ECSP099718A - Compuestos orgánicos - Google Patents
Compuestos orgánicosInfo
- Publication number
- ECSP099718A ECSP099718A EC2009009718A ECSP099718A ECSP099718A EC SP099718 A ECSP099718 A EC SP099718A EC 2009009718 A EC2009009718 A EC 2009009718A EC SP099718 A ECSP099718 A EC SP099718A EC SP099718 A ECSP099718 A EC SP099718A
- Authority
- EC
- Ecuador
- Prior art keywords
- organic compounds
- conditions
- tautomers
- solvates
- stereoisomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un compuesto de la Fórmula (I) o los tautómeros, o estereoisómeros, o solvatos, o sales farmacéuticamente aceptables del mismo, en donde M1, M2, L1, L2, W1, W2, X1,X2, Y1, Y2, A, R5, y R5a son como se definen en la presente, para el tratamiento de condiciones tratables mediante el bloqueo de un canal de sodio epitelial, en particular condiciones que se beneficien de la hidratación de la mucosa.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07107654 | 2007-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP099718A true ECSP099718A (es) | 2009-12-28 |
Family
ID=38581916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2009009718A ECSP099718A (es) | 2007-05-07 | 2009-11-06 | Compuestos orgánicos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8318935B2 (es) |
| EP (2) | EP2332933A1 (es) |
| JP (1) | JP5244904B2 (es) |
| KR (1) | KR20100005730A (es) |
| CN (1) | CN101687851B (es) |
| AR (1) | AR066458A1 (es) |
| AT (1) | ATE499363T1 (es) |
| AU (1) | AU2008248598B2 (es) |
| BR (1) | BRPI0811562A2 (es) |
| CA (1) | CA2685546A1 (es) |
| CL (1) | CL2008001301A1 (es) |
| CO (1) | CO6290667A2 (es) |
| CR (1) | CR11091A (es) |
| DE (1) | DE602008005140D1 (es) |
| EA (1) | EA200901489A1 (es) |
| EC (1) | ECSP099718A (es) |
| ES (1) | ES2361595T3 (es) |
| GT (1) | GT200900289A (es) |
| HN (1) | HN2009003214A (es) |
| IL (1) | IL201828A0 (es) |
| MA (1) | MA31400B1 (es) |
| MX (1) | MX2009012077A (es) |
| NZ (1) | NZ580737A (es) |
| PE (1) | PE20090733A1 (es) |
| PL (1) | PL2155721T3 (es) |
| PT (1) | PT2155721E (es) |
| SV (1) | SV2009003406A (es) |
| TN (1) | TN2009000469A1 (es) |
| TW (1) | TWI351402B (es) |
| WO (1) | WO2008135557A1 (es) |
| ZA (1) | ZA200907491B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| WO2009139948A1 (en) | 2008-02-26 | 2009-11-19 | Johnson Michael R | Poly aromatic sodium channel blockers |
| KR20110085768A (ko) | 2010-01-21 | 2011-07-27 | 삼성전자주식회사 | Ｃｍｏｓ 이미지 센서, 상기 이미지 센서의 데이터 리드아웃 방법, 및 상기 이미지 센서를 포함하는 전자 시스템 |
| US8372845B2 (en) * | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| US9050339B2 (en) | 2010-09-17 | 2015-06-09 | Novartis Ag | Pyrazine derivatives as ENaC blockers |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| AU2012331275A1 (en) | 2011-11-02 | 2014-04-03 | Boehringer Ingelheim International Gmbh | Novel process for the preparation of acylguanidines and acylthioureas |
| NO2773633T3 (es) * | 2011-11-02 | 2017-12-30 | ||
| US8859559B2 (en) | 2011-12-20 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
| US20140050720A1 (en) | 2012-01-09 | 2014-02-20 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
| WO2013174757A1 (en) | 2012-05-25 | 2013-11-28 | Boehringer Ingelheim International Gmbh | Tertiary amines, medicaments containing said amines, use thereof and processes for the preparation thereof |
| WO2014044849A1 (en) | 2012-09-24 | 2014-03-27 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| KR102396897B1 (ko) | 2012-11-02 | 2022-05-13 | 버텍스 파마슈티칼스 인코포레이티드 | Ｃｆｔｒ 매개된 질환의 치료를 위한 약제학적 조성물 |
| HUE032891T2 (hu) | 2012-12-17 | 2017-11-28 | Parion Sciences Inc | Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére |
| RU2671976C2 (ru) | 2012-12-17 | 2018-11-08 | Пэрион Сайенсиз, Инк. | Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида |
| EP2991981B1 (en) * | 2013-04-30 | 2017-03-01 | Boehringer Ingelheim International GmbH | Diaminopyrazine compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| CA2915633A1 (en) * | 2013-07-02 | 2015-01-08 | The California Institute For Biomedical Research | Compounds for treatment of cystic fibrosis |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| UY36034A (es) | 2014-03-18 | 2015-09-30 | Astrazeneca Ab | Derivados de 3,5-diamino-6-cloro-pirazina-2-carboxamida y sales farmaceuticamente aceptables de estos |
| WO2015145353A1 (en) | 2014-03-27 | 2015-10-01 | Novartis Ag | Spray-dried solid-in-oil-in-water dispersions for inhalation of active pharmaceutical ingredients |
| GB201412545D0 (en) * | 2014-07-15 | 2014-08-27 | Univ Manchester The And Manchester Metropolitan University | Enzymatic processes and uses |
| CN107405505A (zh) * | 2015-01-07 | 2017-11-28 | 加州生物医学研究所 | 用于治疗囊性纤维化的化合物 |
| US10155749B2 (en) * | 2015-01-12 | 2018-12-18 | Boehringer Ingelheim International Gmbh | Substituted benzimidazolium compounds useful in the treatment of respiratory diseases |
| US9932324B2 (en) * | 2015-01-12 | 2018-04-03 | Boehringer Ingelheim International Gmbh | Substituted benzimidazolium compounds useful in the treatment of respiratory diseases |
| EP3245202B1 (en) * | 2015-01-12 | 2020-03-11 | Boehringer Ingelheim International GmbH | Tetrasubstituted benzimidazolium compounds useful in the treatment of respiratory diseases |
| US10291868B2 (en) * | 2016-01-29 | 2019-05-14 | SK Hynix Inc. | Image sensing device |
| GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| WO2018175340A1 (en) | 2017-03-20 | 2018-09-27 | Sienna Biopharmaceuticals, Inc. | Reduced exposure conjugates modulating therapeutic targets |
| WO2018175302A1 (en) | 2017-03-20 | 2018-09-27 | Sienna Biopharmaceuticals, Inc. | Polymer conjugates targeting c-src with reduced exposure |
| GB201717051D0 (en) | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
| GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
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-
2008
- 2008-05-05 EP EP11152559A patent/EP2332933A1/en not_active Withdrawn
- 2008-05-05 CN CN2008800226814A patent/CN101687851B/zh not_active Expired - Fee Related
- 2008-05-05 AT AT08759419T patent/ATE499363T1/de active
- 2008-05-05 JP JP2010506915A patent/JP5244904B2/ja not_active Expired - Fee Related
- 2008-05-05 AU AU2008248598A patent/AU2008248598B2/en not_active Ceased
- 2008-05-05 PL PL08759419T patent/PL2155721T3/pl unknown
- 2008-05-05 WO PCT/EP2008/055497 patent/WO2008135557A1/en not_active Ceased
- 2008-05-05 MX MX2009012077A patent/MX2009012077A/es active IP Right Grant
- 2008-05-05 NZ NZ580737A patent/NZ580737A/en not_active IP Right Cessation
- 2008-05-05 EA EA200901489A patent/EA200901489A1/ru unknown
- 2008-05-05 CA CA002685546A patent/CA2685546A1/en not_active Abandoned
- 2008-05-05 DE DE602008005140T patent/DE602008005140D1/de active Active
- 2008-05-05 US US12/451,152 patent/US8318935B2/en not_active Expired - Fee Related
- 2008-05-05 EP EP08759419A patent/EP2155721B1/en active Active
- 2008-05-05 KR KR1020097025395A patent/KR20100005730A/ko not_active Abandoned
- 2008-05-05 PE PE2008000782A patent/PE20090733A1/es not_active Application Discontinuation
- 2008-05-05 BR BRPI0811562-1A2A patent/BRPI0811562A2/pt not_active IP Right Cessation
- 2008-05-05 PT PT08759419T patent/PT2155721E/pt unknown
- 2008-05-05 ES ES08759419T patent/ES2361595T3/es active Active
- 2008-05-06 AR ARP080101913A patent/AR066458A1/es not_active Application Discontinuation
- 2008-05-06 TW TW097116687A patent/TWI351402B/zh not_active IP Right Cessation
- 2008-05-06 CL CL2008001301A patent/CL2008001301A1/es unknown
-
2009
- 2009-10-26 ZA ZA200907491A patent/ZA200907491B/xx unknown
- 2009-10-29 IL IL201828A patent/IL201828A0/en unknown
- 2009-11-04 CR CR11091A patent/CR11091A/es unknown
- 2009-11-05 GT GT200900289A patent/GT200900289A/es unknown
- 2009-11-06 TN TNP2009000469A patent/TN2009000469A1/fr unknown
- 2009-11-06 EC EC2009009718A patent/ECSP099718A/es unknown
- 2009-11-06 CO CO09125992A patent/CO6290667A2/es not_active Application Discontinuation
- 2009-11-06 SV SV2009003406A patent/SV2009003406A/es active IP Right Grant
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- 2009-11-30 MA MA32385A patent/MA31400B1/fr unknown
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