ECSP12011965A - Anticuerpos neutralizadores contra el receptor de prolactina y su uso terapéutico - Google Patents

Anticuerpos neutralizadores contra el receptor de prolactina y su uso terapéutico

Info

Publication number
ECSP12011965A
ECSP12011965A ECSP12011965A ECSP12011965A EC SP12011965 A ECSP12011965 A EC SP12011965A EC SP12011965 A ECSP12011965 A EC SP12011965A EC SP12011965 A ECSP12011965 A EC SP12011965A
Authority
EC
Ecuador
Prior art keywords
antibodies against
therapeutic use
neutralizing antibodies
prolactin receptor
prolactin
Prior art date
Application number
Other languages
English (en)
Inventor
Christiane Otto
Siegmund Wolf
Christoph Freiberg
Axel Harrenga
Simone Greven
Mark Trautwein
Sandra Bruder
Andrea Eicker
Andreas Wilmen
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42091520&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011965(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of ECSP12011965A publication Critical patent/ECSP12011965A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cell Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ECSP12011965 2009-12-10 2012-06-08 Anticuerpos neutralizadores contra el receptor de prolactina y su uso terapéutico ECSP12011965A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09075546A EP2332995A1 (en) 2009-12-10 2009-12-10 Neutralizing prolactin receptor antibodies and their therapeutic use

Publications (1)

Publication Number Publication Date
ECSP12011965A true ECSP12011965A (es) 2012-07-31

Family

ID=42091520

Family Applications (2)

Application Number Title Priority Date Filing Date
ECSP12011966 ECSP12011966A (es) 2009-12-10 2012-06-08 Anticuerpos neutralizadores contra el receptor de prolactina y su uso terapéutico
ECSP12011965 ECSP12011965A (es) 2009-12-10 2012-06-08 Anticuerpos neutralizadores contra el receptor de prolactina y su uso terapéutico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ECSP12011966 ECSP12011966A (es) 2009-12-10 2012-06-08 Anticuerpos neutralizadores contra el receptor de prolactina y su uso terapéutico

Country Status (40)

Country Link
US (6) US20130171147A1 (es)
EP (13) EP2332995A1 (es)
JP (7) JP2013513362A (es)
KR (2) KR101765968B1 (es)
CN (6) CN102858803A (es)
AP (1) AP2012006343A0 (es)
AR (6) AR079352A1 (es)
AU (2) AU2010330165B2 (es)
BR (2) BR112012014048B1 (es)
CA (6) CA2783678A1 (es)
CL (2) CL2012001540A1 (es)
CR (2) CR20120312A (es)
CU (2) CU20120092A7 (es)
CY (2) CY1118209T1 (es)
DK (2) DK2510006T3 (es)
DO (2) DOP2012000160A (es)
EA (2) EA028678B1 (es)
EC (2) ECSP12011966A (es)
ES (2) ES2610654T3 (es)
GT (1) GT201200186A (es)
HR (2) HRP20161401T1 (es)
HU (2) HUE030143T2 (es)
IL (2) IL220149A (es)
IN (2) IN2012DN05082A (es)
LT (2) LT2510006T (es)
MA (1) MA33888B1 (es)
ME (1) ME02577B (es)
MX (2) MX339343B (es)
NZ (2) NZ600512A (es)
PE (3) PE20171134A1 (es)
PH (2) PH12012501131A1 (es)
PL (2) PL2510002T3 (es)
PT (2) PT2510006T (es)
RS (2) RS55277B1 (es)
SG (2) SG181513A1 (es)
SI (2) SI2510002T1 (es)
TN (1) TN2012000294A1 (es)
TW (5) TWI508744B (es)
WO (6) WO2011069797A1 (es)
ZA (2) ZA201204213B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2332995A1 (en) * 2009-12-10 2011-06-15 Bayer Schering Pharma Aktiengesellschaft Neutralizing prolactin receptor antibodies and their therapeutic use
RS59830B1 (sr) 2010-03-01 2020-02-28 Bayer Healthcare Llc Optimizovana monoklonska antitela protiv inhibitora puta faktora tkiva (tfpi)
EP2530089A1 (en) * 2011-06-03 2012-12-05 Bayer Pharma Aktiengesellschaft Neutralising prolactin receptor antibody Mat3 and its therapeutical use
NZ631565A (en) 2012-03-14 2016-07-29 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
US8883979B2 (en) * 2012-08-31 2014-11-11 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
EP2935331B1 (en) 2012-12-24 2018-02-28 AbbVie Inc. Prolactin receptor binding proteins and uses thereof
JP2016515515A (ja) * 2013-03-15 2016-05-30 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 抗プロラクチン受容体抗体製剤
US9545451B2 (en) 2013-08-21 2017-01-17 Regeneron Pharmaceuticals, Inc. Anti-PRLR antibodies and methods for killing PRLR-expressing cells
TWI641620B (zh) 2013-08-21 2018-11-21 再生元醫藥公司 抗－ｐｒｌｒ抗體及其用途
US10308697B2 (en) 2014-04-30 2019-06-04 President And Fellows Of Harvard College Fusion proteins for treating cancer and related methods
CN106999587B (zh) 2014-10-02 2023-09-29 希望之城公司 多价中间表位，中间表位结合抗体及其用途
TWI703156B (zh) 2015-01-30 2020-09-01 學校法人埼玉醫科大學 抗ａｌｋ２抗體
MY189159A (en) 2015-07-06 2022-01-29 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
WO2017190079A1 (en) 2016-04-28 2017-11-02 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
EP3548514A1 (en) 2016-11-29 2019-10-09 Regeneron Pharmaceuticals, Inc. Methods of treating prlr positive breast cancer
FR3062213B1 (fr) * 2017-01-20 2021-02-26 Endodiag Utilisation du recepteur cd71 dans la detection et le traitement de l’endometriose
TW201836647A (zh) 2017-04-06 2018-10-16 美商艾伯維有限公司 抗－ｐｒｌｒ抗體藥物軛合物（ａｄｃ）及其用途
CA3062880A1 (en) * 2017-05-12 2018-11-15 Millennium Pharmaceuticals, Inc. Treatment of gastroparesis with triazaspiro[4.5]decanone
AU2018300687A1 (en) 2017-07-10 2019-12-19 Bayer Pharma Aktiengesellschaft Prolactin receptor antibody for male and female pattern hair loss
CN112040985A (zh) 2018-02-07 2020-12-04 瑞泽恩制药公司 用于递送治疗性蛋白质的方法和组合物
WO2019169330A1 (en) * 2018-03-02 2019-09-06 Oncolix, Inc. Method for treating cancers expressing prolactin receptor
CN109627340B (zh) * 2018-12-05 2021-02-12 上海交通大学 Cd3和prlr双特异性抗体及其构建与应用
US10467487B1 (en) * 2018-12-11 2019-11-05 Chongqing Jinkang New Energy Automobile Co., Ltd. Fusion-based traffic light recognition for autonomous driving
CN112425568A (zh) * 2020-12-11 2021-03-02 上海市计划生育科学研究所 一种建立具有emt特征的良性前列腺增生bph犬模型的方法
AR124681A1 (es) 2021-01-20 2023-04-26 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
CN114853890B (zh) * 2022-03-16 2023-04-28 沈阳三生制药有限责任公司 一种prlr抗原结合蛋白及其制备方法和应用
CN114634574B (zh) * 2022-04-18 2022-12-20 先进生物(苏州)有限公司 抗B7H6的scFv抗体、其编码基因及其应用
CN120842400A (zh) * 2023-04-24 2025-10-28 深圳真实生物医药科技有限公司 泌乳素受体抗体及其用途
CN117285625B (zh) * 2023-11-24 2024-01-23 南京佰抗生物科技有限公司 抗泌乳素蛋白的单克隆抗体及应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US4986615A (en) 1988-10-17 1991-01-22 The Vendo Company Vending apparatus
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
GB9105245D0 (en) * 1991-03-12 1991-04-24 Lynxvale Ltd Binding molecules
JP4157160B2 (ja) 1991-12-13 2008-09-24 ゾーマ テクノロジー リミテッド 改変抗体可変領域の調製のための方法
ATE219517T1 (de) 1995-08-18 2002-07-15 Morphosys Ag Protein-/(poly)peptidbibliotheken
US6110471A (en) * 1996-09-13 2000-08-29 The Board Of Trustees Of The Leland Stanford Junior University Non-hormonal method of contraception
GB9701425D0 (en) 1997-01-24 1997-03-12 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
US6867187B2 (en) * 2000-12-22 2005-03-15 Trustees Of The University Of Pennsylvania Composition and method for modulating somatolactogenic function
EP1325930A1 (en) * 2002-01-08 2003-07-09 Institut National De La Sante Et De La Recherche Medicale (Inserm) Mammal prolactin variants
CA2509825A1 (en) * 2002-12-13 2004-07-01 The Ohio State University Antagonists for human prolactin
GB0305790D0 (en) * 2003-03-13 2003-04-16 Glaxosmithkline Biolog Sa Novel Composition
JP4954709B2 (ja) * 2004-10-28 2012-06-20 協和発酵キリン株式会社 子宮内膜症治療剤
WO2006089678A2 (en) * 2005-02-22 2006-08-31 Bioinvent International Ab Antibodies and peptides binding to hiv tat, and uses thereof
GB0517878D0 (en) * 2005-09-02 2005-10-12 Bioinvent Int Ab Immunotherapeutic treatment
US7422899B2 (en) 2005-10-05 2008-09-09 Biogen Idec Ma Inc. Antibodies to the human prolactin receptor
EP3018144A1 (en) 2006-08-18 2016-05-11 XOMA Technology Ltd. Prlr-specific antibody and uses thereof
AU2008278704A1 (en) 2007-05-30 2009-01-29 Auckland Uniservices Limited Antibodies and sirna against growth hormone, prolactin and proliferin for use in the treatment of tumors and endometriosis
EP2025683A1 (en) * 2007-08-13 2009-02-18 INSERM (Institut National de la Santé et de la Recherche Medicale) Variants of prolactin as antagonists of its receptor
EP2332995A1 (en) * 2009-12-10 2011-06-15 Bayer Schering Pharma Aktiengesellschaft Neutralizing prolactin receptor antibodies and their therapeutic use
WO2011139375A1 (en) * 2010-05-06 2011-11-10 Ludwig Institute For Cancer Research Ltd Antibodies directed against carbonic anhydrase ix and methods and uses thereof
GB201020995D0 (en) * 2010-12-10 2011-01-26 Bioinvent Int Ab Biological materials and uses thereof

Also Published As

Publication number Publication date
ZA201204213B (en) 2014-08-27
IN2012DN05082A (es) 2015-10-09
PE20121360A1 (es) 2012-10-11
HK1180354A1 (en) 2013-10-18
MX2012006621A (es) 2012-10-05
TWI487536B (zh) 2015-06-11
AP2012006343A0 (en) 2012-06-30
CN102858801A (zh) 2013-01-02
BR112012015852A2 (pt) 2017-05-23
PE20121561A1 (es) 2012-11-25
CN102741291A (zh) 2012-10-17
IL220149A (en) 2017-09-28
JP6066474B2 (ja) 2017-01-25
ECSP12011966A (es) 2012-07-31
AR079351A1 (es) 2012-01-18
RS55589B1 (sr) 2017-06-30
HRP20161401T1 (hr) 2016-12-16
US20130171147A1 (en) 2013-07-04
WO2011069799A1 (en) 2011-06-16
CN102858803A (zh) 2013-01-02
CN102947338B (zh) 2015-11-25
WO2011069797A1 (en) 2011-06-16
CA2783654A1 (en) 2011-06-16
PL2510002T3 (pl) 2017-02-28
KR101790366B1 (ko) 2017-10-26
CN102947338A (zh) 2013-02-27
EA028678B1 (ru) 2017-12-29
AR079349A1 (es) 2012-01-18
CR20120310A (es) 2012-08-01
JP2013513364A (ja) 2013-04-22
HK1180700A1 (en) 2013-10-25
TW201130507A (en) 2011-09-16
CA2783610C (en) 2018-10-30
DOP2012000160A (es) 2012-09-30
NZ600512A (en) 2014-11-28
WO2011069796A1 (en) 2011-06-16
SG181513A1 (en) 2012-07-30
SG181511A1 (en) 2012-07-30
TN2012000294A1 (en) 2013-12-12
PT2510002T (pt) 2016-11-23
AR079352A1 (es) 2012-01-18
TW201130506A (en) 2011-09-16
HRP20170016T1 (hr) 2017-02-24
EP2510006B1 (en) 2016-11-09
CR20120312A (es) 2012-08-27
TW201130505A (en) 2011-09-16
NZ600511A (en) 2014-01-31
WO2011069795A4 (en) 2011-08-18
CA2783610A1 (en) 2011-06-16
EP2510002A1 (en) 2012-10-17
IL220149A0 (en) 2012-07-31
CU23973B1 (es) 2013-12-27
JP2013513361A (ja) 2013-04-22
IL220151A0 (en) 2012-07-31
AR079350A1 (es) 2012-01-18
PL2510006T3 (pl) 2017-06-30
TWI508744B (zh) 2015-11-21
EP2510007A1 (en) 2012-10-17
LT2510006T (lt) 2016-12-12
BR112012015852B8 (pt) 2021-05-25
US20130022606A1 (en) 2013-01-24
CA2783678A1 (en) 2011-06-16
US9649374B2 (en) 2017-05-16
HUE030143T2 (en) 2017-04-28
AU2010330165A1 (en) 2012-07-19
JP2015180690A (ja) 2015-10-15
CL2012001540A1 (es) 2013-01-18
EA201200851A1 (ru) 2013-01-30
SI2510002T1 (sl) 2016-12-30
KR20120112528A (ko) 2012-10-11
EA201200860A1 (ru) 2013-01-30
JP2013513362A (ja) 2013-04-22
KR20120112527A (ko) 2012-10-11
PT2510006T (pt) 2017-01-20
BR112012015852A8 (pt) 2017-06-27
US9241989B2 (en) 2016-01-26
EP2510006A1 (en) 2012-10-17
EP2567977A1 (en) 2013-03-13
EP2332995A1 (en) 2011-06-15
JP2013513363A (ja) 2013-04-22
BR112012014048A2 (pt) 2017-10-31
MA33888B1 (fr) 2013-01-02
CY1118407T1 (el) 2017-06-28
AU2010330161B2 (en) 2015-07-09
US20120321632A1 (en) 2012-12-20
CA2783651A1 (en) 2011-06-16
US20130129739A1 (en) 2013-05-23
DK2510006T3 (en) 2017-01-23
JP6199930B2 (ja) 2017-09-20
CL2012001539A1 (es) 2012-10-12
EP2510002B1 (en) 2016-08-24
JP2013513365A (ja) 2013-04-22
JP2013513559A (ja) 2013-04-22
AU2010330165B2 (en) 2015-07-16
EA029327B1 (ru) 2018-03-30
CN102858804A (zh) 2013-01-02
IN2012DN05078A (es) 2015-10-23
LT2510002T (lt) 2016-11-25
ME02577B (me) 2017-06-20
MX2012006620A (es) 2012-06-21
BR112012014048B1 (pt) 2021-10-26
AU2010330161A1 (en) 2012-07-05
WO2011069795A1 (en) 2011-06-16
TW201138817A (en) 2011-11-16
CA2783514A1 (en) 2011-06-16
CN102884082A (zh) 2013-01-16
EP2510005A1 (en) 2012-10-17
CN102884082B (zh) 2015-05-20
WO2011069798A1 (en) 2011-06-16
RS55277B1 (sr) 2017-02-28
ZA201204214B (en) 2014-08-27
CU20120092A7 (es) 2012-10-15
TW201130504A (en) 2011-09-16
DOP2012000159A (es) 2012-09-30
EP2510004A1 (en) 2012-10-17
EP2570436A1 (en) 2013-03-20
SI2510006T1 (sl) 2017-02-28
EP2567978A1 (en) 2013-03-13
EP2570435A1 (en) 2013-03-20
US20130272968A1 (en) 2013-10-17
BR112012015852B1 (pt) 2020-12-29
GT201200186A (es) 2014-01-06
MX339343B (es) 2016-05-20
ES2603352T3 (es) 2017-02-27
ES2610654T3 (es) 2017-04-28
DK2510002T3 (en) 2016-11-28
EP2567979A1 (en) 2013-03-13
WO2011069794A1 (en) 2011-06-16
CY1118209T1 (el) 2017-06-28
CA2783513A1 (en) 2011-06-16
EP2567980A1 (en) 2013-03-13
PH12012501131A1 (en) 2017-08-23
HUE031631T2 (en) 2017-07-28
AR079641A1 (es) 2012-02-08
CA2783513C (en) 2018-08-14
CU20120093A7 (es) 2012-10-15
AR079348A1 (es) 2012-01-18
EP2510003A1 (en) 2012-10-17
KR101765968B1 (ko) 2017-08-08
PE20171134A1 (es) 2017-08-09
US20120315276A1 (en) 2012-12-13
PH12012501129A1 (en) 2012-11-05

Similar Documents

Publication Publication Date Title
AP2012006343A0 (en) Neutralizing prolactin receptor antibodies and their therapeutic use.
IL261257B (en) Humanized fc㚚šššššr mice
CO6852025A2 (es) El anticuerpo neutralizador del receptor de prolactina mat3 y su uso terapéutico
LT3093291T (lt) Dipakeistieji oktahidropirolo [3,4-c]pirolai, kaip oreksino receptoriaus moduliatoriai
PT3812360T (pt) Compostos de monoclorotrifluoropropeno e composições e métodos utilizando os mesmos
SG10201604093XA (en) Antibody formulation and therapeutic regimens
BR112012005208A2 (pt) antiocorpos contra o receptor de glucagon e seu uso
BR112012005502A2 (pt) dispositivo de estímulo pontual
BRPI0911563A2 (pt) uso de antagonista da progesterona
EP2211793A4 (en) Penis covering
BRPI1013698A2 (pt) métodos para tratamento com o uso de terapia de combinação
BRPI0919903A2 (pt) dispositivo de mobilização corporal e utilização do dispositivo
BR112013008872A2 (pt) mecanismo de ajuste de dose e método de uso do mesmo
BRPI1011036A2 (pt) uso
BRPI0909840A2 (pt) Uso de 4-tio-2-deoxinucleosídios
PL2100692T3 (pl) Sposób wytwarzania urządzenia obróbkowego z korpusem z betonu
BR112012001837A2 (pt) uso de fulvestrant
BRPI1009257A2 (pt) antagonista receptor de mineralocorticoide e métodos de uso.
EP2658497A4 (en) ABSORBENT ARTICLE WITH A STIMULATING COMPOSITE
BR112012018395A2 (pt) retentor de glande
BR112013011728A2 (pt) terapia de combinação com dexametasona
ES2388332T8 (es) Dispositivo de extensión de pene
ES1073435Y (es) Dispositivo para ornamentacion corporal solar
HK1167385A (en) Thiazole derivatives and their use as p2y12 receptor antagonists
ES1071986Y (es) Dispositivo para el tratamiento de la precombustion