EP2123756A4 - Transglutaminase ayant une liaison disulfure introduite dans celle-ci - Google Patents

Transglutaminase ayant une liaison disulfure introduite dans celle-ci

Info

Publication number
EP2123756A4
EP2123756A4 EP08711306A EP08711306A EP2123756A4 EP 2123756 A4 EP2123756 A4 EP 2123756A4 EP 08711306 A EP08711306 A EP 08711306A EP 08711306 A EP08711306 A EP 08711306A EP 2123756 A4 EP2123756 A4 EP 2123756A4
Authority
EP
European Patent Office
Prior art keywords
transglutaminase
disulfide binding
binding introduced
disulfide
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08711306A
Other languages
German (de)
English (en)
Other versions
EP2123756A1 (fr
EP2123756B1 (fr
Inventor
Keiichi Yokoyama
Mototaka Suzuki
Tatsuki Kashiwagi
Eiichiro Suzuki
Masayo Date
Seiichi Taguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of EP2123756A1 publication Critical patent/EP2123756A1/fr
Publication of EP2123756A4 publication Critical patent/EP2123756A4/fr
Application granted granted Critical
Publication of EP2123756B1 publication Critical patent/EP2123756B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/02—Aminoacyltransferases (2.3.2)
    • C12Y203/02013—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP20080711306 2007-02-15 2008-02-14 Transglutaminase ayant une liaison disulfure introduite dans celle-ci Active EP2123756B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007034916 2007-02-15
PCT/JP2008/052470 WO2008099898A1 (fr) 2007-02-15 2008-02-14 Transglutaminase ayant une liaison disulfure introduite dans celle-ci

Publications (3)

Publication Number Publication Date
EP2123756A1 EP2123756A1 (fr) 2009-11-25
EP2123756A4 true EP2123756A4 (fr) 2010-06-30
EP2123756B1 EP2123756B1 (fr) 2014-06-04

Family

ID=39690125

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20080711306 Active EP2123756B1 (fr) 2007-02-15 2008-02-14 Transglutaminase ayant une liaison disulfure introduite dans celle-ci

Country Status (8)

Country Link
US (1) US9062291B2 (fr)
EP (1) EP2123756B1 (fr)
JP (1) JPWO2008099898A1 (fr)
KR (1) KR101162049B1 (fr)
CN (1) CN101631860B (fr)
AU (1) AU2008215422B2 (fr)
NZ (1) NZ579599A (fr)
WO (1) WO2008099898A1 (fr)

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KR20100085083A (ko) 2007-11-19 2010-07-28 아지노모토 가부시키가이샤 섬유 가공물 및 이의 제조법
EP2239335B1 (fr) * 2008-01-18 2013-02-27 Ajinomoto Co., Inc. Procédé de production d'un dérivé de sérine, et protéine utilisée dans ledit procédé
JP5445453B2 (ja) * 2008-07-09 2014-03-19 味の素株式会社 アミノヒドロキシ安息香酸類の製造方法
CN102341497B (zh) * 2009-03-06 2013-11-06 味之素株式会社 放线菌来源的耐热性转谷氨酰胺酶
DE102010062600A1 (de) 2010-12-08 2012-06-14 Evonik Goldschmidt Gmbh Hydrophobisiertes Proteinhydrolysat
WO2012176919A1 (fr) 2011-06-23 2012-12-27 味の素株式会社 Procédé de préparation de protéine multimérique constituée d'une protéine monomérique unissant une protéine ayant une structure pliée d'immunoglobuline et une protéine pouvant prendre une structure de sous unité
WO2013179711A1 (fr) 2012-05-29 2013-12-05 味の素株式会社 Procédé de production d'acide 3-acétylamino-4-hydroxybenzoïque
WO2015191883A1 (fr) * 2014-06-12 2015-12-17 Dophen Biomedical Conjugués anticorps-médicament homogènes par des procédés enzymatiques
NZ762376A (en) 2017-09-19 2022-08-26 Scherrer Inst Paul Transglutaminase conjugation method and linker
BR112020009793A2 (pt) * 2017-11-30 2020-11-03 Amano Enzyme Inc. transglutaminase modificada
CA3128571A1 (fr) 2019-03-19 2020-09-24 Paul Scherrer Institut Procede de conjugaison de transglutaminase avec un lieur a base de glycine
WO2021177392A1 (fr) 2020-03-04 2021-09-10 味の素株式会社 Transglutaminase mutante
EP4118194A4 (fr) * 2020-03-13 2024-08-21 Curie Co. Inc. Variants de transglutaminase
KR20230069211A (ko) 2020-09-18 2023-05-18 아라리스 바이오테크 아게 아미노산-기반 링커를 사용한 트란스글루타미나제 접합 방법
WO2022071061A1 (fr) 2020-09-29 2022-04-07 味の素株式会社 Transglutaminase mutante
KR20230096052A (ko) 2020-10-25 2023-06-29 아라리스 바이오테크 아게 항체-링커 접합체를 생성하기 위한 수단 및 방법
CN112980759B (zh) * 2021-03-08 2022-08-26 上海交通大学 增强Subtilisin基因转录水平以提高TG酶发酵水平的方法
WO2023072934A1 (fr) 2021-10-25 2023-05-04 Araris Biotech Ag Procédés de production de conjugués anticorps-lieur
KR20240150807A (ko) 2022-02-22 2024-10-16 아라리스 바이오테크 아게 2개 이상의 페이로드를 포함하는 펩티드 링커
WO2025082990A1 (fr) 2023-10-15 2025-04-24 Araris Biotech Ag Conjugués anticorps-médicament utilisant deux types différents d'inhibiteurs de topo-isomérase i
WO2026013234A1 (fr) 2024-07-10 2026-01-15 Araris Biotech Ag Conjugués anticorps-médicament à triple charge utile (adcs)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1310560A1 (fr) * 2000-08-17 2003-05-14 Ajinomoto Co., Inc. Procede de modification de transglutaminase de micro-organismes (mtg)

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US4990452A (en) * 1986-02-12 1991-02-05 Genex Corporation Combining mutations for stabilization of subtilisin
JPH0665280B2 (ja) 1987-03-04 1994-08-24 味の素株式会社 タンパクゲル化剤及びそれを用いるタンパクのゲル化方法
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JPH03213574A (ja) 1990-01-10 1991-09-18 Ajinomoto Co Inc 獣毛繊維の改質方法
JP3010589B2 (ja) 1990-10-19 2000-02-21 天野製薬株式会社 リコンビナントトランスグルタミナーゼ
EP0481504B1 (fr) 1990-10-19 1996-01-17 Amano Pharmaceutical Co., Ltd. Transglutaminase recombinante
JPH0630771A (ja) 1992-07-14 1994-02-08 Ajinomoto Co Inc バクテリアルトランスグルタミナーゼの製造法及び関連物
NZ291414A (en) 1994-08-26 1998-05-27 Novo Nordisk As Microbial transglutaminases and methods of production using fungi and dna constructs
BR0014059B1 (pt) 1999-09-30 2013-02-05 processo para produzir transglutaminase.
JP2001321192A (ja) 2000-05-15 2001-11-20 Ajinomoto Co Inc 構造解析用タンパク質試料の調製方法
JP2002253272A (ja) * 2000-08-17 2002-09-10 Ajinomoto Co Inc 微生物由来トランスグルタミナーゼの改変方法
DE10042993B4 (de) 2000-09-01 2005-09-15 Trumpler Gmbh & Co. Chemische Fabrik Verfahren zum enzymatischen Gerben von Häuten
CN1250722C (zh) 2001-03-30 2006-04-12 味之素株式会社 分泌生产蛋白质的方法
KR20050106502A (ko) * 2003-03-07 2005-11-09 아지노모토 가부시키가이샤 미생물 트랜스글루타미나제의 제조방법
WO2005007841A1 (fr) * 2003-07-16 2005-01-27 Ajinomoto Co., Inc. Serine acetyltransferase de variant et procede de production de l-cysteine
JP4730302B2 (ja) 2004-04-20 2011-07-20 味の素株式会社 タンパク質の製造法
JP4704144B2 (ja) 2005-07-29 2011-06-15 東芝テック株式会社 商品販売登録データ処理装置

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EP1310560A1 (fr) * 2000-08-17 2003-05-14 Ajinomoto Co., Inc. Procede de modification de transglutaminase de micro-organismes (mtg)

Non-Patent Citations (2)

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O'FAGAIN C: "Enzyme stabilization: Recent experimental progress", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 33, no. 2-3, 13 August 2003 (2003-08-13), pages 137 - 149, XP002310332, ISSN: 0141-0229 *
See also references of WO2008099898A1 *

Also Published As

Publication number Publication date
CN101631860A (zh) 2010-01-20
KR101162049B1 (ko) 2012-07-04
KR20090120485A (ko) 2009-11-24
EP2123756A1 (fr) 2009-11-25
US20100143970A1 (en) 2010-06-10
CN101631860B (zh) 2012-07-18
EP2123756B1 (fr) 2014-06-04
US9062291B2 (en) 2015-06-23
WO2008099898A1 (fr) 2008-08-21
AU2008215422A1 (en) 2008-08-21
JPWO2008099898A1 (ja) 2010-05-27
NZ579599A (en) 2012-03-30
AU2008215422B2 (en) 2011-07-14

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