ECSP024388A - Inhibidores de proteasas - Google Patents

Inhibidores de proteasas

Info

Publication number: ECSP024388A
Authority: EC; Ecuador
Prior art keywords: compounds; provides; proteases; cathepsin; diseases
Prior art date: 2000-06-14

Application number

EC2002004388A

Other languages

English (en)

Spanish (es)

Inventor

Robert Wells Marquis

Daniel Frank Veber

Yu Ru

Scott Kevin Thompson

Dennis Shinji Yamashita

Maxwell David Cummings

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-14

Filing date

2002-12-12

Publication date

2003-02-06

2002-12-12 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2003-02-06 Publication of ECSP024388A publication Critical patent/ECSP024388A/es

Links

229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 7
239000004365 Protease Substances 0.000 abstract 5
201000010099 disease Diseases 0.000 abstract 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
108010005843 Cysteine Proteases Proteins 0.000 abstract 3
102000005927 Cysteine Proteases Human genes 0.000 abstract 3
102000035195 Peptidases Human genes 0.000 abstract 3
108091005804 Peptidases Proteins 0.000 abstract 3
108090000625 Cathepsin K Proteins 0.000 abstract 2
102000004171 Cathepsin K Human genes 0.000 abstract 2
102000005600 Cathepsins Human genes 0.000 abstract 2
108010084457 Cathepsins Proteins 0.000 abstract 2
108090000526 Papain Proteins 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
235000019834 papain Nutrition 0.000 abstract 2
229940055729 papain Drugs 0.000 abstract 2
206010065687 Bone loss Diseases 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
210000000845 cartilage Anatomy 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
239000002852 cysteine proteinase inhibitor Substances 0.000 abstract 1
238000006731 degradation reaction Methods 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
208000024693 gingival disease Diseases 0.000 abstract 1
208000007565 gingivitis Diseases 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
201000008482 osteoarthritis Diseases 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
201000001245 periodontitis Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
235000019419 proteases Nutrition 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
239000003001 serine protease inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Tropical Medicine & Parasitology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

EC2002004388A 2000-06-14 2002-12-12 Inhibidores de proteasas ECSP024388A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US59384500A	2000-06-14	2000-06-14

Publications (1)

Publication Number	Publication Date
ECSP024388A true ECSP024388A (es)	2003-02-06

Family

ID=24376433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EC2002004388A ECSP024388A (es)	2000-06-14	2002-12-12	Inhibidores de proteasas

Country Status (25)

Country	Link
EP (1)	EP1307204A4 (fr)
JP (1)	JP2004503502A (fr)
KR (1)	KR20030008220A (fr)
CN (1)	CN1444481A (fr)
AP (1)	AP2002002671A0 (fr)
AR (1)	AR032622A1 (fr)
AU (1)	AU2001268407A1 (fr)
BG (1)	BG107327A (fr)
BR (1)	BR0111693A (fr)
CA (1)	CA2412353A1 (fr)
CZ (1)	CZ20024086A3 (fr)
EA (1)	EA200300018A1 (fr)
EC (1)	ECSP024388A (fr)
HU (1)	HUP0301231A2 (fr)
IL (1)	IL153421A0 (fr)
MA (1)	MA25758A1 (fr)
MX (1)	MXPA02012442A (fr)
NO (1)	NO20025786L (fr)
NZ (1)	NZ522965A (fr)
OA (1)	OA12288A (fr)
PE (1)	PE20011374A1 (fr)
PL (1)	PL360508A1 (fr)
SK (1)	SK17592002A3 (fr)
WO (1)	WO2001095911A1 (fr)
ZA (1)	ZA200209808B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001034159A1 (fr) *	1999-11-10	2001-05-17	Smithkline Beecham Corporation	Inhibiteurs de protease
EP1231921A4 (fr) *	1999-11-10	2004-06-23	Smithkline Beecham Corp	Inhibiteurs de proteases
CN1635903A (zh) *	2000-11-22	2005-07-06	史密丝克莱恩比彻姆公司	蛋白酶抑制剂
NZ526883A (en)	2001-02-20	2005-11-25	Chugai Pharmaceutical Co Ltd	Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators
US7709510B2 (en)	2001-02-20	2010-05-04	Chugai Seiyaku Kabushiki Kaisha	Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
AU2002342682A1 (en) *	2001-05-17	2002-11-25	Smithkline Beecham Corporation	Protease inhibitors
GB0220187D0 (en) *	2002-08-30	2002-10-09	Novartis Ag	Organic compounds
CA2533749C (fr)	2003-08-01	2012-07-10	Chugai Seiyaku Kabushiki Kaisha	Composes de piperidine utiles en tant qu'inhibiteurs de malonyl-coa decarboxylase
JP4727578B2 (ja)	2003-08-01	2011-07-20	中外製薬株式会社	マロニル−ＣｏＡデカルボキシラーゼ阻害剤として有用な複素環式化合物
EP2208495B1 (fr)	2003-08-01	2011-12-14	Chugai Seiyaku Kabushiki Kaisha	Composes azole a base de cyanoguanidine-utilises comme inhibiteurs de malonyl-coa decarboxylase
EP2240491B1 (fr)	2008-01-09	2015-07-15	Amura Therapeutics Limited	DÉRIVÉS DE TÉTRAHYDROFURO(2,3-b)PYRROL-3-ONE COMME INHIBITEURS DE CYSTÉINE PROTÉINASES
CN103275070A (zh) *	2013-05-10	2013-09-04	郑彪	调节单核细胞增殖的四环化合物及其应用
US9427441B2 (en)	2014-02-19	2016-08-30	Indiana University Research And Technology Corporation	Targeting primary cilia to treat glaucoma

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DZ2285A1 (fr) *	1996-08-08	2002-12-25	Smithkline Beecham Corp	Inhibiteurs de protéase de la cystéine.
KR100630986B1 (ko) *	1998-12-23	2006-10-09	스미스클라인 비참 코포레이션	프로테아제 억제제
EP1231921A4 (fr) *	1999-11-10	2004-06-23	Smithkline Beecham Corp	Inhibiteurs de proteases
EP1235577A4 (fr) *	1999-11-10	2003-04-09	Smithkline Beecham Corp	Inhibiteurs de protease
WO2002017924A1 (fr) *	2000-09-01	2002-03-07	Smithkline Beecham Corporation	Procede de traitement
CN1635903A (zh) *	2000-11-22	2005-07-06	史密丝克莱恩比彻姆公司	蛋白酶抑制剂
AU2002342682A1 (en) *	2001-05-17	2002-11-25	Smithkline Beecham Corporation	Protease inhibitors

2001
- 2001-06-14 NZ NZ522965A patent/NZ522965A/en unknown
- 2001-06-14 IL IL15342101A patent/IL153421A0/xx unknown
- 2001-06-14 AR ARP010102840A patent/AR032622A1/es not_active Application Discontinuation
- 2001-06-14 PE PE2001000566A patent/PE20011374A1/es not_active Application Discontinuation
- 2001-06-14 PL PL36050801A patent/PL360508A1/xx not_active Application Discontinuation
- 2001-06-14 AP APAP/P/2002/002671A patent/AP2002002671A0/en unknown
- 2001-06-14 HU HU0301231A patent/HUP0301231A2/hu unknown
- 2001-06-14 JP JP2002510089A patent/JP2004503502A/ja active Pending
- 2001-06-14 BR BR0111693-2A patent/BR0111693A/pt not_active IP Right Cessation
- 2001-06-14 EP EP01946344A patent/EP1307204A4/fr not_active Withdrawn
- 2001-06-14 SK SK1759-2002A patent/SK17592002A3/sk not_active Application Discontinuation
- 2001-06-14 CA CA002412353A patent/CA2412353A1/fr not_active Abandoned
- 2001-06-14 OA OA1200200377A patent/OA12288A/en unknown
- 2001-06-14 AU AU2001268407A patent/AU2001268407A1/en not_active Abandoned
- 2001-06-14 CZ CZ20024086A patent/CZ20024086A3/cs unknown
- 2001-06-14 CN CN01813500A patent/CN1444481A/zh active Pending
- 2001-06-14 MX MXPA02012442A patent/MXPA02012442A/es unknown
- 2001-06-14 WO PCT/US2001/019062 patent/WO2001095911A1/fr not_active Ceased
- 2001-06-14 EA EA200300018A patent/EA200300018A1/ru unknown
- 2001-06-14 KR KR1020027017045A patent/KR20030008220A/ko not_active Withdrawn
2002
- 2002-11-28 BG BG107327A patent/BG107327A/bg unknown
- 2002-12-02 NO NO20025786A patent/NO20025786L/no not_active Application Discontinuation
- 2002-12-03 ZA ZA200209808A patent/ZA200209808B/en unknown
- 2002-12-12 EC EC2002004388A patent/ECSP024388A/es unknown
- 2002-12-13 MA MA26952A patent/MA25758A1/fr unknown

Also Published As

Publication number	Publication date
PE20011374A1 (es)	2002-04-07
SK17592002A3 (sk)	2003-05-02
WO2001095911A1 (fr)	2001-12-20
NO20025786D0 (no)	2002-12-02
CA2412353A1 (fr)	2001-12-20
BR0111693A (pt)	2004-04-06
EP1307204A4 (fr)	2004-06-02
PL360508A1 (en)	2004-09-06
OA12288A (en)	2003-12-12
JP2004503502A (ja)	2004-02-05
EA200300018A1 (ru)	2003-06-26
BG107327A (bg)	2003-07-31
AP2002002671A0 (en)	2002-12-31
NZ522965A (en)	2004-06-25
EP1307204A1 (fr)	2003-05-07
AR032622A1 (es)	2003-11-19
NO20025786L (no)	2003-02-12
MA25758A1 (fr)	2003-04-01
MXPA02012442A (es)	2003-04-25
IL153421A0 (en)	2003-07-06
ZA200209808B (en)	2004-07-09
CN1444481A (zh)	2003-09-24
KR20030008220A (ko)	2003-01-24
AU2001268407A1 (en)	2001-12-24
CZ20024086A3 (cs)	2003-05-14
HUP0301231A2 (hu)	2003-08-28

Publication	Publication Date	Title
ECSP024388A (es)	2003-02-06	Inhibidores de proteasas
NO20024528D0 (no)	2002-09-20	Proteaseinhibitorer
GT200400076A (es)	2004-12-16	Ligandos de receptores de cannabinoides y sus usos
PA8601001A1 (es)	2005-02-04	Fenacilo 2-hidroxi-3-diaminoalcanos
NO20044207L (no)	2004-11-24	Katepsin som cysteinproteaseinbibitorer
EP1372655A4 (fr)	2005-10-12	Inhibiteurs de cathepsines de la cysteine protease
NO20013124D0 (no)	2001-06-22	Protease inhibitorer
ECSP044998A (es)	2004-04-28	Pirrolo pirimidinas como agentes para la inhibicion de proteasas de cisteina
DOP2004000888A (es)	2004-11-15	2-hidroxi-3-diaminoalcanos de benzamida (benzamide 2-hydroxy-3-diaminoalkanes
PY0202788A (es)	2004-06-01	Inhibidores de la metaloproteinasa de la matriz
TR200002940T2 (tr)	2001-02-21	Parazitlerin sebep olduğu hastalıkların papain süperfamilyasından sistein proteazların inhibisyonu yoluyla tedavisi
DE60231207D1 (de)	2009-04-02	Inhibitoren
BRPI0408417A (pt)	2006-03-21	métodos para a produção de um resìduo de gla purificado contendo serina protease, para a purificação de um resìduo de gla contendo serina protease e para estabilização de um resìduo de gla contendo serina protease, e, composição
AR123132A1 (es)	2022-11-02	Formas cristalinas de un inhibidor de la o-glucoproteína-2-acetamido-2-desoxi-3-d-glucopiranosidasa
UY26026A1 (es)	2000-10-31	Inhibidores de proteasas
WO2005013909A3 (fr)	2005-08-18	Nouveaux inhibiteurs de la cathepsine k
UY26088A1 (es)	2000-10-31	Inhibidores de proteasas
WO2002092563A3 (fr)	2003-04-03	Inhibiteurs de protease
AR029855A1 (es)	2003-07-16	Formas de sal de un inhibidor de la proteasa del hiv
ECSP992905A (es)	1999-08-12	Compuestos y composiciones farmaceuticas para el tratamiento de la malaria
PA8601101A1 (es)	2004-12-16	2-hidroxi-3-diaminoalcanos de benzamida
ECSP003353A (es)	2000-06-19	Inhibidores de proteasas ix
ECSP982493A (es)	1999-01-12	Inhibidores de proteasas iii
BR9909530A (pt)	2000-12-26	Tratamento de doenças parasitárias pela inibição das proteases de cisteìna da superfamìlia da papaìna
UY25147A1 (es)	1998-11-27	Procedimiento para la preparación de inhibidores de proteasas.