EE03520B1 - Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid - Google Patents

Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid

Info

Publication number
EE03520B1
EE03520B1 EE9700375A EE9700375A EE03520B1 EE 03520 B1 EE03520 B1 EE 03520B1 EE 9700375 A EE9700375 A EE 9700375A EE 9700375 A EE9700375 A EE 9700375A EE 03520 B1 EE03520 B1 EE 03520B1
Authority
EE
Estonia
Prior art keywords
dialkyl ethers
terminal carboxyl
containing terminal
ethers containing
tetrazolyl groups
Prior art date
Application number
EE9700375A
Other languages
English (en)
Estonian (et)
Other versions
EE9700375A (et
Inventor
Larry Bisgaier Charles
Leroy Creger Paul
Robert Saltiel Alan
Rae Tafuri Sherrie
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE9700375A publication Critical patent/EE9700375A/xx
Publication of EE03520B1 publication Critical patent/EE03520B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/28—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/37—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C07C59/315—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
    • C07C59/353—Saturated compounds containing more than one carboxyl group containing keto groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Dental Preparations (AREA)
  • Medicinal Preparation (AREA)
EE9700375A 1995-03-24 1996-02-05 Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid EE03520B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/409,780 US5648387A (en) 1995-03-24 1995-03-24 Carboxyalkylethers, formulations, and treatment of vascular diseases
PCT/US1996/001639 WO1996030328A1 (en) 1995-03-24 1996-02-05 Terminal carboxy or tetrazole groups containing dialkyl ethers

Publications (2)

Publication Number Publication Date
EE9700375A EE9700375A (et) 1998-06-15
EE03520B1 true EE03520B1 (et) 2001-10-15

Family

ID=23621941

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700375A EE03520B1 (et) 1995-03-24 1996-02-05 Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid

Country Status (26)

Country Link
US (4) US5648387A (no)
EP (1) EP0820428B1 (no)
JP (1) JP3885115B2 (no)
KR (1) KR100408612B1 (no)
CN (1) CN1100747C (no)
AT (1) ATE192732T1 (no)
AU (1) AU692359B2 (no)
BG (1) BG63534B1 (no)
CA (1) CA2215233C (no)
CZ (1) CZ289556B6 (no)
DE (1) DE69608268T2 (no)
DK (1) DK0820428T3 (no)
EE (1) EE03520B1 (no)
ES (1) ES2148733T3 (no)
FI (1) FI973713A7 (no)
GR (1) GR3034109T3 (no)
HU (1) HUP9801825A3 (no)
NO (1) NO307878B1 (no)
NZ (1) NZ302170A (no)
PL (1) PL181673B1 (no)
PT (1) PT820428E (no)
RU (1) RU2191772C2 (no)
SK (1) SK282897B6 (no)
UA (1) UA46020C2 (no)
WO (1) WO1996030328A1 (no)
ZA (1) ZA962275B (no)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119971A (en) 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
US20030105154A1 (en) 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
EP1037623A1 (en) * 1997-12-12 2000-09-27 Warner-Lambert Company Antihyperlipidemic statin-lp(a) inhibitor combinations
EP1481962A1 (en) * 1997-12-12 2004-12-01 Warner-Lambert Company LLC New cholesterolemia-lowering carboxyalkylether compound
NZ503982A (en) * 1997-12-12 2002-03-28 Warner Lambert Co Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus
US6861555B2 (en) * 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
JP2002501887A (ja) * 1998-01-28 2002-01-22 ワーナー−ランバート・カンパニー アルツハイマー病の治療方法
OA11787A (en) * 1998-09-30 2005-07-26 Warner Lambert Co Method for preventing or delaying catheter-based revascularization.
EP1862444A3 (en) * 1999-04-01 2008-01-09 Esperion Therapeutics, Inc. Ether compounds, compositions, and uses thereof
IL145712A0 (en) 1999-04-01 2002-07-25 Esperion Therapeutics Inc Ether compounds, compositions, and uses thereof
EP1259474B1 (en) 2000-01-25 2009-05-13 Warner-Lambert Company LLC Calcium dicarboxylate ethers, methods of making same
US20040092574A1 (en) * 2000-02-07 2004-05-13 Bisgaier Charles Larry Statin-Lp(a) inhibitor combinations
DE60107559T2 (de) * 2000-04-26 2005-04-14 Warner-Lambert Co. Kombination von carboxyalkylethern mit antihypertensiva und pharmazeutische verwendung
AU2001264731A1 (en) * 2000-07-14 2002-01-30 Warner-Lambert Company Treatment of eating disorders using carboxyalkylethers
AU2002211666A1 (en) 2000-10-11 2002-04-22 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
IL155246A0 (en) 2000-10-11 2003-11-23 Esperion Therapeutics Inc Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
CA2425311C (en) 2000-10-11 2011-06-14 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US6713507B2 (en) 2000-10-11 2004-03-30 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20030225123A1 (en) * 2001-03-22 2003-12-04 Auerbach Bruce Jeffrey Antihypertensive agents and use
US20040072903A1 (en) * 2001-05-08 2004-04-15 Auerbach Bruce Jeffrey Carboxyalkylether-acat inhibitors combinations
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
EP1495034A2 (en) * 2002-04-10 2005-01-12 Esperion Therapeutics, Inc. Mimics of acyl coenzyme-a comprising pantolactone and pantothenic acid derivatives, compositions thereof, and methods of cholesterol management and related uses
AU2003255937A1 (en) * 2002-08-22 2004-03-11 Warner-Lambert Company Llc Method of treating osteoarthritis
US20040048910A1 (en) * 2002-08-22 2004-03-11 Bove Susan Elizabeth Method of treating osteoarthritis
WO2004024094A2 (en) * 2002-09-13 2004-03-25 Samford University Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
EP1572189A1 (en) * 2002-11-15 2005-09-14 Warner-Lambert Company LLC Method of lowering crp and reducing systemic inflammation
CA2513660C (en) * 2003-01-23 2012-05-08 Esperion Therapeutics, Inc. Hydroxyl compounds and compositions for cholesterol management and related uses
US20040229954A1 (en) * 2003-05-16 2004-11-18 Macdougall Diane Elaine Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
WO2005002557A1 (en) * 2003-07-03 2005-01-13 Warner-Lambert Company Llc Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof
US20050026979A1 (en) * 2003-07-31 2005-02-03 Maha Ghazzi Methods for treating inflammation and inflammation-associated diseases with a statin and ether
US7390504B2 (en) * 2003-11-07 2008-06-24 Jj Pharma, Inc. HDL-boosting combination therapy complexes
US20050192347A1 (en) * 2003-12-23 2005-09-01 Dasseux Jean-Louis H. Urea and thiourea compounds and compositions for cholesterol management and related uses
WO2005068412A1 (en) 2003-12-24 2005-07-28 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
AU2003300438A1 (en) * 2003-12-24 2005-08-03 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
WO2005123700A1 (en) * 2004-06-09 2005-12-29 Avanir Pharmaceuticals Small molecules for treatment of hypercholesterolemia and related diseases
EP1753782A1 (en) * 2004-06-09 2007-02-21 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
UY28953A1 (es) * 2004-06-09 2006-01-31 Avanir Pharmaceuticals Derivados heterocíclicos para el tratamiento de hiperlipidemia y enfermedades relacionadas
CA2584485C (en) * 2004-10-20 2013-12-31 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
JP5368792B2 (ja) * 2005-07-29 2013-12-18 レスバーロジックス コーポレイション 複合疾患の予防および処置のための薬学的組成物および挿入可能な医療用デバイスによるその送達
US7777071B2 (en) * 2006-08-11 2010-08-17 Ssv Therapeutics, Inc. Production of carnitine conjugate intermediates
DK2118074T3 (en) * 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
PL2167069T3 (pl) 2007-05-23 2012-04-30 Amcol International Corp Krzemiany warstwowe oddziałujące z cholesterolem oraz sposoby zmniejszania hipercholesterolemii u ssaka
US7985727B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Apo A-I mimetic peptides and methods of treatment
US8101565B2 (en) * 2007-09-20 2012-01-24 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US7985728B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US9173890B2 (en) * 2007-09-20 2015-11-03 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US8044021B2 (en) * 2007-09-20 2011-10-25 Abbott Cardiovascular Systems Inc. Sustained release of apo A-I mimetic peptides and methods of treatment
KR101629356B1 (ko) 2008-06-26 2016-06-13 리스버로직스 코퍼레이션 퀴나졸리논 유도체의 제조방법
NZ594332A (en) 2009-01-08 2013-09-27 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular disease
KR101709492B1 (ko) 2009-03-18 2017-02-23 리스버로직스 코퍼레이션 신규한 소염제
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
DK2473605T3 (en) 2009-09-03 2018-05-28 Pfizer Vaccines Llc PCSK9-VACCINE
US8623897B2 (en) 2010-09-20 2014-01-07 Kareus Therapeutics, Sa Methods and compositions for treatment of diabetes and dyslipidemia
CN106167483B (zh) 2010-10-18 2019-02-15 塞伦尼斯医疗控股有限公司 可用于胆固醇动员的化合物、组合物和方法
EP3170495B1 (en) 2010-12-27 2023-04-26 Gemphire Therapeutics Inc. Gemcabene for treating pancreatitis
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
RU2640115C2 (ru) 2011-11-01 2017-12-26 Ресверлоджикс Корп. Фармацевтические композиции замещенных хиназолинонов
CN110025608A (zh) * 2012-01-06 2019-07-19 燿石治疗公司 降低心血管疾病风险的方法
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
KR20170003611A (ko) 2014-05-02 2017-01-09 세레니스 쎄라퓨틱스 홀딩 에스에이 Ｈｄｌ 요법 마커
SG10201912713YA (en) * 2014-11-14 2020-02-27 Gemphire Therapeutics Inc PROCESSES AND INTERMEDIATES FOR PREPARING α,ω-DICARBOXYLIC ACID-TERMINATED DIALKANE ETHERS
CN107530307A (zh) 2015-03-13 2018-01-02 艾斯柏伦治疗公司 包含etc1002和依泽替米贝的固定剂量组合和制剂以及治疗心血管疾病或降低心血管疾病风险的方法
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
EP3370713A4 (en) * 2015-11-06 2019-10-23 Gemphire Therapeutics Inc. TREATMENT OF MIXED DYSLIPIDEMIA
WO2018165120A1 (en) * 2017-03-06 2018-09-13 Gemphire Therapeutics Inc. Effect of carboxyalkylethers on obesity symptoms and lipodystropy
CA3059073A1 (en) 2017-04-18 2018-10-25 Gemphire Therapeutics Inc. Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor
EP4438114A3 (en) 2019-06-21 2024-12-25 Esperion Therapeutics, Inc. Methods of making bempedoic acid and compositions of the same
EP4003314B1 (en) 2019-07-26 2024-07-10 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids useful for the prevention or treatment of disease
WO2021262992A1 (en) 2020-06-24 2021-12-30 Neurobo Pharmaceuticals, Inc. Gemcabene for treatment of cytokine storms and viral-induced inflammation
TW202245804A (zh) 2021-01-25 2022-12-01 美商艾斯佩維他治療學公司 官能化長鏈烴單羧酸及二羧酸及其衍生物以及其於預防或治療疾病之用途
WO2022159808A2 (en) 2021-01-25 2022-07-28 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2466419A (en) * 1948-02-07 1949-04-05 Eastman Kodak Co beta, beta'-oxydipropionic acids and process of preparation
US3320079A (en) * 1960-07-11 1967-05-16 Eastman Kodak Co Ether-acid polyester composition
US3431298A (en) * 1965-01-05 1969-03-04 Asahi Chemical Ind Process for the preparation of oxadicarboxylic acids
US3674836A (en) * 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
BE755997A (fr) * 1969-09-11 1971-03-10 Bp Chem Int Ltd Production d'acides dicarboxyliques
US3742068A (en) * 1970-04-17 1973-06-26 G Moersch Ethers of 2,2,9,9-tetramethyl-1,10-decanediol
IT1168389B (it) * 1981-05-06 1987-05-20 Alfa Farmaceutici Spa Derivati di alcandioli con attivita' ipolipidemizzante,metodi per la loro preparazione e composizioni farmaceutiche che li contengono
DE3423166A1 (de) * 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
IL84953A (en) * 1987-12-28 1992-01-15 Bromine Compounds Ltd 3,3'-oxy-bis((2,2'-di(bromomethyl)propanoic acid)derivatives,processes for their preparation and their use as flame retardant agents
DE3814498A1 (de) * 1988-04-29 1989-11-09 Basf Ag Verfahren zur herstellung von hydroxicarbonsaeureestern
DE4142913A1 (de) * 1991-12-24 1993-07-01 Basf Ag Verfahren zur herstellung von oxadimethacrylsaeure
US5395917A (en) * 1993-05-21 1995-03-07 E. I. Du Pont De Nemours And Company Polyimides from 4-(3-aminophenoxy)benzoic acid

Also Published As

Publication number Publication date
NO974397D0 (no) 1997-09-23
ZA962275B (en) 1996-11-27
FI973713A0 (fi) 1997-09-17
EE9700375A (et) 1998-06-15
GR3034109T3 (en) 2000-11-30
BG63534B1 (bg) 2002-04-30
HK1009438A1 (en) 1999-09-10
UA46020C2 (uk) 2002-05-15
DE69608268T2 (de) 2000-11-09
US5783600A (en) 1998-07-21
PL181673B1 (pl) 2001-08-31
PL322407A1 (en) 1998-01-19
AU4776896A (en) 1996-10-16
SK282897B6 (sk) 2003-01-09
KR100408612B1 (ko) 2004-03-26
NO307878B1 (no) 2000-06-13
HUP9801825A3 (en) 2001-01-29
FI973713L (fi) 1997-09-24
BG101993A (bg) 1998-05-29
CZ289556B6 (cs) 2002-02-13
PT820428E (pt) 2000-09-29
WO1996030328A1 (en) 1996-10-03
DK0820428T3 (da) 2000-08-28
CN1100747C (zh) 2003-02-05
MX9707198A (es) 1997-11-29
AU692359B2 (en) 1998-06-04
FI973713A7 (fi) 1997-09-24
US5756544A (en) 1998-05-26
US5648387A (en) 1997-07-15
ES2148733T3 (es) 2000-10-16
ATE192732T1 (de) 2000-05-15
EP0820428A1 (en) 1998-01-28
HUP9801825A2 (hu) 1998-12-28
CA2215233C (en) 2006-07-11
RU2191772C2 (ru) 2002-10-27
EP0820428B1 (en) 2000-05-10
NZ302170A (en) 1999-04-29
SK128697A3 (en) 1999-02-11
CZ292297A3 (cs) 1998-10-14
JP3885115B2 (ja) 2007-02-21
KR19980703233A (ko) 1998-10-15
DE69608268D1 (de) 2000-06-15
US5750569A (en) 1998-05-12
NO974397L (no) 1997-11-20
CN1182415A (zh) 1998-05-20
JPH11502532A (ja) 1999-03-02
CA2215233A1 (en) 1996-10-03

Similar Documents

Publication Publication Date Title
EE9700375A (et) Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid
DE69007781D1 (de) Wandlungsbauteil zur Druckentlastung.
FI903221L (fi) Anordning foer soekning av menyer i en telefonanordning.
FI910625A0 (fi) Aetbar belagd komposition oh foerfarande foer dess framstaellning.
AU9555998A (en) Multi-layered wound dressing
FI913788L (fi) Inhibitorer foer serinproteaser.
DE59106678D1 (de) Optisch nichtlineare Polymerschichten.
EP0636525A3 (en) Integrated pressure control unit and a plug connection.
MA22828A1 (fr) Ameliorants de l'indice de viscosite et dispersants, constitues par un poly(meth) acrylate.
AU2307695A (en) High solubility multicomponent inclusion complexes consisting of an acidic drug, a cyclodextrin and a base
DE69104448D1 (de) Faserbehandlungsmittelzusammensetzung.
EP0657996A3 (de) Verstärkerstufe.
DK1158948T3 (da) Placeringsenhed til et menneske
DE69407593D1 (de) Polyisocyanatzusammensetzung
DK0589879T4 (da) Apparat til spurringer
FI894264A7 (fi) Hopsaettning i anordning foer repetering av ljudmeddelande i telefonlinje.
ITRM930634A0 (it) Complessi monoazoici del rame reattivi verso le fibre. (caso 150-5653)
NL1002140C2 (nl) Tafel.
FI933249L (fi) (2r,3s)-b-fenyl-isoserin, dess salter, dess framstaellning och dess anvaendning
RU1774836C (ru) Устройство дл отделени клубней картофел от ботвы Ф.С.Осипова
FI914426A0 (fi) Foerfarande foer framstaellning av 1-( (2s)-3-merkaptometyl-1-oxopropyl)l-prolin.
NL1002052A1 (nl) Ballasttankinrichting.
ES1031366Y (es) Cuna convertible.
ITME950020A0 (it) Impianto trattamento r.s.u.
ES1014575Y (es) Pantalla luminosa compacta, estanca, perfeccionada.

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

LD4A Amendment in the specification
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

MM4A Lapsed by not paying the annual fees

Effective date: 20050205