EP2915804A4 - Neuartiges aminderivat oder salz davon - Google Patents

Neuartiges aminderivat oder salz davon

Info

Publication number
EP2915804A4
EP2915804A4 EP13851612.5A EP13851612A EP2915804A4 EP 2915804 A4 EP2915804 A4 EP 2915804A4 EP 13851612 A EP13851612 A EP 13851612A EP 2915804 A4 EP2915804 A4 EP 2915804A4
Authority
EP
European Patent Office
Prior art keywords
amine derivative
corresponding salt
new amine
new
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13851612.5A
Other languages
English (en)
French (fr)
Other versions
EP2915804A1 (de
EP2915804B1 (de
Inventor
Tadashi Tanaka
Yoshitake Konishi
Daisuke Kubo
Masataka Fujino
Issei Doi
Daisuke Nakagawa
Tatsuya Murakami
Takayuki Yamakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Corp
Fujifilm Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd, Fujifilm Corp filed Critical Toyama Chemical Co Ltd
Priority to PL13851612T priority Critical patent/PL2915804T3/pl
Priority to SM20190228T priority patent/SMT201900228T1/it
Priority to SI201331421T priority patent/SI2915804T1/sl
Priority to HRP20190723TT priority patent/HRP20190723T1/hr
Priority to RS20190681A priority patent/RS58786B1/sr
Publication of EP2915804A1 publication Critical patent/EP2915804A1/de
Publication of EP2915804A4 publication Critical patent/EP2915804A4/de
Application granted granted Critical
Publication of EP2915804B1 publication Critical patent/EP2915804B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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EP13851612.5A 2012-10-31 2013-10-30 Neuartiges aminderivat oder salz davon als tnf-alpha-inhibitoren Active EP2915804B1 (de)

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PL13851612T PL2915804T3 (pl) 2012-10-31 2013-10-30 Nowe pochodne aminy lub ich sole jako inhibitory tnf alfa
SM20190228T SMT201900228T1 (it) 2012-10-31 2013-10-30 Nuovo derivato amminico o suo sale come inibitori di tnf alfa
SI201331421T SI2915804T1 (sl) 2012-10-31 2013-10-30 Novi derivati aminov ali njihove soli kot inhibitorji TNF ALFA
HRP20190723TT HRP20190723T1 (hr) 2012-10-31 2013-10-30 Novi derivat amina ili njegova sol kao inhibitor tnf alfa
RS20190681A RS58786B1 (sr) 2012-10-31 2013-10-30 Novi aminski derivati ili njihove soli kao inhibitori tnf alfa

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KR101725292B1 (ko) * 2016-03-30 2017-04-10 한국과학기술연구원 항암 활성을 갖는 신규 피리미딘-4-카르복시산 유도체
WO2018159734A1 (ja) * 2017-03-01 2018-09-07 富士フイルム株式会社 ５－シクロプロピル－２－（（１－（３－フルオロベンジル）－１ｈ－インドール－５－イル）アミノ）ニコチン酸の結晶の製造方法
WO2019235572A1 (ja) * 2018-06-06 2019-12-12 富士フイルム株式会社 固形がんの処置剤および医薬組成物
WO2019235570A1 (ja) 2018-06-06 2019-12-12 富士フイルム株式会社 グリオーマの処置剤および医薬組成物
WO2019235571A1 (ja) * 2018-06-06 2019-12-12 富士フイルム株式会社 血液がんの処置剤および医薬組成物
JP7126556B2 (ja) * 2018-09-28 2022-08-26 富士フイルム株式会社 シタラビンを含む抗腫瘍剤、シタラビンと併用される抗腫瘍効果増強剤、抗腫瘍用キット、およびシタラビンと併用される抗腫瘍剤
AR120173A1 (es) * 2019-10-09 2022-02-02 Biocryst Pharm Inc Inhibidores del factor d del complemento para administración oral
EP4052760B1 (de) 2019-10-31 2024-03-13 FUJIFILM Corporation Pyrazinderivate oder deren salze und deren verwendung
EP4190402B1 (de) 2020-07-30 2025-08-27 FUJIFILM Corporation Stickstoffhaltige heterocyclische verbindung oder salz davon, verwendung davon und zwischenprodukt davon
CN112574095A (zh) * 2020-12-21 2021-03-30 常州大学 一种靛红衍生物硝化的新方法
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DE102022203732A1 (de) * 2022-04-13 2023-10-19 Continental Reifen Deutschland Gmbh Verbindung, Kautschukmischung enthaltend die Verbindung, Fahrzeugreifen, der die Kautschukmischung in wenigstens einem Bauteil aufweist, Verfahren zur Herstellung der Verbindung sowie Verwendung der Verbindung als Alterungsschutzmittel und/oder Antioxidationsmittel
CN117003754B (zh) * 2022-04-28 2025-07-25 腾讯科技（深圳）有限公司 吡咯并[2,3-d]嘧啶或吡唑并[3,4-d]嘧啶衍生物及其用途
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HRP20190723T1 (hr) 2019-06-14
PT2915804T (pt) 2019-06-06
DK2915804T3 (da) 2019-06-03
SMT201900228T1 (it) 2019-05-10
SI2915804T1 (sl) 2019-06-28
BR112015009777A2 (pt) 2017-07-11
JPWO2014069510A1 (ja) 2016-09-08
KR20150079916A (ko) 2015-07-08
EP2915804A1 (de) 2015-09-09
US20150299189A1 (en) 2015-10-22
HUE043663T2 (hu) 2019-08-28
AU2013339167A1 (en) 2015-05-14
EP2915804B1 (de) 2019-03-27
LT2915804T (lt) 2019-06-10
TWI638814B (zh) 2018-10-21
ES2721627T3 (es) 2019-08-02
CA2890003A1 (en) 2014-05-08
CN104870422A (zh) 2015-08-26
WO2014069510A1 (ja) 2014-05-08
RU2015120558A (ru) 2016-12-20
RU2668550C2 (ru) 2018-10-02
US9624215B2 (en) 2017-04-18
CY1121599T1 (el) 2020-05-29
JP6466171B2 (ja) 2019-02-06
CN104870422B (zh) 2019-03-15
AU2013339167B2 (en) 2018-03-15

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