ECSP11011027A - Terapia de combinación con epoxicetonas peptídicas - Google Patents

Terapia de combinación con epoxicetonas peptídicas

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Publication number
ECSP11011027A
ECSP11011027A EC2011011027A ECSP11011027A ECSP11011027A EC SP11011027 A ECSP11011027 A EC SP11011027A EC 2011011027 A EC2011011027 A EC 2011011027A EC SP11011027 A ECSP11011027 A EC SP11011027A EC SP11011027 A ECSP11011027 A EC SP11011027A
Authority
EC
Ecuador
Prior art keywords
peptide
combination therapy
epoxycetones
administered
cancer
Prior art date
Application number
EC2011011027A
Other languages
English (en)
Inventor
Christiopher J Kirk
Susan D Demo
Mark K Bennett
Original Assignee
Onyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42119657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11011027(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Onyx Therapeutics Inc filed Critical Onyx Therapeutics Inc
Publication of ECSP11011027A publication Critical patent/ECSP11011027A/es

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    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Abstract

La invención proporciona terapia de combinación, donde uno o más de otros agentes terapéuticos se administran con epoxicetonas peptídicas o una sal farmacéuticamente aceptable de las mismas. Otro aspecto de la invención se refiere al tratamiento del cáncer con una epoxicetona peptídica administrada junto con otro agente terapéutico.
EC2011011027A 2008-10-21 2011-05-03 Terapia de combinación con epoxicetonas peptídicas ECSP11011027A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19694508P 2008-10-21 2008-10-21
PCT/US2009/061498 WO2010048298A1 (en) 2008-10-21 2009-10-21 Combination therapy with peptide epoxyketones

Publications (1)

Publication Number Publication Date
ECSP11011027A true ECSP11011027A (es) 2011-06-30

Family

ID=42119657

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011027A ECSP11011027A (es) 2008-10-21 2011-05-03 Terapia de combinación con epoxicetonas peptídicas

Country Status (26)

Country Link
US (5) US20110236428A1 (es)
EP (3) EP2349313A4 (es)
JP (4) JP5675629B2 (es)
KR (1) KR20110073584A (es)
CN (1) CN102256616A (es)
AP (1) AP2011005690A0 (es)
AU (4) AU2009308516B2 (es)
BR (1) BRPI0919668A2 (es)
CA (1) CA2741312C (es)
CL (1) CL2011000916A1 (es)
CO (1) CO6361942A2 (es)
CR (1) CR20110221A (es)
DO (1) DOP2011000108A (es)
EA (2) EA024364B1 (es)
EC (1) ECSP11011027A (es)
ES (1) ES2617560T3 (es)
IL (1) IL212506A0 (es)
MA (1) MA32806B1 (es)
ME (1) ME01133B (es)
MX (2) MX2011004225A (es)
NI (1) NI201100077A (es)
PE (1) PE20120059A1 (es)
TN (1) TN2011000200A1 (es)
UA (1) UA104600C2 (es)
WO (1) WO2010048298A1 (es)
ZA (1) ZA201103493B (es)

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US8129346B2 (en) 2004-04-15 2012-03-06 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
US8716322B2 (en) 2005-11-09 2014-05-06 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
NZ597545A (en) 2006-06-19 2013-07-26 Proteolix Inc Peptide epoxyketones for proteasome inhibition
JP5734656B2 (ja) 2007-10-04 2015-06-17 オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. ペプチドエポキシケトンプロテアーゼ阻害剤結晶及びアミノ酸ケトエポキシドの調製
EA024364B1 (ru) 2008-10-21 2016-09-30 Оникс Терапьютикс, Инк. Способ лечения множественной миеломы
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
WO2011060179A1 (en) * 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Use of peptide epoxyketones for metastasis suppression
CA2791651C (en) 2010-03-01 2019-08-20 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
EP2555621A4 (en) 2010-04-07 2014-07-02 Onyx Therapeutics Inc CRYSTALLINE EPOXYCETONE PEPTIDE IMMUNOPROTEASOME INHIBITOR
MX364393B (es) 2012-05-08 2019-04-24 Onyx Therapeutics Inc Procedimientos para la formacion de complejos de ciclodextrina para formular inhibidores del proteasoma peptidico.
WO2014011695A2 (en) 2012-07-09 2014-01-16 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
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