ES2070810T3 - Sistemas de hidrogeles heterodispersos con liberacion sostenida para farmacos insolubles. - Google Patents

Sistemas de hidrogeles heterodispersos con liberacion sostenida para farmacos insolubles.

Info

Publication number
ES2070810T3
ES2070810T3 ES94401925T ES94401925T ES2070810T3 ES 2070810 T3 ES2070810 T3 ES 2070810T3 ES 94401925 T ES94401925 T ES 94401925T ES 94401925 T ES94401925 T ES 94401925T ES 2070810 T3 ES2070810 T3 ES 2070810T3
Authority
ES
Spain
Prior art keywords
sustained release
insoluble drugs
hydrogel systems
hydrophobic polymer
gelling agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94401925T
Other languages
English (en)
Other versions
ES2070810T1 (es
Inventor
Anand R Baichwal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mendell Edward Co Inc
Original Assignee
Mendell Edward Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mendell Edward Co Inc filed Critical Mendell Edward Co Inc
Publication of ES2070810T1 publication Critical patent/ES2070810T1/es
Application granted granted Critical
Publication of ES2070810T3 publication Critical patent/ES2070810T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE PRESENTA UNA FORMULACION FARMACEUTICA DE LIBERACION SOSTENIDA QUE INCLUYE UN EXCIPIENTE DE LIBERACION SOSTENIDA QUE INCLUYE UN AGENTE AGLUTINANTE, UN DILUYENTE FARMACEUTICO INERTE, OPCIONAL UN AGENTE DE ENTRECRUZAMIENTO CATIONICO, Y UN MEDICAMENTO QUE TIENE SOLUBILIDAD DE MODERADA A POBRE. EN CIERTAS PUESTAS EN PRACTICA, EL EXCIPIENTE DE LIBERACION SOSTENIDO SE GRANULA CON UNA SOLUCION O SUSPENSION DE UN POLIMERO HIDROFOBICO EN UNA CANTIDAD EFECTIVA PARA RETRASAR LA HIDRATACION DEL AGENTE AGLUTINANTE CUANDO LA FORMULACION SE EXPONE A UN FLUIDO MEDIOAMBIENTAL. EN OTRA PUESTA EN PRACTICA, LA PASTILLA SE REVISTE CON UN POLIMERO HIDROFOBICO.
ES94401925T 1993-09-09 1994-08-30 Sistemas de hidrogeles heterodispersos con liberacion sostenida para farmacos insolubles. Expired - Lifetime ES2070810T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/118,924 US5455046A (en) 1993-09-09 1993-09-09 Sustained release heterodisperse hydrogel systems for insoluble drugs

Publications (2)

Publication Number Publication Date
ES2070810T1 ES2070810T1 (es) 1995-06-16
ES2070810T3 true ES2070810T3 (es) 2001-12-16

Family

ID=22381584

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01104276T Expired - Lifetime ES2254274T3 (es) 1993-09-09 1994-08-30 Sistemas de hidrogel heterodispersos de liberacion sostenida para farmacos insolubles.
ES94401925T Expired - Lifetime ES2070810T3 (es) 1993-09-09 1994-08-30 Sistemas de hidrogeles heterodispersos con liberacion sostenida para farmacos insolubles.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES01104276T Expired - Lifetime ES2254274T3 (es) 1993-09-09 1994-08-30 Sistemas de hidrogel heterodispersos de liberacion sostenida para farmacos insolubles.

Country Status (11)

Country Link
US (6) US5455046A (es)
EP (2) EP0642785B1 (es)
JP (1) JP4077886B2 (es)
AT (2) ATE318586T1 (es)
CA (1) CA2131647C (es)
DE (3) DE69428853T2 (es)
DK (1) DK0642785T3 (es)
ES (2) ES2254274T3 (es)
GR (1) GR950300035T1 (es)
IL (1) IL110744A (es)
PT (2) PT1101489E (es)

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EP1101489A3 (en) 2001-09-19
PT642785E (pt) 2002-02-28
ES2070810T1 (es) 1995-06-16
EP0642785B1 (en) 2001-10-31
DE69428853T2 (de) 2002-04-11
EP1101489A2 (en) 2001-05-23
DE69434640D1 (de) 2006-04-27
US5455046A (en) 1995-10-03
US5846563A (en) 1998-12-08
US5512297A (en) 1996-04-30
US5667801A (en) 1997-09-16
EP1101489B1 (en) 2006-03-01
JPH07165615A (ja) 1995-06-27
JP4077886B2 (ja) 2008-04-23
IL110744A0 (en) 1994-08-22
EP0642785A2 (en) 1995-03-15
DE642785T1 (de) 1995-09-28
DE69434640T2 (de) 2006-08-10
US6136343A (en) 2000-10-24
ATE318586T1 (de) 2006-03-15
US5554387A (en) 1996-09-10
IL110744A (en) 1998-12-27
DE69428853D1 (de) 2001-12-06
GR950300035T1 (en) 1995-07-31
EP0642785A3 (en) 1996-11-06
CA2131647C (en) 1999-08-10
CA2131647A1 (en) 1995-03-10
PT1101489E (pt) 2006-05-31
ES2254274T3 (es) 2006-06-16
DK0642785T3 (da) 2001-12-31
ATE207742T1 (de) 2001-11-15

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