ATE109160T1 - Antibiotische mittel. - Google Patents

Antibiotische mittel.

Info

Publication number
ATE109160T1
ATE109160T1 AT90307124T AT90307124T ATE109160T1 AT E109160 T1 ATE109160 T1 AT E109160T1 AT 90307124 T AT90307124 T AT 90307124T AT 90307124 T AT90307124 T AT 90307124T AT E109160 T1 ATE109160 T1 AT E109160T1
Authority
AT
Austria
Prior art keywords
antibiotic agents
cultivation
isolation
production
activity against
Prior art date
Application number
AT90307124T
Other languages
English (en)
Inventor
Robert E Schwartz
Raymond F White
Jerrold M Liesch
Otto D Hensens
Henry Joshua
Dennis M Schmatz
Jan S Tkacz
Louis Kaplan
Margaret S Sosa
Jimmy M Fountoulakis
Robert A Giacobbe
Prakash S Masurekar
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/492,026 external-priority patent/US5021341A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE109160T1 publication Critical patent/ATE109160T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT90307124T 1989-06-30 1990-06-29 Antibiotische mittel. ATE109160T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37441689A 1989-06-30 1989-06-30
US49202590A 1990-03-12 1990-03-12
US49202490A 1990-03-12 1990-03-12
US07/492,026 US5021341A (en) 1990-03-12 1990-03-12 Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol

Publications (1)

Publication Number Publication Date
ATE109160T1 true ATE109160T1 (de) 1994-08-15

Family

ID=27503114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90307124T ATE109160T1 (de) 1989-06-30 1990-06-29 Antibiotische mittel.

Country Status (16)

Country Link
EP (1) EP0405997B1 (de)
JP (1) JPH0764873B2 (de)
KR (1) KR0145693B1 (de)
AT (1) ATE109160T1 (de)
AU (1) AU639698B2 (de)
CA (1) CA2020062C (de)
CY (1) CY1962A (de)
DE (1) DE69011006T2 (de)
DK (1) DK0405997T3 (de)
ES (1) ES2057413T3 (de)
FI (1) FI93647C (de)
HK (1) HK209496A (de)
IL (1) IL94862A (de)
NO (1) NO178343C (de)
NZ (1) NZ234225A (de)
PT (1) PT94555B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
US5310873A (en) * 1990-03-12 1994-05-10 Merck & Co., Inc. Cyclohexapeptide compound
US5330973A (en) 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
JPH06502536A (ja) * 1990-10-09 1994-03-24 メルク　エンド　カンパニー　インコーポレーテッド 有機化合物の新規生物学的リン酸化方法
US5219985A (en) * 1990-10-31 1993-06-15 Merck & Co., Inc. Antifungal agent
US5229363A (en) * 1991-02-19 1993-07-20 Merck & Co., Inc. Cyclic hexapeptide compounds
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5336756A (en) * 1991-05-01 1994-08-09 Merck & Co., Inc. Process for crystalline cyclic lipopeptides
US6030944A (en) * 1991-10-01 2000-02-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compounds
US5348940A (en) * 1991-10-01 1994-09-20 Merck & Co., Inc. Cyclohexapeptidyl hydroxypropionitrile compounds
EP0539088B1 (de) * 1991-10-17 1996-07-17 Merck & Co. Inc. Echinocandin-B-Derivat
US5914313A (en) * 1991-10-17 1999-06-22 Merck & Co., Inc. 1- 4-hydroxy-5-aminoethyloxy-N2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3-hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
CA2161149A1 (en) * 1993-05-04 1994-11-10 James M. Balkovec Cyclohexapeptidyl aminoalkyl ethers
EP1646370A1 (de) * 2003-07-11 2006-04-19 Glaxo Group Limited Pharmazeutische formulierungen
CN102618604B (zh) * 2011-01-31 2014-09-03 上海天伟生物制药有限公司 一种环脂肽化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1183127A (en) * 1979-12-13 1985-02-26 Manuel Debono Process for the preparation of derivatives of cyclic peptide nuclei
CA1182812A (en) * 1979-12-13 1985-02-19 Bernard J. Abbott Process for the preparation of derivatives of cyclic peptide nuclei
JPS57501266A (de) * 1980-08-15 1982-07-22
DE3886001T2 (de) * 1987-10-07 1994-05-26 Merck & Co Inc Fungizides Fermentationsprodukt.

Also Published As

Publication number Publication date
DE69011006T2 (de) 1995-01-26
EP0405997A1 (de) 1991-01-02
NO178343B (no) 1995-11-27
JPH03163096A (ja) 1991-07-15
PT94555B (pt) 1997-02-28
CA2020062C (en) 1997-01-14
IL94862A0 (en) 1991-04-15
NO902921D0 (no) 1990-06-29
HK209496A (en) 1996-11-29
ES2057413T3 (es) 1994-10-16
JPH0764873B2 (ja) 1995-07-12
DK0405997T3 (da) 1994-10-31
AU639698B2 (en) 1993-08-05
DE69011006D1 (de) 1994-09-01
FI903280A0 (fi) 1990-06-28
FI93647C (fi) 1995-05-10
EP0405997B1 (de) 1994-07-27
KR910001068A (ko) 1991-01-30
PT94555A (pt) 1991-05-22
FI93647B (fi) 1995-01-31
CA2020062A1 (en) 1990-12-31
IL94862A (en) 1994-10-07
CY1962A (en) 1997-07-04
NZ234225A (en) 1993-09-27
KR0145693B1 (ko) 1998-08-01
NO178343C (no) 1996-03-06
AU5797390A (en) 1991-01-03
NO902921L (no) 1991-01-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time