EE04017B1 - Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena - Google Patents

Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena

Info

Publication number: EE04017B1
Authority: EE; Estonia
Prior art keywords: condensed; receptor inhibitors; ampa receptor; benzodiazepine derivatives; hydrogen
Prior art date: 1996-02-01

Application number

EE9800225A

Other languages

English (en)

Estonian (et)

Other versions

EE9800225A (et

Inventor

Csuzdi Ernese

H�mori Tam�s

�brah�m Gizella

S�lyom S�ndor

Tarnawa Istv�n

Berzsenyi P�l

Andr�si Ferenc

Ling Istv�N

Simay Antal

G�l Melinda

Horv�th Katalin

Szentkuti Eszter

Sz�llosy M�rta

Pallagi Istv�n

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-01

Filing date

1997-01-29

Publication date

2003-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7785064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE04017(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-01-29 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

1998-12-15 Publication of EE9800225A publication Critical patent/EE9800225A/xx

2003-04-15 Publication of EE04017B1 publication Critical patent/EE04017B1/xx

Links

102000003678 AMPA Receptors Human genes 0.000 title abstract 2
108090000078 AMPA Receptors Proteins 0.000 title abstract 2
RPBDCDQMCRHNLM-UHFFFAOYSA-N C1=NNC=C2C=CC=CC2=C1 Chemical class C1=NNC=C2C=CC=CC2=C1 RPBDCDQMCRHNLM-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
230000036963 noncompetitive effect Effects 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EE9800225A 1996-02-01 1997-01-29 Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena EE04017B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19604919A DE19604919A1 (de)	1996-02-01	1996-02-01	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
PCT/DE1997/000234 WO1997028163A1 (de)	1996-02-01	1997-01-29	Kondensierte 2,3-benzodiazepin derivate und deren verwendung als ampa-rezeptoren-hemmer

Publications (2)

Publication Number	Publication Date
EE9800225A EE9800225A (et)	1998-12-15
EE04017B1 true EE04017B1 (et)	2003-04-15

Family

ID=7785064

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800225A EE04017B1 (et)	1996-02-01	1997-01-29	Kondenseerunud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssijatena

Country Status (30)

Country	Link
US (2)	US6323197B1 (pl)
EP (1)	EP0888356B1 (pl)
JP (1)	JP4141499B2 (pl)
KR (1)	KR100465269B1 (pl)
CN (1)	CN1096464C (pl)
AT (1)	ATE214703T1 (pl)
AU (1)	AU724956B2 (pl)
BG (1)	BG63394B1 (pl)
BR (1)	BR9707335A (pl)
CA (1)	CA2245539C (pl)
CZ (1)	CZ289658B6 (pl)
DE (2)	DE19604919A1 (pl)
DK (1)	DK0888356T3 (pl)
EE (1)	EE04017B1 (pl)
ES (1)	ES2173435T3 (pl)
HU (1)	HU224636B1 (pl)
IL (1)	IL125480A (pl)
IS (1)	IS2103B (pl)
MY (1)	MY119140A (pl)
NO (1)	NO983510L (pl)
NZ (1)	NZ331187A (pl)
PL (1)	PL187128B1 (pl)
PT (1)	PT888356E (pl)
RU (1)	RU2179557C2 (pl)
SK (1)	SK283563B6 (pl)
TR (1)	TR199801485T2 (pl)
TW (1)	TW438801B (pl)
UA (1)	UA56157C2 (pl)
WO (1)	WO1997028163A1 (pl)
ZA (1)	ZA97848B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP9701325A1 (hu) *	1997-07-31	2000-08-28	Gyógyszerkutató Intézet Kft.	Új 2,3-benzodiazepin-származékok
UA67749C2 (uk) *	1997-08-12	2004-07-15	Егіш Дьйодьсердьяр Рт.	Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
EP1100504A2 (en) *	1998-07-02	2001-05-23	Eisai Co., Ltd.	Pharmaceutical compositions and their uses for treatment of demyelinating disorders
EP1296960A2 (en) *	2000-06-16	2003-04-02	Annovis, Inc.	5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
DE10041671C1 (de) *	2000-08-10	2002-06-13	Schering Ag	Verfahren zur Herstellung von Imidazo[1,2-c][2,3]benzodiazepinen sowie Phenylessigsäureester und Oxazol-Derivate als Zwischenprodukte bei deren Herstellung
WO2005113434A1 (en) *	2004-03-25	2005-12-01	William Marsh Rice University	Functionalization of carbon nanotubes in acidic media
US20060166969A1 (en) *	2005-01-14	2006-07-27	Turski Lechoslaw A	AMPA antagonists for the treatment of dizziness, including vertigo and Meniere's disorder
AR056080A1 (es) *	2005-09-23	2007-09-19	Schering Corp	7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine
EP2338492A1 (en)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Methods and compositions for the treatment of alzheimer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU179018B (en) *	1978-10-19	1982-08-28	Gyogyszerkutato Intezet	Process for producing new 5h-2,3-benzodiazepine derivatives
IE910939A1 (en) *	1990-04-13	1991-10-23	Neurosearch As	Use of benzodiazepine compounds
US5891871A (en)	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) *	1996-04-04	1996-05-28	Gyogyszerkutato Intezet	New 2,3-benzodiazepine derivatives

1996
- 1996-02-01 DE DE19604919A patent/DE19604919A1/de not_active Withdrawn
1997
- 1997-01-29 CZ CZ19982427A patent/CZ289658B6/cs not_active IP Right Cessation
- 1997-01-29 SK SK1033-98A patent/SK283563B6/sk unknown
- 1997-01-29 EP EP97916315A patent/EP0888356B1/de not_active Expired - Lifetime
- 1997-01-29 AT AT97916315T patent/ATE214703T1/de not_active IP Right Cessation
- 1997-01-29 PL PL97328224A patent/PL187128B1/pl not_active IP Right Cessation
- 1997-01-29 DE DE59706686T patent/DE59706686D1/de not_active Expired - Lifetime
- 1997-01-29 RU RU98116292/04A patent/RU2179557C2/ru not_active IP Right Cessation
- 1997-01-29 TR TR1998/01485T patent/TR199801485T2/xx unknown
- 1997-01-29 US US09/117,508 patent/US6323197B1/en not_active Expired - Fee Related
- 1997-01-29 JP JP52724897A patent/JP4141499B2/ja not_active Expired - Fee Related
- 1997-01-29 NZ NZ331187A patent/NZ331187A/xx unknown
- 1997-01-29 CN CN97192012A patent/CN1096464C/zh not_active Expired - Fee Related
- 1997-01-29 AU AU25029/97A patent/AU724956B2/en not_active Ceased
- 1997-01-29 ES ES97916315T patent/ES2173435T3/es not_active Expired - Lifetime
- 1997-01-29 UA UA98084653A patent/UA56157C2/uk unknown
- 1997-01-29 DK DK97916315T patent/DK0888356T3/da active
- 1997-01-29 BR BR9707335A patent/BR9707335A/pt not_active IP Right Cessation
- 1997-01-29 WO PCT/DE1997/000234 patent/WO1997028163A1/de not_active Ceased
- 1997-01-29 EE EE9800225A patent/EE04017B1/xx not_active IP Right Cessation
- 1997-01-29 IL IL12548097A patent/IL125480A/en not_active IP Right Cessation
- 1997-01-29 KR KR10-1998-0705917A patent/KR100465269B1/ko not_active Expired - Fee Related
- 1997-01-29 HU HU9901417A patent/HU224636B1/hu not_active IP Right Cessation
- 1997-01-29 PT PT97916315T patent/PT888356E/pt unknown
- 1997-01-29 CA CA002245539A patent/CA2245539C/en not_active Expired - Fee Related
- 1997-01-31 ZA ZA9700848A patent/ZA97848B/xx unknown
- 1997-01-31 MY MYPI97000379A patent/MY119140A/en unknown
- 1997-02-01 TW TW086101218A patent/TW438801B/zh not_active IP Right Cessation
1998
- 1998-07-06 IS IS4794A patent/IS2103B/is unknown
- 1998-07-29 BG BG102658A patent/BG63394B1/bg unknown
- 1998-07-30 NO NO983510A patent/NO983510L/no unknown
2001
- 2001-11-27 US US09/993,646 patent/US6600036B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2000503997A (ja)	2000-04-04
NO983510L (no)	1998-09-30
HU224636B1 (hu)	2005-12-28
IL125480A (en)	2002-07-25
WO1997028163A1 (de)	1997-08-07
NZ331187A (en)	2000-01-28
CZ289658B6 (cs)	2002-03-13
US6323197B1 (en)	2001-11-27
JP4141499B2 (ja)	2008-08-27
BG102658A (en)	1999-06-30
ATE214703T1 (de)	2002-04-15
TW438801B (en)	2001-06-07
CZ242798A3 (cs)	1999-01-13
BG63394B1 (bg)	2001-12-29
EP0888356A1 (de)	1999-01-07
PT888356E (pt)	2002-09-30
AU2502997A (en)	1997-08-22
HUP9901417A2 (hu)	1999-08-30
CN1210538A (zh)	1999-03-10
HK1018782A1 (en)	2000-01-07
CA2245539A1 (en)	1997-08-07
AU724956B2 (en)	2000-10-05
UA56157C2 (uk)	2003-05-15
PL187128B1 (pl)	2004-05-31
US6600036B2 (en)	2003-07-29
RU2179557C2 (ru)	2002-02-20
DE19604919A1 (de)	1997-08-07
KR100465269B1 (ko)	2005-04-14
BR9707335A (pt)	1999-07-20
KR19990082192A (ko)	1999-11-25
PL328224A1 (en)	1999-01-18
IS4794A (is)	1998-07-06
TR199801485T2 (xx)	1998-10-21
US20020052364A1 (en)	2002-05-02
ZA97848B (en)	1997-08-04
HUP9901417A3 (en)	2001-11-28
IS2103B (is)	2006-05-15
DE59706686D1 (de)	2002-04-25
MY119140A (en)	2005-04-30
EP0888356B1 (de)	2002-03-20
NO983510D0 (no)	1998-07-30
IL125480A0 (en)	1999-03-12
SK283563B6 (sk)	2003-09-11
SK103398A3 (en)	1999-01-11
CA2245539C (en)	2005-10-04
ES2173435T3 (es)	2002-10-16
CN1096464C (zh)	2002-12-18
EE9800225A (et)	1998-12-15
DK0888356T3 (da)	2002-06-03

Legal Events

Date	Code	Title	Description
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2009-10-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20090129

Publication	Publication Date	Title
DE69328975D1 (de)	2000-08-10	Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
DE69719350D1 (de)	2003-04-03	2-pyrimidinamin derivaten und verfahrens zu deren herstellung
BG106493A (en)	2003-01-31	Heteropolycyclic compounds and their use as metabotropic glutamate receptor
BG105596A (en)	2002-02-28	Substituted benzimidazoles and their use as parp inhibitors
EP1558586A4 (en)	2007-06-27	HEMMER OF ACT ACTIVITY
ES2170252T3 (es)	2002-08-01	Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
BR9206500A (pt)	1995-10-03	Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P
FI942187A0 (fi)	1994-05-11	Asyklisiä etyleenidiamiinijohdannaisia aine P-reseptoriantagonisteina
GEP20063915B (en)	2006-09-11	PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS AND USE THEREOF FOR TREATING p38 KINASE-ASSOCIATED CONDITIONS
FI970150A0 (fi)	1997-01-14	Substituoituja pyrimidiiniyhdisteitä ja niiden käyttö
MX9806171A (es)	1998-10-31	Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa.
ES2101858T3 (es)	1997-07-16	Derivados de geneserina como inhibidores de colinesterasa.
EE9800225A (et)	1998-12-15	Kondenseeritud 2,3-bensodiasepiini derivaadid ja nende kasutamine AMPA-retseptorite pärssimiseks
EE200000059A (et)	2000-10-16	Tetrahüdro-gamma-karboliinid
TW429255B (en)	2001-04-11	Pyrazine compounds having treatment of central nervous system diseases and disorders
BG105710A (en)	2002-02-28	5ht1 antagonists for antidepressant therapy
TW360650B (en)	1999-06-11	Pyridin-2-ylmethyloxy-pyridin-5-ylcarbamoyl-indoline derivatives, a process for the preparation thereof, and a pharmaceutical composition comprising them
FR2767527B1 (fr)	1999-11-12	Derives de piperazines indoliques, utiles comme medicaments et procede de preparation
MXPA02011464A (es)	2003-04-25	Derivados 1,4-diazepan-2,5-diona y su uso como antagonistas del receptor de la nk-1.
ATE237614T1 (de)	2003-05-15	Benzo(c)chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren
AR021094A1 (es)	2002-06-12	Compuestos heterociclicos inhibidores de la fosfodiesterasa iv y su uso para el tratamiento de enfermedades inflamatorias
ES2173167T3 (es)	2002-10-16	Derivados de benzodiazepina.
DK0451626T3 (da)	1998-04-20	Anvendelse af benzodiazepinforbindelser til fremstilling af et farmaceutisk præparat mod med excitatoriske aminosyrer forbundne forstyrrelser i centralnervesystemet
ATE212356T1 (de)	2002-02-15	Carbamoylmethylharnstoffderivate
FR2823749B1 (fr)	2004-02-20	Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant