ES2047033T3 - Un metodo para preparar compuestos de hidroxivitamina d. - Google Patents

Un metodo para preparar compuestos de hidroxivitamina d.

Info

Publication number
ES2047033T3
ES2047033T3 ES88306245T ES88306245T ES2047033T3 ES 2047033 T3 ES2047033 T3 ES 2047033T3 ES 88306245 T ES88306245 T ES 88306245T ES 88306245 T ES88306245 T ES 88306245T ES 2047033 T3 ES2047033 T3 ES 2047033T3
Authority
ES
Spain
Prior art keywords
compounds
hydroxivitamine
preparing
vitamin
mycalium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88306245T
Other languages
English (en)
Inventor
Sadafumi Omura
Akiko Mikami
Joji Sasaki
Kazutoshi Mizoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2047033T3 publication Critical patent/ES2047033T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/826—Actinomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE INTRODUCEN UNO O DOS GRUPOS HIDROXILO EN COMPUESTOS DE VITAMINA D EN LAS POSICIONES 1-(ALFA) Y/ 25 MEDIANTE UNA DISOLUCION QUE CONTIENE EL MICELIO DE ACTINOMICETALES, QUE ES CAPAZ DE HIDROXILAR EL COMPUESTO DE VITAMINA D, O EL ENZIMA OBTENIDO A PARTIR DEL MICELIO.
ES88306245T 1987-07-08 1988-07-08 Un metodo para preparar compuestos de hidroxivitamina d. Expired - Lifetime ES2047033T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17066987 1987-07-08
JP33132387 1987-12-26

Publications (1)

Publication Number Publication Date
ES2047033T3 true ES2047033T3 (es) 1994-02-16

Family

ID=26493597

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88306245T Expired - Lifetime ES2047033T3 (es) 1987-07-08 1988-07-08 Un metodo para preparar compuestos de hidroxivitamina d.

Country Status (5)

Country Link
US (1) US4892821A (es)
EP (1) EP0298757B1 (es)
KR (1) KR960004452B1 (es)
DE (1) DE3884870T2 (es)
ES (1) ES2047033T3 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3201411B2 (ja) * 1990-06-15 2001-08-20 メルシャン株式会社 ビタミンｄ類の生物学的製造方法
CA2258282C (en) * 1996-06-27 2010-02-02 Koji Takeda Biological process for producing steroids hydroxylated at the 25-position
TW584627B (en) 1996-07-01 2004-04-21 Chugai Pharmaceutical Co Ltd The method for purifying vitamin D derivatives and its crystalline products
WO2000061776A1 (en) * 1999-04-14 2000-10-19 Mercian Corporation Vitamin d derivatives and process for producing the same
ES2593047T3 (es) 2006-02-03 2016-12-05 Opko Renal, Llc Tratamiento de la insuficiencia y deficiencia de vitamina D con 25-hidroxivitamina D2 y 25-hidroxivitamina D3
WO2007138894A1 (ja) 2006-05-31 2007-12-06 Mercian Corporation 水酸化酵素遺伝子及びその用途
ES2670029T3 (es) 2006-06-21 2018-05-29 Opko Ireland Global Holdings, Ltd. Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D
KR20190028822A (ko) 2007-04-25 2019-03-19 사이토크로마 인코포레이티드 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
US11752158B2 (en) 2007-04-25 2023-09-12 Eirgen Pharma Ltd. Method of treating vitamin D insufficiency and deficiency
EP2281058B1 (en) 2008-04-02 2016-06-29 Opko Ireland Global Holdings, Ltd. Methods, compositions, uses, and kits useful for vitamin d deficiency and related disorders
US8545915B2 (en) * 2008-05-02 2013-10-01 Oakshire Holdings, Inc. Method and apparatus for vitamin D enhancement in mushrooms
WO2011123476A1 (en) 2010-03-29 2011-10-06 Cytochroma Inc. Methods and compositions for reducing parathyroid levels
US9326540B2 (en) 2012-09-27 2016-05-03 Oakshire Holdings, Inc. Method and apparatus for vitamin D enhancement in mushrooms
US20160205981A1 (en) 2012-09-27 2016-07-21 Oakshire Holdings, Inc. Method and apparatus for vitamin d enhancement in mushrooms
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
JP7032322B2 (ja) 2016-03-28 2022-03-08 オプコ アイルランド グローバル ホールディングス リミテッド ビタミンｄ治療法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
US4279826A (en) * 1980-09-22 1981-07-21 Wisconsin Alumni Research Foundation 23,25-Dihydroxyvitamin D3
US4338250A (en) * 1981-04-27 1982-07-06 Wisconsin Alumni Research Foundation 1-Hydroxylation process
US4502991A (en) * 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US4689180A (en) * 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
US4717721A (en) * 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity

Also Published As

Publication number Publication date
DE3884870D1 (de) 1993-11-18
DE3884870T2 (de) 1994-02-03
EP0298757A1 (en) 1989-01-11
US4892821A (en) 1990-01-09
KR960004452B1 (ko) 1996-04-06
KR890001566A (ko) 1989-03-27
EP0298757B1 (en) 1993-10-13

Similar Documents

Publication Publication Date Title
ES2047033T3 (es) Un metodo para preparar compuestos de hidroxivitamina d.
ES2061512T3 (es) Polipeptidos de nor-estatina y nor-cicloestatina.
ES2054919T3 (es) Acidos y esteres 4-(quinolin-2-il-metoxi)fenilaceticos alfa-substituidos en caso dado.
ES2054676T5 (es) Regulacion de transcripcion especifica de semillas.
ES2126626T3 (es) Tecnicas para preparar especimenes para ensayos bacterianos.
ES2025641T3 (es) Un inoculante para fundicion o hierro ductil.
DE3777536D1 (de) Behaelter, bestimmt zur aufnahme eines oder mehrerer mikroorganismenkulturmedien.
YU45720B (sh) POSTOPEK ZA PRIPRAVO NOVIH TRIFENILMETILNIH DERIVATOV Sn-GLICERO-3-FOSFOHOLINA IN SN-GLICERO-3-FOSFOETANOLAMINA
ES2051675T1 (es) Uso de ciertos herbicidas en el tratamiento del cancer y produccion de protoporfirina ix.
ES2086408T3 (es) Mejora en el blanqueo de una pasta.
TR23883A (tr) Lignin maddesinin derecesinin düsürülmesinde ve islah edilmesinde katalizör olarak etki yapan yenilik arz eden enzimler.
BG44379A3 (en) Method for preparing of 9- chlor- 1, 5- benzothiazepine derivatives
DE3876769D1 (de) Mikrobiologische herstellung von 9-alpha-hydroxy-17-keto-steroiden.
ES2043610T3 (es) Procedimiento para la produccion de un polipeptido hibrido del tipo activador de plasminogeno.
ES2058141T3 (es) Utilizacion de gamma-glutamil-transpeptidasa.
KR910009270A (ko) 15-케토-프로스타글란딘 화합물을 이용한 심기능장애의 치료방법
BR8404194A (pt) Processo industrial para a producao de poliois,especialmente eritritol e/ou ribitol,pela fermentacao aerobica de um agucar apropriado por moniliella tomentosa var.pollinis,e caldo de cultura contendo poliol
DE3884654D1 (de) Herstellung von chromogenischen Cryptahemispheranden.
NO872875L (no) Modifisert vevsplasminaktivator, samt fremgangsmŸte for fremstilling av en slik.
CA1262912C (en) TETRAHYDROFURANYLIC SUBSTITUTION DERIVATIVES OF PROSTAGLANDIN ANALOGS
ES2058372T3 (es) Procedimiento para la obtencion de esteres del acido 5-cloro-3-clorosulfonil-2-tiofenocarboxilico.
DE3787499D1 (de) Herstellung eines Plasminogenaktivators.
BG46004A3 (bg) Метод за получаване на оптично активни 2-хлор-12-/3-диметиламин-2- метилпропил/12н-дибензо-/d,g//1,3,6/-диоксазоцини
ES2061942T3 (es) Composicion farmaceutica util para el tratamiento de enfermedades cardiovasculares.
BR8404195A (pt) Processo industrial para a producao de poliois,especialmente eritritol e/ou ribitol,pela fermentacao aerobica de um agucar apropriado por moniliella tomentosa var.pollinis e caldo de cultura contendo poliol