ECSP22011692A - Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2 - Google Patents

Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2

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Publication number
ECSP22011692A
ECSP22011692A ECSENADI202211692A ECDI202211692A ECSP22011692A EC SP22011692 A ECSP22011692 A EC SP22011692A EC SENADI202211692 A ECSENADI202211692 A EC SENADI202211692A EC DI202211692 A ECDI202211692 A EC DI202211692A EC SP22011692 A ECSP22011692 A EC SP22011692A
Authority
EC
Ecuador
Prior art keywords
pyrimidinilamine
imidazolil
compounds
cdk2 inhibitors
cdk2
Prior art date
Application number
ECSENADI202211692A
Other languages
English (en)
Inventor
Yingnan Chen
Min Ye
Ken Mukai
Jingwei Li
Margaret Favata
Wenqing Yao
Qinda Ye
Liangxing Wu
Brandon Smith
Yvonne Lo
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP22011692A publication Critical patent/ECSP22011692A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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Abstract

La presente solicitud proporciona inhibidores de imidazolil pirimidinilamina de la quinasa 2 dependiente de ciclina (CDK2), así como sus composiciones farmacéuticas, y métodos para tratar el cáncer usando los mismos.
ECSENADI202211692A 2019-08-14 2022-02-14 Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2 ECSP22011692A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962886735P 2019-08-14 2019-08-14

Publications (1)

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ECSP22011692A true ECSP22011692A (es) 2022-05-31

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ECSENADI202211692A ECSP22011692A (es) 2019-08-14 2022-02-14 Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2

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US (3) US11427567B2 (es)
EP (1) EP4013750A1 (es)
JP (2) JP7660556B2 (es)
KR (1) KR20220064369A (es)
CN (1) CN116348458A (es)
AR (1) AR119765A1 (es)
AU (1) AU2020328025A1 (es)
BR (1) BR112022002698A2 (es)
CA (1) CA3150681A1 (es)
CL (1) CL2022000339A1 (es)
CO (1) CO2022001453A2 (es)
CR (1) CR20220066A (es)
EC (1) ECSP22011692A (es)
IL (1) IL290527A (es)
MX (2) MX2022001940A (es)
PE (1) PE20221010A1 (es)
PH (1) PH12022550361A1 (es)
TW (1) TW202115024A (es)
WO (1) WO2021030537A1 (es)

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