ES2136888T3 - Inhibidores de la proliferacion de las celulas de la musculatura lisa. - Google Patents

Inhibidores de la proliferacion de las celulas de la musculatura lisa.

Info

Publication number
ES2136888T3
ES2136888T3 ES95939137T ES95939137T ES2136888T3 ES 2136888 T3 ES2136888 T3 ES 2136888T3 ES 95939137 T ES95939137 T ES 95939137T ES 95939137 T ES95939137 T ES 95939137T ES 2136888 T3 ES2136888 T3 ES 2136888T3
Authority
ES
Spain
Prior art keywords
sup
inhibitors
smooth muscle
muscle cells
proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95939137T
Other languages
English (en)
Inventor
Sarah Tobin Allen Novak
Richard Michael Soll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2136888T3 publication Critical patent/ES2136888T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCION, COMPRENDE BENCILGLICOSIDOS POLIANIONICOS DE AMIDAS DE TRIACIDO DE BENCENO, DE FORMULA GENERAL (I), DONDE CADA UNO DE R{SUP,1}, R{SUP,2}, R{SUP,3} Y R{SUP,4} SON, INDEPENDIENTEMENTE, H, SO{SUB,3}M, O (A), Y CADA GRUPO OLIGOSACARIDO CONTIENE DE 1 A 3 GRUPOS DE AZUCAR; M ES LITIO, SODIO, POTASIO, O AMONIO; N ES 1 O 2; X ES UN HALOGENO, ALQUILO INFERIOR QUE TIENE DE 1 A 6 ATOMOS DE CARBONO, O ALCOXI INFERIOR QUE TIENE DE 1 A 6 ATOMOS DE CARBONO; Y ES CARBONILO O SULFONILO; O LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LA INVENCION TRATA ASIMISMO DE LA UTILIZACION DE DICHOS COMPUESTOS, COMO INHIBIDORES ANTIPROLIFERATIVOS DE CELULAS DE MUSCULO LISO, Y COMO COMPOSICIONES TERAPEUTICAS PARA EL TRATAMIENTO DE ENFERMEDADES Y ALTERACIONES CARACTERIZADAS POR UNA EXCESIVA PROLIFERACION DEL MUSCULO LISO.
ES95939137T 1994-11-07 1995-11-03 Inhibidores de la proliferacion de las celulas de la musculatura lisa. Expired - Lifetime ES2136888T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/335,010 US5565432A (en) 1994-11-07 1994-11-07 Smooth muscle cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
ES2136888T3 true ES2136888T3 (es) 1999-12-01

Family

ID=23309857

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95939137T Expired - Lifetime ES2136888T3 (es) 1994-11-07 1995-11-03 Inhibidores de la proliferacion de las celulas de la musculatura lisa.

Country Status (19)

Country Link
US (1) US5565432A (es)
EP (1) EP0791005B1 (es)
JP (1) JPH10508607A (es)
KR (1) KR970707140A (es)
AT (1) ATE185143T1 (es)
AU (1) AU699670B2 (es)
BR (1) BR9509608A (es)
DE (1) DE69512528T2 (es)
DK (1) DK0791005T3 (es)
ES (1) ES2136888T3 (es)
FI (1) FI971936A0 (es)
GR (1) GR3031682T3 (es)
HU (2) HUT77756A (es)
IL (1) IL115747A (es)
MX (1) MX9703286A (es)
NZ (1) NZ296459A (es)
TW (1) TW403758B (es)
WO (1) WO1996014324A1 (es)
ZA (1) ZA959436B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2174582A1 (en) * 1995-05-05 1996-11-06 Alexander Chucholowski Sulphuric acid esters of amino-sugars
ES2248847T3 (es) 1996-05-24 2006-03-16 Angiotech Pharmaceuticals, Inc. Composiciones y metodos para tratar o prevenir enfermedades de las vias de conduccion del cuerpo.
US7081448B2 (en) 1998-11-24 2006-07-25 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
JP2003521460A (ja) * 1998-11-24 2003-07-15 ワイス 平滑筋細胞増殖の阻害薬としてのアセチル化ベンジルマルトシド
US6340670B1 (en) 1998-11-24 2002-01-22 American Home Products Corporation Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6664243B1 (en) 1998-11-24 2003-12-16 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
US7132402B2 (en) 1998-11-24 2006-11-07 Wyeth Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6291434B1 (en) 1998-11-24 2001-09-18 American Home Products Corp. Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
US6339064B1 (en) 1998-11-24 2002-01-15 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
US6451767B1 (en) 1998-11-24 2002-09-17 Wyeth Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
US6258784B1 (en) 1998-11-24 2001-07-10 American Home Products Corp. Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6362170B1 (en) 1998-11-24 2002-03-26 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
US6187755B1 (en) 1998-11-24 2001-02-13 American Home Products Corporation Benzylmaltosides as inhibitors of smooth muscle cell proliferation
AU8889101A (en) 2000-09-07 2002-03-22 Telik Inc Benzene tricarboxylic acid derivatives as insulin receptor activators

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562485A (en) * 1979-08-10 1985-12-31 Canon Kabushiki Kaisha Copying apparatus
US4431636A (en) * 1982-05-24 1984-02-14 American Cyanamid Company Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use
US4431637A (en) * 1982-10-25 1984-02-14 American Cyanamid Company Polycation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate derivatives
US4440758A (en) * 1982-10-25 1984-04-03 American Cyanamid Company Poly-cation salts of bis(or tris)[4-O-monohexose-oxy]-arylene sulfate derivatives
US4431638A (en) * 1982-10-25 1984-02-14 American Cyanamid Company Poly-cation salts of bis(or tris)[4-0-monohexose-thio]-arylene sulfate derivatives
US4435387A (en) * 1982-10-25 1984-03-06 American Cyanamid Company Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives
US4870500A (en) * 1985-09-30 1989-09-26 Canon Kabushiki Kaisha Image signal processing apparatus
US4788599A (en) * 1986-04-01 1988-11-29 Canon Kabushiki Kaisha Image processing with image-slant control and/or image-size control
US5029017A (en) * 1986-10-08 1991-07-02 Konishiroku Photo Industry Co., Ltd. Image processing apparatus capable of enlarging/reducing apparatus
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
DE3734853A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Bis-aldonsaeureamide und verfahren zu ihrer herstellung
US5019562A (en) * 1988-01-19 1991-05-28 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Growth inhibiting agent and the use thereof
FR2634485B1 (fr) * 1988-07-21 1992-02-28 Sanopi Glycosaminoglycanes selectivement o-acyles, leur preparation et compositions pharmaceutiques les contenant
JPH02161872A (ja) * 1988-12-14 1990-06-21 Fuji Xerox Co Ltd 画像処理装置の縮拡処理方式
US5032679A (en) * 1988-12-15 1991-07-16 Glycomed, Inc. Heparin fragments as inhibitors of smooth muscle cell proliferation
DK0454220T3 (da) * 1990-04-23 1993-11-22 Sanofi Elf Carbohydratderivater omfattende en trisaccharidenhed
AU678760B2 (en) * 1991-11-11 1997-06-12 Trustees Of The University Of Pennsylvania, The Methods of inhibiting restenosis

Also Published As

Publication number Publication date
EP0791005A1 (en) 1997-08-27
JPH10508607A (ja) 1998-08-25
FI971936A7 (fi) 1997-05-06
IL115747A (en) 1999-12-31
EP0791005B1 (en) 1999-09-29
AU699670B2 (en) 1998-12-10
DE69512528T2 (de) 2000-05-31
IL115747A0 (en) 1996-01-19
US5565432A (en) 1996-10-15
DK0791005T3 (da) 2000-03-27
NZ296459A (en) 1999-01-28
GR3031682T3 (en) 2000-02-29
HUT77005A (hu) 1998-03-02
DE69512528D1 (de) 1999-11-04
HUT77756A (hu) 1998-07-28
ATE185143T1 (de) 1999-10-15
ZA959436B (en) 1997-08-07
WO1996014324A1 (en) 1996-05-17
TW403758B (en) 2000-09-01
KR970707140A (ko) 1997-12-01
MX9703286A (es) 1997-08-30
AU4108196A (en) 1996-05-31
FI971936L (fi) 1997-05-06
BR9509608A (pt) 1997-10-28
FI971936A0 (fi) 1997-05-06

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