ECSP13012385A - Compuestos heterocíclicos agonistas del receptor ip - Google Patents

Compuestos heterocíclicos agonistas del receptor ip

Info

Publication number
ECSP13012385A
ECSP13012385A ECSP13012385A ECSP13012385A EC SP13012385 A ECSP13012385 A EC SP13012385A EC SP13012385 A ECSP13012385 A EC SP13012385A EC SP13012385 A ECSP13012385 A EC SP13012385A
Authority
EC
Ecuador
Prior art keywords
receiver
heterocyclic compounds
derivatives
receptor
agonist
Prior art date
Application number
Other languages
English (en)
Inventor
Catherine Leblanc
Steven John Charlton
Stephen Carl Mckeown
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP13012385A publication Critical patent/ECSP13012385A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención proporciona derivados heterocíclicos que activan el receptor IP. La activación de la senda de señalización del receptor IP es útil para tratar muchas formas de hipertensión arterial pulmonar (PAH), fibrosis pulmonar, y para ejercer efectos benéficos sobre las condiciones fibróticas de diferentes órganos en modelos animales y en los pacientes. También se abarcan las composiciones farmacéuticas que comprenden estos derivados.
ECSP13012385 2010-07-14 2013-01-14 Compuestos heterocíclicos agonistas del receptor ip ECSP13012385A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36413510P 2010-07-14 2010-07-14

Publications (1)

Publication Number Publication Date
ECSP13012385A true ECSP13012385A (es) 2013-03-28

Family

ID=44628483

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012385 ECSP13012385A (es) 2010-07-14 2013-01-14 Compuestos heterocíclicos agonistas del receptor ip

Country Status (35)

Country Link
US (2) US8754085B2 (es)
EP (1) EP2593452B1 (es)
JP (1) JP5781159B2 (es)
KR (1) KR101491938B1 (es)
CN (1) CN103097385B (es)
AU (1) AU2011278279C1 (es)
BR (1) BR112013000946B1 (es)
CA (1) CA2804744C (es)
CL (1) CL2013000104A1 (es)
CO (1) CO6660445A2 (es)
CR (1) CR20130012A (es)
CU (1) CU24147B1 (es)
CY (1) CY1118819T1 (es)
DK (1) DK2593452T3 (es)
EA (1) EA022046B1 (es)
EC (1) ECSP13012385A (es)
ES (1) ES2622519T3 (es)
GT (1) GT201300018A (es)
HR (1) HRP20170617T1 (es)
HU (1) HUE031710T2 (es)
IL (1) IL224164A (es)
LT (1) LT2593452T (es)
MA (1) MA34373B1 (es)
MX (1) MX2013000537A (es)
MY (1) MY156795A (es)
NZ (1) NZ605528A (es)
PE (1) PE20130404A1 (es)
PH (1) PH12013500084A1 (es)
PL (1) PL2593452T3 (es)
PT (1) PT2593452T (es)
RS (1) RS55856B1 (es)
SG (1) SG186989A1 (es)
SI (1) SI2593452T1 (es)
UA (1) UA109786C2 (es)
WO (1) WO2012007539A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA34373B1 (fr) 2010-07-14 2013-07-03 Novartis Ag Composés hétérocycliques agonistes du récepteur ip
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
ES2565826T3 (es) 2012-01-13 2016-04-07 Novartis Ag Pirroles fusionados como agonistas del receptor IP para el tratamiento de hipertensión arterial pulmonar (PAH) y trastornos relacionados
WO2013105065A1 (en) 2012-01-13 2013-07-18 Novartis Ag Fused piperidines as ip receptor agonists for the treatment of pah and related disorders
US20150005311A1 (en) 2012-01-13 2015-01-01 Novartis Ag IP receptor agonist heterocyclic compounds
JP6058698B2 (ja) * 2012-01-13 2017-01-11 ノバルティス アーゲー Ｉｐ受容体アゴニストの塩
WO2013105061A1 (en) 2012-01-13 2013-07-18 Novartis Ag Fused dihydropyrido [2,3 -b] pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
US9604981B2 (en) 2013-02-13 2017-03-28 Novartis Ag IP receptor agonist heterocyclic compounds
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
CN106458980A (zh) 2014-04-24 2017-02-22 诺华股份有限公司 作为磷脂酰肌醇3‑激酶抑制剂的氨基吡啶衍生物
BR112016024533A8 (pt) 2014-04-24 2021-03-30 Novartis Ag derivados de amino pirazina como inibidores de fosfatidilinositol 3-cinase ou sal, seu uso, e composição e combinação farmacêuticas
KR20160141856A (ko) 2014-04-24 2016-12-09 노파르티스 아게 포스파티딜이노시톨 3-키나제 억제제로서의 피라진 유도체
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
KR102598895B1 (ko) * 2016-07-12 2023-11-07 레볼루션 메디슨즈, 인크. 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
BR112019012251A2 (pt) 2016-12-14 2019-11-05 Respira Therapeutics, Inc métodos e composições para tratamento de hipertensão pulmonar e outros distúrbios pulmonares
TWI800498B (zh) 2016-12-21 2023-05-01 義大利商吉斯藥品公司 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物
JP7240319B2 (ja) 2017-01-23 2023-03-15 レヴォリューション・メディスンズ，インコーポレイテッド アロステリックｓｈｐ２阻害剤としての二環式化合物
KR20190110588A (ko) 2017-01-23 2019-09-30 레볼루션 메디슨즈, 인크. 알로스테릭 shp2 억제제로서의 피리딘 화합물
CA3047212A1 (en) 2017-01-30 2018-08-02 Chiesi Farmaceutici S.P.A. Tyrosine amide derivatives as rho- kinase inhibitors
AU2018302179A1 (en) 2017-07-18 2020-02-13 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
MX2020000693A (es) * 2017-07-18 2020-07-29 Nuvation Bio Inc Compuestos de 1,8-naftiridinona, y usos de los mismos.
WO2019048479A1 (en) 2017-09-07 2019-03-14 Chiesi Farmaceutici S.P.A. DERIVATIVES OF TYROSINE ANALOGS AS INHIBITORS OF RHO-KINASE
MX2020003579A (es) 2017-10-12 2020-07-22 Revolution Medicines Inc Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos.
TW201927791A (zh) 2017-12-15 2019-07-16 美商銳新醫藥公司 作為變構shp2抑制劑的多環化合物
US11578068B2 (en) 2017-12-18 2023-02-14 Chiesi Farmaceutici S.P.A. Oxadiazole derivatives as Rho-Kinase Inhibitors
EP3728246B1 (en) 2017-12-18 2021-09-22 Chiesi Farmaceutici S.p.A. Meta tyrosine derivatives as rho-kinase inhibitors
MA51285A (fr) 2017-12-18 2021-04-28 Chiesi Farm Spa Dérivés d'azaindole comme inhibiteurs de rho-kinase
AR114926A1 (es) 2018-06-13 2020-10-28 Chiesi Farm Spa Derivados de azaindol como inhibidores de rho-quinasa
TW202019923A (zh) 2018-07-16 2020-06-01 義大利商吉斯藥品公司 作為Ｒｈｏ－激酶抑制劑之酪胺酸醯胺衍生物
WO2020150676A1 (en) * 2019-01-18 2020-07-23 Nuvation Bio Inc. 1,8-naphthyridinone compounds and uses thereof
AU2020208644A1 (en) 2019-01-18 2021-08-26 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
JP2022517811A (ja) * 2019-01-18 2022-03-10 ニューベイション・バイオ・インコーポレイテッド 化合物およびそれらの使用
WO2021252951A1 (en) 2020-06-12 2021-12-16 Vanderbilt University Methods of treatment for gastrointestinal motility disorders
KR20230121811A (ko) 2020-12-15 2023-08-21 키에시 파르마슈티시 엣스. 피. 에이. Rho-키나아제 억제제로서 다이하이드로퓨로피리딘 유도체
MX2023005867A (es) 2020-12-15 2023-06-05 Chiesi Farm Spa Derivados de dihidrofuropiridina como inhibidores de la cinasa rho.
KR20230121812A (ko) 2020-12-15 2023-08-21 키에시 파르마슈티시 엣스. 피. 에이. Rho-키나아제 억제제로서 다이하이드로퓨로피리딘 유도체
WO2023110700A1 (en) 2021-12-13 2023-06-22 Chiesi Farmaceutici S.P.A. Dihydrofuropyridine derivatives as rho-kinase inhibitors

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1454864A (en) 1974-03-05 1976-11-03 Wyeth John & Brother Ltd Thioureas
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
AU658646B2 (en) 1991-05-10 1995-04-27 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
US5516652A (en) 1993-10-06 1996-05-14 Merck Frosst Canada Inc. DNA encoding prostaglandin receptor IP
EP0753528A4 (en) 1994-02-10 1999-03-10 Ono Pharmaceutical Co PROTAGLANDIN I 2? RECEPTOR
WO1996035713A1 (en) 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
GB9622386D0 (en) 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
TWI242011B (en) 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
US6166037A (en) 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
UA71586C2 (en) 1998-12-04 2004-12-15 Smithkline Beecham Corp A vitronectin receptor antagonist
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
EP1175402B1 (en) 1999-05-04 2005-07-20 Schering Corporation Piperidine derivatives useful as ccr5 antagonists
TR200103214T2 (tr) 1999-05-04 2002-03-21 Schering Corporation CCR5 antagonistleri olarak yararlì piperazin trevleri.
GB9914255D0 (en) 1999-06-18 1999-08-18 Lilly Forschung Gmbh Pharmaceutical compounds
EG24179A (en) 1999-09-07 2008-09-28 Smithkline Beecham Corp Vitronectin receptor antagonists
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
ES2316383T3 (es) 1999-09-17 2009-04-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
CN1414966A (zh) 1999-11-08 2003-04-30 麦克公司 用于制备咪唑烷酮αu蛋白拮抗剂的方法和中间体
EP1274700B1 (en) 2000-01-03 2004-11-17 Pharmacia Corporation Dihydrobenzopyrans, dihydrobenzothiopyrans, and tetrahydroquinolines for the treatment of cox-2-mediated disorders
JP2003522142A (ja) 2000-02-08 2003-07-22 スミスクライン・ビーチャム・コーポレイション 炎症性疾患の治療法および治療用組成物
NZ521028A (en) * 2000-03-16 2004-07-30 F Carboxylic acid derivatives as IP antagonists
US7119207B2 (en) 2000-04-10 2006-10-10 Pfizer Inc Benzoamide piperidine containing compounds and related compounds
EA005409B1 (ru) * 2000-04-10 2005-02-24 Пфайзер Продактс Инк. Производные бензамидопиперидина в качестве антагонистов рецепторов вещества p
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
TWI316055B (es) * 2001-04-26 2009-10-21 Nippon Shinyaku Co Ltd
MY130622A (en) 2001-11-05 2007-07-31 Novartis Ag Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors
TW200305423A (en) 2002-02-14 2003-11-01 Ono Pharmaceutical Co N-carbamoyl nitrogen-containing condensed ring compound and medicament containing same as active ingredient
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
ES2201907B1 (es) 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
SE0202483D0 (sv) 2002-08-21 2002-08-21 Astrazeneca Ab Chemical compounds
JP2006096662A (ja) 2002-09-18 2006-04-13 Sumitomo Pharmaceut Co Ltd 新規６−置換ウラシル誘導体及びアレルギー性疾患の治療剤
BR0314304A (pt) 2002-09-18 2005-07-26 Ono Pharmaceutical Co Drogas e derivados de triazapiro[5.5]undecano compreendendo o mesmo como o ingrediente ativo
JP2004107299A (ja) 2002-09-20 2004-04-08 Japan Energy Corp 新規１−置換ウラシル誘導体及びアレルギー性疾患の治療剤
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
WO2004083207A1 (en) 2003-03-12 2004-09-30 Abbott Laboratories Naphthyridine derivatives as antibacterial agents
ATE372324T1 (de) 2003-04-30 2007-09-15 Inst For Pharm Discovery Inc Substituierte heteroarylverbindungen als inhibitoren von proteintyrosinphosphatasen
WO2005020926A2 (en) 2003-08-28 2005-03-10 Pharmacia Corporation Treatment or prevention of vascular disorders with cox-2 inhibitors in combination with cyclic amp-specific phosphodiesterase inhibitors
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
RU2006116421A (ru) 2003-11-25 2008-01-10 Ново Нордиск А/С (DK) Анилиды салициловой кислоты
DE602004025504D1 (de) 2003-12-23 2010-03-25 Novartis Ag Bicyclische heterocyclische p-38-kinase-inhibitoren
GB0413960D0 (en) 2004-06-22 2004-07-28 Novartis Ag Organic compounds
AR051780A1 (es) 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
EP2392328A1 (en) 2005-05-09 2011-12-07 Hydra Biosciences, Inc. Compounds for modulating TRPV3 Function
ES2270715B1 (es) 2005-07-29 2008-04-01 Laboratorios Almirall S.A. Nuevos derivados de pirazina.
ATE517883T1 (de) 2005-08-25 2011-08-15 Schering Corp Imidazolderivate als funktionelle selektive agonisten des alpha2c-adrenorezeptors
GB0601951D0 (en) * 2006-01-31 2006-03-15 Novartis Ag Organic compounds
US7541371B2 (en) 2006-02-20 2009-06-02 Eisai R&D Management Co., Ltd. Method for treating a motor neuron disease
US20080305169A1 (en) 2006-05-26 2008-12-11 Japan Tobacco Inc. Pharmaceutical Compositions Comprising Nitrogen-Containing Fused Ring Coumpounds
US20080064871A1 (en) 2006-05-26 2008-03-13 Japan Tobacco Inc. Production Method of Nitrogen-Containing Fused Ring Compounds
US8163817B2 (en) 2007-05-11 2012-04-24 Canon Kabushiki Kaisha Aqueous ink, ink set, image forming method and image forming apparatus
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US20090054304A1 (en) * 2007-08-23 2009-02-26 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
EP2300425A4 (en) 2008-06-24 2012-03-21 Panmira Pharmaceuticals Llc PROSTAGLANDIN D2 RECEPTOR CYCLOALCANEÝBINDLUCK ANTAGONISTS
EP2324036B1 (en) 2008-07-16 2014-12-03 Merck Sharp & Dohme Corp. Bicyclic heterocycle derivatives and methods of use thereof
DE102008039082A1 (de) 2008-08-21 2010-02-25 Bayer Schering Pharma Aktiengesellschaft Azabicyclisch-substituierte 5-Aminopyrazole und ihre Verwendung
TWI368513B (en) 2009-04-30 2012-07-21 Univ Kaohsiung Medical Synthesis of pulmodil and pulmodil-1, two chlorophenylpiperazine salt derivatives, and rhokinase-dependent inhibition activity on pulmonary artery endothelium dysfunction, medial wall thickness and vascular obstruction thereof
WO2011111880A1 (ko) 2010-03-08 2011-09-15 주식회사 메디젠텍 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물
MA34373B1 (fr) 2010-07-14 2013-07-03 Novartis Ag Composés hétérocycliques agonistes du récepteur ip
ES2565826T3 (es) 2012-01-13 2016-04-07 Novartis Ag Pirroles fusionados como agonistas del receptor IP para el tratamiento de hipertensión arterial pulmonar (PAH) y trastornos relacionados
JP6058698B2 (ja) 2012-01-13 2017-01-11 ノバルティス アーゲー Ｉｐ受容体アゴニストの塩
WO2013105061A1 (en) 2012-01-13 2013-07-18 Novartis Ag Fused dihydropyrido [2,3 -b] pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
US20150005311A1 (en) 2012-01-13 2015-01-01 Novartis Ag IP receptor agonist heterocyclic compounds
US20140378463A1 (en) 2012-01-13 2014-12-25 Novartis Ag IP receptor agonist heterocyclic compounds
WO2013105065A1 (en) 2012-01-13 2013-07-18 Novartis Ag Fused piperidines as ip receptor agonists for the treatment of pah and related disorders

Also Published As

Publication number Publication date
ES2622519T3 (es) 2017-07-06
MA34373B1 (fr) 2013-07-03
HRP20170617T1 (hr) 2017-06-30
EP2593452B1 (en) 2017-01-18
CO6660445A2 (es) 2013-04-30
JP5781159B2 (ja) 2015-09-16
RS55856B1 (sr) 2017-08-31
CA2804744C (en) 2019-05-28
CL2013000104A1 (es) 2013-05-17
UA109786C2 (xx) 2015-10-12
SG186989A1 (en) 2013-02-28
AU2011278279C1 (en) 2014-11-27
US20130102611A1 (en) 2013-04-25
MY156795A (en) 2016-03-31
AU2011278279B2 (en) 2014-08-07
NZ605528A (en) 2015-02-27
EA022046B1 (ru) 2015-10-30
LT2593452T (lt) 2017-04-10
CN103097385A (zh) 2013-05-08
WO2012007539A9 (en) 2012-11-01
EA201300118A1 (ru) 2013-06-28
US9132127B2 (en) 2015-09-15
HUE031710T2 (en) 2017-07-28
CR20130012A (es) 2013-02-19
PE20130404A1 (es) 2013-04-17
GT201300018A (es) 2015-11-24
MX2013000537A (es) 2013-01-29
BR112013000946B1 (pt) 2020-09-08
US20140243346A1 (en) 2014-08-28
DK2593452T3 (en) 2017-04-24
KR101491938B1 (ko) 2015-02-10
CU20130009A7 (es) 2013-04-19
AU2011278279A1 (en) 2013-02-21
SI2593452T1 (sl) 2017-06-30
WO2012007539A1 (en) 2012-01-19
JP2013531025A (ja) 2013-08-01
CY1118819T1 (el) 2018-01-10
IL224164A (en) 2016-08-31
US8754085B2 (en) 2014-06-17
CU24147B1 (es) 2016-02-29
BR112013000946A2 (pt) 2016-05-17
CA2804744A1 (en) 2012-01-19
CN103097385B (zh) 2016-08-03
KR20130038924A (ko) 2013-04-18
EP2593452A1 (en) 2013-05-22
PT2593452T (pt) 2017-04-24
PL2593452T3 (pl) 2017-07-31
PH12013500084A1 (en) 2015-09-11

Similar Documents

Publication Publication Date Title
ECSP13012385A (es) Compuestos heterocíclicos agonistas del receptor ip
EA201200049A1 (ru) 1,3-дизамещенные производные имидазолидин-2-она в качестве ингибиторов cyp 17
ECSP17016797A (es) Indazoles sustituidos con benzilo como inhibidores de bub1
ATE502921T1 (de) Substituierte indole
CR20110455A (es) Derivados de indol como antagonistas del receptor crth2
CL2017000902A1 (es) Dihidropirrolopiridinas inhibidoras de ror-gamma
CY1117745T1 (el) Ετεροκυκλικες ενωσεις και χρηση αυτων ως ρυθμιστες υποδοχεα τυπου iii κινασων τυροσινης
EA201170227A1 (ru) Имидазолкарбоксамиды
SV2010003642A (es) Compuestos
UY32859A (es) Compuestos y composiciones como inhibidores de cinasa de proteina
UY34305A (es) Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
MX381487B (es) Ciertos inhibidores de la proteina quinasa.
CR11264A (es) Compuestos de 5-(4-halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa
EA201500628A1 (ru) Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов
EA201600128A1 (ru) СОЛИ ПРОИЗВОДНЫХ 2-АМИНО-1-ГИДРОКСИЭТИЛ-8-ГИДРОКСИХИНОЛИН-2(1Н)-ОНА, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ И АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ
BRPI0814772A2 (pt) Indazóis substituídos por 5-piridinona
ECSP12011837A (es) Derivados de pirazol que modulan la estearoil-coa-desaturasa
EA201001882A1 (ru) Гидроксизамещенные тиенопиримидиноны как антагонисты рецептора-i меланинконцентрирующего гормона
UY34543A (es) Derivados de sulfonilaminopirrolidinona, su preparación y aplicación terapéutica.
ECSP10010379A (es) Derivados de oxindol sustituido y su uso para el tratamiento de enfermedades dependientes de la vasopresina
EA201171373A1 (ru) Способы и составы для борьбы с эктопаразитами
GT201300225A (es) Tieno (2,3-d) derivados de pirimidina y su uso para el tratamiento de la arritmia
UY31423A1 (es) Compuestos de indolina
MX2019013970A (es) Composiciones farmaceuticas de liberacion sostenida retardada.
GT200800296A (es) Derivados de ácido fenilacético