245203A (en)	1997-07-27
FI106864B (fi)	2001-04-30
HU217611B (hu)	2000-03-28
ATE130617T1 (de)	1995-12-15
JP2629542B2 (ja)	1997-07-09
BG61036B1 (bg)	1996-09-30
RU2117671C1 (ru)	1998-08-20
AU650376B2 (en)	1994-06-16
DE69206242T2 (de)	1996-03-28
PL304729A1 (en)	1995-01-09
FI925422L (fi)	1993-05-30
CZ287304B6 (cs)	2000-10-11
CA2083534A1 (fr)	1993-05-30
FI925422A0 (fi)	1992-11-27
PL171468B1 (pl)	1997-05-30
NO178929B (no)	1996-03-25
BG97970A (bg)	1994-04-29
KR100275976B1 (ko)	2001-02-01
SA93130351B1 (ar)	2005-10-16
EP0545195B1 (fr)	1995-11-22
RO113469B1 (ro)	1998-07-30
HU211254A9 (en)	1995-11-28
NO924593D0 (no)	1992-11-27
HU9203754D0 (en)	1993-03-29
DE69206242D1 (de)	1996-01-04
DK0545195T3 (da)	1995-12-18
NO924593L (no)	1993-06-01
YU102692A (sh)	1996-02-19
NO178929C (no)	1996-07-03
ES2079774T3 (es)	1996-01-16
MY114655A (en)	2002-12-31
MX9206847A (es)	1993-06-30
CA2083534C (fr)	2003-01-28
IL103844A0 (en)	1993-04-04
GR3018527T3 (en)	1996-03-31
TW224469B (fr)	1994-06-01
EP0545195A1 (fr)	1993-06-09

Publication	Publication Date	Title
DK0545195T3 (da)	1995-12-18	Indolopyrrolocarbazolderivater
NZ233735A (en)	1992-10-28	Heterocyclic substituted aminophenol derivatives
ATE158288T1 (de)	1997-10-15	Antiatherosklerotische und antithrombotische 1- benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on- derivate
KR930700485A (ko)	1993-03-15	피리미딘 뉴클레오시드 유도체
ES2002012A6 (es)	1988-07-01	Procedimiento para preparar (1,2,4)triazol (1,5-c)pirimidinas e-fusionadas
NZ514662A (en)	2004-01-30	Amine derivatives
MX9306110A (es)	1994-06-30	Fenoxi y fenopxialquil-piperidinas como agentes anti-virales.
ES451575A1 (es)	1977-10-16	Procedimiento para preparar derivados de 1-(4-fenoxi-fenil)-1,3,5-triazina.
ES2021182A6 (es)	1991-10-16	Procedimiento para preparar derivados de capsaicina.
DK226285D0 (da)	1985-05-21	Beta-lactamforbindelser, deres fremstilling og anvendelse som laegemidler eller vaekstfremmende midler til dyr samt mellemprodukter til fremstillingen
ES433462A1 (es)	1976-12-16	Un procedimiento de produccion de un derivado de pirazina.
GB2090833B (en)	1984-10-31	Trisubstituted pyrimido (5,4-d) pyrimidines
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DE59404557D1 (de)	1997-12-18	Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
DK0640608T3 (da)	2002-03-18	Mellemprodukter til syntese af cephalosporiner
CA2206125A1 (fr)	1996-06-06	Hydrazinophenylsulfonylurees n-substituees utilisees comme herbicides et regulateurs de croissance vegetale
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ES8306099A1 (es)	1983-05-01	Un procedimiento para la preparacion de derivados de acido 2-(2-cianoetil)-2-benzoilamino-alcanoicos.
ES2133376T3 (es)	1999-09-16	Derivados de imidazol y su uso como agentes agroquimicos.
ES478049A1 (es)	1979-07-16	Procedimiento para preparar derivados de trifluormetilimino-tiazolidina.
IE860281L (en)	1986-08-02	5-sulfonamido-1-aryl-pyrazoles