EP1499331B1 - Solution saline pour le nettoyage du colon - Google Patents

Solution saline pour le nettoyage du colon Download PDF

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Publication number
EP1499331B1
EP1499331B1 EP03724291A EP03724291A EP1499331B1 EP 1499331 B1 EP1499331 B1 EP 1499331B1 EP 03724291 A EP03724291 A EP 03724291A EP 03724291 A EP03724291 A EP 03724291A EP 1499331 B1 EP1499331 B1 EP 1499331B1
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EP
European Patent Office
Prior art keywords
solution
grams
soda
phospho
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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EP03724291A
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German (de)
English (en)
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EP1499331A2 (fr
EP1499331A4 (fr
Inventor
Mark Vb. Cleveland
John S. Fordtran
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Braintree Laboratories Inc
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Braintree Laboratories Inc
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Priority to EP10001224A priority Critical patent/EP2233147B1/fr
Priority to DK10001224.4T priority patent/DK2233147T3/da
Priority to EP10182219.5A priority patent/EP2292244B1/fr
Priority to SI200331799T priority patent/SI1499331T1/sl
Application filed by Braintree Laboratories Inc filed Critical Braintree Laboratories Inc
Publication of EP1499331A2 publication Critical patent/EP1499331A2/fr
Publication of EP1499331A4 publication Critical patent/EP1499331A4/fr
Publication of EP1499331B1 publication Critical patent/EP1499331B1/fr
Application granted granted Critical
Priority to CY20101100407T priority patent/CY1110011T1/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Definitions

  • This formulation is effective to produce colonic purging to prepare the colon for surgical or diagnostic procedures and surprisingly does not cause clinically significant changes in electrolyte balance.
  • sigmoidoscopy In sigmoidoscopy, colonoscopy, radiographic examination, preparation for patients undergoing bowel surgery, and other medical or diagnostic procedures on the colon, it is important that the colon be thoroughly purged and cleaned. In particular, it is essential that as much fecal matter as possible be removed from the colon to permit adequate visualization of the intestinal mucosa. This is important prior to, for example, diagnositc procedures such as flexible sigmoidoscopy or colonoscopy, diagnostic examinations widely performed to screen patients for diseases of the colon. In addition, it is important that the intestines be cleansed thoroughly in order to obtain satisfactory radiographs of the colon. The same condition also applies when the colon is preoperatively prepared for surgery, where removal of fecal waste materials is critically important for patient safety.
  • compositions have been developed for use as gastrointestinal washes for diagnostic purposes or for use as cathartic laxatives.
  • Such orally administered preparations are usually formulated as dilute or isotonic solutions of electrolytes such as sodium sulfate, sodium bicarbonate, sodium chloride and potassium chloride. These orally administered compositions are useful in the rapid cleansing of the colon for diagnostic purposes.
  • These formulations may include other agents such as polyethylene glycol.
  • These formulations have generally been administered in a quantity of about four liters as isotonic solutions.
  • GoLYTELY® formulated according to the following: polyethylene glycol 59 g, sodium sulfate 5.68 g, sodium bicarbonate 1.69 g, sodium chloride 1.46 g, potassium chloride 0.745 g and water to make up one liter ( Davis et al. Gastroenterology 1980;78:991-995 ).
  • Sodium sulfate and phosphate salts have been used as laxatives when diluted in a small volume ( ⁇ 300 mL) concentrated solution and taken in tablespoon sized (15ml) daily doses.
  • An example of this use is Glauber's Salt's (containing sodium sulfate).
  • Glauber's Salt's containing sodium sulfate.
  • these small volume preparations do not contain polyethylene glycol.
  • Sodium sulfate combined with polyethylene glycol and various other salts, administered in large volumes (1 gallon) over a short period of time is an effective gastrointestinal lavage, which cleanses the colon prior to colonoscopy or surgical procedures as described above.
  • ingestible preparations which consist of aqueous solutions of concentrated phosphate salts.
  • the aqueous phosphate salt concentrate produces a tremendous osmotic effect on the intra-luminal contents of the bowel and therefore, evacuation of the bowel occurs with a large influx of water and electrolytes into the colon from the body.
  • These phosphate salt preparations have been developed for the purpose of decreasing the volume required in colonic purgations.
  • One such preparation basically is comprised of 480 grams per liter monobasic sodium phosphate and 180 grams per liter dibasic sodium phosphate in stabilized buffered aqueous solution and is sold under the brand name Fleets Phospho-Soda.TM.
  • One purpose of the present research was to develop a safe, effective, and well tolerated small volume solution made up of a high concentration of poorly absorbable salts that induce a colon cleansing catharsis after oral ingestion without clinically significant alternation of sodium, chloride, bicarbonate, potassium, calcium, and phosphate level and balance or other untoward effects on the recipient.
  • EP0396165 is directed to orally administered pharmaceutical composition for use in gastrointestinal washes, in particular for diagnostic use, or as cathartic laxative.
  • WO 00/44240 relates to the treatment of colic and gut spasms in horses and other vertebrates.
  • EP 0 900 562 describes a lavage solution for the intestinal tract.
  • JP 01 132527 relates to an intestine washing solution.
  • EP 0 298 655 is directed to a aqueous cathartic solution.
  • the disclosed colonic purgative formulations provide safe and effective purgative activity at lower dosages of salt than prior art sodium phosphate tablets, solutions of phosphates and sulfates, or combinations thereof.
  • a lower volume of fluid is ingested and there are no clinically significant changes in body electrolyte chemistry.
  • This colonic purgative can be administered with a minimum amount of patient discomfort and is better tolerated than prior art purgatives.
  • the colonic purgative includes an effective amount of Na 2 SO 4 , MgSO 4 , and K 2 SO 4 .
  • Polyethylene glycol may also be advantageously added to the colonic purgative composition.
  • hypertonic sodium phosphate solutions are also efficacious in cleansing the colon. Howcver, use of hypertonic sodium phosphate has been shown to cause upset in electrolyte balance including: hyperphosphatemia, hypocalcemia, positive sodium balance, and negative potassium balance.
  • hyperphosphatemia a serum phosphate concentration rose from 2.8 to 6.5 mg/dL
  • serum phosphate concentrations as high as 11.6 mg/dL
  • Vanner et al. Am. J. Gastroenterology 85:422-427, 1990 .
  • the normal range for serum phosphate is generally considered to be 2.6 to 4.5 mg/dL.
  • Hypertonic phosphate gastrointestinal cleansing solutions have also been associated with hypokalemia and hypocalcemia in some patients, resulting in serious injury and even death ( Ahmed et al. Am. J. Gastro. 1998;91:1261-1262 ).
  • Mixtures of sulfate salts that omit phosphates (which are avidly absorbed) can be effective to produce colonic purgation.
  • formulations comprising effective amounts of Na 2 SO 4 , MgSO 4 , and K 2 SO 4 in the amounts according to claims 1, 3 and 7 are effective.
  • PEG polyethylene glycol
  • the above mixture of salts can be dissolved in a convenient volume of water. A volume of less than one liter of water is well tolerated by most patients. The mixture is dissolved in 100 and 500 ml of water.
  • the effective dose may be divided and administered, to the patient in two, or more administrations over an appropriate time period. Generally, 2 doses administered of equal portions of the effective dose, separated by 6 to 24 hours produce satisfactory purgation
  • Subjects were otherwise healthy adults between the ages of 18 and 55. There were no preferences or exclusions based on gender or ethnic background.
  • the ingested experimental solutions were also 330 mL in volume, and their composition is shown in the tables below. All salts were obtained from Mallinckrodt (Paris, KY 40361) and Polyethylene glycol (PEG) was obtained from J. T. Baker (Phillipsburg, NJ 08865). One half of each experimental solution was ingested by the subjects on two occasions, at 7 p.m. on day 1 and at 5 a.m. on day 2.
  • Solution E also contained 34g of Polyethylene glycol (PEG).
  • Body weight was measured at 6:45 p.m. on day 1, and at noon on day 2.
  • Blood pressure (lying and after standing for 30 seconds) was measured every two hours, starting at 6:45 p.m. on day 1 and finishing at 11:45 a.m. on day 2.
  • Blood was drawn at 6:45 p.m. on day 1 and at 6 a.m., 8 a.m., 10 a.m. and 12 noon on day 2.
  • Blood was analyzed for calcium, sulfate, magnesium, phosphate, sodium, chloride, potassium, bicarbonate, osmolality, albumin, total protein, BUN, creatinine, and hematocrit.
  • Each stool was quantitatively collected in separate containers and its weight and consistency were measured. The degree to which the stool contained fecal material was graded, using a scale from 0-5 (0 would be similar to urine, 5 would be a large amount of solid fecal material). Stools collected from 7 p.m. (day 1) until 5 a.m. (day 2) were pooled: this pool represents the effects of the first dose of salts. Stools collected from 5 a.m. until 12 noon were pooled; this pool represents the effect of the second dose of salts. The electrolyte composition of the two pooled specimens was measured (osmolality, Na, K, Cl, HCO 3 , PO 4 , SO 4 , Ca and Mg ).
  • Urine was quantitatively collected from 6 a.m. until 6 p.m. on day 1 (prior to ingestion of salts), from 7 p.m. on day 1 until 5 a.m. on day 2, and from 5 a.m. on day 2 until 12 noon on day 2. Urine was analyzed for sulfate, phosphate, calcium, magnesium and monovalent electrolytes.
  • Solution A contained 100 mmoles of Na 2 SO 4 and 100 mmoles of MgSO 4 , as well as small amounts of KCl and KHCO 3 to replace anticipated K, Cl, and HCO 3 losses.
  • stool output (1500) was short of the Phospho-Soda output benchmark (2403 ml).
  • Solution D contained 142.5 mmoles of both Na 2 SO 4 and MgSO 4 , and 23.75 mmoles of K 2 SO 4 . This solution resulted in a stool volume of 2202 mL, which was slightly (180 mL) short of benchmark. Electrolyte changes were clinically insignificant with this formulation. A further increase in the ingested amounts of salts would likely be effective but, we were concerned about taste problems.
  • solution E PEG 3350 was added and the K 2 SO 4 content reduced slightly as compared to solution D.
  • solution E produced an average fecal output that slightly exceeded the Phospho-Soda benchmark, and the taste was acceptable.
  • This solution caused no increase in Ca x P product, and its effect on potassium balance appeared to be close to zero.
  • the absorption of sulfate after ingestion of solution E was 165 mEq, or 27% of the ingested load. However, the serum sulfate concentration remained well below the level at which calcium sulfate precipitates form, therefore calcium levels remained unchanged. The absorption of magnesium after ingestion of solution E was 66 mEq, or 23% of the ingested load.
  • the second method that can be used involves changes in urine output of the solutes.
  • Solution E contains three sulfate salts (Na 2 SO 4 , K 2 SO 4 and MgSO 4 ) as well as polyethylene glycol. Sulfate, magnesium and polyethylene glycol are poorly absorbed, and ingestion of this solution therefore induces osmotic diarrhea.
  • the sodium content of solution E is less than the sodium content of Phospho-Soda, and solution E contains potassium whereas Phospho-Soda does not.
  • Solution E and Fleet Phospho-Soda appear to provide equivalent colonic cleansing. However, in contrast to Phospho-Soda, solution E does not cause serum phosphate concentration to rise and does not cause a net gastrointestinal loss of potassium.
  • Phopho-Soda phosphate solution and solutions D and E produce similar volumes of osmotic diarrhea, and the quality of colon cleansing (as judged by examination of fecal fluid) with the two solutions were similar.
  • both solutions will be associated with some residual colonic fluid, which is not a problem during colonoscopy since such fluid is readily aspirated via the suction lumen of the colonoscope.

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Claims (8)

  1. Composition destinée à être utilisée pour purger le côlon d'un patient, constituée par un volume de 100 mL à 500 mL d'une solution aqueuse, la solution comprenant de 2 grammes à 40 grammes de Na2SO4, de 2 grammes à 20 grammes de MgSO4, de 1 gramme à 10 grammes de K2SO4, et de 0,1 gramme à 50 grammes de PEG.
  2. Composition destinée à être utilisée pour purger le côlon d'un patient selon la revendication 1, la composition comprenant 20 grammes de Na2SO4, 20 grammes de MgSO4, 3 grammes de K2SO4 et 34 grammes de PEG.
  3. Composition destinée à être utilisée pour purger le côlon d'un patient qui comprend une solution aqueuse, la composition comprenant 20 grammes de Na2SO4, 20 grammes de MgSO4, 3 grammes de K2SO4, et 34 grammes de PEG dans 330 mL d'eau.
  4. Utilisation d'une composition selon la revendication 1, pour la préparation d'un médicament destiné à purger le côlon d'un patient, ladite composition devant être administrée par voie orale.
  5. Utilisation d'une composition selon la revendication 4, la composition comprenant 20 grammes de Na2SO4, 20 grammes de MgSO4, 3 grammes de K2SO4 et 34 grammes de PEG dans 330 mL d'eau.
  6. Utilisation d'une composition selon la revendication 4, ladite composition devant être administrée en deux doses ou plus au cours d'une période de traitement.
  7. Composition destinée à être utilisée pour purger le côlon d'un patient, qui est constituée par un volume compris entre 100 mL et 500 mL d'une solution aqueuse, la solution comprenant de 2 grammes à 40 grammes de Na2SO4, de 2 grammes à 20 grammes de MgSO4 et de 1 gramme à 10 grammes de K2SO4.
  8. Utilisation d'une composition selon la revendication 7, pour la préparation d'un médicament destiné à purger le côlon d'un patient, ladite composition devant être administrée par voie orale.
EP03724291A 2002-04-30 2003-04-28 Solution saline pour le nettoyage du colon Expired - Lifetime EP1499331B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP10001224A EP2233147B1 (fr) 2002-04-30 2003-04-28 Solution salée pour le nettoyage du colon
DK10001224.4T DK2233147T3 (da) 2002-04-30 2003-04-28 Saltopløsning til colonrensning
EP10182219.5A EP2292244B1 (fr) 2002-04-30 2003-04-28 Solution salée pour le nettoyage du colon
SI200331799T SI1499331T1 (sl) 2002-04-30 2003-04-28 Solna raztopina za čiščenje kolona
CY20101100407T CY1110011T1 (el) 2002-04-30 2010-05-10 Αλατουχο διαλυμα για τον καθαρισμο του κολου

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US135857 2002-04-30
US10/135,857 US6946149B2 (en) 2002-04-30 2002-04-30 Salt solution for colon cleansing
PCT/US2003/013133 WO2003092589A2 (fr) 2002-04-30 2003-04-28 Solution saline pour le nettoyage du côlon

Publications (3)

Publication Number Publication Date
EP1499331A2 EP1499331A2 (fr) 2005-01-26
EP1499331A4 EP1499331A4 (fr) 2007-04-18
EP1499331B1 true EP1499331B1 (fr) 2010-02-10

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Family Applications (3)

Application Number Title Priority Date Filing Date
EP10001224A Expired - Lifetime EP2233147B1 (fr) 2002-04-30 2003-04-28 Solution salée pour le nettoyage du colon
EP03724291A Expired - Lifetime EP1499331B1 (fr) 2002-04-30 2003-04-28 Solution saline pour le nettoyage du colon
EP10182219.5A Expired - Lifetime EP2292244B1 (fr) 2002-04-30 2003-04-28 Solution salée pour le nettoyage du colon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10001224A Expired - Lifetime EP2233147B1 (fr) 2002-04-30 2003-04-28 Solution salée pour le nettoyage du colon

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10182219.5A Expired - Lifetime EP2292244B1 (fr) 2002-04-30 2003-04-28 Solution salée pour le nettoyage du colon

Country Status (15)

Country Link
US (1) US6946149B2 (fr)
EP (3) EP2233147B1 (fr)
JP (1) JP2005530743A (fr)
AT (2) ATE457172T1 (fr)
AU (1) AU2003231160B2 (fr)
BE (1) BE2013C049I2 (fr)
CA (1) CA2484303C (fr)
CY (3) CY1110011T1 (fr)
DE (1) DE60331220D1 (fr)
DK (3) DK2292244T3 (fr)
ES (3) ES2340920T3 (fr)
FR (1) FR13C0055I2 (fr)
PT (3) PT2292244E (fr)
SI (3) SI2233147T1 (fr)
WO (1) WO2003092589A2 (fr)

Cited By (1)

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US9919007B2 (en) 2013-03-15 2018-03-20 Braintree Laboratories, Inc. Dual use oral pharmaceutical composition tablets of sulfate salts and methods of use thereof

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AU2004290580A1 (en) * 2003-11-17 2005-06-02 Braintree Laboratories, Inc. Therapeutic PEG solution concentrate
US7687075B2 (en) 2003-11-19 2010-03-30 Salix Pharmaceuticals, Ltd. Colonic purgative composition with soluble binding agent
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US7495063B2 (en) * 2006-02-03 2009-02-24 Dow Global Technologies Inc. Reduced oligomer concentration in high purity polyalkylene glycols
US7985429B2 (en) 2006-03-03 2011-07-26 C. B. Fleet Company, Inc. Flavored colonic cleansing system
US7998510B2 (en) 2006-08-17 2011-08-16 C. B. Fleet Company, Inc. Low dose colonic cleansing system
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US20090053304A1 (en) * 2007-08-23 2009-02-26 Jinling Chen Composition and method of producing a taste masking formulation of laxatives for bowel cleaning preparation prior to colonoscopy
AU2009205927A1 (en) * 2008-01-16 2009-07-23 Braintree Laboratories, Inc. Sulfate salt prophylaxis and therapies
DE102008035542A1 (de) 2008-07-30 2010-02-04 Siemens Aktiengesellschaft Verfahren zur Ermittlung von Messdaten aus dem Magen eines Patienten
PL2421373T3 (pl) * 2009-04-21 2020-03-31 Dale R. Bachwich Układ do płukania okrężnicy
GB0913295D0 (en) 2009-07-30 2009-09-02 Norgine Bv Improvements in and relating to pharmaceutical compositions
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AU2011342368B2 (en) 2010-12-13 2016-11-17 Rite-Prep Pty Ltd Gastric and colonic formulations and methods for making and using them
MX346936B (es) 2011-01-28 2017-04-05 A Shaver William Metodo, composiciones y empaque para limpieza del intestino.
TWI535461B (zh) 2011-03-11 2016-06-01 諾金私人有限公司 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法
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KR101659746B1 (ko) 2014-01-28 2016-09-26 주식회사한국파마 황산염을 함유하는 장관 하제 조성물 및 이의 제조 방법
CA2947434A1 (fr) 2014-04-29 2015-11-05 Colonaryconcepts Llc Aliments, systemes, procedes et kits pour fournir un remplacement d'electrolyte
EP3191105A4 (fr) * 2014-09-12 2018-05-02 Braintree Laboratories, Inc. Compositions laxatives à base de solution de sel de sulfate et leurs procédés d'utilisation
WO2016140981A1 (fr) 2015-03-02 2016-09-09 Colonaryconcepts Llc Composés et procédés pour dosages de métabolite du poly(éthylèneglycol) (peg) et de produit de décomposition du peg
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KR102127003B1 (ko) * 2017-10-12 2020-06-25 주식회사 한국팜비오 황산염을 포함하는 대장 하제 조성물
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EP2292244A2 (fr) 2011-03-09
EP2233147A1 (fr) 2010-09-29
EP1499331A2 (fr) 2005-01-26
PT1499331E (pt) 2010-05-11
WO2003092589A2 (fr) 2003-11-13
BE2013C049I2 (fr) 2022-08-09
US20030202957A1 (en) 2003-10-30
EP2292244A3 (fr) 2011-07-06
FR13C0055I2 (fr) 2014-11-07
WO2003092589A3 (fr) 2004-02-05
DK2233147T3 (da) 2012-02-06
HK1148935A1 (en) 2011-09-23
CY1114745T1 (el) 2016-12-14
PT2233147E (pt) 2012-01-12
ATE457172T1 (de) 2010-02-15
ES2441890T3 (es) 2014-02-06
CY1112522T1 (el) 2015-12-09
DE60331220D1 (de) 2010-03-25
ATE528011T1 (de) 2011-10-15
CA2484303A1 (fr) 2003-11-13
HK1154492A1 (en) 2012-04-27
AU2003231160B2 (en) 2009-01-22
CY1110011T1 (el) 2015-01-14
ES2340920T3 (es) 2010-06-11
EP1499331A4 (fr) 2007-04-18
DK2292244T3 (da) 2014-01-13
EP2233147B1 (fr) 2011-10-12
EP2292244B1 (fr) 2013-10-09
SI2233147T1 (sl) 2012-02-29
SI2292244T1 (sl) 2014-01-31
DK1499331T3 (da) 2010-05-31
SI1499331T1 (sl) 2010-07-30
ES2375446T3 (es) 2012-02-29
FR13C0055I1 (fr) 2013-11-01
AU2003231160A1 (en) 2003-11-17
US6946149B2 (en) 2005-09-20
CA2484303C (fr) 2014-07-15
PT2292244E (pt) 2014-01-14

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