ES2068201T3 - Produccion de kalicreina. - Google Patents

Produccion de kalicreina.

Info

Publication number
ES2068201T3
ES2068201T3 ES88306039T ES88306039T ES2068201T3 ES 2068201 T3 ES2068201 T3 ES 2068201T3 ES 88306039 T ES88306039 T ES 88306039T ES 88306039 T ES88306039 T ES 88306039T ES 2068201 T3 ES2068201 T3 ES 2068201T3
Authority
ES
Spain
Prior art keywords
kalicreine
production
kolicrein
kallycrein
procariotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88306039T
Other languages
English (en)
Inventor
Fu-Kuen Lin
Hsieng Sen Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ES2068201T3 publication Critical patent/ES2068201T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)

Abstract

UNA CALICREINA HUMANA RECOMBINANTE, QUE TIENE UNA O MAS DE LAS PROPIEDADES BIOLOGICAS ASOCIADAS CON CALICREINAS DE MAMIFEROS Y SE CARACTERIZA POR SER EL PRODUCTO DE EXPRESION DE HUESPEDES PROCARIOTICOS O EUCARIOTICOS DE UN EXOGENO DE DNA. LOS NUEVOS PRODUCTOS POLIPEPTIDOS DE CALICREINA SON UTILES COMO VASODILATADORES Y PARA EL TRATAMIENTO DE INFERTILIDAD MASCULINA.
ES88306039T 1987-06-30 1988-06-30 Produccion de kalicreina. Expired - Lifetime ES2068201T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6859487A 1987-06-30 1987-06-30
US21025688A 1988-06-27 1988-06-27

Publications (1)

Publication Number Publication Date
ES2068201T3 true ES2068201T3 (es) 1995-04-16

Family

ID=26749136

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88306039T Expired - Lifetime ES2068201T3 (es) 1987-06-30 1988-06-30 Produccion de kalicreina.

Country Status (14)

Country Link
EP (1) EP0297913B1 (es)
JP (1) JPH01503679A (es)
KR (1) KR890701731A (es)
AT (1) ATE118547T1 (es)
AU (1) AU627427B2 (es)
DE (1) DE3853023T2 (es)
DK (1) DK91389A (es)
ES (1) ES2068201T3 (es)
FI (1) FI890889L (es)
GR (1) GR3015881T3 (es)
NO (1) NO890833L (es)
NZ (1) NZ225230A (es)
PT (1) PT87887B (es)
WO (1) WO1989000192A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4036392A1 (de) * 1990-11-15 1992-05-21 Behr Gmbh & Co Latentwaermespeicher
US5516639A (en) * 1993-07-22 1996-05-14 Mayo Foundation For Medical Education And Research Antibodies specific for human prostate glandular kallkrein
US6103237A (en) * 1993-07-22 2000-08-15 Hybritech Incorporated Stable variant hK2 polypeptide
WO1995030758A1 (en) * 1994-05-10 1995-11-16 Mayo Foundation For Medical Education And Research Recombinant hk2 polypeptide
US5955306A (en) * 1996-09-17 1999-09-21 Millenium Pharmaceuticals, Inc. Genes encoding proteins that interact with the tub protein
US6479263B1 (en) 1996-11-14 2002-11-12 Baylor College Of Medicine Method for detection of micrometastatic prostate cancer
US5840871A (en) * 1997-01-29 1998-11-24 Incyte Pharmaceuticals, Inc. Prostate-associated kallikrein
US5948616A (en) * 1997-05-14 1999-09-07 Musc Foundation For Research Development Methods and compositions of correlating tissue kallikrein gene promoter polymorphisms with essential hypertension
US6376182B1 (en) 1997-05-14 2002-04-23 Medical University Of South Carolina Methods and compositions for correlating tissue kallikrein gene promoter polymorphisms with treatment of essential hypertension
AU8259798A (en) 1997-06-20 1999-01-04 George G Klee Method for detection of breast cancer
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
PT2287288E (pt) 2002-07-09 2012-12-10 Baxter Int Meio isento de proteína animal para cultura de células
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
EP3653699A1 (en) 2006-01-04 2020-05-20 Baxalta Incorporated Oligopeptide-free cell culture media
WO2009039704A1 (en) * 2007-09-27 2009-04-02 Shanghai Wanxing Biopharmaceuticals, Co., Ltd. A method for producing human kallikrein 1
US20130315891A1 (en) * 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
EP2854841B1 (en) 2012-06-04 2017-02-22 Diamedica Inc. Human tissue kallikrein 1 glycosylation isoforms
CN110446501A (zh) * 2017-03-09 2019-11-12 代阿麦迪卡股份有限公司 组织激肽释放酶1的剂型

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905870A (en) * 1972-11-03 1975-09-16 Bayer Ag Purification of kallikrein
DE3103257A1 (de) * 1981-01-31 1982-08-26 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung des hochreinen enzyms kallikrein aus schweinepankreas-extrakten
JPS5838151B2 (ja) * 1981-07-03 1983-08-20 衛 杉浦 カリクレインの精製法
JPS596883A (ja) * 1982-06-30 1984-01-13 Nippon Chem Res Kk 人尿カリクレインの濃縮精製法
JPS59102392A (ja) * 1982-12-02 1984-06-13 Nippon Chem Res Kk 熱安定性を有するヒト尿キニノゲナーゼ水溶液の製造法
JPS6092220A (ja) * 1983-10-26 1985-05-23 Ss Pharmaceut Co Ltd カリクレインの精製法
JPS6121086A (ja) * 1984-07-10 1986-01-29 Amano Pharmaceut Co Ltd カリクレインおよびエラスタ−ゼの取得方法
AU6549186A (en) * 1985-10-24 1987-05-19 Biotechnology Research Partners Limited Blood tests diagnostic for hypertension
JPS62126980A (ja) * 1985-11-26 1987-06-09 Shigetada Nakanishi Ｄｎａ断片

Also Published As

Publication number Publication date
EP0297913B1 (en) 1995-02-15
FI890889A0 (fi) 1989-02-24
NO890833L (no) 1989-04-27
NZ225230A (en) 1991-06-25
JPH01503679A (ja) 1989-12-14
AU627427B2 (en) 1992-08-27
FI890889A7 (fi) 1989-02-24
NO890833D0 (no) 1989-02-27
EP0297913A3 (en) 1990-03-07
PT87887A (pt) 1989-05-31
ATE118547T1 (de) 1995-03-15
EP0297913A2 (en) 1989-01-04
KR890701731A (ko) 1989-12-21
DK91389D0 (da) 1989-02-27
DE3853023T2 (de) 1995-06-08
DK91389A (da) 1989-05-01
PT87887B (pt) 1994-05-31
AU2075588A (en) 1989-01-30
DE3853023D1 (de) 1995-03-23
WO1989000192A1 (en) 1989-01-12
FI890889L (fi) 1989-02-24
GR3015881T3 (en) 1995-07-31

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