NO924593L - Indolopyrolkarbazol-derivater - Google Patents

Indolopyrolkarbazol-derivater

Info

Publication number: NO924593L
Authority: NO; Norway
Prior art keywords: substd; opt; carboxyl; alkyl; carbamoyl
Prior art date: 1991-11-29

Application number

NO92924593A

Other languages

English (en)

Other versions

NO924593D0 (no

NO178929B (no

NO178929C (no

Inventor

Katsuhisa Kojiri

Hisao Kondo

Hiroharu Arakawa

Mitsuru Ohkubo

Hiroyuki Suda

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-29

Filing date

1992-11-27

Publication date

1993-06-01

1992-11-27 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

1992-11-27 Publication of NO924593D0 publication Critical patent/NO924593D0/no

1993-06-01 Publication of NO924593L publication Critical patent/NO924593L/no

1996-03-25 Publication of NO178929B publication Critical patent/NO178929B/no

1996-07-03 Publication of NO178929C publication Critical patent/NO178929C/no

Links

125000000217 alkyl group Chemical group 0.000 abstract 5
-1 alkenyl alkynyl Chemical group 0.000 abstract 4
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 4
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
125000004663 dialkyl amino group Chemical group 0.000 abstract 3
RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002402 hexoses Chemical class 0.000 abstract 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
150000002972 pentoses Chemical class 0.000 abstract 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Silicon Polymers (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO924593A 1991-11-29 1992-11-27 Indolopyrolkarbazol-derivater NO178929C (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP34191691		1991-11-29
JP6926992		1992-02-18
JP25730692		1992-09-01

Publications (4)

Publication Number	Publication Date
NO924593D0 NO924593D0 (no)	1992-11-27
NO924593L true NO924593L (no)	1993-06-01
NO178929B NO178929B (no)	1996-03-25
NO178929C NO178929C (no)	1996-07-03

Family

ID=27300000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO924593A NO178929C (no)	1991-11-29	1992-11-27	Indolopyrolkarbazol-derivater

Country Status (27)

Country	Link
EP (1)	EP0545195B1 (no)
JP (1)	JP2629542B2 (no)
KR (1)	KR100275976B1 (no)
AT (1)	ATE130617T1 (no)
AU (1)	AU650376B2 (no)
BG (1)	BG61036B1 (no)
CA (1)	CA2083534C (no)
CZ (1)	CZ287304B6 (no)
DE (1)	DE69206242T2 (no)
DK (1)	DK0545195T3 (no)
DZ (1)	DZ1634A1 (no)
ES (1)	ES2079774T3 (no)
FI (1)	FI106864B (no)
GR (1)	GR3018527T3 (no)
HU (3)	HU9203754D0 (no)
IL (1)	IL103844A (no)
MX (1)	MX9206847A (no)
MY (1)	MY114655A (no)
NO (1)	NO178929C (no)
NZ (1)	NZ245203A (no)
PL (1)	PL171468B1 (no)
RO (1)	RO113469B1 (no)
RU (1)	RU2117671C1 (no)
SA (1)	SA93130351B1 (no)
TW (1)	TW224469B (no)
WO (1)	WO1993011145A1 (no)
YU (1)	YU48963B (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995030682A1 (en) *	1994-05-09	1995-11-16	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyprolocarbazole derivative
DE69532198T2 (de) *	1994-05-09	2004-08-26	Banyu Pharmaceutical Co., Ltd.	Antitumor-indolopyrolocarbazolderivat
DE69531686T2 (de) *	1994-06-13	2004-07-15	Banyu Pharmaceutical Co., Ltd.	Glycosyltransferase kodierendes gen und seine verwendung
WO1996004293A1 (en) *	1994-08-02	1996-02-15	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazoles
US5591855A (en) *	1994-10-14	1997-01-07	Cephalon, Inc.	Fused pyrrolocarbazoles
US5594009A (en) *	1994-10-14	1997-01-14	Cephalon, Inc.	Fused pyrrolocarbazoles
US5475110A (en) *	1994-10-14	1995-12-12	Cephalon, Inc.	Fused Pyrrolocarbazoles
US5705511A (en) *	1994-10-14	1998-01-06	Cephalon, Inc.	Fused pyrrolocarbazoles
WO1997009339A1 (fr) *	1995-09-05	1997-03-13	Banyu Pharmaceutical Co., Ltd.	Derives antitumoraux d'indolopyrrolocarbazole
US5616724A (en) *	1996-02-21	1997-04-01	Cephalon, Inc.	Fused pyrrolo[2,3-c]carbazole-6-ones
NZ333536A (en) *	1996-08-22	1999-10-28	Bristol Myers Squibb Co	Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles, and use as antitumour agents
GB9811624D0 (en) *	1998-05-29	1998-07-29	Merck Sharp & Dohme	Therapeutic use
US6013646A (en) *	1998-07-02	2000-01-11	Bayer Corporation	Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6703373B1 (en)	1999-09-10	2004-03-09	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives and antitumor agents
FR2801054B1 (fr) *	1999-11-17	2003-06-13	Adir	Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TR200302314T4 (tr)	2000-02-24	2004-01-21	Banyu Pharmaceutical Co., Ltd.	İndolopirolokarbazol türevinin hazırlanması için bir işlem, hazırlık işlemindeki ara ürünler ve ara ürünlerin hazırlanmsı için bir işlem.
US6653290B2 (en)	2000-10-06	2003-11-25	Bristol-Myers Squibb Company	Tumor proliferation inhibitors
US6677450B2 (en)	2000-10-06	2004-01-13	Bristol-Myers Squibb Company	Topoisomerase inhibitors
US6610727B2 (en)	2000-10-06	2003-08-26	Bristol-Myers Squibb Company	Anhydro sugar derivatives of indolocarbazoles
US6555677B2 (en)	2000-10-31	2003-04-29	Merck & Co., Inc.	Phase transfer catalyzed glycosidation of an indolocarbazole
RU2003131269A (ru)	2001-03-22	2005-05-10	Бристол-Маерс Сквибб Компани (Us)	Производные индолопирролокарбазолов и сахаров, цитотоксические и селективные по отношению к топоизомеразе i
US6559299B2 (en)	2001-03-29	2003-05-06	Merck & Co., Inc.	Preparation and isolation of indolocarbazole glycosides
PL370866A1 (en) *	2002-03-26	2005-05-30	Banyu Pharmaceutical Co, Ltd.	Use of antitumor indolopyrrolocarbazole derivative and other anticancer agent in combination
CA2398828A1 (en)	2002-08-09	2004-02-09	Merck & Co., Inc.	A pharmaceutical composition containing an indolopyrrolocarbazole derivative
KR20050058444A (ko) *	2002-08-23	2005-06-16	반유 세이야꾸 가부시끼가이샤	인돌로피롤로카르바졸 유도체의 제조법
WO2005010017A1 (ja) *	2003-07-24	2005-02-03	Banyu Pharmaceutical Co., Ltd	インドロピロロカルバゾール誘導体及び抗腫瘍剤
US20070042975A1 (en) *	2003-09-16	2007-02-22	Koji Yamada	Novel indolopyrrolocarbazole derivative with antitumor activity
US7241779B2 (en)	2003-12-23	2007-07-10	Cephalon, Inc.	Fused pyrrolocarbazoles
US7169802B2 (en)	2003-12-23	2007-01-30	Cephalon, Inc.	Fused pyrrolocarbazoles
RU2255089C1 (ru) *	2003-12-26	2005-06-27	Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории"	Производные гликозидов индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-дионов, обладающие цитотоксической и противоопухолевой активностью
ES2326459B1 (es)	2008-04-08	2010-05-28	Universidad De Oviedo	Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CA2742790C (en)	2008-11-19	2018-02-13	Cephalon, Inc.	Novel forms of an indazolo[5,4-a]pyrrolo [3,4-c] carbazole compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4785085A (en) *	1986-11-21	1988-11-15	Bristol-Myers Company	Rebeccamycin analogs
DE4005969A1 (de) *	1990-02-26	1991-08-29	Boehringer Mannheim Gmbh	Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
IL97233A (en) *	1990-03-06	1995-03-30	Bristol Myers Squibb Co	Rebeccamycin analogs, their production and pharmaceutical compositions containing them
JPH0725787B2 (ja) *	1990-03-06	1995-03-22	ブリストル−マイヤーズスクイブカンパニー	臭化物前駆物質物質供給によるレベカマイシン類似体
CA2108146A1 (en) *	1991-04-11	1992-10-12	Stuart W. Mccombie	Anti-tumor and anti-psoriatic agents

1992
- 1992-11-20 NZ NZ245203A patent/NZ245203A/en not_active IP Right Cessation
- 1992-11-22 DZ DZ920145A patent/DZ1634A1/fr active
- 1992-11-23 ES ES92119904T patent/ES2079774T3/es not_active Expired - Lifetime
- 1992-11-23 DK DK92119904.8T patent/DK0545195T3/da active
- 1992-11-23 AT AT92119904T patent/ATE130617T1/de not_active IP Right Cessation
- 1992-11-23 CA CA002083534A patent/CA2083534C/en not_active Expired - Fee Related
- 1992-11-23 DE DE69206242T patent/DE69206242T2/de not_active Expired - Fee Related
- 1992-11-23 EP EP92119904A patent/EP0545195B1/en not_active Expired - Lifetime
- 1992-11-23 IL IL103844A patent/IL103844A/xx not_active IP Right Cessation
- 1992-11-24 JP JP4336560A patent/JP2629542B2/ja not_active Expired - Fee Related
- 1992-11-25 TW TW081109448A patent/TW224469B/zh active
- 1992-11-25 MY MYPI92002167A patent/MY114655A/en unknown
- 1992-11-26 AU AU29637/92A patent/AU650376B2/en not_active Ceased
- 1992-11-27 NO NO924593A patent/NO178929C/no not_active IP Right Cessation
- 1992-11-27 HU HU9203754A patent/HU9203754D0/hu unknown
- 1992-11-27 HU HU9203754A patent/HU217611B/hu not_active IP Right Cessation
- 1992-11-27 MX MX9206847A patent/MX9206847A/es unknown
- 1992-11-27 RO RO93-01067A patent/RO113469B1/ro unknown
- 1992-11-27 PL PL92304729A patent/PL171468B1/pl not_active IP Right Cessation
- 1992-11-27 FI FI925422A patent/FI106864B/fi active
- 1992-11-27 YU YU102692A patent/YU48963B/sh unknown
- 1992-11-27 CZ CS19923508A patent/CZ287304B6/cs not_active IP Right Cessation
- 1992-11-27 WO PCT/JP1992/001549 patent/WO1993011145A1/en not_active Ceased
- 1992-11-27 RU RU93050130A patent/RU2117671C1/ru not_active IP Right Cessation
- 1992-11-28 KR KR1019920022729A patent/KR100275976B1/ko not_active Expired - Fee Related
1993
- 1993-01-30 SA SA93130351A patent/SA93130351B1/ar unknown
- 1993-07-20 BG BG97970A patent/BG61036B1/bg unknown
1995
- 1995-06-08 HU HU95P/P00172P patent/HU211254A9/hu unknown
- 1995-12-22 GR GR950403667T patent/GR3018527T3/el unknown

Also Published As

Publication number	Publication date
PL304729A1 (en)	1995-01-09
TW224469B (no)	1994-06-01
IL103844A (en)	1997-09-30
CZ287304B6 (cs)	2000-10-11
DZ1634A1 (fr)	2002-02-17
FI106864B (fi)	2001-04-30
NO924593D0 (no)	1992-11-27
YU48963B (sh)	2003-01-31
CA2083534A1 (en)	1993-05-30
YU102692A (sh)	1996-02-19
DE69206242D1 (de)	1996-01-04
DE69206242T2 (de)	1996-03-28
RU2117671C1 (ru)	1998-08-20
ATE130617T1 (de)	1995-12-15
PL171468B1 (pl)	1997-05-30
KR930010039A (ko)	1993-06-21
NZ245203A (en)	1997-07-27
EP0545195B1 (en)	1995-11-22
JP2629542B2 (ja)	1997-07-09
FI925422L (fi)	1993-05-30
SA93130351B1 (ar)	2005-10-16
IL103844A0 (en)	1993-04-04
KR100275976B1 (ko)	2001-02-01
RO113469B1 (ro)	1998-07-30
MY114655A (en)	2002-12-31
HU211254A9 (en)	1995-11-28
BG97970A (bg)	1994-04-29
ES2079774T3 (es)	1996-01-16
EP0545195A1 (en)	1993-06-09
GR3018527T3 (en)	1996-03-31
FI925422A0 (fi)	1992-11-27
HU9203754D0 (en)	1993-03-29
HU217611B (hu)	2000-03-28
HUT65699A (en)	1994-07-28
CA2083534C (en)	2003-01-28
NO178929B (no)	1996-03-25
NO178929C (no)	1996-07-03
CZ350892A3 (en)	1993-10-13
JPH06128283A (ja)	1994-05-10
DK0545195T3 (da)	1995-12-18
WO1993011145A1 (en)	1993-06-10
AU2963792A (en)	1993-06-03
MX9206847A (es)	1993-06-30
BG61036B1 (bg)	1996-09-30
AU650376B2 (en)	1994-06-16

Legal Events

Date	Code	Title	Description
2010-06-28	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO924593L (no)	1993-06-01	Indolopyrolkarbazol-derivater
ES470134A1 (es)	1979-10-01	Un procedimiento para la produccion de derivados sustituidosde ciclohexano-1,3-diona
NZ233735A (en)	1992-10-28	Heterocyclic substituted aminophenol derivatives
NZ514662A (en)	2004-01-30	Amine derivatives
GB1402498A (en)	1975-08-06	Triazine derivatives their production and their medicinal use
MX9306110A (es)	1994-06-30	Fenoxi y fenopxialquil-piperidinas como agentes anti-virales.
MX9700928A (es)	1997-04-30	Derivado de triazian y medicina que lo contiene.
ES451575A1 (es)	1977-10-16	Procedimiento para preparar derivados de 1-(4-fenoxi-fenil)-1,3,5-triazina.
EA200100422A1 (ru)	2001-10-22	Производные мононитрата изосорбида и их использование в качестве сосудорасширяющих агентов с пониженной толерантностью
ES2021182A6 (es)	1991-10-16	Procedimiento para preparar derivados de capsaicina.
ES433462A1 (es)	1976-12-16	Un procedimiento de produccion de un derivado de pirazina.
GB2090833B (en)	1984-10-31	Trisubstituted pyrimido (5,4-d) pyrimidines
ATE196137T1 (de)	2000-09-15	Thiazolin-derivate
ES8707718A1 (es)	1987-08-16	Procedimiento para la obtencion de 1-aril-5-alcoxiiminoalquilamino-pirazoles
DK0617035T3 (da)	1998-07-27	Hetero-tricyclisk-substituerede phenyl-cyclohexan-carboxylsyrederivater.
DE3473270D1 (de)	1988-09-15	2-amino alkenyl sulfonyl ureas
ES8607264A1 (es)	1986-05-16	Procedimiento para la obtencion de b-naftilalquilaminas
ES8306099A1 (es)	1983-05-01	Un procedimiento para la preparacion de derivados de acido 2-(2-cianoetil)-2-benzoilamino-alcanoicos.
AP9700933A0 (en)	1997-04-30	Quinoxaline derivatives useful in therapy.
ES2133376T3 (es)	1999-09-16	Derivados de imidazol y su uso como agentes agroquimicos.
ES478049A1 (es)	1979-07-16	Procedimiento para preparar derivados de trifluormetilimino-tiazolidina.
NL7708967A (en)	1977-12-30	Psycholeptic benzodiazepines