ES2078082T3 - (1h-indol-1-il)-2-(amino)acetamidas y (1h-indol-1-il)-(aminoalquil)amidas afines, compuestos intermedios y un procedimiento para su preparacion y su uso como medicamentos. - Google Patents

(1h-indol-1-il)-2-(amino)acetamidas y (1h-indol-1-il)-(aminoalquil)amidas afines, compuestos intermedios y un procedimiento para su preparacion y su uso como medicamentos.

Info

Publication number
ES2078082T3
ES2078082T3 ES93105332T ES93105332T ES2078082T3 ES 2078082 T3 ES2078082 T3 ES 2078082T3 ES 93105332 T ES93105332 T ES 93105332T ES 93105332 T ES93105332 T ES 93105332T ES 2078082 T3 ES2078082 T3 ES 2078082T3
Authority
ES
Spain
Prior art keywords
loweralkyl
hydrogen
indol
bromo
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93105332T
Other languages
English (en)
Inventor
Raymond W Kosley Jr
Denise M Flanagan
Lawrence Leo Martin
Peter Allen Nemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2078082T3 publication Critical patent/ES2078082T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN COMPUESTOS QUE TIENEN LA FORMULA: EN LA QUE X ES HIDROGENO, CLORO, BROMO, FLUOR, HIDROXI, ALCOXI INFERIOR, ALCOXI INFERIOR ARILO, ACICLOXI, ALQUILO AMINO CARBONILOXI INFERIOR, ALQUILAMINO CARBONILOXI DIINFERIOR, AMINO, ALQUILAMINO INFERIOR, ALQUILAMINO DIINFERIOR, ACILAMINO, ALQUILO INFERIOR O TRIFLUORMETILO; Y ES HIDROGENO, ALQUILO INFERIOR, CLORO O BROMO; Z ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR O HALOGENO; O X Y Z TOMADOS JUNTOS PUEDEN FORMAR UN GRUPO METILENO DIOXI; R1 ES HIDROGENO, ALQUILO INFERIOR, ALQUILO INFERIOR ARILO, ALQUILO INFERIOR CARBOXILO, ALQUILO INFERIOR CARBONILO ALCOXI INFERIOR ARILO O ALQUILO INFERIOR CARBONILO ALCOXI INFERIOR; R2 ES HIDROGENO, ALQUILO INFERIOR O ALQUILO INFERIOR HIDROXI; R3 ES HIDROGENO O ALQUILO INFERIOR; O R2 Y R3 JUNTOS CON EL CARBONO AL CUAL ESTAN ENLAZADOS FORMAN CICLOALQUILO (C3.C7); R4 ES HIDROGENO O ALQUILO INFERIOR; R5 ES HIDROGENO, ALQUILO INFERIOR, ARILO, ALQUILO INFERIOR ARILO, ACILO, CARBONILO ALCOXI INFERIOR ARILO, CARBONILO ALCOXI INFERIOR O CARBONILO ARILOXI; R6 ES HIDROGENO, CLORO, BROMO, CARBONILO ARILO, CARBONILO ALQUILO INFERIOR, ALQUILO INFERIOR (HIDROXI) ARILO O ALQUILO INFERIOR HIDROXI; Y M Y N SON INDEPENDIENTEMENTE 0 HASTA 5 CON LA CONDICION DE QUE LA SUMA DE M MAS N NO ES MAYOR DE 5; Y SALES DE ADICION DE ELLOS ACEPTABLES FARMACEUTICAMENTE, O CUANDO SEAN APLICABLES, LOS ISOMEROS OPTICOS O GEOMETRICOS O MEZCLAS RACEMICAS DE ELLOS, PRODUCTOS INTERMEDIOS EN EL PROCESO PARA FORMAR LOS COMPUESTOS, UN PROCESO PARA FORMAR LOS COMPUESTOS Y COMPOSICIONES FARMACEUTICAMENTE Y SU USO COMO AGENTES NEUROPROTECTORES.
ES93105332T 1992-04-03 1993-03-31 (1h-indol-1-il)-2-(amino)acetamidas y (1h-indol-1-il)-(aminoalquil)amidas afines, compuestos intermedios y un procedimiento para su preparacion y su uso como medicamentos. Expired - Lifetime ES2078082T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/863,273 US5319096A (en) 1992-04-03 1992-04-03 (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use

Publications (1)

Publication Number Publication Date
ES2078082T3 true ES2078082T3 (es) 1995-12-01

Family

ID=25340739

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93105332T Expired - Lifetime ES2078082T3 (es) 1992-04-03 1993-03-31 (1h-indol-1-il)-2-(amino)acetamidas y (1h-indol-1-il)-(aminoalquil)amidas afines, compuestos intermedios y un procedimiento para su preparacion y su uso como medicamentos.

Country Status (14)

Country Link
US (4) US5319096A (es)
EP (1) EP0563916B1 (es)
JP (1) JP2669765B2 (es)
KR (1) KR100286406B1 (es)
AT (1) ATE126505T1 (es)
AU (1) AU663363B2 (es)
CA (1) CA2093306C (es)
DE (1) DE69300373T2 (es)
DK (1) DK0563916T3 (es)
ES (1) ES2078082T3 (es)
GR (1) GR3017446T3 (es)
MX (1) MX9301889A (es)
NZ (1) NZ247298A (es)
TW (1) TW254935B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
RU2106864C1 (ru) * 1995-10-23 1998-03-20 Николай Серафимович Зефиров Средство для лечения болезни альцгеймера
US6137927A (en) * 1998-01-16 2000-10-24 Corning Incorporated N-port reconfigurable DWDM multiplexer and demultiplexer
JP2000264876A (ja) 1998-09-10 2000-09-26 Sumitomo Chem Co Ltd 縮合複素環化合物
CA2363244C (en) * 2000-11-07 2006-06-13 Research In Motion Limited Multifunctional keyboard for a mobile communication device and method of operating the same
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
ITRM20020016A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza
RU2283108C2 (ru) * 2003-12-08 2006-09-10 Сергей Олегович Бачурин ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
US20070179174A1 (en) * 2003-12-08 2007-08-02 Bachurin Sergei O Methods and compositions for slowing aging
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
US20070117834A1 (en) * 2005-10-04 2007-05-24 David Hung Methods and compositions for treating Huntington's disease
FR2926077A1 (fr) * 2008-01-04 2009-07-10 Servier Lab Nouveaux derives d'1h-indol-1-yl uree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203691A (en) * 1968-03-06 1970-09-03 Science Union & Cie New disubstituted n-amino indoline derivatives and process for preparing them
US3903150A (en) * 1972-02-03 1975-09-02 Merck & Co Inc Process for preparing 3-fluoro-D-alanine
US4204998A (en) * 1974-03-28 1980-05-27 Siegfried Aktiengesellschaft N-Amino indole derivatives having pharmacological activity
US4496542A (en) * 1981-03-30 1985-01-29 Usv Pharmaceutical Corporation N-substituted-amido-amino acids
JPS60142955A (ja) * 1983-12-28 1985-07-29 Fuji Photo Film Co Ltd インド−ル誘導体の製造方法
US5017578A (en) * 1989-06-09 1991-05-21 Hoechst-Roussel Pharmaceuticals Inc. N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
WO1991017156A1 (en) * 1990-05-10 1991-11-14 Pfizer Inc Neuroprotective indolone and related derivatives
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates

Also Published As

Publication number Publication date
ATE126505T1 (de) 1995-09-15
JP2669765B2 (ja) 1997-10-29
AU663363B2 (en) 1995-10-05
AU3565293A (en) 1993-10-07
EP0563916A1 (en) 1993-10-06
DE69300373T2 (de) 1996-02-29
CA2093306C (en) 2005-09-27
EP0563916B1 (en) 1995-08-16
KR100286406B1 (ko) 2001-04-16
US5319096A (en) 1994-06-07
DE69300373D1 (de) 1995-09-21
KR930021616A (ko) 1993-11-22
US5646300A (en) 1997-07-08
US5591866A (en) 1997-01-07
GR3017446T3 (en) 1995-12-31
TW254935B (es) 1995-08-21
DK0563916T3 (da) 1995-12-04
NZ247298A (en) 1995-03-28
US5565579A (en) 1996-10-15
JPH0641069A (ja) 1994-02-15
MX9301889A (es) 1993-10-01
CA2093306A1 (en) 1993-10-04

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