EP3402483A4 - Procédés et compositions pour l'activation de lymphocytes t gamma-delta - Google Patents

Procédés et compositions pour l'activation de lymphocytes t gamma-delta Download PDF

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Publication number
EP3402483A4
EP3402483A4 EP17739028.3A EP17739028A EP3402483A4 EP 3402483 A4 EP3402483 A4 EP 3402483A4 EP 17739028 A EP17739028 A EP 17739028A EP 3402483 A4 EP3402483 A4 EP 3402483A4
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EP
European Patent Office
Prior art keywords
lymphocytes
delta
gamma
activation
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17739028.3A
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German (de)
English (en)
Other versions
EP3402483B1 (fr
EP3402483A1 (fr
Inventor
Charles David Pauza
Li HAISHAN
Tyler LAHUSEN
Mei-Ling Liou
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American Gene Technologies International Inc
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American Gene Technologies International Inc
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Priority to EP23199847.7A priority Critical patent/EP4310500A3/fr
Publication of EP3402483A1 publication Critical patent/EP3402483A1/fr
Publication of EP3402483A4 publication Critical patent/EP3402483A4/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
EP17739028.3A 2016-01-15 2017-01-13 Procédés et compositions pour l'activation de lymphocytes t gamma-delta Active EP3402483B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP23199847.7A EP4310500A3 (fr) 2016-01-15 2017-01-13 Procédés et compositions pour l'activation de lymphocytes t gamma delta

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662279474P 2016-01-15 2016-01-15
PCT/US2017/013399 WO2017123918A1 (fr) 2016-01-15 2017-01-13 Procédés et compositions pour l'activation de lymphocytes t gamma-delta

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP23199847.7A Division-Into EP4310500A3 (fr) 2016-01-15 2017-01-13 Procédés et compositions pour l'activation de lymphocytes t gamma delta
EP23199847.7A Division EP4310500A3 (fr) 2016-01-15 2017-01-13 Procédés et compositions pour l'activation de lymphocytes t gamma delta

Publications (3)

Publication Number Publication Date
EP3402483A1 EP3402483A1 (fr) 2018-11-21
EP3402483A4 true EP3402483A4 (fr) 2019-07-10
EP3402483B1 EP3402483B1 (fr) 2023-11-08

Family

ID=59311597

Family Applications (2)

Application Number Title Priority Date Filing Date
EP23199847.7A Pending EP4310500A3 (fr) 2016-01-15 2017-01-13 Procédés et compositions pour l'activation de lymphocytes t gamma delta
EP17739028.3A Active EP3402483B1 (fr) 2016-01-15 2017-01-13 Procédés et compositions pour l'activation de lymphocytes t gamma-delta

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP23199847.7A Pending EP4310500A3 (fr) 2016-01-15 2017-01-13 Procédés et compositions pour l'activation de lymphocytes t gamma delta

Country Status (10)

Country Link
US (8) US9914938B2 (fr)
EP (2) EP4310500A3 (fr)
JP (4) JP7260898B2 (fr)
CN (3) CN116064678A (fr)
AU (2) AU2017207906B2 (fr)
CA (1) CA3011529A1 (fr)
DK (1) DK3402483T3 (fr)
ES (1) ES2965357T3 (fr)
IL (4) IL297238B2 (fr)
WO (1) WO2017123918A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010045659A1 (fr) 2008-10-17 2010-04-22 American Gene Technologies International Inc. Vecteurs lentiviraux sûrs pour une administration ciblée de multiples molécules thérapeutiques
US11980663B2 (en) 2015-07-08 2024-05-14 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
IL297238B2 (en) 2016-01-15 2024-08-01 American Gene Tech Int Inc Methods and preparations for gamma-delta T-cell activation
JP7153332B2 (ja) 2016-02-08 2022-10-14 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖワクチン接種および免疫療法
ES2911448T3 (es) * 2016-03-09 2022-05-19 American Gene Tech Int Inc Vectores combinados y métodos para el tratamiento del cáncer
WO2017213697A1 (fr) 2016-06-08 2017-12-14 American Gene Technologies International Inc. Système d'administration viral sans intégration et procédés associés à ce dernier
CA3028982A1 (fr) 2016-07-08 2018-01-11 American Gene Technologies International Inc. Pre-immunisation et immunotherapie du vih
WO2018017882A1 (fr) 2016-07-21 2018-01-25 American Gene Technologies International Inc. Vecteurs viraux pour le traitement de la maladie de parkinson
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
US12559769B2 (en) 2017-06-16 2026-02-24 American Gene Technologies International Inc. Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells
CA3075168A1 (fr) * 2017-09-08 2019-03-14 Generation Bio Co. Adn a extremite fermee (cedna) modifie
US20210254103A1 (en) * 2018-07-02 2021-08-19 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis and disorders associated with the spinal cord
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
EP3876952A4 (fr) 2018-11-05 2022-08-24 American Gene Technologies International Inc. Système de vecteurs pour exprimer un arn régulateur
CN109363955B (zh) * 2018-11-14 2021-09-21 广州玮弘祺生物科技有限公司 一种发用固体定型喷雾及其制备方法
CN109456993A (zh) * 2018-11-28 2019-03-12 上海安民生物技术有限公司 含cag启动子的白蛋白表达载体
KR20220012266A (ko) * 2019-05-23 2022-02-03 스페이스크래프트 세븐, 엘엘씨 영아 악성 골화석증을 위한 유전자 요법 벡터
PE20241891A1 (es) * 2021-09-01 2024-09-19 Jaguar Gene Therapy Llc Vectores y viriones adenoasociados para tratar la galactosemia y metodos de uso y fabricacion
WO2025067472A1 (fr) * 2023-09-27 2025-04-03 Nanjing Legend Biotech Co., Ltd. Procédés pour la culture de lymphocytes t gamma delta

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008025025A2 (fr) * 2006-08-25 2008-02-28 Avi Biopharma, Inc. Composition antisens et procédé permettant d'inhiber la biogénèse de l'arnmi
WO2012145624A2 (fr) * 2011-04-21 2012-10-26 University Of Massachusetts Compositions à base de raav et procédés pour traiter des déficiences en anti-trypsine alpha-1
WO2014117050A2 (fr) * 2013-01-26 2014-07-31 Mirimus, Inc. Arnmi modifié en tant qu'échafaudage pour de l'arnsh

Family Cites Families (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668255A (en) 1984-06-07 1997-09-16 Seragen, Inc. Hybrid molecules having translocation region and cell-binding region
JPH08500965A (ja) 1992-05-22 1996-02-06 デイナ ファーバー キャンサー インスチチュート ハイブリッドウイルス発現ベクター，その使用および新規アッセイ
AU6014094A (en) 1992-12-02 1994-06-22 Baylor College Of Medicine Episomal vectors for gene therapy
CA2144040A1 (fr) 1993-07-13 1995-01-26 Michel Perricaudet Vecteurs adenoviraux defectifs et utilisation en therapie genique
AU4645697A (en) 1996-09-11 1998-04-02 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Aav4 vector and uses thereof
CA2300957A1 (fr) 1997-08-15 1999-02-25 Rubicon Laboratory, Inc. Retrovirus et vecteurs viraux
AU1124499A (en) 1997-10-28 1999-05-17 Maxygen, Inc. Human papillomavirus vectors
ATE286138T1 (de) 1998-03-20 2005-01-15 Univ Pennsylvania Zusammensetzungen und verfahren zur helfer-freien herstellung von rekombinante adeno-assoziierten viren
DE69940521D1 (de) 1998-10-01 2009-04-16 Univ Southern California Retrovirales genübertragungssystem und entsprechendes verwendungverfahren
US6156514A (en) 1998-12-03 2000-12-05 Sunol Molecular Corporation Methods for making recombinant cells
US6410013B1 (en) 1999-01-25 2002-06-25 Musc Foundation For Research Development Viral vectors for use in monitoring HIV drug resistance
WO2000072886A1 (fr) 1999-05-26 2000-12-07 Dana-Farber Cancer Institute, Inc. Vecteurs lentiviraux a replication episomique
AU2001257611A1 (en) 2000-04-28 2001-11-12 Avigen, Inc. Polynucleotides for use in recombinant adeno-associated virus virion production
CA2408830A1 (fr) 2000-05-12 2001-11-22 The Regents Of The University Of California Traitement de cellules infectees par le papillomavirus humain (hpv)
WO2001091802A1 (fr) * 2000-05-30 2001-12-06 Baylor College Of Medicine Vecteurs viraux chimeres pour therapie genique
NO314588B1 (no) 2000-09-04 2003-04-14 Bionor Immuno As HIV-peptider, antigener, vaksinesammensetning, immunoassay- testsett og en fremgangsmåte for å påvise antistoffer indusert av HIV
US7122181B2 (en) * 2000-12-19 2006-10-17 Research Development Foundation Lentiviral vector-mediated gene transfer and uses thereof
US20030138444A1 (en) 2001-08-18 2003-07-24 Myriad Genetics, Incorporated Composition and method for treating HIV infection
US20030119770A1 (en) 2001-08-02 2003-06-26 Zhennan Lai Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors
US7737124B2 (en) 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
US7368114B2 (en) 2001-10-25 2008-05-06 The United States Of America As Represented By The Department Of Health And Human Services Fusion protein including of CD4
US20070203333A1 (en) 2001-11-30 2007-08-30 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
WO2003079757A2 (fr) 2002-03-20 2003-10-02 Massachusetts Institute Of Technology Therapeutique du vih
WO2003093436A2 (fr) 2002-04-30 2003-11-13 University Of Florida Traitement de la phenylcetonurie
US7811580B2 (en) 2002-05-07 2010-10-12 Novartis Vaccines & Diagnostics, Inc. Chimeric HIV Env proteins comprising CD4 mini-proteins or CD4 mimetics that are capable of inducing neutralizing antibody responses against cryptic Env epitopes
US7199107B2 (en) 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
US20040161412A1 (en) 2002-08-22 2004-08-19 The Cleveland Clinic Foundation Cell-based VEGF delivery
US8034334B2 (en) 2002-09-06 2011-10-11 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy
AU2003290586B2 (en) 2002-11-04 2009-07-02 University Of Massachusetts Allele-specific RNA interference
WO2004053137A2 (fr) 2002-12-11 2004-06-24 Cytos Biotechnology Ag Procede de production de proteines
US20060246520A1 (en) * 2003-05-23 2006-11-02 Institut National De La Sante Et De La Recherche Medicale Gamma delta t cell-mediated therapy
EP1644508A1 (fr) 2003-07-11 2006-04-12 Cytos Biotechnology AG Systeme d'expression genetique
US20050019927A1 (en) 2003-07-13 2005-01-27 Markus Hildinger DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER
US20050138677A1 (en) 2003-09-16 2005-06-23 Pfister Herbert J. Transgenic animal model for the treatment of skin tumors
EP1678292A4 (fr) 2003-09-18 2008-05-07 Univ Emory Vaccins mva ameliores
WO2005033282A2 (fr) 2003-10-01 2005-04-14 Pharmacia & Upjohn Company Llc Compositions polyamide et methodes therapeutiques pour traiter un papillomavirus humain
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
EP1753777B1 (fr) 2004-02-25 2014-05-07 Dana-Farber Cancer Institute, Inc. METHODES ET COMPOSITIONS POUR LE TRAITEMENT ET LA PREVENTION D'UNE INFECTION PAR LE VIH AU MOYEN DE TRIM5a
WO2005085443A2 (fr) 2004-03-01 2005-09-15 Massachusetts Institute Of Technology Agents therapeutiques a base d'arni pour le traitement de la rhinite allergique et de l'asthme
TWI439284B (zh) 2004-04-09 2014-06-01 艾伯維生物技術有限責任公司 用於治療ＴＮＦα相關失調症之多重可變劑量療法
WO2005118802A2 (fr) 2004-06-03 2005-12-15 The Regents Of The University Of California Ciblage de vecteurs retroviraux pseudotypes
US20080131940A1 (en) 2004-06-25 2008-06-05 Robert Chiu Target Cell-Specific Short Interfering Rna and Methods of Use Thereof
WO2006023491A2 (fr) 2004-08-16 2006-03-02 The Cbr Institute For Biomedical Research, Inc. Methode d'interference arn et utilisations
WO2006039721A2 (fr) 2004-10-08 2006-04-13 The Board Of Trustees Of The University Of Illinois Composes de bisphosphonate et methodes de traitement de maladies de resorption osseuse, de cancers, de douleurs osseuses, de troubles immunitaires et de maladies infectieuses
EP1647595A1 (fr) 2004-10-15 2006-04-19 Academisch Medisch Centrum bij de Universiteit van Amsterdam Acides nucléiques contre des virus, en particulier contre le VIH
CA2585523A1 (fr) 2004-11-02 2006-05-11 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Amplicon adenoviral et cellules productrices de vecteurs adenoviraux a defaut de replication, et leurs methodes de preparation et d'utilisation
US7790446B2 (en) 2005-02-11 2010-09-07 Kosagen Cell Factory Oü Vectors, cell lines and their use in obtaining extended episomal maintenance replication of hybrid plasmids and expression of gene products
EP2573185A3 (fr) * 2005-02-16 2013-06-05 Lentigen Corporation Vecteurs de lentivirus et leur utilisation
DK2002003T3 (en) 2005-05-27 2016-03-21 Ospedale San Raffaele Srl Gene vector comprising miRNA
US20070032443A1 (en) * 2005-08-02 2007-02-08 Jaeseob Kim Therapy for Alzheimer's disease
WO2007015122A1 (fr) * 2005-08-02 2007-02-08 Genexel, Inc. Traitement de la maladie d'alzheimer
US20070105835A1 (en) 2005-11-07 2007-05-10 Kazantsev Aleksey G Compositions and methods for modulating poly(ADP-ribose) polymerase activity
WO2007133674A2 (fr) 2006-05-12 2007-11-22 Lentigen Corporation Compositions à base de vecteurs lentiviraux, procédés et applications
WO2007149476A2 (fr) * 2006-06-19 2007-12-27 Trustees Of Columbia University In The City Of New York Déterminations de la mort cellulaire non apoptotique et leurs utilisations
US20080003225A1 (en) 2006-06-29 2008-01-03 Henri Vie Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors
US8124752B2 (en) 2006-07-10 2012-02-28 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the MYC gene
EP1878440A1 (fr) 2006-07-13 2008-01-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methodes et compositions pour augmenter l'efficacite d'anticorps therapeutiques au moyen de composes activateurs de cellules gamma delta
RU2009106214A (ru) * 2006-07-26 2010-09-10 Новартис АГ (CH) Ингибиторы ундекапренилпирофосфатсинтазы
EP2415783B1 (fr) * 2006-10-16 2016-12-14 Genelux Corporation Souches de virus de vaccin modifiées pour une utilisation pour le diagnostic et procédé thérapeutique
WO2008090185A1 (fr) 2007-01-23 2008-07-31 Virco Bvba Procédé de mise au point d'un régime de médicaments pour des patients affectés par le vih
JP2010523709A (ja) * 2007-04-12 2010-07-15 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ Ｆｐｐｓ、ｇｇｐｐｓ及びｄｐｐｓを含む複数の標的に対して高い効能を有するビスホスホネート化合物及び方法
US20080293142A1 (en) 2007-04-19 2008-11-27 The Board Of Regents For Oklahoma State University Multiple shRNA Expression Vectors and Methods of Construction
WO2009001224A2 (fr) 2007-06-22 2008-12-31 Eth Zurich Antiviraux
EP2008656A1 (fr) 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Compositions pour le traitement d'hyperphénylalaninémie
WO2009026328A2 (fr) 2007-08-21 2009-02-26 Immune Disease Institute, Inc. Procédés d'administration d'agents à des leucocytes et des cellules endothéliales
EP2203176B1 (fr) 2007-09-28 2014-11-26 Anthrogenesis Corporation Elimination des tumeurs au moyen d'un perfusat placentaire humain et de cellules tueuses naturelles intermediaires provenant d'un placenta humain
EP2090659A1 (fr) 2008-02-14 2009-08-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Particule infectieuse, son processus de préparation et utilisation
GB0810209D0 (en) 2008-06-04 2008-07-09 Cambridge Entpr Ltd Pluripotency associated epigenetic factor
EP2301105A4 (fr) 2008-06-16 2013-06-19 Polyplus Battery Co Inc Piles lithium/air aqueuses
US8629334B2 (en) 2008-07-16 2014-01-14 University Of Florida Research Foundation, Inc. Viral-based transient-expression vector system for trees
US20110207226A1 (en) 2008-08-20 2011-08-25 Virxsys Corporation Non-integrating lenti/adeno-associated virus hybrid vector system
EP2342321B1 (fr) 2008-09-17 2018-04-11 Isogenis, Inc. Construction de vecteurs pour la délivrance de gènes basés sur un adénovirus complètement délété et leurs utilisations
WO2010045659A1 (fr) 2008-10-17 2010-04-22 American Gene Technologies International Inc. Vecteurs lentiviraux sûrs pour une administration ciblée de multiples molécules thérapeutiques
JP2012507299A (ja) 2008-10-31 2012-03-29 バイオジェン・アイデック・エムエイ・インコーポレイテッド Ｌｉｇｈｔ標的分子およびその使用
WO2010051521A1 (fr) 2008-10-31 2010-05-06 Lentigen Corporation Produit de thérapie cellulaire pour le traitement de l'infection par le vih
JP2012508591A (ja) 2008-11-14 2012-04-12 ライフ テクノロジーズ コーポレーション 細胞を操作するための組成物および方法
EP2191834A1 (fr) 2008-11-26 2010-06-02 Centre National De La Recherche Scientifique (Cnrs) Compositions et procédé pour traiter des infections à rétrovirus
CA2756670A1 (fr) 2009-03-26 2010-09-30 The Regents Of The University Of California Cellules souches mesenchymateuses produisant de l'arn inhibiteur pouvant etre utilisees pour agir sur le cours d'une maladie
CN102438631A (zh) 2009-04-09 2012-05-02 史坦赛特股份有限公司 抗hiv干细胞及其用途
JP5727458B2 (ja) 2009-04-13 2015-06-03 アプセト ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフトＡｐｃｅｔｈ Ｇｍｂｈ ＆ Ｃｏ． Ｋｇ 改変間葉系幹細胞及びそれを使用した腫瘍の治療方法
EP2425001A4 (fr) 2009-04-30 2012-11-14 Univ California Vecteurs d'association anti-vih, vecteurs de ciblage, et procédés d'utilisation
US20120201794A1 (en) 2009-07-15 2012-08-09 Calimmune Inc. Dual vector for inhibition of human immunodeficiency virus
US20120027725A1 (en) * 2009-11-30 2012-02-02 Galvin Jeffrey A Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules to treat liver cancer
CN101805750B (zh) * 2009-12-29 2011-11-30 浙江大学 法呢基焦磷酸合成酶rna干扰重组慢病毒载体构建及用途
AU2011217955A1 (en) 2010-02-18 2012-08-16 Emory University Vectors expressing HIV antigens and GM-CSF and related methods for generating an immune response
WO2011119942A1 (fr) 2010-03-25 2011-09-29 Vistagen Therapeutics, Inc. Induction de cellules ips en utilisant des vecteurs épisomiques transitoires
US20130090371A1 (en) * 2010-04-20 2013-04-11 President And Fellows Of Harvard College Methods and compositions for inhibition of beta2-adrenergic receptor degradation
PT2561078T (pt) 2010-04-23 2018-12-03 Cold Spring Harbor Laboratory Sharn com uma conceção estrutural inovadora
CN102946907A (zh) 2010-05-28 2013-02-27 牛津生物医学（英国）有限公司 慢病毒载体向脑的递送
JP5805089B2 (ja) 2010-08-10 2015-11-04 タカラバイオ株式会社 細胞集団の製造方法
EP2625294A4 (fr) 2010-10-07 2014-03-26 Univ Columbia PROCÉDÉ DE TRAITEMENT DU CANCER AVEC MUTATION A p53
WO2012061075A2 (fr) 2010-10-25 2012-05-10 The Regents Of The University Of California Cellules souches/progénitrices hématopoïétiques et macrophages résistants au vih et fonctionnels provenant de cellules souches pluripotentes induites
CA2816883A1 (fr) 2010-11-23 2012-05-31 Presage Biosciences, Inc. Procedes et compositions therapeutiques pour administration de solide
JP6091435B2 (ja) 2011-02-22 2017-03-08 カリフォルニア インスティチュート オブ テクノロジー アデノ随伴ウイルス（ａａｖ）ベクターを用いたタンパク質の送達
US9358250B2 (en) 2011-10-15 2016-06-07 Genentech, Inc. Methods of using SCD1 antagonists
EP2782596A4 (fr) 2011-11-22 2015-07-29 Philadelphia Children Hospital Vecteurs viraux pour administration de transgènes hautement efficace
US9745631B2 (en) * 2011-12-20 2017-08-29 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
SG10201604810UA (en) 2012-02-07 2016-08-30 Global Bio Therapeutics Inc Compartmentalized method of nucleic acid delivery and compositions and uses thereof
WO2013174404A1 (fr) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer
US20150174235A1 (en) 2012-06-06 2015-06-25 Bionor Immuno As Vaccine
US9556433B2 (en) 2012-07-17 2017-01-31 Université De Genève Nucleic acids for down-regulation of gene expression
WO2014052855A1 (fr) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Procédés et compositions de dépistage et de traitement de troubles du développement
EP3415627A1 (fr) 2012-11-13 2018-12-19 Codiak BioSciences, Inc. Administration d'agent thérapeutique
CA2892448A1 (fr) 2012-12-05 2014-06-12 Sangamo Biosciences, Inc. Procedes et compositions pour la regulation de troubles metaboliques
US9642921B2 (en) 2012-12-20 2017-05-09 Tocagen Inc. Cancer combination therapy and recombinant vectors
CN103184224A (zh) 2013-04-03 2013-07-03 衡阳师范学院 一种抗艾滋病病毒感染的三联miRNA及构建方法
US10501803B2 (en) 2013-05-21 2019-12-10 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Isoforms of GATA6 and NKX2-1 as markers for diagnosis and therapy of cancer and as targets for anti-cancer therapy
WO2014195159A1 (fr) 2013-06-03 2014-12-11 Theravectys Vecteurs lentiviraux contenant une séquence promotrice amont de microglobuline bêta-2 ou de cmh de classe ii, ou de cmh de classe i
EP3027755B1 (fr) 2013-08-02 2019-10-09 The Regents of The University of California Modification d'une immunité antivirale médiée par les cellules t par des cellules souches et des récepteurs d'antigène chimériques
WO2015042308A2 (fr) 2013-09-18 2015-03-26 City Of Hope Inhibiteurs du vih à base d'arn
EP3574923A1 (fr) 2013-10-22 2019-12-04 Translate Bio, Inc. Thérapie d'arnm pour phénylcétonurie
CN111218447B (zh) 2013-11-07 2024-10-11 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
EP2878674A1 (fr) 2013-11-28 2015-06-03 Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Épisomes stables sur la base des vecteurs lentiviraux non intégratifs
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
CN113699159A (zh) 2014-03-28 2021-11-26 明尼苏达大学评议会 涉及经工程改造的cd16的多肽、细胞和方法
IL292038B2 (en) 2014-04-23 2024-12-01 Juno Therapeutics Inc Methods for enriching or producing immune cell populations for adoptive therapy
WO2015164759A2 (fr) * 2014-04-25 2015-10-29 Bluebird Bio, Inc. Récepteurs d'antigènes chimériques de promoteur mnd
ES2744565T3 (es) 2014-04-25 2020-02-25 Genethon Tratamiento de la hiperbilirrubinemia
WO2016033163A1 (fr) 2014-08-29 2016-03-03 Immunomedics, Inc. Identification de gènes cancéreux par fusion in vivo de cellules cancéreuses humaines et de cellules animales
WO2016046234A2 (fr) 2014-09-22 2016-03-31 Nexttobe Ab Protéines recombinées sans phe destinées à être utilisées dans le traitement de la phénylcétonurie
AU2015329696A1 (en) 2014-10-10 2017-04-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods to eliminate cancer stem cells by targeting CD47
US10968451B2 (en) 2014-10-14 2021-04-06 Texas Tech University System Multiplexed shRNAs and uses thereof
WO2016069716A1 (fr) 2014-10-30 2016-05-06 The Scripps Research Institute Compositions et procédés comprenant des tyrosyl-arnt synthétases et des composés de resvératrol
GB201509202D0 (en) 2015-05-28 2015-07-15 Ge Healthcare Bio Sciences Ab Semi-static cell culture
WO2016200997A1 (fr) 2015-06-10 2016-12-15 America Gene Technologies International, Inc. Systèmes d'administration viraux non intégratifs et procédés d'utilisation associés
US11980663B2 (en) 2015-07-08 2024-05-14 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
CA2994192C (fr) 2015-08-13 2020-06-16 Peking University Cellules souches pluripotentes etendues et induites, procedes de fabrication et d'utilisation
CN105112370B (zh) * 2015-08-25 2019-02-05 杭州优善生物科技有限公司 一种体外刺激外周血γδT细胞高效增殖的方法及其应用
JP7059179B2 (ja) 2015-10-20 2022-04-25 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 遺伝子操作のための方法及び製品
WO2017100551A1 (fr) 2015-12-09 2017-06-15 Alexion Pharmaceuticals, Inc. Séquences utr hétérologues pour l'amplification de l'expression d'arnm
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
IL297238B2 (en) 2016-01-15 2024-08-01 American Gene Tech Int Inc Methods and preparations for gamma-delta T-cell activation
JP7153332B2 (ja) 2016-02-08 2022-10-14 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖワクチン接種および免疫療法
ES2911448T3 (es) 2016-03-09 2022-05-19 American Gene Tech Int Inc Vectores combinados y métodos para el tratamiento del cáncer
BR112018069090A2 (pt) 2016-03-23 2019-01-29 Univ New York State Res Found tratamento de câncer com base na distribuição de oligos por meio de junções comunicantes a partir de células estaminais mesenquimatosas humanas (hmsc)
WO2017173453A1 (fr) 2016-04-01 2017-10-05 The Brigham And Women's Hospital, Inc. Nanoparticules sensibles aux stimuli pour applications biomédicales
WO2017213697A1 (fr) 2016-06-08 2017-12-14 American Gene Technologies International Inc. Système d'administration viral sans intégration et procédés associés à ce dernier
CA3028982A1 (fr) 2016-07-08 2018-01-11 American Gene Technologies International Inc. Pre-immunisation et immunotherapie du vih
WO2018017882A1 (fr) 2016-07-21 2018-01-25 American Gene Technologies International Inc. Vecteurs viraux pour le traitement de la maladie de parkinson
EP3562494A4 (fr) 2016-12-30 2020-08-19 The Trustees Of The University Of Pennsylvania Thérapie génique pour le traitement de la phénylcétonurie
KR20230093381A (ko) 2017-01-09 2023-06-27 아메리칸 진 테크놀로지스 인터내셔널 인코포레이티드 예비-면역화 단계가 없는 hiv 면역요법
US12023385B2 (en) 2017-02-08 2024-07-02 Dana-Farber Cancer Institute, Inc. Tunable endogenous protein degradation with heterobifunctional compounds
RS65241B1 (sr) * 2017-02-28 2024-03-29 Univ Pennsylvania Vektor adeno-asociranih virusa (aav) iz podgrupe f i njegove upotrebe
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
US12559769B2 (en) 2017-06-16 2026-02-24 American Gene Technologies International Inc. Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells
KR20200057766A (ko) 2017-10-02 2020-05-26 아메리칸 진 테크놀로지스 인터내셔널 인코포레이티드 페닐케톤뇨증을 치료하기 위한 프로모터 및 인핸서 조합을 포함하는 벡터
US12280092B2 (en) 2018-01-05 2025-04-22 Nantbio, Inc. Reprogrammed T cell-like NK cells
KR20210031898A (ko) 2018-07-13 2021-03-23 난징 레전드 바이오테크 씨오., 엘티디. 전염병을 치료하기 위한 공동수용체 시스템
EP3876952A4 (fr) 2018-11-05 2022-08-24 American Gene Technologies International Inc. Système de vecteurs pour exprimer un arn régulateur
BR112021024124A2 (pt) 2019-05-31 2022-01-11 American Gene Tech Int Inc Expressão otimizada de fenilalanina hidroxilase
AU2021232603A1 (en) 2020-03-03 2022-10-20 American Gene Technologies International Inc. On demand expression of exogenous factors in lymphocytes to treat HIV

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008025025A2 (fr) * 2006-08-25 2008-02-28 Avi Biopharma, Inc. Composition antisens et procédé permettant d'inhiber la biogénèse de l'arnmi
WO2012145624A2 (fr) * 2011-04-21 2012-10-26 University Of Massachusetts Compositions à base de raav et procédés pour traiter des déficiences en anti-trypsine alpha-1
WO2014117050A2 (fr) * 2013-01-26 2014-07-31 Mirimus, Inc. Arnmi modifié en tant qu'échafaudage pour de l'arnsh

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