ECSP099601A - Inhibidores de proteasa de serina - Google Patents

Inhibidores de proteasa de serina

Info

Publication number
ECSP099601A
ECSP099601A EC2009009601A ECSP099601A ECSP099601A EC SP099601 A ECSP099601 A EC SP099601A EC 2009009601 A EC2009009601 A EC 2009009601A EC SP099601 A ECSP099601 A EC SP099601A EC SP099601 A ECSP099601 A EC SP099601A
Authority
EC
Ecuador
Prior art keywords
serina
protease inhibitors
compounds
protease
virus
Prior art date
Application number
EC2009009601A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39469472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP099601(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of ECSP099601A publication Critical patent/ECSP099601A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención relaciona a los compuestos de la fórmula (I) o una sal farmacéuticamente aceptable del mismo. Estos compuestos inhiben la proteasa de serina, particularmente el virus NS3-NS4A proteasa de la hepatitis C.
EC2009009601A 2007-02-27 2009-08-27 Inhibidores de proteasa de serina ECSP099601A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/711,845 US7964624B1 (en) 2005-08-26 2007-02-27 Inhibitors of serine proteases

Publications (1)

Publication Number Publication Date
ECSP099601A true ECSP099601A (es) 2009-10-30

Family

ID=39469472

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009601A ECSP099601A (es) 2007-02-27 2009-08-27 Inhibidores de proteasa de serina

Country Status (22)

Country Link
US (2) US7964624B1 (es)
EP (2) EP2114958A1 (es)
JP (1) JP2010523474A (es)
KR (1) KR20090127292A (es)
CN (1) CN102015727A (es)
AP (1) AP2009004971A0 (es)
AR (1) AR065499A1 (es)
AU (1) AU2008219689A1 (es)
BR (1) BRPI0807904A2 (es)
CA (1) CA2679429A1 (es)
CL (1) CL2008000579A1 (es)
CO (1) CO6220931A2 (es)
EA (1) EA200970805A1 (es)
EC (1) ECSP099601A (es)
GE (1) GEP20125683B (es)
IL (1) IL200611A0 (es)
MX (1) MX2009009174A (es)
NZ (1) NZ579296A (es)
PE (1) PE20081792A1 (es)
TW (1) TW200843738A (es)
UY (1) UY30941A1 (es)
WO (1) WO2008106139A1 (es)

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BR112014029295B1 (pt) 2012-05-25 2021-04-27 Nutech Ventures Ciclobutenos e ciclobutanos anfifílicos e composição farmacêutica que os compreende
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CN105924353A (zh) * 2016-06-29 2016-09-07 山东未名生物医药股份有限公司 2-羟基酸酯的制备方法
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KR20190063473A (ko) 2016-09-28 2019-06-07 블레이드 테라퓨틱스, 인크. 칼페인 조정자 및 그 치료학적 용도
MX2020010033A (es) * 2018-03-28 2020-10-14 Blade Therapeutics Inc Moduladores calpaina y usos terapeuticos de los mismos.
JP7584418B2 (ja) 2018-12-04 2024-11-15 ブリストル－マイヤーズ スクイブ カンパニー 多重反応同位体分子種反応モニタリングによる、サンプル内検量線を用いた分析方法
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US8372873B2 (en) 2013-02-12
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