ES2068166T3 - Taxano con actividad antitumoral. - Google Patents

Taxano con actividad antitumoral.

Info

Publication number
ES2068166T3
ES2068166T3 ES93111366T ES93111366T ES2068166T3 ES 2068166 T3 ES2068166 T3 ES 2068166T3 ES 93111366 T ES93111366 T ES 93111366T ES 93111366 T ES93111366 T ES 93111366T ES 2068166 T3 ES2068166 T3 ES 2068166T3
Authority
ES
Spain
Prior art keywords
taxano
antitumoral activity
antitumoral
insulable
antileukemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93111366T
Other languages
English (en)
Other versions
ES2068166T1 (es
Inventor
Bruno Gabetta
Ezio Bombardelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Publication of ES2068166T1 publication Critical patent/ES2068166T1/es
Application granted granted Critical
Publication of ES2068166T3 publication Critical patent/ES2068166T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UNA NUEVA "TAXANE" QUE TIENE LA ESTRUCTURA (1), QUE ES AISLABLE DE LA CORTEZA DE LA RAIZ DE LAS PLANTAS DEL GENERO TAXUS. EL COMPONENTE (1) ESTA DOTADO DE ACTIVIDAD ANTITUMORAL SUPERIOR A LA DEL TAXOL, SIENDO EL PRIMERO ACTIVO, A DIFERENCIA DEL ULTIMO, TAMBIEN CONTRA LAS CELULAS RESISTENTES A LA ADRIAMICINA, Y COMO MEDICINA ANTILEUCEMICA.
ES93111366T 1993-05-20 1993-07-15 Taxano con actividad antitumoral. Expired - Lifetime ES2068166T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930334A IT1261667B (it) 1993-05-20 1993-05-20 Tassano ad attivita' antitumorale.

Publications (2)

Publication Number Publication Date
ES2068166T1 ES2068166T1 (es) 1995-04-16
ES2068166T3 true ES2068166T3 (es) 1999-03-01

Family

ID=11401772

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93111366T Expired - Lifetime ES2068166T3 (es) 1993-05-20 1993-07-15 Taxano con actividad antitumoral.

Country Status (21)

Country Link
US (1) US5407674A (es)
EP (1) EP0625517B1 (es)
JP (1) JPH07509259A (es)
KR (1) KR100315495B1 (es)
CN (1) CN1054381C (es)
AT (1) ATE174595T1 (es)
AU (1) AU6795194A (es)
CA (1) CA2140519A1 (es)
CZ (1) CZ286959B6 (es)
DE (2) DE625517T1 (es)
DK (1) DK0625517T3 (es)
ES (1) ES2068166T3 (es)
FI (1) FI950207A0 (es)
GR (1) GR950300009T1 (es)
HU (1) HU221503B (es)
IT (1) IT1261667B (es)
NO (1) NO310510B1 (es)
PL (1) PL178363B1 (es)
RU (1) RU2129551C1 (es)
SK (1) SK280873B6 (es)
WO (1) WO1994027984A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4139993A1 (de) * 1991-12-04 1993-06-09 Merck Patent Gmbh, 6100 Darmstadt, De Pigmentzubereitung
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
US5756536A (en) * 1995-11-03 1998-05-26 Purdue Research Foundation Microbial transformation of taxol and cephalomannine
US5965752A (en) * 1996-08-23 1999-10-12 Institut National De La Recherche Scientifique Preparative scale isolation and purification of taxanes
CA2188190A1 (en) 1996-10-18 1998-04-18 Sarala Balachandran The semi-synthesis of a protected bacatin iii compound
AU4768797A (en) 1996-10-24 1998-05-15 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
HK1047934A1 (zh) * 2000-02-02 2003-03-14 佛罗里达州立大学研究基金有限公司 用作抗肿瘤剂的c7碳酸酯取代的紫杉烷
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
PL350028A1 (en) * 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
RU2319482C2 (ru) * 2001-11-23 2008-03-20 Чугаи Сейяку Кабусики Кайся Способ идентификации противоопухолевых целевых ферментов
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
SV2006002010A (es) * 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
US7169307B2 (en) * 2004-09-02 2007-01-30 Jian Liu Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
MX2007009748A (es) * 2005-02-14 2007-09-26 Univ Florida State Res Found Composiciones de taxano sustituidas con esteres ciclopropilicos en c10.
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
EP3252128B1 (en) 2006-04-03 2019-01-02 Pharmatherm Chemicals Inc. Thermal extraction method for producing a taxane extract
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics, Inc. composto de ligação de domìnio bir da iap
US7905990B2 (en) 2007-11-20 2011-03-15 Ensyn Renewables, Inc. Rapid thermal conversion of biomass
EP2080764B1 (en) 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel
EP2276755A4 (en) * 2008-03-31 2011-05-04 Univ Florida State Res Found C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
US20110284359A1 (en) 2010-05-20 2011-11-24 Uop Llc Processes for controlling afterburn in a reheater and for controlling loss of entrained solid particles in combustion product flue gas
US8499702B2 (en) 2010-07-15 2013-08-06 Ensyn Renewables, Inc. Char-handling processes in a pyrolysis system
US9441887B2 (en) 2011-02-22 2016-09-13 Ensyn Renewables, Inc. Heat removal and recovery in biomass pyrolysis
US9347005B2 (en) 2011-09-13 2016-05-24 Ensyn Renewables, Inc. Methods and apparatuses for rapid thermal processing of carbonaceous material
US10400175B2 (en) 2011-09-22 2019-09-03 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US10041667B2 (en) 2011-09-22 2018-08-07 Ensyn Renewables, Inc. Apparatuses for controlling heat for rapid thermal processing of carbonaceous material and methods for the same
US9044727B2 (en) 2011-09-22 2015-06-02 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US9109177B2 (en) 2011-12-12 2015-08-18 Ensyn Renewables, Inc. Systems and methods for renewable fuel
US9670413B2 (en) 2012-06-28 2017-06-06 Ensyn Renewables, Inc. Methods and apparatuses for thermally converting biomass
EP3492559A1 (en) 2013-06-26 2019-06-05 Ensyn Renewables, Inc. Methods for renewable fuel
EP3337966B1 (en) 2015-08-21 2021-12-15 Ensyn Renewables, Inc. Liquid biomass heating system
MY193949A (en) 2016-12-29 2022-11-02 Ensyn Renewables Inc Demetallization Of Liquid Biomass

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206221A (en) * 1979-01-03 1980-06-03 The United States Of America As Represented By The Secretary Of Agriculture Cephalomannine and its use in treating leukemic tumors
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
FR2662441B1 (fr) * 1990-05-22 1992-10-23 Rhone Poulenc Sante Procede de preparation enantioselective de derives de la phenylisoserine.
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
IT1254515B (it) * 1992-03-06 1995-09-25 Indena Spa Tassani di interesse oncologico, loro metodo di preparazione ed uso
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol

Also Published As

Publication number Publication date
NO310510B1 (no) 2001-07-16
DE69322619T2 (de) 1999-06-24
DE625517T1 (de) 1995-07-13
RU95105981A (ru) 1996-10-27
DK0625517T3 (da) 1999-08-23
FI950207L (fi) 1995-01-18
ITRM930334A1 (it) 1994-11-20
PL307089A1 (en) 1995-05-02
US5407674A (en) 1995-04-18
CN1054381C (zh) 2000-07-12
ATE174595T1 (de) 1999-01-15
DE69322619D1 (de) 1999-01-28
FI950207A7 (fi) 1995-01-18
ES2068166T1 (es) 1995-04-16
CA2140519A1 (en) 1994-12-08
SK6095A3 (en) 1995-07-11
HU221503B (en) 2002-10-28
NO950184L (no) 1995-01-18
RU2129551C1 (ru) 1999-04-27
SK280873B6 (sk) 2000-08-14
WO1994027984A1 (en) 1994-12-08
PL178363B1 (pl) 2000-04-28
NO950184D0 (no) 1995-01-18
JPH07509259A (ja) 1995-10-12
KR100315495B1 (ko) 2002-06-20
HUT72607A (en) 1996-05-28
FI950207A0 (fi) 1995-01-18
HK1012628A1 (en) 1999-08-06
CZ12295A3 (en) 1995-09-13
EP0625517A1 (en) 1994-11-23
CZ286959B6 (en) 2000-08-16
AU6795194A (en) 1994-12-20
IT1261667B (it) 1996-05-29
HU9500152D0 (en) 1995-03-28
CN1110055A (zh) 1995-10-11
GR950300009T1 (en) 1995-03-31
ITRM930334A0 (it) 1993-05-20
EP0625517B1 (en) 1998-12-16

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