ES2016070T3 - Ensayos y dispositivos de captura de iones. - Google Patents

Ensayos y dispositivos de captura de iones.

Info

Publication number
ES2016070T3
ES2016070T3 ES89101263T ES89101263T ES2016070T3 ES 2016070 T3 ES2016070 T3 ES 2016070T3 ES 89101263 T ES89101263 T ES 89101263T ES 89101263 T ES89101263 T ES 89101263T ES 2016070 T3 ES2016070 T3 ES 2016070T3
Authority
ES
Spain
Prior art keywords
analyte
reagent
capture
complex
indicator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89101263T
Other languages
English (en)
Other versions
ES2016070A4 (es
Inventor
Robert G Hiltibran
Yi-Her Jou
Steven J Kline
Steven George Schultz
Stephen Denham Stroupe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES2016070A4 publication Critical patent/ES2016070A4/es
Application granted granted Critical
Publication of ES2016070T3 publication Critical patent/ES2016070T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57565—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving carcinoembryonic antigen [CEA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

ESTA INVENCION PRESENTA NUEVOS PROCEDIMIENTOS DE SEPARACION Y ENSAYO QUE PERMITEN ESTAR EN DISOLUCION AL INDICADOR Y A LOS REACTIVOS DE CAPTURA, PARA EVITAR PROBLEMAS DE CINETICA DE INMUNORREACCION RETARDADA. EL PROCEDIMIENTO DE SEPARACION INCLUYE UN REACTIVO DE CAPTURA SOLUBLE ESPECIFICO DEL ANALITO, QUE ESTA CONJUGADO A UNA SUSTANCIA CARGADA, UN MATERIAL EN FASE SOLIDA INSOLUBLE QUE TIENE CARGA OPUESTA. UNA MUESTRA LIQUIDA, QUE SE SOSPECHA CONTIENE EL ANALITO, SE MEZCLA CON EL REACTIVO DE CAPTURA EN DISOLUCION PARA FORMAR UN COMPLEJO DE REACTIVO DE CAPTURA CARGADO/ANALITO. CUANDO SE COMPLETA EL ENLACE, LA DISOLUCION SE PONE EN CONTACTO CON EL MATERIAL EN FASE SOLIDA DE CARGA OPUESTA PARA ATRAER, ATACAR, Y SEPARAR EL COMPLEJO DE REACTIVO DE CAPTURA/ANALITO DE LA MUESTRA FLUIDA. CON EL REACTIVO INDICADOR ADECUADO, O SEA, UNA SEGUNDA SUSTANCIA ENLAZANTE ESPECIFICA DEL ANALITO, QUE ESTA CONJUGADA A UN MARCADOR CAPAZ DE PRODUCIR UNA SEÑAL DETECTABLE, SE PUEDEN LLEVAR A CABO LOS ENSAYOS SANDWICH Y COMPETITIVO. EL COMPLEJO DE LA REACCION DE ENSAYO SE PUEDE SEPARAR DE LA DISOLUCION POR CONTACTO CON EL MATERIAL EN FASE SOLIDA DE CARGA OPUESTA, Y LA PRESENCIA O CANTIDAD DE ANALITO SE PUEDE CONTROLAR DETECTANDO EL MARCADOR DEL REACTIVO INDICADOR
ES89101263T 1988-01-29 1989-01-25 Ensayos y dispositivos de captura de iones. Expired - Lifetime ES2016070T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15027888A 1988-01-29 1988-01-29

Publications (2)

Publication Number Publication Date
ES2016070A4 ES2016070A4 (es) 1990-10-16
ES2016070T3 true ES2016070T3 (es) 1997-01-16

Family

ID=22533816

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89101263T Expired - Lifetime ES2016070T3 (es) 1988-01-29 1989-01-25 Ensayos y dispositivos de captura de iones.

Country Status (7)

Country Link
EP (1) EP0326100B1 (es)
JP (1) JPH0737988B2 (es)
KR (1) KR890012165A (es)
AU (1) AU609241B2 (es)
CA (1) CA1338928C (es)
DE (2) DE68927118T2 (es)
ES (1) ES2016070T3 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670381A (en) * 1988-01-29 1997-09-23 Abbott Laboratories Devices for performing ion-capture binding assays
CA1333883C (en) * 1988-04-07 1995-01-10 Shashidhara H. M. Murthy Immunoassay utilizing biotin bridge with universal solid phase
US5244630A (en) * 1988-04-22 1993-09-14 Abbott Laboratories Device for performing solid-phase diagnostic assay
US5089424A (en) * 1988-06-14 1992-02-18 Abbott Laboratories Method and apparatus for heterogeneous chemiluminescence assay
US5310916A (en) * 1988-07-19 1994-05-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Trifunctional agents useful as irreversible inhibitors of A1-adenosine receptors
US5298508A (en) * 1988-07-19 1994-03-29 The United States Of America As Represented By The Department Of Health And Human Services Irreversible inhibitors of adenosine receptors
CA1341592C (en) * 1989-07-07 2009-04-14 Abbott Laboratories Ion capture reagents and methods for performing binding assays
CA1337639C (en) * 1989-08-01 1995-11-28 Joseph Eugene Celebuski Dna probe assay using neutrally charged probe strands
US5474911A (en) * 1989-12-01 1995-12-12 The Board Of Trustees Of Leland Stanford Jr. University Promotion of high specificity molecular assembly
AU633686B2 (en) * 1990-01-19 1993-02-04 Boehringer Mannheim Gmbh Process for enzymatically treating substrates
EP0641442B1 (en) * 1991-05-30 1997-12-17 Abbott Laboratories Devices for performing ion-capture binding assays
CA2109925C (en) * 1991-05-30 2004-11-09 Janina Adamczyk Reagents and methods for performing two-step ion-capture binding assays
ATE181965T1 (de) * 1991-05-30 1999-07-15 Abbott Lab Reagenzien, die einen nichtspezifischen bindungshemmer in einem ioneneinfang-assay enthalten
JP3267614B2 (ja) * 1991-05-30 2002-03-18 アボツト・ラボラトリーズ カルボキシメチルアミロースに結合させた結合メンバーを使用するイオン捕獲アッセイ
DK130991D0 (da) * 1991-07-04 1991-07-04 Immunodex K S Polymere konjugater
DK0594772T3 (es) * 1991-07-04 1997-02-24 Immunodex K S
EP0589001B1 (en) * 1992-03-04 2002-07-24 Abbott Laboratories Determination of glycated hemoglobin by fluorescence quenching
SE9303272D0 (sv) * 1993-10-07 1993-10-07 Pharmacia Biosensor Ab Improvement in immunoassays
US5643721A (en) * 1994-02-09 1997-07-01 Abbott Laboratories Bioreagent immobilization medium
AU1997895A (en) * 1994-03-15 1995-10-03 Abbott Laboratories Ion-capture reagents and methods for performing binding assays
CA2181109A1 (en) 1995-07-18 1997-01-19 Nobuko Imajo Polypeptide and process for measuring living body components using the same
JP3825501B2 (ja) * 1996-06-10 2006-09-27 吉郎 岡見 微小物質保持担体、その懸濁系、微小物質操作装置及び微小物質位置制御方法
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US7153651B1 (en) 1996-10-31 2006-12-26 Inverness Medical - Biostar, Inc. Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof
US6846905B2 (en) 1997-08-15 2005-01-25 Abbott Laboratories Antigen constructs useful in the detection and differentiation of antibodies to HIV
ATE362615T1 (de) * 2000-03-20 2007-06-15 Massachusetts Inst Technology Anorganische teilchenkonjugate
US7776605B2 (en) 2006-10-26 2010-08-17 Abbott Laboratories Assay for cardiac troponin autoantibodies
CA2667012A1 (en) 2006-10-26 2008-05-02 Abbott Laboratories Immunoassay of analytes in samples containing endogenous anti-analyte antibodies
US8835120B2 (en) 2009-12-02 2014-09-16 Abbott Laboratories Assay for cardiac troponin-T (cTnT)
US8652788B2 (en) 2009-12-02 2014-02-18 Abbott Laboratories Assay for diagnosis of cardiac myocyte damage
US8183002B2 (en) 2009-12-03 2012-05-22 Abbott Laboratories Autoantibody enhanced immunoassays and kits
CN105388287A (zh) 2011-03-11 2016-03-09 内布拉斯加大学董事委员会 冠状动脉疾病的生物标志物
CN107102135A (zh) 2011-05-20 2017-08-29 阿波特日本有限公司 用于减少非特异性结合的免疫检验方法和试剂
JP2013029372A (ja) * 2011-07-27 2013-02-07 Konica Minolta Advanced Layers Inc イオン性官能基修飾センサーチップおよびリガンド担持荷電微粒子を使用する分子間相互作用測定方法
US10309976B2 (en) 2014-06-30 2019-06-04 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
WO2016002729A1 (ja) 2014-06-30 2016-01-07 パナソニックヘルスケアホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
CN106662595B (zh) 2014-06-30 2019-10-15 普和希控股公司 试样分析用基板、试样分析装置、试样分析系统及从含磁性颗粒的液体中去除液体的方法
EP3163306A4 (en) 2014-06-30 2018-01-24 Panasonic Healthcare Holdings Co., Ltd. Substrate for sample analysis, and sample analysis apparatus
US10539583B2 (en) 2014-12-12 2020-01-21 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
CN121013950A (zh) 2023-11-08 2025-11-25 株式会社力森诺科 树脂齿轮

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US4145406A (en) * 1977-04-11 1979-03-20 Miles Laboratories, Inc. Specific binding - adsorbent assay method and test means
US4434150A (en) * 1981-10-19 1984-02-28 Ortho Diagnostic Systems, Inc. Immunological reagents employing polymeric backbone possessing reactive functional groups
FR2586689B1 (fr) * 1985-09-02 1990-06-08 Plant Genetic Systems Nv Moyens et procedes de transfert de proteines sur une surface receptrice supportee
AU560779B2 (en) * 1985-01-24 1987-04-16 Quidel Assay for drugs of abuse
EP0214909A1 (fr) * 1985-09-02 1987-03-18 Plant Genetic Systems N.V. Moyens et procedes de transfert de proteines et/ou d'acides nucleiques sur une surface receptrice supportee
JP2806924B2 (ja) * 1985-12-20 1998-09-30 ベーリングヴェルケ・アクチェンゲゼルシャフト 粒子分離方法
US4935147A (en) * 1985-12-20 1990-06-19 Syntex (U.S.A.) Inc. Particle separation method
US4948726A (en) * 1986-06-02 1990-08-14 Longoria Claude C Enzyme immunoassay based on membrane separation of antigen-antibody complexes

Also Published As

Publication number Publication date
ES2016070A4 (es) 1990-10-16
DE326100T1 (de) 1989-12-07
AU609241B2 (en) 1991-04-26
JPH0737988B2 (ja) 1995-04-26
JPH01227061A (ja) 1989-09-11
EP0326100A3 (en) 1990-11-07
DE68927118T2 (de) 1997-04-10
AU2866089A (en) 1989-08-03
KR890012165A (ko) 1989-08-24
CA1338928C (en) 1997-02-25
EP0326100B1 (en) 1996-09-11
EP0326100A2 (en) 1989-08-02
DE68927118D1 (de) 1996-10-17

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