ES2063292T3 - Proteina fibrinolitica y su metodo de elaboracion. - Google Patents

Proteina fibrinolitica y su metodo de elaboracion.

Info

Publication number
ES2063292T3
ES2063292T3 ES90312855T ES90312855T ES2063292T3 ES 2063292 T3 ES2063292 T3 ES 2063292T3 ES 90312855 T ES90312855 T ES 90312855T ES 90312855 T ES90312855 T ES 90312855T ES 2063292 T3 ES2063292 T3 ES 2063292T3
Authority
ES
Spain
Prior art keywords
peptizate
processing method
fibrinolytic protein
natto
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90312855T
Other languages
English (en)
Inventor
Koichiro Nakanishi
Keiichi Nomura
Kyoko Tajima
Hajime Hiratani
Kazuo Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JCR Pharmaceuticals Co Ltd
Original Assignee
JCR Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JCR Pharmaceuticals Co Ltd filed Critical JCR Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of ES2063292T3 publication Critical patent/ES2063292T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UN NUEVO PEPTIZADO QUE TIENE UN PESO MOLECULAR DE 31,000 SE OBTIENE A PARTIR DE UN EXTRACTO ACUOSO DE NATTO O DEL CULTIVO DE BACILLUS NATTO MEDIANTE PROCEDIMIENTOS DE PURIFICACION QUE INCLUYEN EL FRACCIONAMIENTO Y/O PRECIPITACION DE ALCOHOL Y CROMATOGRAFIA HIDROFOBICA, Y LAS PROPIEDADES FISICO-QUIMICAS, INCLUYENDO SECUENCIA AMINO ACIDA DEL PEPTIZADO QUE SE DETERMINAN. EL PEPTIZADO ESTA ACTIVO EN FIBRINOLISIS, EXHIBE PODER DE ACTIVIDAD TROMBOLITICA A TRAVES DE LA ADMINISTRACION ORAL Y SE USA COMO AGENTE ORAL TROMBOLITICO.
ES90312855T 1989-11-27 1990-11-27 Proteina fibrinolitica y su metodo de elaboracion. Expired - Lifetime ES2063292T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1308191A JPH0813271B2 (ja) 1989-11-27 1989-11-27 線溶活性蛋白質およびその製造法

Publications (1)

Publication Number Publication Date
ES2063292T3 true ES2063292T3 (es) 1995-01-01

Family

ID=17978012

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90312855T Expired - Lifetime ES2063292T3 (es) 1989-11-27 1990-11-27 Proteina fibrinolitica y su metodo de elaboracion.

Country Status (5)

Country Link
EP (1) EP0430637B1 (es)
JP (1) JPH0813271B2 (es)
CA (1) CA2030927A1 (es)
DE (1) DE69012958T2 (es)
ES (1) ES2063292T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0624642B1 (en) * 1993-05-12 1999-01-20 Indian Council For Medical Research Novel thrombolytic agent, process for preparing same and its use for the preparation of a thrombi dissolving medicament
JPWO2006025276A1 (ja) * 2004-08-31 2008-05-08 国立大学法人 熊本大学 ナットウキナーゼを含む眼科疾患の治療・予防剤
JP2006143601A (ja) 2004-11-16 2006-06-08 Yamato Yakuhin Kk 血液粘度低下剤
CN119630280A (zh) 2022-05-14 2025-03-14 诺维信公司 用于预防、处理、抑制和/或消除植物病原性侵染和感染的组合物和方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases

Also Published As

Publication number Publication date
EP0430637B1 (en) 1994-09-28
CA2030927A1 (en) 1991-05-28
JPH0813271B2 (ja) 1996-02-14
DE69012958D1 (de) 1994-11-03
EP0430637A1 (en) 1991-06-05
DE69012958T2 (de) 1995-02-02
JPH03168082A (ja) 1991-07-19

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