NO315076B1 - Dimerpreparat av molekyl¶rvariant av apolipoprotein og fremgangsmåter for fremstilling og anvendelse derav, til fremstilling av et medikamentfor behandling av aterosklerose og kardiovaskul¶re sykdommer - Google Patents
Dimerpreparat av molekyl¶rvariant av apolipoprotein og fremgangsmåter for fremstilling og anvendelse derav, til fremstilling av et medikamentfor behandling av aterosklerose og kardiovaskul¶re sykdommer Download PDFInfo
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- NO315076B1 NO315076B1 NO19932866A NO932866A NO315076B1 NO 315076 B1 NO315076 B1 NO 315076B1 NO 19932866 A NO19932866 A NO 19932866A NO 932866 A NO932866 A NO 932866A NO 315076 B1 NO315076 B1 NO 315076B1
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- Prior art keywords
- apo
- dimer
- apolipoprotein
- milano
- preparation
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9103701A SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Apolipoprotein |
| PCT/SE1992/000858 WO1993012143A1 (fr) | 1991-12-13 | 1992-12-11 | Dimere de variantes moleculaires d'apolipoproteines et procedes d'obtention de ce dimere |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO932866D0 NO932866D0 (no) | 1993-08-12 |
| NO932866L NO932866L (no) | 1993-08-12 |
| NO315076B1 true NO315076B1 (no) | 2003-07-07 |
Family
ID=20384608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19932866A NO315076B1 (no) | 1991-12-13 | 1993-08-12 | Dimerpreparat av molekyl¶rvariant av apolipoprotein og fremgangsmåter for fremstilling og anvendelse derav, til fremstilling av et medikamentfor behandling av aterosklerose og kardiovaskul¶re sykdommer |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US5876968A (fr) |
| EP (1) | EP0571602B1 (fr) |
| JP (1) | JPH07502892A (fr) |
| AT (1) | ATE242269T1 (fr) |
| AU (2) | AU3175593A (fr) |
| BG (1) | BG61451B1 (fr) |
| BR (1) | BR9205640A (fr) |
| CA (1) | CA2103996C (fr) |
| CZ (1) | CZ289879B6 (fr) |
| DE (1) | DE69233092T2 (fr) |
| DK (1) | DK0571602T3 (fr) |
| EE (1) | EE03058B1 (fr) |
| ES (1) | ES2199939T3 (fr) |
| FI (1) | FI115771B (fr) |
| HU (2) | HU217203B (fr) |
| IL (1) | IL103956A (fr) |
| MX (1) | MX9207224A (fr) |
| NO (1) | NO315076B1 (fr) |
| NZ (2) | NZ280516A (fr) |
| PL (3) | PL172544B1 (fr) |
| PT (1) | PT571602E (fr) |
| RO (1) | RO115636B1 (fr) |
| RU (1) | RU2134696C1 (fr) |
| SE (1) | SE9103701D0 (fr) |
| SG (1) | SG47453A1 (fr) |
| SK (1) | SK86893A3 (fr) |
| WO (1) | WO1993012143A1 (fr) |
| ZA (1) | ZA928989B (fr) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9103701D0 (sv) * | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
| SE9203753D0 (sv) * | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
| SE9500778D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
| FR2734568B1 (fr) * | 1995-05-22 | 1997-06-20 | Rhone Poulenc Rorer Sa | Nouveaux variants de l'apolipoproteine |
| US6258596B1 (en) | 1995-05-22 | 2001-07-10 | Aventis Pharmaceuticals Products Inc. | Variants of apolipoprotein A-I |
| SE9603068D0 (sv) * | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603303D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603304D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
| US6306433B1 (en) | 1997-08-12 | 2001-10-23 | Pharmacia Ab | Method of preparing pharmaceutical compositions |
| US20020064820A1 (en) * | 2000-03-13 | 2002-05-30 | Jean-Michel Dayer | Apo-A-I regulation of T-cell signaling |
| DK1290013T3 (da) * | 2000-04-21 | 2006-06-26 | Amgen Inc | Apo-A1/All-peptidderivater |
| BRPI0003386B8 (pt) * | 2000-08-08 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | pró-droga homo ou heterodiméricas úteis no tratamento de doenças ou disfunções mediadas por fosfodiesterases; composições farmacêuticas contendo a pró-droga ou seus sais farmacêuticos aceitáveis; processo de obtenção destas pró-drogas |
| US6664230B1 (en) * | 2000-08-24 | 2003-12-16 | The Regents Of The University Of California | Orally administered peptides to ameliorate atherosclerosis |
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| WO2002038609A2 (fr) * | 2000-11-10 | 2002-05-16 | Proteopharma Aps | Analogues d'apolipoproteine |
| US7217785B2 (en) * | 2001-05-09 | 2007-05-15 | The Regents Of The University Of California | Cysteine-containing peptides having antioxidant properties |
| NZ532217A (en) * | 2001-09-28 | 2006-12-22 | Esperion Therapeutics Inc | Use of an alpha helical apolipoprotein or HDL associating protein adapted to be administered locally to prevent or reduce stenosis or restenosis or to stabilize a plaque |
| US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
| AU2002360489A1 (en) * | 2001-12-07 | 2003-06-23 | The Regents Of The University Of California | Treatment for age-related macular degeneration |
| US20030229062A1 (en) * | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
| US7223726B2 (en) * | 2002-01-14 | 2007-05-29 | The Regents Of The University Of California | Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same |
| US20100204103A1 (en) * | 2002-05-08 | 2010-08-12 | The Regents Of The University Of California | Helical synthetic peptides that stimulate cellular cholesterol efflux |
| MXPA04011312A (es) | 2002-05-17 | 2005-02-14 | Esperion Therapeutics Inc | Metodo para el tratamiento de desordenes dislipidemicos. |
| CN1668645A (zh) * | 2002-05-17 | 2005-09-14 | 埃斯佩里安医疗公司 | 治疗缺血再灌注的方法和组合物 |
| SE0302312D0 (sv) * | 2002-10-04 | 2003-08-27 | Forskarpatent I Syd Ab | Peptide-based passive immunization therapy for treatment of atherosclerosis |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| PE20050438A1 (es) * | 2003-10-20 | 2005-06-14 | Esperion Therapeutics Inc | Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos |
| WO2005051413A2 (fr) * | 2003-11-26 | 2005-06-09 | Novartis Ag | Genes associes a une maladie |
| EP1706131A4 (fr) * | 2003-12-15 | 2009-08-12 | Univ California | Peptides synthetiques helicoidaux stimulant la sortie du cholesterol des cellules |
| EP1732383A4 (fr) * | 2004-04-06 | 2007-05-02 | Cedars Sinai Medical Center | Prevention et traitement des maladies vasculaires avec des vecteurs de virus associes aux adenovirus de recombinaison codant l'apolipoproteine a-i et l'apolipoproteine a-i milano |
| KR100560102B1 (ko) * | 2004-06-25 | 2006-03-13 | 한국생명공학연구원 | 프로아포리포단백질 ａ－ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제 |
| WO2012047930A2 (fr) * | 2010-10-04 | 2012-04-12 | The Regents Of The University Of California | Compositions et procédés de traitement de cancers gynécologiques |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| AU2006242651B2 (en) | 2005-04-29 | 2013-05-16 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| WO2007000924A1 (fr) * | 2005-06-28 | 2007-01-04 | Osaka University | Préparation pharmaceutique comprenant une substance susceptible d'inhiber ou de promouvoir l'activité de la progranuline et méthode de criblage pour la recherche d'une substance susceptible d'inhiber ou de promouvoir l'activité de la progranuline |
| KR100719389B1 (ko) | 2005-10-18 | 2007-05-17 | 주식회사 녹십자 | 인간혈장으로부터 아포리포단백질 ａ-ｉ을 분리 정제하는방법 |
| US20070254832A1 (en) * | 2006-02-17 | 2007-11-01 | Pressler Milton L | Methods for the treatment of macular degeneration and related eye conditions |
| EP2049137A4 (fr) | 2006-08-08 | 2013-05-01 | Univ California | Les salicylanilides renforcent l'administration par voie orale de peptides thérapeutiques |
| US9637753B2 (en) * | 2006-08-10 | 2017-05-02 | Plantechno S.R.L. | In-plant production of oligomeric (comprising three or more units) forms of human Apo A-1 protein muteins |
| US8541236B2 (en) * | 2006-12-08 | 2013-09-24 | University Of Washington | Mutant apolipoprotein A-1 polypeptide with increased resistance to oxidation and reactive carbonyls |
| JP2010538005A (ja) | 2007-08-28 | 2010-12-09 | ユーエービー リサーチ ファウンデーション | 合成アポリポ蛋白質ｅ模倣ポリペプチドおよび使用方法 |
| AU2008296487A1 (en) | 2007-08-28 | 2009-03-12 | The Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
| US20100212030A1 (en) * | 2007-10-19 | 2010-08-19 | Pronota N.V. | Use of n-terminal and c-terminal proteomics technology to enhance protein therapeutics and diagnostics |
| ES2601830T3 (es) | 2007-10-23 | 2017-02-16 | The Cleveland Clinic Foundation | Apolipoproteína A-1 resistente a oxidantes y péptidos miméticos |
| US8241861B1 (en) | 2008-07-08 | 2012-08-14 | Insilicos, Llc | Methods and compositions for diagnosis or prognosis of cardiovascular disease |
| EP3699172A3 (fr) | 2008-11-10 | 2020-11-18 | Arbutus Biopharma Corporation | Nouveaux lipides et compositions d'administration d'agents thérapeutiques |
| EP2391343B1 (fr) | 2009-01-29 | 2017-03-01 | Arbutus Biopharma Corporation | Préparation lipidique améliorée pour la delivrance d'acides nucleiques |
| CA2754043A1 (fr) | 2009-03-12 | 2010-09-16 | Alnylam Pharmaceuticals, Inc. | Compositions formulees de lipides et procedes d'inhibition de l'expression de genes de eg5 et de vegf |
| CA3042927C (fr) | 2009-05-05 | 2022-05-17 | Arbutus Biopharma Corporation | Compositions de lipides servant a distribuer des agents therapeutiques |
| KR20220038506A (ko) | 2009-06-10 | 2022-03-28 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| US9029338B2 (en) | 2009-08-14 | 2015-05-12 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
| WO2011044545A2 (fr) | 2009-10-09 | 2011-04-14 | Sigalov Alexander B | Procédés et compositions pour une imagerie ciblée |
| US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| CA3044884A1 (fr) | 2009-12-07 | 2011-06-16 | Arbutus Biopharma Corporation | Compositions utilisees pour l'administration d'acides nucleiques |
| BR112012014417B1 (pt) * | 2009-12-14 | 2021-11-09 | Scil Proteins Gmbh | Proteínas ubiquitinas modificadas tendo uma atividade de ligação específica para o extradomínio b de fibronectina |
| US20130017223A1 (en) | 2009-12-18 | 2013-01-17 | The University Of British Columbia | Methods and compositions for delivery of nucleic acids |
| WO2011139911A2 (fr) | 2010-04-29 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Arn simple brin à formulation lipidique |
| WO2011143362A1 (fr) * | 2010-05-11 | 2011-11-17 | Esperion Therapeutics, Inc. | Variants d'apolipoprotéine a1 résistants à l'oxydation dimères |
| EP4481047A3 (fr) | 2010-06-03 | 2025-04-16 | Alnylam Pharmaceuticals, Inc. | Lipides biodégradables pour l'administration d'agents actifs |
| WO2012016188A2 (fr) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Procédés et compositions pour l'administration d'agents actifs |
| WO2012016184A2 (fr) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Procédés et compositions pour la délivrance d'agents actifs |
| WO2012024309A2 (fr) | 2010-08-18 | 2012-02-23 | Cedars-Sinai Medical Center | Inhibition de l'athérosclérose par le biais de la modulation du phénotype des monocytes-macrophages en utilisant le transfert du gène apo a-i milano |
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| US9999673B2 (en) | 2011-01-11 | 2018-06-19 | Alnylam Pharmaceuticals, Inc. | PEGylated lipids and their use for drug delivery |
| LT2673296T (lt) | 2011-02-07 | 2019-02-25 | Cerenis Therapeutics Holding Sa | Lipoproteino kompleksai ir jų gamyba ir jų panaudojimai |
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| CA2838070A1 (fr) | 2011-08-25 | 2013-02-28 | F. Hoffmann-La Roche Ag | Proteine hybride raccourcie tetranectine-apolipoproteine a-i, particule lipidique la contenant, et utilisations associees |
| JP6250543B2 (ja) | 2011-09-27 | 2017-12-20 | アルニラム・ファーマシューティカルズ・インコーポレーテッド | ジ脂肪族置換ｐｅｇ化脂質 |
| WO2014011908A1 (fr) | 2012-07-11 | 2014-01-16 | Esperion Therapeutics, Inc. | Mélanges d'apolipoprotéine |
| EP2853259A1 (fr) | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Composition de lipoprotéines haute densité reconstituées et leurs utilisations |
| RU2016144908A (ru) | 2014-05-02 | 2018-06-05 | Серени Терапеутикс Холдинг Са | Маркеры hdl-терапии |
| JP7081923B2 (ja) | 2014-07-31 | 2022-06-07 | ユーエイビー リサーチ ファンデーション | アポｅ模倣ペプチド及び血漿コレステロールを取り除くためのより高い効果 |
| EP3253785B1 (fr) | 2015-02-06 | 2019-04-10 | Navigo Proteins Gmbh | Nouvelles protéines se liant aux egfr |
| DK3322721T3 (da) | 2015-07-16 | 2022-03-14 | Navigo Proteins Gmbh | Nye immunglobulin-bindende proteiner og deres anvendelse i affinitetsoprensning |
| JP2018520675A (ja) | 2015-07-20 | 2018-08-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法 |
| AU2017260274A1 (en) | 2016-05-04 | 2018-11-01 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
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| KR20210104106A (ko) | 2018-12-18 | 2021-08-24 | 나피고 프로타인스 게엠베하 | 암 진단 및 치료를 위한 신규 folr1 특이적 결합 단백질 |
| KR20230004605A (ko) | 2020-04-16 | 2023-01-06 | 아비오닉스 파마 에스에이 | 지질 결합 단백질-기반 복합체를 사용하여 급성 상태를 치료하는 방법 |
| CA3197168A1 (fr) | 2020-10-01 | 2022-04-07 | Abionyx Pharma Sa | Methodes de traitement de maladies oculaires faisant appel a des complexes a base de proteine de liaison aux lipides |
| CA3216226A1 (fr) | 2021-04-15 | 2022-10-20 | Abionyx Pharma Sa | Utilisation de complexes a base de proteines se liant aux lipides dans des solutions de conservation d'organes |
| US20250230208A1 (en) | 2022-04-06 | 2025-07-17 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| CN119317440A (zh) | 2022-04-06 | 2025-01-14 | 阿比奥尼克斯制药公司 | 使用基于脂质结合蛋白的复合物治疗白细胞增多、内皮功能障碍和心脏炎的方法 |
| CA3258787A1 (fr) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Méthodes de traitement de pathologies hyperinflammatoires à l'aide de complexes à base de protéines liant les lipides |
| WO2023237935A2 (fr) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Méthodes de traitement d'affections aiguës à l'aide de complexes à base de protéines se liant à des lipides |
| KR20260010675A (ko) | 2023-01-13 | 2026-01-21 | 아비오닉스 파마 에스에이 | 지질 결합 단백질 분자 치료 |
| IL327995A (en) | 2023-10-31 | 2026-06-01 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
| IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
| SE9103701D0 (sv) * | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
-
1991
- 1991-12-13 SE SE9103701A patent/SE9103701D0/xx unknown
-
1992
- 1992-11-20 ZA ZA928989A patent/ZA928989B/xx unknown
- 1992-12-03 IL IL10395692A patent/IL103956A/en not_active IP Right Cessation
- 1992-12-11 AT AT93900484T patent/ATE242269T1/de not_active IP Right Cessation
- 1992-12-11 PT PT93900484T patent/PT571602E/pt unknown
- 1992-12-11 CA CA002103996A patent/CA2103996C/fr not_active Expired - Fee Related
- 1992-12-11 HU HU9302344A patent/HU217203B/hu not_active IP Right Cessation
- 1992-12-11 PL PL92314894A patent/PL172544B1/pl not_active IP Right Cessation
- 1992-12-11 US US08/104,063 patent/US5876968A/en not_active Expired - Lifetime
- 1992-12-11 AU AU31755/93A patent/AU3175593A/en not_active Abandoned
- 1992-12-11 BR BR9205640A patent/BR9205640A/pt not_active Application Discontinuation
- 1992-12-11 CZ CZ19931589A patent/CZ289879B6/cs not_active IP Right Cessation
- 1992-12-11 EP EP93900484A patent/EP0571602B1/fr not_active Expired - Lifetime
- 1992-12-11 MX MX9207224A patent/MX9207224A/es unknown
- 1992-12-11 ES ES93900484T patent/ES2199939T3/es not_active Expired - Lifetime
- 1992-12-11 SG SG1996001800A patent/SG47453A1/en unknown
- 1992-12-11 SK SK868-93A patent/SK86893A3/sk unknown
- 1992-12-11 DE DE69233092T patent/DE69233092T2/de not_active Expired - Lifetime
- 1992-12-11 RO RO93-01116A patent/RO115636B1/ro unknown
- 1992-12-11 JP JP5510842A patent/JPH07502892A/ja active Pending
- 1992-12-11 RU RU93054168A patent/RU2134696C1/ru not_active IP Right Cessation
- 1992-12-11 DK DK93900484T patent/DK0571602T3/da active
- 1992-12-11 NZ NZ280516A patent/NZ280516A/en unknown
- 1992-12-11 WO PCT/SE1992/000858 patent/WO1993012143A1/fr not_active Ceased
- 1992-12-11 PL PL92314896A patent/PL172168B1/pl unknown
- 1992-12-11 NZ NZ246223A patent/NZ246223A/en unknown
- 1992-12-11 PL PL92300262A patent/PL171907B1/pl not_active IP Right Cessation
-
1993
- 1993-08-11 BG BG98036A patent/BG61451B1/bg unknown
- 1993-08-12 FI FI933557A patent/FI115771B/fi not_active IP Right Cessation
- 1993-08-12 NO NO19932866A patent/NO315076B1/no not_active IP Right Cessation
-
1994
- 1994-11-16 EE EE9400375A patent/EE03058B1/xx unknown
-
1995
- 1995-06-30 HU HU95P/P00630P patent/HU211667A9/hu unknown
-
1996
- 1996-07-12 AU AU59473/96A patent/AU703283B2/en not_active Ceased
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1999
- 1999-03-01 US US09/259,434 patent/US6617134B1/en not_active Expired - Fee Related
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