ES2021942A6 - Procedimiento para preparar composiciones farmaceuticas a base de ciclosporinas. - Google Patents

Procedimiento para preparar composiciones farmaceuticas a base de ciclosporinas.

Info

Publication number: ES2021942A6
Authority: ES; Spain
Prior art keywords: cyclosporin; thinner; vehicle; compositions; cyclosporin compositions
Prior art date: 1989-02-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES9000397A

Other languages

English (en)

Spanish (es)

Inventor

Birgit Hauer

Ulrich Posanski

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-09

Filing date

1990-02-09

Publication date

1991-11-16

1989-02-09 Priority claimed from GB898902901A external-priority patent/GB8902901D0/en

1989-02-09 Priority claimed from GB898902898A external-priority patent/GB8902898D0/en

1989-02-13 Priority claimed from GB898903147A external-priority patent/GB8903147D0/en

1989-02-17 Priority claimed from GB898903663A external-priority patent/GB8903663D0/en

1990-02-09 Application filed by Sandoz AG filed Critical Sandoz AG

1991-11-16 Publication of ES2021942A6 publication Critical patent/ES2021942A6/es

2010-02-09 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

229930182912 cyclosporin Natural products 0.000 title abstract 4
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
229930105110 Cyclosporin A Natural products 0.000 title abstract 3
108010036949 Cyclosporine Proteins 0.000 title abstract 3
229960001265 ciclosporin Drugs 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 2
108010036941 Cyclosporins Proteins 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000002141 anti-parasite Effects 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
230000004927 fusion Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Biophysics (AREA)
Hematology (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Neurology (AREA)
Tropical Medicine & Parasitology (AREA)
Transplantation (AREA)
Biochemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)

ES9000397A 1989-02-09 1990-02-09 Procedimiento para preparar composiciones farmaceuticas a base de ciclosporinas. Expired - Lifetime ES2021942A6 (es)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB898902901A GB8902901D0 (en)	1989-02-09	1989-02-09	Improvements in or relating to organic compounds
GB898902898A GB8902898D0 (en)	1989-02-09	1989-02-09	Improvements in or relating to organic compounds
GB898903147A GB8903147D0 (en)	1989-02-13	1989-02-13	Improvements in or relating to organic compounds
GB898903663A GB8903663D0 (en)	1989-02-17	1989-02-17	Improvements in or relating to organic compounds

Publications (1)

Publication Number	Publication Date
ES2021942A6 true ES2021942A6 (es)	1991-11-16

Family

ID=27450262

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES9000397A Expired - Lifetime ES2021942A6 (es)	1989-02-09	1990-02-09	Procedimiento para preparar composiciones farmaceuticas a base de ciclosporinas.

Country Status (25)

Country	Link
JP (3)	JP3484190B2 (da)
KR (1)	KR0170769B1 (da)
AT (1)	AT404552B (da)
AU (1)	AU630413B2 (da)
BE (1)	BE1003009A5 (da)
CA (1)	CA2009533C (da)
CH (1)	CH679277A5 (da)
CY (1)	CY1903A (da)
DE (1)	DE4003844B4 (da)
DK (1)	DK176209B1 (da)
ES (1)	ES2021942A6 (da)
FI (1)	FI97524C (da)
FR (1)	FR2642650B1 (da)
GB (1)	GB2230440B (da)
HK (1)	HK37296A (da)
HU (1)	HU213394B (da)
IT (1)	IT1240758B (da)
LU (1)	LU87675A1 (da)
MY (1)	MY107377A (da)
NL (1)	NL195028C (da)
NO (1)	NO301576B1 (da)
NZ (1)	NZ232401A (da)
PH (1)	PH30917A (da)
PT (1)	PT93079B (da)
SE (1)	SE511398C2 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2222770B (en) *	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
HU208491B (en) *	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
MX9201782A (es) †	1991-04-19	1992-10-01	Sandoz Ag	Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) *	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
SG45449A1 (en)	1992-05-13	1998-01-16	Sandoz Ltd	Ophthalmic compositions
US5759566A (en) *	1992-07-28	1998-06-02	Poli Industria Chimica Spa	Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
DK0589843T3 (da)	1992-09-25	2002-04-02	Novartis Ag	Cyclosporinholdige farmaceutiske præparater
ATE218878T1 (de) †	1993-04-20	2002-06-15	Novartis Erfind Verwalt Gmbh	Neue pharmazeutische zubereitungen zur oralen verabreichung enthaltend cyclosporin
DE4412201A1 (de) *	1993-04-20	1994-11-10	Rentschler Arzneimittel	Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
DE4340781C3 (de) *	1993-11-30	2000-01-27	Novartis Ag	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) *	1994-02-25	1998-08-17	김충환	사이클로스포린-함유 분말 조성물
ATE218359T1 (de)	1994-11-03	2002-06-15	Novartis Erfind Verwalt Gmbh	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5679566A (en) *	1995-01-20	1997-10-21	University Of Massachusetts Medical Center	Yeast NMD2 gene
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
DE19544507B4 (de)	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
US5798333A (en) *	1996-09-17	1998-08-25	Sherman; Bernard C.	Water-soluble concentrates containing cyclosporins
AU762247B2 (en) *	1997-01-30	2003-06-19	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin A
PT988046E (pt) *	1997-01-30	2004-12-31	Novartis Ag	Composicoes farmaceuticas sem oleo contendo ciclosporina a
HU228855B1 (en) *	1997-03-12	2013-06-28	Abbott Lab	Hydrophilic binary systems for the administration of cyclosporine
NZ328751A (en) *	1997-09-16	1999-01-28	Bernard Charles Sherman	Solid medicament containing an anionic surfactant and cyclosporin
US6447806B1 (en)	1999-02-25	2002-09-10	Novartis Ag	Pharmaceutical compositions comprised of stabilized peptide particles
EP1435910B9 (en)	2001-10-19	2010-02-03	Isotechnika Inc.	Novel cyclosporin analog microemulsion preconcentrates
US6979672B2 (en)	2002-12-20	2005-12-27	Polichem, S.A.	Cyclosporin-based pharmaceutical compositions
JP4521554B2 (ja) *	2004-03-31	2010-08-11	マイラン製薬株式会社	シクロスポリン製剤
JP5406530B2 (ja) *	2005-10-26	2014-02-05	バナーファーマキャプス，インコーポレイテッド	親水性ベヒクルに基づく二重制御された放出マトリクスシステム
EP2522343A1 (en)	2006-03-28	2012-11-14	Javelin Pharmaceuticals, Inc.	Formulations of Low Dose Diclofenac and Beta-Cyclodextrin
US7495024B2 (en)	2006-08-07	2009-02-24	Via Pharmaceuticals, Inc.	Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102008059201A1 (de) *	2008-11-27	2010-06-02	GÖPFERICH, Achim, Prof. Dr.	In situ präzipitierende Arzneistofflösungen
KR102146704B1 (ko)	2018-04-13	2020-08-21	가천대학교 산학협력단	사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체
US20250302912A1 (en) *	2021-10-13	2025-10-02	Chugai Seiyaku Kabushiki Kaisha	Composition including peptide compound and surfactant
WO2023214509A1 (ja) *	2022-05-02	2023-11-09	中外製薬株式会社	界面活性剤と併用するためのペプチド化合物を含む組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI65914C (fi) *	1978-03-07	1984-08-10	Sandoz Ag	Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
JPS61280435A (ja) *	1985-04-04	1986-12-11	Kanji Takada	サイクロスポリン類のリンパ指向性製剤
NL8600050A (nl) *	1986-01-13	1987-08-03	Sanico Nv	Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.
GB8602372D0 (en) *	1986-01-31	1986-03-05	Sandoz Ltd	Organic compounds
CA1290249C (en) *	1986-04-09	1991-10-08	Cetus Corporation	COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR
EP0267615A3 (en) *	1986-11-13	1989-05-03	Sloan-Kettering Institute For Cancer Research	Compositions and method for treatment of cancer using monoclonal antibody against gd3 ganglioside together with il-2
ATE95193T1 (de) *	1987-06-17	1993-10-15	Sandoz Ag	Cyclosporine und deren benutzung als arzneimittel.
JP2536876B2 (ja) *	1987-07-31	1996-09-25	寛治高田	シクロスポリンの溶解性粉末状製剤
DE3830494B4 (de) *	1987-09-15	2006-05-18	Novartis Ag	Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
US5756450A (en) *	1987-09-15	1998-05-26	Novartis Corporation	Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
HU205010B (en) *	1987-09-15	1992-03-30	Sandoz Ag	Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
JP2792862B2 (ja) *	1988-07-30	1998-09-03	寛治高田	経口腸溶製剤
GB2222770B (en) *	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
JPH1038029A (ja) *	1996-07-26	1998-02-13	Ebara Corp	制振機能付き円板状構造物
JPH10280435A (ja) *	1997-04-03	1998-10-20	Sekisui Chem Co Ltd	地下室の構築方法

1990
- 1990-02-05 BE BE9000133A patent/BE1003009A5/fr not_active IP Right Cessation
- 1990-02-05 CH CH359/90A patent/CH679277A5/de not_active IP Right Cessation
- 1990-02-05 FR FR9001389A patent/FR2642650B1/fr not_active Expired - Lifetime
- 1990-02-05 GB GB9002504A patent/GB2230440B/en not_active Expired - Lifetime
- 1990-02-07 FI FI900604A patent/FI97524C/fi active IP Right Grant
- 1990-02-07 NZ NZ232401A patent/NZ232401A/en unknown
- 1990-02-07 PH PH40014A patent/PH30917A/en unknown
- 1990-02-07 SE SE9000441A patent/SE511398C2/sv not_active Application Discontinuation
- 1990-02-07 DK DK199000327A patent/DK176209B1/da not_active IP Right Cessation
- 1990-02-07 LU LU87675A patent/LU87675A1/fr unknown
- 1990-02-07 CA CA002009533A patent/CA2009533C/en not_active Expired - Lifetime
- 1990-02-07 PT PT93079A patent/PT93079B/pt not_active IP Right Cessation
- 1990-02-07 NO NO900577A patent/NO301576B1/no not_active IP Right Cessation
- 1990-02-07 HU HU90701A patent/HU213394B/hu unknown
- 1990-02-07 MY MYPI90000191A patent/MY107377A/en unknown
- 1990-02-08 AT AT0027290A patent/AT404552B/de not_active IP Right Cessation
- 1990-02-08 AU AU49252/90A patent/AU630413B2/en not_active Expired
- 1990-02-08 DE DE4003844A patent/DE4003844B4/de not_active Expired - Lifetime
- 1990-02-08 KR KR1019900001492A patent/KR0170769B1/ko not_active Expired - Lifetime
- 1990-02-08 NL NL9000299A patent/NL195028C/nl not_active IP Right Cessation
- 1990-02-08 IT IT47609A patent/IT1240758B/it active IP Right Grant
- 1990-02-08 JP JP03134890A patent/JP3484190B2/ja not_active Expired - Lifetime
- 1990-02-09 ES ES9000397A patent/ES2021942A6/es not_active Expired - Lifetime
1996
- 1996-03-07 HK HK37296A patent/HK37296A/xx not_active IP Right Cessation
- 1996-11-22 CY CY190396A patent/CY1903A/en unknown
2001
- 2001-04-25 JP JP2001127538A patent/JP4073641B2/ja not_active Expired - Lifetime
2005
- 2005-09-13 JP JP2005265724A patent/JP2006001947A/ja active Pending

Also Published As

Publication number	Publication date
AU630413B2 (en)	1992-10-29
NO301576B1 (no)	1997-11-17
LU87675A1 (fr)	1991-10-08
NL195028B (nl)	2003-08-01
IT1240758B (it)	1993-12-17
GB2230440B (en)	1993-05-19
BE1003009A5 (fr)	1991-10-22
DK176209B1 (da)	2007-02-05
GB9002504D0 (en)	1990-04-04
NZ232401A (en)	1992-10-28
CY1903A (en)	1996-11-22
MY107377A (en)	1995-11-30
HK37296A (en)	1996-03-15
DE4003844B4 (de)	2007-09-20
AU4925290A (en)	1990-08-16
JP4073641B2 (ja)	2008-04-09
HU900701D0 (en)	1990-04-28
JPH02235817A (ja)	1990-09-18
DK32790D0 (da)	1990-02-07
FI97524C (fi)	1997-01-10
KR0170769B1 (ko)	1999-02-01
CA2009533C (en)	2002-11-12
CH679277A5 (da)	1992-01-31
SE511398C2 (sv)	1999-09-20
IT9047609A1 (it)	1991-08-08
FR2642650B1 (fr)	1994-12-09
NO900577D0 (no)	1990-02-07
DK32790A (da)	1990-08-10
PH30917A (en)	1997-12-23
JP2001302538A (ja)	2001-10-31
KR900012625A (ko)	1990-09-01
HU213394B (en)	1997-06-30
NL195028C (nl)	2003-12-02
IT9047609A0 (it)	1990-02-08
JP3484190B2 (ja)	2004-01-06
PT93079A (pt)	1990-08-31
FI900604A0 (fi)	1990-02-07
NO900577L (no)	1990-08-10
SE9000441D0 (sv)	1990-02-07
JP2006001947A (ja)	2006-01-05
GB2230440A (en)	1990-10-24
FI97524B (fi)	1996-09-30
DE4003844A1 (de)	1990-08-16
FR2642650A1 (fr)	1990-08-10
ATA27290A (de)	1998-05-15
NL9000299A (nl)	1990-09-03
CA2009533A1 (en)	1990-08-09
SE9000441L (sv)	1991-08-08
PT93079B (pt)	1996-04-30
AT404552B (de)	1998-12-28

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Date	Code	Title	Description
1997-11-16	PC1A	Transfer granted
2014-11-20	FD2A	Announcement of lapse in spain	Effective date: 20141120

Publication	Publication Date	Title
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RU92016471A (ru)	1995-03-10	Твердая непористая микросфера, способ ее получения и применение в фармакологическом препарате
AR032073A1 (es)	2003-10-22	Las nanoparticulas lipidas anfifilicas para la incorporacion de los peptidos y/o las proteinas
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IT8520769A0 (it)	1985-05-17	Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
ES2062530T3 (es)	1994-12-16	Procedimiento para producir particulas pequeñas de moleculas biologicamente activas.
PT85055A (pt)	1988-07-01	Processo para a preparacao de composicoes farmaceuticas contendo ester metilico da levodopa
ES2070322T3 (es)	1995-06-01	Polipeptidos biologicamente activos basados en las secuencias del factor de crecimiento de transformacion beta.
ES2147320T3 (es)	2000-09-01	Derivados de n-(3-benzofuranil)urea.
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CA2039491A1 (en)	1991-10-01	Stable compositions for parenteral administration and method of making same
ES2081384T3 (es)	1996-03-01	Preparado farmaceutico que contiene complejos de polielectrolitos en forma de microparticulas y por lo menos una sustancia activa.
ES2163444T3 (es)	2002-02-01	Composiciones y metodos para la administracion oral de farmacos.
IT8920170A0 (it)	1989-04-17	Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
BR9806271A (pt)	2000-04-04	Formulação oral de ciclosporina, e, processo para se obter imunossupressão em um hospedeiro.
NL195028B (nl)	2003-08-01	Cyclosporinebevattend farmaceutisch preparaat.
ES2170259T3 (es)	2002-08-01	Empleo de lipidos como agentes auxiliares en la obtencion de formas farmaceuticas solidas segun el procedimiento de extrusion en fusion.
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IT8920784A0 (it)	1989-06-05	2 alchinilfenoli sostituiti ad azione anti infiammatoria, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
KR920701213A (ko)	1992-08-11	메틸렌디포스폰산 화합물 및 그것을 유효성분으로 하는 항염증제
FI890841A7 (fi)	1989-09-02	Menetelmä uusien terapeuttisesti aktiivisten substituoitujen 7-hydroksi-2,3,4,5-tetrahydro-1H-3-bentsatsepiinien karbamiinihappoestereiden valmistamiseksi
ES2034951T1 (es)	1993-04-16	Microgranulados cargados de una substancia activa, constituidos esencialmente por un triglicerido de acidos grasos saturados y su utilizacion por via topica en el campo terapeutico.
TWI255720B (en)	2006-06-01	Novel preparation and administration form comprising an acid-labile active compound and process for production thereof
MX9302327A (es)	1993-10-01	Aminoacidos ciclicos novedosos y derivados de los mismos.
DK246985D0 (da)	1985-06-03	Triterpenylestere af organiske syrer, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende saadanne triterpenylestere