ES2031457T3 - Derivados de 5-aminialquil-beta-carbolina, a su preparacion y a su utilizacion como medicamentos. - Google Patents

Derivados de 5-aminialquil-beta-carbolina, a su preparacion y a su utilizacion como medicamentos.

Info

Publication number
ES2031457T3
ES2031457T3 ES198686730212T ES86730212T ES2031457T3 ES 2031457 T3 ES2031457 T3 ES 2031457T3 ES 198686730212 T ES198686730212 T ES 198686730212T ES 86730212 T ES86730212 T ES 86730212T ES 2031457 T3 ES2031457 T3 ES 2031457T3
Authority
ES
Spain
Prior art keywords
hydrogen
acil
lower alkyl
aminialkyl
carboline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686730212T
Other languages
English (en)
Inventor
Helmut Dr. Biere
Andreas Dr. Huth
Dieter Dr. Rahtz
Ralph Dr. Schmiechen
Dieter Dr. Seidelmann
David Norman Dr. Stephens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2031457T3 publication Critical patent/ES2031457T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fats And Perfumes (AREA)
  • Braking Arrangements (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPUESTOS DE FORMULA GENERAL (I) EN LA QUE N=0 O 1, R1 SIGNIFICA HIDROGENO, O ALQUILO INFERIOR, R2 Y R3 REPRESENTAN CADA UNO HIDROGENO, ALQUILO, ACILO O ARILO, OPCIONALMENTE SUSTITUIDOS, O BIEN, FORMAN JUNTO CON EL ATOMO DE NITROGENO UN HETEROCICLO DE 5-6 ATOMOS, R4 REPRESENTA HIDROGENO, ALQUILO INFERIOR O ALCOXILO INFERIOR, Y X ES UN RADICAL OXADIAZOLILO DE FORMULA (II) O (III) EN LA QUE R5 REPRESENTA HIDROGENO, ALQUILO INFERIOR O CICLOALQUILO INFERIOR, O BIEN, UN GRUPO COOR6 EN EL QUE R6 ES HIDROGENO O ALQUILO INFERIOR, O BIEN, UN GRUPO CO-NR7R8 EN EL QUE R7 Y R8 REPRESENTAN CADA UNO HIDROGENO O ALQUILO, ACILO O ARILO INFERIORES, OPCIONALMENTE SUSTITUIDOS, PUDIENDO FORMAR R7 Y R8 JUNTO CON EL ATOMO DE NITROGENO UN HETEROCICLO DE 5-6 ATOMOS. ESTOS COMPUESTOS CONSTITUYEN VALIOSOS FARMACOS.
ES198686730212T 1985-12-20 1986-12-19 Derivados de 5-aminialquil-beta-carbolina, a su preparacion y a su utilizacion como medicamentos. Expired - Lifetime ES2031457T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853545776 DE3545776A1 (de) 1985-12-20 1985-12-20 5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES2031457T3 true ES2031457T3 (es) 1992-12-16

Family

ID=6289387

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686730212T Expired - Lifetime ES2031457T3 (es) 1985-12-20 1986-12-19 Derivados de 5-aminialquil-beta-carbolina, a su preparacion y a su utilizacion como medicamentos.

Country Status (17)

Country Link
US (2) US4731365A (es)
EP (1) EP0232675B1 (es)
JP (1) JPH0780878B2 (es)
AT (1) ATE58536T1 (es)
AU (1) AU597923B2 (es)
CA (1) CA1277319C (es)
DD (1) DD252829A5 (es)
DE (2) DE3545776A1 (es)
DK (1) DK165878C (es)
ES (1) ES2031457T3 (es)
FI (1) FI82245C (es)
GR (1) GR3001468T3 (es)
HU (1) HU195656B (es)
IE (1) IE59757B1 (es)
IL (1) IL81003A (es)
NO (1) NO165106C (es)
PT (1) PT83975B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3609699A1 (de) * 1986-03-20 1987-09-24 Schering Ag 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester
DE4130933A1 (de) * 1991-09-13 1993-03-18 Schering Ag Neue (beta)-carbolinderivate, deren herstellung und verwendung in arzneimitteln
DE4212529A1 (de) * 1992-04-10 1993-10-14 Schering Ag Verwendung von µ-Carbolinen als nicht-kompetitive Glutamat-Antagonisten
DE4330175A1 (de) * 1993-08-31 1995-03-02 Schering Ag Alkoxy-substituierte beta-Carboline
EP4144707A1 (de) 2021-09-07 2023-03-08 Biolac GmbH & Co. KG Mischung zur herstellung eines formkörpers mit verbessertem bindemittel

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3322895A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)
DE3322894A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h)
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DK240084D0 (da) * 1984-05-15 1984-05-15 Ferrosan As New beta-carboline-3-oxadiazolyl derivatives
DE3504045A1 (de) * 1985-02-04 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinen durch dehydrierung

Also Published As

Publication number Publication date
DD252829A5 (de) 1987-12-30
NO865180D0 (no) 1986-12-19
CA1277319C (en) 1990-12-04
US4757070A (en) 1988-07-12
DE3545776A1 (de) 1987-06-25
EP0232675B1 (de) 1990-11-22
FI865234A7 (fi) 1987-06-21
FI82245B (fi) 1990-10-31
JPS62195378A (ja) 1987-08-28
IL81003A (en) 1990-04-29
NO165106C (no) 1990-12-27
IE863329L (en) 1987-06-20
NO865180L (no) 1987-06-22
DE3675758D1 (de) 1991-01-03
DK610586D0 (da) 1986-12-17
DK610586A (da) 1987-06-21
IL81003A0 (en) 1987-03-31
AU6679786A (en) 1987-06-25
FI865234A0 (fi) 1986-12-19
IE59757B1 (en) 1994-03-23
US4731365A (en) 1988-03-15
ATE58536T1 (de) 1990-12-15
AU597923B2 (en) 1990-06-14
DK165878B (da) 1993-02-01
EP0232675A1 (de) 1987-08-19
HUT43068A (en) 1987-09-28
GR3001468T3 (en) 1992-10-08
NO165106B (no) 1990-09-17
PT83975B (pt) 1989-05-12
JPH0780878B2 (ja) 1995-08-30
PT83975A (en) 1987-01-01
DK165878C (da) 1993-06-21
HU195656B (en) 1988-06-28
FI82245C (fi) 1991-02-11

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