EG18945A - Process for preparing of 3(1,2,5,6 tetrahydropyridyl pyrrolopyrides. - Google Patents

Process for preparing of 3(1,2,5,6 tetrahydropyridyl pyrrolopyrides.

Info

Publication number
EG18945A
EG18945A EG2690A EG2690A EG18945A EG 18945 A EG18945 A EG 18945A EG 2690 A EG2690 A EG 2690A EG 2690 A EG2690 A EG 2690A EG 18945 A EG18945 A EG 18945A
Authority
EG
Egypt
Prior art keywords
alkyl
tetrahydropyridyl
pyrrolopyrides
preparing
alkoxy
Prior art date
Application number
EG2690A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG18945A publication Critical patent/EG18945A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EG2690A 1989-01-20 1990-01-17 Process for preparing of 3(1,2,5,6 tetrahydropyridyl pyrrolopyrides. EG18945A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/000231 WO1990007926A1 (en) 1989-01-20 1989-01-20 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Publications (1)

Publication Number Publication Date
EG18945A true EG18945A (en) 1994-09-29

Family

ID=22214793

Family Applications (1)

Application Number Title Priority Date Filing Date
EG2690A EG18945A (en) 1989-01-20 1990-01-17 Process for preparing of 3(1,2,5,6 tetrahydropyridyl pyrrolopyrides.

Country Status (26)

Country Link
US (2) US5051412A (cs)
EP (1) EP0379314B1 (cs)
JP (1) JPH0751576B2 (cs)
KR (1) KR920010642B1 (cs)
CN (1) CN1025998C (cs)
AT (1) ATE103282T1 (cs)
CA (1) CA2008016A1 (cs)
CS (1) CS277611B6 (cs)
DD (2) DD298398A5 (cs)
DE (1) DE69007501T2 (cs)
DK (1) DK0379314T3 (cs)
EG (1) EG18945A (cs)
ES (1) ES2062319T3 (cs)
FI (1) FI94641C (cs)
HU (1) HU206349B (cs)
IE (1) IE62757B1 (cs)
IL (1) IL93041A (cs)
MX (1) MX19185A (cs)
MY (1) MY106305A (cs)
NO (1) NO912860L (cs)
NZ (1) NZ232166A (cs)
PL (2) PL163626B1 (cs)
PT (1) PT92889A (cs)
WO (1) WO1990007926A1 (cs)
YU (1) YU47553B (cs)
ZA (1) ZA90393B (cs)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX19185A (es) * 1989-01-20 1993-12-01 Pfizer Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
EP1082958A3 (en) * 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F agonists in chronic pain
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
ZA989389B (en) * 1997-11-14 2000-04-14 Lilly Co Eli Pyrrolo [3,2-b] pyridine processes and intermediates.
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
PT1575566E (pt) 2002-12-26 2012-03-29 Pozen Inc Formas de dosagem em multicamada contendo naproxeno e triptanos
KR20110137838A (ko) * 2003-11-21 2011-12-23 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제
US7452993B2 (en) * 2004-07-27 2008-11-18 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
AU2005269386A1 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
SI2054418T1 (sl) 2006-07-06 2012-02-29 Array Biopharma Inc Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2049500B1 (en) 2006-07-06 2011-09-07 Array Biopharma, Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
DE602007011628D1 (de) 2006-07-06 2011-02-10 Array Biopharma Inc Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
CA2710230C (en) 2006-12-29 2016-02-23 Rigel Pharmaceuticals, Inc. Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
CN101801955B (zh) 2007-07-05 2013-05-08 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
SI2173723T1 (sl) * 2007-07-05 2011-12-30 Array Biopharma Inc Pirimidil ciklopentani kot inhibitorji AKT-protein-kinaze
EP2247578B1 (en) * 2008-01-09 2013-05-22 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
AU2009204019B2 (en) * 2008-01-09 2014-02-20 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
CA2749843C (en) 2009-01-16 2017-09-05 Rigel Pharmaceuticals, Inc. Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer
NZ597059A (en) 2009-06-17 2014-01-31 Vertex Pharma Inhibitors of influenza viruses replication
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
RU2013148817A (ru) 2011-04-01 2015-05-10 Дженентек, Инк. Комбинации соединений-ингибиторов акт и мек и способы их применения
KR102021157B1 (ko) 2011-04-01 2019-09-11 제넨테크, 인크. Ａｋｔ 억제제 화합물 및 아비라테론의 조합물, 및 사용 방법
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
SG10201804026WA (en) 2013-11-13 2018-06-28 Vertex Pharma Inhibitors of influenza viruses replication
HUE052178T2 (hu) 2013-11-13 2021-04-28 Vertex Pharma Eljárások influenzavírus-replikáció inhibitorainak elõállítására
CA2960567C (en) 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Thienopyrimidine derivatives as nik inhibitors
EA033237B1 (ru) * 2014-10-23 2019-09-30 Янссен Фармацевтика Нв Новые производные пиразолопиримидина в качестве ингибиторов nik, фармацевтическая композиция и лекарственное средство, содержащее ее
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272804A (en) * 1963-12-23 1966-09-13 Sterling Drug Inc Process and intermediates for preparing indoles
GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels
US5025096A (en) * 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
MX19185A (es) * 1989-01-20 1993-12-01 Pfizer Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.

Also Published As

Publication number Publication date
WO1990007926A1 (en) 1990-07-26
PL287840A1 (en) 1991-07-15
NZ232166A (en) 1992-10-28
YU9990A (en) 1992-05-28
MX19185A (es) 1993-12-01
ES2062319T3 (es) 1994-12-16
DK0379314T3 (da) 1994-05-09
IE900210L (en) 1990-07-23
US5169947A (en) 1992-12-08
PT92889A (pt) 1990-07-31
DE69007501T2 (de) 1994-06-30
AU613259B2 (en) 1991-07-25
NO912860D0 (no) 1991-07-22
JPH0751576B2 (ja) 1995-06-05
JPH02247175A (ja) 1990-10-02
CN1025998C (zh) 1994-09-28
FI94641B (fi) 1995-06-30
IL93041A0 (en) 1990-11-05
IL93041A (en) 1994-02-27
CA2008016A1 (en) 1990-07-20
ZA90393B (en) 1991-08-28
HUT57762A (en) 1991-12-30
CS26090A3 (en) 1992-02-19
PL283354A1 (en) 1991-08-12
US5051412A (en) 1991-09-24
DE69007501D1 (de) 1994-04-28
EP0379314B1 (en) 1994-03-23
KR900011772A (ko) 1990-08-02
FI94641C (fi) 1995-10-10
AU4867390A (en) 1990-07-26
CS277611B6 (en) 1993-03-17
DD298398A5 (de) 1992-02-20
NO912860L (no) 1991-07-22
PL163626B1 (pl) 1994-04-29
YU47553B (sh) 1995-10-03
FI913509A0 (fi) 1991-07-22
MY106305A (en) 1995-04-29
ATE103282T1 (de) 1994-04-15
IE62757B1 (en) 1995-02-22
DD291559A5 (de) 1991-07-04
CN1044465A (zh) 1990-08-08
HU206349B (en) 1992-10-28
EP0379314A1 (en) 1990-07-25
KR920010642B1 (ko) 1992-12-12

Similar Documents

Publication Publication Date Title
EG18945A (en) Process for preparing of 3(1,2,5,6 tetrahydropyridyl pyrrolopyrides.
PT77645B (en) Process for preparing epimeril aza homoerytheomycin a derivati-ves and intermediates therefor
ZA886798B (en) Substituted cycloalkanols
PT79110B (en) 3-(piperidinyl)- and 3-(pyrrolidinyl)-1h-indazoles a process for their preparation and their use as a medicament
IL89807A (en) Topical preparation containing ofloxacin for treating otopathy
GR3036754T3 (en) Use of isoxazole- and crotonamide derivatives for the manufacture of a medicament for the treatment of cancers
GR852037B (cs)
GR79710B (cs)
HUT47537A (en) Process for producing new 2,3-diamino-acrylic acid-nitrile derivatives
ZA200003035B (en) Compounds of 7-oxo-2,3,7,14-tetrahydro-1H-benzo[B]-pyrano[3,2-H] acridin carboxylate, a process for their preparation and pharmaceutical compositions containing them.
HUT41364A (en) Process for preparing triphenyl-alkenes by means of the dehydratation of triphenyl-alkanols
JPS5530492A (en) Apparatus for automatically controlling spinning unit of open end fine spinning machine
EP0171812A3 (en) Cephem derivatives
PT81324A (en) Process for the preparation of s-aralkyltrithiophosphonate having an insecticidal effect
RO102918B1 (en) Driving device of ventilator at pneumofil spinning machine
HU903199D0 (en) Process for producing new macrolideous compounds
HU201789B (en) Process for producing solution crosslinkable by acidic treatment containing ort,orto'-novolac modified by epoxid
CS153685A1 (en) Treatment method of staple yarn spinned by rotor system