ECSP11011027A - Terapia de combinación con epoxicetonas peptídicas - Google Patents
Terapia de combinación con epoxicetonas peptídicasInfo
- Publication number
- ECSP11011027A ECSP11011027A EC2011011027A ECSP11011027A ECSP11011027A EC SP11011027 A ECSP11011027 A EC SP11011027A EC 2011011027 A EC2011011027 A EC 2011011027A EC SP11011027 A ECSP11011027 A EC SP11011027A EC SP11011027 A ECSP11011027 A EC SP11011027A
- Authority
- EC
- Ecuador
- Prior art keywords
- peptide
- combination therapy
- epoxycetones
- administered
- cancer
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N epoxyketone group Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
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- Rheumatology (AREA)
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Abstract
La invención proporciona terapia de combinación, donde uno o más de otros agentes terapéuticos se administran con epoxicetonas peptídicas o una sal farmacéuticamente aceptable de las mismas. Otro aspecto de la invención se refiere al tratamiento del cáncer con una epoxicetona peptídica administrada junto con otro agente terapéutico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19694508P | 2008-10-21 | 2008-10-21 | |
| PCT/US2009/061498 WO2010048298A1 (en) | 2008-10-21 | 2009-10-21 | Combination therapy with peptide epoxyketones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11011027A true ECSP11011027A (es) | 2011-06-30 |
Family
ID=42119657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011011027A ECSP11011027A (es) | 2008-10-21 | 2011-05-03 | Terapia de combinación con epoxicetonas peptídicas |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US20110236428A1 (es) |
| EP (3) | EP2349313A4 (es) |
| JP (4) | JP5675629B2 (es) |
| KR (1) | KR20110073584A (es) |
| CN (1) | CN102256616A (es) |
| AP (1) | AP2011005690A0 (es) |
| AU (4) | AU2009308516B2 (es) |
| BR (1) | BRPI0919668A2 (es) |
| CA (1) | CA2741312C (es) |
| CL (1) | CL2011000916A1 (es) |
| CO (1) | CO6361942A2 (es) |
| CR (1) | CR20110221A (es) |
| DO (1) | DOP2011000108A (es) |
| EA (2) | EA024364B1 (es) |
| EC (1) | ECSP11011027A (es) |
| ES (1) | ES2617560T3 (es) |
| IL (1) | IL212506A0 (es) |
| MA (1) | MA32806B1 (es) |
| ME (1) | ME01133B (es) |
| MX (2) | MX2011004225A (es) |
| NI (1) | NI201100077A (es) |
| PE (1) | PE20120059A1 (es) |
| TN (1) | TN2011000200A1 (es) |
| UA (1) | UA104600C2 (es) |
| WO (1) | WO2010048298A1 (es) |
| ZA (1) | ZA201103493B (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8198270B2 (en) | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| US8129346B2 (en) | 2004-04-15 | 2012-03-06 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
| US8716322B2 (en) | 2005-11-09 | 2014-05-06 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
| NZ597545A (en) | 2006-06-19 | 2013-07-26 | Proteolix Inc | Peptide epoxyketones for proteasome inhibition |
| JP5734656B2 (ja) | 2007-10-04 | 2015-06-17 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | ペプチドエポキシケトンプロテアーゼ阻害剤結晶及びアミノ酸ケトエポキシドの調製 |
| EA024364B1 (ru) | 2008-10-21 | 2016-09-30 | Оникс Терапьютикс, Инк. | Способ лечения множественной миеломы |
| TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
| WO2011060179A1 (en) * | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
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