EE03058B1 - Apolipoproteiini molekulaarse teisendi dimeer ja selle valmistamismeetod - Google Patents
Apolipoproteiini molekulaarse teisendi dimeer ja selle valmistamismeetodInfo
- Publication number
- EE03058B1 EE03058B1 EE9400375A EE9400375A EE03058B1 EE 03058 B1 EE03058 B1 EE 03058B1 EE 9400375 A EE9400375 A EE 9400375A EE 9400375 A EE9400375 A EE 9400375A EE 03058 B1 EE03058 B1 EE 03058B1
- Authority
- EE
- Estonia
- Prior art keywords
- apolipoprotein
- dimer
- pct
- apo
- preparation
- Prior art date
Links
- 239000000539 dimer Substances 0.000 title abstract 6
- 102000007592 Apolipoproteins Human genes 0.000 title abstract 4
- 108010071619 Apolipoproteins Proteins 0.000 title abstract 4
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9103701A SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Apolipoprotein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE03058B1 true EE03058B1 (et) | 1997-12-15 |
Family
ID=20384608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9400375A EE03058B1 (et) | 1991-12-13 | 1994-11-16 | Apolipoproteiini molekulaarse teisendi dimeer ja selle valmistamismeetod |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US5876968A (fr) |
| EP (1) | EP0571602B1 (fr) |
| JP (1) | JPH07502892A (fr) |
| AT (1) | ATE242269T1 (fr) |
| AU (2) | AU3175593A (fr) |
| BG (1) | BG61451B1 (fr) |
| BR (1) | BR9205640A (fr) |
| CA (1) | CA2103996C (fr) |
| CZ (1) | CZ289879B6 (fr) |
| DE (1) | DE69233092T2 (fr) |
| DK (1) | DK0571602T3 (fr) |
| EE (1) | EE03058B1 (fr) |
| ES (1) | ES2199939T3 (fr) |
| FI (1) | FI115771B (fr) |
| HU (2) | HU217203B (fr) |
| IL (1) | IL103956A (fr) |
| MX (1) | MX9207224A (fr) |
| NO (1) | NO315076B1 (fr) |
| NZ (2) | NZ280516A (fr) |
| PL (3) | PL171907B1 (fr) |
| PT (1) | PT571602E (fr) |
| RO (1) | RO115636B1 (fr) |
| RU (1) | RU2134696C1 (fr) |
| SE (1) | SE9103701D0 (fr) |
| SG (1) | SG47453A1 (fr) |
| SK (1) | SK86893A3 (fr) |
| WO (1) | WO1993012143A1 (fr) |
| ZA (1) | ZA928989B (fr) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9103701D0 (sv) * | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
| SE9203753D0 (sv) * | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
| SE9500778D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
| US6258596B1 (en) | 1995-05-22 | 2001-07-10 | Aventis Pharmaceuticals Products Inc. | Variants of apolipoprotein A-I |
| FR2734568B1 (fr) * | 1995-05-22 | 1997-06-20 | Rhone Poulenc Rorer Sa | Nouveaux variants de l'apolipoproteine |
| SE9603068D0 (sv) * | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603303D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603304D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
| US6306433B1 (en) | 1997-08-12 | 2001-10-23 | Pharmacia Ab | Method of preparing pharmaceutical compositions |
| US20020064820A1 (en) * | 2000-03-13 | 2002-05-30 | Jean-Michel Dayer | Apo-A-I regulation of T-cell signaling |
| DE60117781T2 (de) * | 2000-04-21 | 2006-11-23 | Amgen Inc., Thousand Oaks | Peptidderivate des apolipoproteins-a1/aii |
| BRPI0003386B8 (pt) * | 2000-08-08 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | pró-droga homo ou heterodiméricas úteis no tratamento de doenças ou disfunções mediadas por fosfodiesterases; composições farmacêuticas contendo a pró-droga ou seus sais farmacêuticos aceitáveis; processo de obtenção destas pró-drogas |
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| US6664230B1 (en) * | 2000-08-24 | 2003-12-16 | The Regents Of The University Of California | Orally administered peptides to ameliorate atherosclerosis |
| BR0115257A (pt) * | 2000-11-10 | 2003-08-12 | Proteopharma Aps | Análogos de apolipoproteìna |
| US7217785B2 (en) * | 2001-05-09 | 2007-05-15 | The Regents Of The University Of California | Cysteine-containing peptides having antioxidant properties |
| PL372925A1 (en) * | 2001-09-28 | 2005-08-08 | Esperion Therapeutics Inc. | Prevention and treatment of restenosis by local administration of drug |
| US20030229062A1 (en) * | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
| WO2003049685A2 (fr) * | 2001-12-07 | 2003-06-19 | The Regents Of The University Of California | Traitement de la degenerescence maculaire liee au vieillissement |
| US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
| US7223726B2 (en) * | 2002-01-14 | 2007-05-29 | The Regents Of The University Of California | Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same |
| US20100204103A1 (en) * | 2002-05-08 | 2010-08-12 | The Regents Of The University Of California | Helical synthetic peptides that stimulate cellular cholesterol efflux |
| BR0310100A (pt) * | 2002-05-17 | 2007-04-27 | Esperion Therapeutics Inc | métodos para tratar, prevenir ou reduzir a lesão de reperfusão isquêmica em um tecido ou órgão, e para prevenir ou tratar de uma condição associada com a privação de oxigênio, seguida por suprimento de oxigênio aumentado a um tecido ou órgão em necessidade disto |
| JP2006507223A (ja) | 2002-05-17 | 2006-03-02 | エスペリオン セラピューティクス,インコーポレイテッド | 脂質代謝異常疾患の治療方法 |
| SE0302312D0 (sv) * | 2002-10-04 | 2003-08-27 | Forskarpatent I Syd Ab | Peptide-based passive immunization therapy for treatment of atherosclerosis |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| PE20050438A1 (es) * | 2003-10-20 | 2005-06-14 | Esperion Therapeutics Inc | Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos |
| WO2005051413A2 (fr) * | 2003-11-26 | 2005-06-09 | Novartis Ag | Genes associes a une maladie |
| CA2549529A1 (fr) * | 2003-12-15 | 2005-06-30 | The Regents Of The University Of California | Peptides synthetiques helicoidaux stimulant la sortie du cholesterol des cellules |
| JP2007531537A (ja) * | 2004-04-06 | 2007-11-08 | セダーズ−シナイ メディカル センター | アポリポタンパク質a−iおよびアポリポタンパク質a−imilanoをコードする組換えアデノ随伴ウイルスベクターによる血管疾患の予防および処置 |
| KR100560102B1 (ko) * | 2004-06-25 | 2006-03-13 | 한국생명공학연구원 | 프로아포리포단백질 a-ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제 |
| WO2012047930A2 (fr) * | 2010-10-04 | 2012-04-12 | The Regents Of The University Of California | Compositions et procédés de traitement de cancers gynécologiques |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| MX2007013430A (es) | 2005-04-29 | 2008-03-19 | Univ California | Peptidos y peptidos mimeticos para tratar patologias caracterizadas por una respuesta inflamatoria. |
| WO2007000924A1 (fr) * | 2005-06-28 | 2007-01-04 | Osaka University | Préparation pharmaceutique comprenant une substance susceptible d'inhiber ou de promouvoir l'activité de la progranuline et méthode de criblage pour la recherche d'une substance susceptible d'inhiber ou de promouvoir l'activité de la progranuline |
| KR100719389B1 (ko) | 2005-10-18 | 2007-05-17 | 주식회사 녹십자 | 인간혈장으로부터 아포리포단백질 a-i을 분리 정제하는방법 |
| US20070254832A1 (en) * | 2006-02-17 | 2007-11-01 | Pressler Milton L | Methods for the treatment of macular degeneration and related eye conditions |
| AU2007284801A1 (en) | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
| US9637753B2 (en) * | 2006-08-10 | 2017-05-02 | Plantechno S.R.L. | In-plant production of oligomeric (comprising three or more units) forms of human Apo A-1 protein muteins |
| US8541236B2 (en) * | 2006-12-08 | 2013-09-24 | University Of Washington | Mutant apolipoprotein A-1 polypeptide with increased resistance to oxidation and reactive carbonyls |
| WO2009032702A2 (fr) | 2007-08-28 | 2009-03-12 | Uab Research Foundation | Polypeptides synthétiques analogues d'apolipoprotéine e et procédés d'utilisation |
| EP2195331B1 (fr) | 2007-08-28 | 2013-11-20 | Uab Research Foundation | Polypeptides de synthèse imitant l'apolipoprotéine e et leurs procédés d'utilisation |
| US20100212030A1 (en) * | 2007-10-19 | 2010-08-19 | Pronota N.V. | Use of n-terminal and c-terminal proteomics technology to enhance protein therapeutics and diagnostics |
| WO2009055538A1 (fr) | 2007-10-23 | 2009-04-30 | The Cleveland Clinic Foundation | Apolipoprotéine a-1 résistante aux oxydants et peptides mimétiques |
| US8241861B1 (en) | 2008-07-08 | 2012-08-14 | Insilicos, Llc | Methods and compositions for diagnosis or prognosis of cardiovascular disease |
| CN111808084A (zh) | 2008-11-10 | 2020-10-23 | 阿布特斯生物制药公司 | 用于递送治疗剂的新型脂质和组合物 |
| EP3243504A1 (fr) | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Formulation lipidique améliorée |
| AU2010223967B2 (en) | 2009-03-12 | 2015-07-30 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes |
| SG10201911942UA (en) | 2009-05-05 | 2020-02-27 | Muthiah Manoharan | Lipid compositions |
| KR101766408B1 (ko) | 2009-06-10 | 2017-08-10 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| AP2015008874A0 (en) | 2009-08-14 | 2015-11-30 | Alnylam Pharmaceuticals Inc | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
| US10525152B2 (en) | 2009-10-09 | 2020-01-07 | Signablok, Inc. | Methods and compositions for targeted imaging |
| US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| EP3296398A1 (fr) | 2009-12-07 | 2018-03-21 | Arbutus Biopharma Corporation | Nanoparticules pour l'administration d'acide nucléique |
| RU2553333C2 (ru) * | 2009-12-14 | 2015-06-10 | Сцил Протеинс Гмбх | Способ идентификации гетеромультимерных модифицированных убиквитиновых белков со способностью связываться с лигандами |
| EP3494963A1 (fr) | 2009-12-18 | 2019-06-12 | The University of British Columbia | Procédés et compositions d'administration d'acides nucléiques |
| US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| US20130137628A1 (en) * | 2010-05-11 | 2013-05-30 | Esperion Therapeutics, Inc. | Dimeric Oxidation-Resistant Apolipoprotein A1 Variants |
| KR20190039347A (ko) | 2010-06-03 | 2019-04-10 | 알닐람 파마슈티칼스 인코포레이티드 | 활성제의 전달을 위한 생분해성 지질 |
| WO2012016184A2 (fr) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Procédés et compositions pour la délivrance d'agents actifs |
| WO2012016188A2 (fr) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Procédés et compositions pour l'administration d'agents actifs |
| US20130142760A1 (en) | 2010-08-18 | 2013-06-06 | Cedars-Sinai Medical Center | Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer |
| WO2012064824A1 (fr) | 2010-11-09 | 2012-05-18 | Alnylam Pharmaceuticals, Inc. | Compositions à formulation lipidique et procédés d'inhibition de l'expression des gènes eg5 et vegf |
| CA2824526C (fr) | 2011-01-11 | 2020-07-07 | Alnylam Pharmaceuticals, Inc. | Lipides pegyles et leur utilisation pour une administration de medicament |
| HUE042314T2 (hu) | 2011-02-07 | 2019-06-28 | Cerenis Therapeutics Holding Sa | Lipoprotein komplexek és azok gyártása és alkalmazásai |
| CA2837804C (fr) | 2011-06-15 | 2018-03-20 | Scil Proteins Gmbh | Proteines liantes dimeres obtenues a partir d'ubiquitines modifiees |
| EP2748191A1 (fr) | 2011-08-25 | 2014-07-02 | F.Hoffmann-La Roche Ag | Protéine hybride raccourcie tétranectine-apolipoprotéine a-i, particule lipidique la contenant, et utilisations associées |
| EP3456317B1 (fr) | 2011-09-27 | 2025-09-24 | Alnylam Pharmaceuticals, Inc. | Lipides di-aliphatiques pegylés substitués |
| WO2014011908A1 (fr) | 2012-07-11 | 2014-01-16 | Esperion Therapeutics, Inc. | Mélanges d'apolipoprotéine |
| EP2853259A1 (fr) | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Composition de lipoprotéines haute densité reconstituées et leurs utilisations |
| CA2947127A1 (fr) | 2014-05-02 | 2015-11-19 | Cerenis Therapeutics Holding Sa | Marqueurs de therapie hdl |
| WO2016018665A1 (fr) | 2014-07-31 | 2016-02-04 | Uab Research Foundation | Peptides e-mimétiques d'apo ayant une puissance supérieure afin de dégager le taux de cholestérol plasmatique |
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH | 新規なegfr結合タンパク質 |
| JP6856938B2 (ja) | 2015-07-16 | 2021-04-14 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングNavigo Proteins GmbH | 新規な免疫グロブリン結合タンパク質およびアフィニティ精製におけるそれらの使用 |
| WO2017013136A1 (fr) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Nouvelles protéines de liaison à base de mutéines de di-ubiquitine et procédés de production |
| US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CN109963864B (zh) | 2016-08-11 | 2024-01-02 | 瑞普利金公司 | 用于亲和色谱的碱性稳定性fc结合蛋白 |
| EP3668600B1 (fr) | 2017-08-10 | 2024-05-15 | Abionyx Pharma SA | Cargomères |
| ES2984286T3 (es) | 2017-08-10 | 2024-10-29 | Abionyx Pharma Sa | Apómeros |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| MX2021007283A (es) | 2018-12-18 | 2021-07-15 | Navigo Proteins Gmbh | Proteinas de union especificas del folr1 novedosas para diagnostico y tratamiento del cancer. |
| MX2022012969A (es) | 2020-04-16 | 2022-11-09 | Abionyx Pharma Sa | Metodos para el tratamiento de condiciones agudas usando complejos basados en proteinas de union a lipidos. |
| IL301769A (en) | 2020-10-01 | 2023-05-01 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| MX2023012223A (es) | 2021-04-15 | 2023-10-26 | Abionyx Pharma Sa | Uso de complejos a base de proteinas de union a lipidos en soluciones de conservacion de organos. |
| CN119317440A (zh) | 2022-04-06 | 2025-01-14 | 阿比奥尼克斯制药公司 | 使用基于脂质结合蛋白的复合物治疗白细胞增多、内皮功能障碍和心脏炎的方法 |
| AU2023250345A1 (en) | 2022-04-06 | 2024-11-14 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| JP2025519606A (ja) | 2022-06-10 | 2025-06-26 | アビオニクス ファーマ エスエー | 脂質結合タンパク質に基づく複合体を使用して急性状態を処置するための方法 |
| IL317448A (en) | 2022-06-10 | 2025-02-01 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using complexes based on lipid-binding proteins |
| IL322074A (en) | 2023-01-13 | 2025-09-01 | Abionyx Pharma Sa | Treatment using a lipid-binding protein molecule |
| WO2025093929A1 (fr) | 2023-10-31 | 2025-05-08 | Abionyx Pharma Sa | Thérapie par molécules à protéine d'ancrage lipidique |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
| IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
| SE9103701D0 (sv) * | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
-
1991
- 1991-12-13 SE SE9103701A patent/SE9103701D0/xx unknown
-
1992
- 1992-11-20 ZA ZA928989A patent/ZA928989B/xx unknown
- 1992-12-03 IL IL10395692A patent/IL103956A/en not_active IP Right Cessation
- 1992-12-11 HU HU9302344A patent/HU217203B/hu not_active IP Right Cessation
- 1992-12-11 PT PT93900484T patent/PT571602E/pt unknown
- 1992-12-11 US US08/104,063 patent/US5876968A/en not_active Expired - Lifetime
- 1992-12-11 DK DK93900484T patent/DK0571602T3/da active
- 1992-12-11 PL PL92300262A patent/PL171907B1/pl not_active IP Right Cessation
- 1992-12-11 ES ES93900484T patent/ES2199939T3/es not_active Expired - Lifetime
- 1992-12-11 JP JP5510842A patent/JPH07502892A/ja active Pending
- 1992-12-11 RU RU93054168A patent/RU2134696C1/ru not_active IP Right Cessation
- 1992-12-11 WO PCT/SE1992/000858 patent/WO1993012143A1/fr not_active Ceased
- 1992-12-11 AT AT93900484T patent/ATE242269T1/de not_active IP Right Cessation
- 1992-12-11 PL PL92314894A patent/PL172544B1/pl not_active IP Right Cessation
- 1992-12-11 RO RO93-01116A patent/RO115636B1/ro unknown
- 1992-12-11 PL PL92314896A patent/PL172168B1/pl unknown
- 1992-12-11 CA CA002103996A patent/CA2103996C/fr not_active Expired - Fee Related
- 1992-12-11 BR BR9205640A patent/BR9205640A/pt not_active Application Discontinuation
- 1992-12-11 NZ NZ280516A patent/NZ280516A/en unknown
- 1992-12-11 DE DE69233092T patent/DE69233092T2/de not_active Expired - Lifetime
- 1992-12-11 EP EP93900484A patent/EP0571602B1/fr not_active Expired - Lifetime
- 1992-12-11 SG SG1996001800A patent/SG47453A1/en unknown
- 1992-12-11 NZ NZ246223A patent/NZ246223A/en unknown
- 1992-12-11 SK SK868-93A patent/SK86893A3/sk unknown
- 1992-12-11 MX MX9207224A patent/MX9207224A/es unknown
- 1992-12-11 AU AU31755/93A patent/AU3175593A/en not_active Abandoned
- 1992-12-11 CZ CZ19931589A patent/CZ289879B6/cs not_active IP Right Cessation
-
1993
- 1993-08-11 BG BG98036A patent/BG61451B1/bg unknown
- 1993-08-12 NO NO19932866A patent/NO315076B1/no not_active IP Right Cessation
- 1993-08-12 FI FI933557A patent/FI115771B/fi not_active IP Right Cessation
-
1994
- 1994-11-16 EE EE9400375A patent/EE03058B1/xx unknown
-
1995
- 1995-06-30 HU HU95P/P00630P patent/HU211667A9/hu unknown
-
1996
- 1996-07-12 AU AU59473/96A patent/AU703283B2/en not_active Ceased
-
1999
- 1999-03-01 US US09/259,434 patent/US6617134B1/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE03058B1 (et) | Apolipoproteiini molekulaarse teisendi dimeer ja selle valmistamismeetod | |
| RU93054168A (ru) | Димер молекулярного варианта аро-липопротеина, способ его получения, фармацевтическая композиция на его основе | |
| RU2159761C2 (ru) | Замещенные 4-биарилмасляные или 5-биарилпентановые кислоты или их производные, способы их получения, фармацевтическая композиция и способ лечения | |
| IL126038A0 (en) | Novel benzothiepines and derivatives thereof and pharmaceutical compositions comprising them | |
| PT706398E (pt) | Composicao farmaceutica contendo heparina fragmentos de heparina ou seus derivados em combinacao com esteres de glicerol | |
| DK0754048T3 (da) | Behandling af partielt væksthormon-insentivitetssyndrom | |
| ATE185548T1 (de) | Verwendung von n-arylmethylen ethylendiamintriacetate, n-arylmethylen iminodiacetat oder n,n'-diarylmethylen ethylendiamindiacetat gegen oxidativen stress | |
| NO962664L (no) | Forbindelser med veksthormonfrigjörende egenskaper | |
| DE3684409D1 (de) | Verwendung von gamma-linolensaeure und verwandten verbindungen zur herstellung eubnes arzneimittels zur behandlung von endometriose. | |
| ATE73332T1 (de) | Neuartige verwendung von taurolin. | |
| DK0690721T3 (da) | Behandling af Mycobakterielle sygdomme ved indgivelse af baktericidt/permeabilitets-forøgende proteinprodukter | |
| EA200200348A1 (ru) | Фармацевтические растворы левосимендана | |
| EP0719791A2 (fr) | Médicaments pour le traitement de la restenose et de la sclérose artérielle | |
| KR0148213B1 (en) | Phenyla lkan(en)oic acid and pharmaceutical composition comprising the same | |
| AU2696584A (en) | Pharmaceutical compositions of anti-pancreatic inflammatory effect | |
| KR930012023A (ko) | 환원된 형태의 비글리코실화 재조합 인체 il2의 안정화된 제약 조성물 및 그의 제조방법 | |
| DK0966455T3 (da) | Oxirancarboxylsyrer til behandling af diabetes | |
| ZA954826B (en) | New hydrazino and hydroxyamino-14beta-hydroxyandrostane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same | |
| WO1999050286A3 (fr) | Peptides antioxydants | |
| SE9301324D0 (sv) | New method of treatment | |
| DK0733371T3 (da) | Middel til subkutan administrering af protein C | |
| IT1247508B (it) | Composizioni farmaceutiche contenenti l'estere 4-(2 metilamminoetil)- 1,2- fenilenicodell`acido 2-metilpropanoico per il trattamento della neurootticopatia glaucomatosa | |
| DK563886A (da) | Terapeutisk komposition | |
| IT215302Z2 (it) | Tavolo provvisto di porzioni di estremita' sfilabili, disposte inferiormente al suo ripiano e suscettibili di disporsi complanarmente allo stesso. |