ECSP055704A - 4-(indazol-3-il) fenoles sustituidos como ligandos del receptor de estrógeno (re) y su uso en el tratamiento de enfermedades inflamatorias - Google Patents

4-(indazol-3-il) fenoles sustituidos como ligandos del receptor de estrógeno (re) y su uso en el tratamiento de enfermedades inflamatorias

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Publication number
ECSP055704A
ECSP055704A EC2005005704A ECSP055704A ECSP055704A EC SP055704 A ECSP055704 A EC SP055704A EC 2005005704 A EC2005005704 A EC 2005005704A EC SP055704 A ECSP055704 A EC SP055704A EC SP055704 A ECSP055704 A EC SP055704A
Authority
EC
Ecuador
Prior art keywords
treatment
strategen
legands
indazol
receiver
Prior art date
Application number
EC2005005704A
Other languages
English (en)
Inventor
Robert John Steffan
Edward Martin Matelan
Mark Anthony Ashwell
William Ronald Solvibile
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP055704A publication Critical patent/ECSP055704A/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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  • Health & Medical Sciences (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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Abstract

La invención proporciona un compuesto de las fórmulas I o II que tienen la estructura en donde R1, R2, R3, R4, R5, R6, R7, R8, R9 y R10 son como se definieron en la memoria descriptiva o una de sus sales farmacéuticamente aceptables que son útiles para el tratamiento del componente inflamatorio de enfermedades y son particularmente útiles para tratar arterioesclerosis, infarto de miocardio, insuficiencia cardíaca congestiva, enfermedad de intestino inflamado, artritis, diabetes de tipo II y enfermedades autoinmunes tales como esclerosis múltiple y artritis reumatoidea.
EC2005005704A 2002-09-25 2005-03-23 4-(indazol-3-il) fenoles sustituidos como ligandos del receptor de estrógeno (re) y su uso en el tratamiento de enfermedades inflamatorias ECSP055704A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41393102P 2002-09-25 2002-09-25

Publications (1)

Publication Number Publication Date
ECSP055704A true ECSP055704A (es) 2005-07-06

Family

ID=32069719

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005704A ECSP055704A (es) 2002-09-25 2005-03-23 4-(indazol-3-il) fenoles sustituidos como ligandos del receptor de estrógeno (re) y su uso en el tratamiento de enfermedades inflamatorias

Country Status (21)

Country Link
US (2) US7241791B2 (es)
EP (1) EP1542976B1 (es)
JP (1) JP4459813B2 (es)
KR (1) KR20050053702A (es)
CN (2) CN1321984C (es)
AR (1) AR041378A1 (es)
AT (1) ATE422202T1 (es)
AU (1) AU2003276940A1 (es)
BR (1) BR0314475A (es)
CA (1) CA2499736A1 (es)
CR (1) CR7769A (es)
DE (1) DE60326077D1 (es)
DK (1) DK1542976T3 (es)
EC (1) ECSP055704A (es)
ES (1) ES2319519T3 (es)
MX (1) MXPA05003275A (es)
NO (1) NO20051942L (es)
RU (1) RU2005109387A (es)
TW (1) TW200409759A (es)
WO (1) WO2004031159A1 (es)
ZA (1) ZA200502462B (es)

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