ES2078190A1 - Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. - Google Patents

Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.

Info

Publication number
ES2078190A1
ES2078190A1 ES09401121A ES9401121A ES2078190A1 ES 2078190 A1 ES2078190 A1 ES 2078190A1 ES 09401121 A ES09401121 A ES 09401121A ES 9401121 A ES9401121 A ES 9401121A ES 2078190 A1 ES2078190 A1 ES 2078190A1
Authority
ES
Spain
Prior art keywords
goticles
particles
solvent
polymer
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09401121A
Other languages
English (en)
Other versions
ES2078190B1 (es
Inventor
Mas Jose Alberto Vallet
Valdivia Francisco J Galan
Perdiguer Nuria Carreras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Cusi SA
Original Assignee
Laboratorios Cusi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Cusi SA filed Critical Laboratorios Cusi SA
Priority to ES09401121A priority Critical patent/ES2078190B1/es
Priority to HU9600386A priority patent/HU9600386D0/hu
Priority to PL94312666A priority patent/PL312666A1/xx
Priority to EP94925490A priority patent/EP0717989B1/en
Priority to FI961348A priority patent/FI961348A7/fi
Priority to AU75379/94A priority patent/AU696400B2/en
Priority to KR1019960700306A priority patent/KR960703577A/ko
Priority to AT94925490T priority patent/ATE198548T1/de
Priority to JP7530066A priority patent/JPH09501101A/ja
Priority to PCT/ES1994/000085 priority patent/WO1995031975A1/es
Priority to CA002167681A priority patent/CA2167681A1/en
Priority to PT94925490T priority patent/PT717989E/pt
Priority to HK98113202.0A priority patent/HK1017807B/en
Priority to CN94193333A priority patent/CN1130868A/zh
Priority to BR9407333A priority patent/BR9407333A/pt
Priority to DE69426568T priority patent/DE69426568T2/de
Priority to US08/586,731 priority patent/US5851452A/en
Priority to DK94925490T priority patent/DK0717989T3/da
Publication of ES2078190A1 publication Critical patent/ES2078190A1/es
Priority to NO960232A priority patent/NO960232L/no
Priority to OA60769A priority patent/OA10257A/en
Priority to BG100372A priority patent/BG100372A/xx
Application granted granted Critical
Publication of ES2078190B1 publication Critical patent/ES2078190B1/es
Priority to GR20010400505T priority patent/GR3035655T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/22—Coating
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/89—Deposition of materials, e.g. coating, cvd, or ald
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/89—Deposition of materials, e.g. coating, cvd, or ald
    • Y10S977/891—Vapor phase deposition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Luminescent Compositions (AREA)
  • Paints Or Removers (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Glanulating (AREA)

Abstract

PROCEDIMIENTO PARA EL RECUBRIMIENTO DE GOTICULAS O PARTICULAS DE TAMAÑO NANOMETRICO. COMPRENDE: (1) PREPARAR UNA FINA DISPERSION DE GOTICULAS O DE PARTICULAS QUE CONTIENEN O ESTAN FORMADAS POR UNA SUSTANCIA QUIMICA O BIOLOGICAMENTE ACTIVA EN UNA FASE COMPUESTA POR UN SOLVENTE Y UN NO SOLVENTE DEL POLIMERO FORMADOR DE LA CUBIERTA Y OPCIONALMENTE UN TENSIOACTIVO O AGENTE SUSPENSOR (2) PREPARAR UNA FASE QUE CONTIENE DISUELTO EL POLIMERO FORMADOR DE LA CUBIERTA EN UN SOLVENTE MISCIBLE EN CUALQUIER PROPORCION CON LA DISPERSION ANTERIOR, (3) MEZCLAR LAS DOS FASES DE FORMA CONTINUA MANTENIENDO CONSTANTE LA RELACION DE FASES Y EL VOLUMEN DE MEZCLA Y PULVERIZANDO SIMULTANEAMENTE LA MEZCLA RESULTANTE EN UN SISTEMA DE EVAPORACION CON UNAS CONDICIONES DE TEMPERATURA Y DE VACIO QUE PERMITAN LA INSTANTANEA EVAPORACION DEL SOLVENTE DEL POLIMERO, DANDO LUGAR A LA DEPOSICION DEL POLIMERO ALREDEDOR DE LAS PARTICULAS O GOTICULAS. APLICACION EN FARMACIA, MEDICINA, COSMETICA, VETERINARIA, INDUSTRIA QUIMICA, AGRICULTURA, ETC.
ES09401121A 1994-05-20 1994-05-20 Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. Expired - Lifetime ES2078190B1 (es)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ES09401121A ES2078190B1 (es) 1994-05-20 1994-05-20 Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
HU9600386A HU9600386D0 (en) 1994-05-20 1994-09-07 Process for coating droplets or nanometric particles
DE69426568T DE69426568T2 (de) 1994-05-20 1994-09-30 Verfahren zur umhüllung von nanopartikeln oder -tröpfchen
FI961348A FI961348A7 (fi) 1994-05-20 1994-09-30 Menetelmä pienten pisaroiden tai nanometristen hiukkasten päällystämis eksi
AU75379/94A AU696400B2 (en) 1994-05-20 1994-09-30 Process for coating droplets or nanometric particles
KR1019960700306A KR960703577A (ko) 1994-05-20 1994-09-30 비말이나 극미립자의 코팅공정(process for coating droplets or nanometric particles)
AT94925490T ATE198548T1 (de) 1994-05-20 1994-09-30 Verfahren zur umhüllung von nanopartikeln oder - tröpfchen
JP7530066A JPH09501101A (ja) 1994-05-20 1994-09-30 液滴またはナノメータ粒子の被覆方法
PCT/ES1994/000085 WO1995031975A1 (es) 1994-05-20 1994-09-30 Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico
CA002167681A CA2167681A1 (en) 1994-05-20 1994-09-30 Process for coating droplets or nanometric particles
PT94925490T PT717989E (pt) 1994-05-20 1994-09-30 Processo para o revestimento de gpticulas ou particulas nanometricas
HK98113202.0A HK1017807B (en) 1994-05-20 1994-09-30 Process for coating droplets or nanometric particles
PL94312666A PL312666A1 (en) 1994-05-20 1994-09-30 Method of coating droplets or particles of nanometer size
BR9407333A BR9407333A (pt) 1994-05-20 1994-09-30 Processo para revestir goticulas ou particulas sólidas
EP94925490A EP0717989B1 (en) 1994-05-20 1994-09-30 Process for coating droplets or nanometric particles
US08/586,731 US5851452A (en) 1994-05-20 1994-09-30 Process for coating droplets or nanometric particles
DK94925490T DK0717989T3 (da) 1994-05-20 1994-09-30 Fremgangsmåde til overtrækning af smådråber eller nanopartikler
CN94193333A CN1130868A (zh) 1994-05-20 1994-09-30 用于包覆纳米级微滴或颗粒的方法
NO960232A NO960232L (no) 1994-05-20 1996-01-19 Fremgangsmåte for belegging av dråper eller nanopartikler
OA60769A OA10257A (en) 1994-05-20 1996-01-19 Process for coating droplets or nanometric particles
BG100372A BG100372A (en) 1994-05-20 1996-02-20 Process for coating droplets or nanometric particles
GR20010400505T GR3035655T3 (en) 1994-05-20 2001-03-29 Process for coating droplets or nanometric particles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09401121A ES2078190B1 (es) 1994-05-20 1994-05-20 Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.

Publications (2)

Publication Number Publication Date
ES2078190A1 true ES2078190A1 (es) 1995-12-01
ES2078190B1 ES2078190B1 (es) 1996-08-01

Family

ID=8286348

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09401121A Expired - Lifetime ES2078190B1 (es) 1994-05-20 1994-05-20 Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.

Country Status (21)

Country Link
US (1) US5851452A (es)
EP (1) EP0717989B1 (es)
JP (1) JPH09501101A (es)
KR (1) KR960703577A (es)
CN (1) CN1130868A (es)
AT (1) ATE198548T1 (es)
AU (1) AU696400B2 (es)
BG (1) BG100372A (es)
BR (1) BR9407333A (es)
CA (1) CA2167681A1 (es)
DE (1) DE69426568T2 (es)
DK (1) DK0717989T3 (es)
ES (1) ES2078190B1 (es)
FI (1) FI961348A7 (es)
GR (1) GR3035655T3 (es)
HU (1) HU9600386D0 (es)
NO (1) NO960232L (es)
OA (1) OA10257A (es)
PL (1) PL312666A1 (es)
PT (1) PT717989E (es)
WO (1) WO1995031975A1 (es)

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US5922403A (en) 1996-03-12 1999-07-13 Tecle; Berhan Method for isolating ultrafine and fine particles
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
ES2435944T3 (es) * 1997-06-27 2013-12-26 Abraxis Bioscience, Llc Nuevas formulaciones de agentes farmacológicos, métodos para su preparación y métodos para su uso
EP2000803A1 (en) * 1998-11-30 2008-12-10 Nanosphere, Inc. Nanoparticles with Polymer Shells
DE19856432A1 (de) * 1998-12-08 2000-06-15 Basf Ag Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen
FR2805761B1 (fr) * 2000-03-02 2002-08-30 Mainelab Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
WO2003037359A1 (en) * 2001-10-29 2003-05-08 Chengdu Somo Namotechnology Co., Ltd. Nanoparticle of insoluble medicinal components and method to produce thereof
US7053034B2 (en) * 2002-04-10 2006-05-30 Salvona, Llc Targeted controlled delivery compositions activated by changes in pH or salt concentration
EP2316567B1 (en) * 2003-09-26 2018-01-24 3M Innovative Properties Co. Nanoscale gold catalysts, activating agents, support media, and related methodologies useful for making such catalyst systems especially when the gold is deposited onto the support media using physical vapor deposition
DE602004006523T2 (de) * 2003-10-01 2008-01-31 Debio Recherche Pharmaceutique S.A. Vorrichtung und verfahren zur herstellung von partikeln
US8058202B2 (en) 2005-01-04 2011-11-15 3M Innovative Properties Company Heterogeneous, composite, carbonaceous catalyst system and methods that use catalytically active gold
KR20130079645A (ko) 2005-07-18 2013-07-10 유니버시티 오브 메사츄세츠 로웰 나노에멀젼 조성물 및 이의 제조 및 사용 방법
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
CN101374498A (zh) 2005-12-01 2009-02-25 麻萨诸塞州洛厄尔大学 肉毒杆菌纳米乳液
SG10201607909WA (en) 2006-12-01 2016-11-29 Anterios Inc Peptide nanoparticles and uses therefor
WO2008070538A2 (en) 2006-12-01 2008-06-12 Anterios, Inc. Micellar nanoparticles comprising botulinum toxin
CN101765423B (zh) 2007-05-31 2014-08-06 安特里奥公司 核酸纳米粒子和其用途
US8359820B2 (en) 2010-01-13 2013-01-29 Dohrmann Daniel R Ultra-low flow agricultural pump with unobstructed flow path and electronic flow control, tank refill indication, and detection of loss of flow
BR102015032910B1 (pt) 2015-12-29 2021-03-09 Companhia Nitro Química Brasileira processo de obtenção de uma dispersão coloidal, dispersão coloidal e seu uso
EP3510161A4 (en) 2016-08-23 2020-04-22 Akouos, Inc. COMPOSITIONS AND METHODS FOR TREATING PERSONAL HEARING LOSS IN A PERSON
EP3541358A1 (en) 2016-11-21 2019-09-25 Eirion Therapeutics, Inc. Transdermal delivery of large agents
JPWO2018180966A1 (ja) * 2017-03-28 2019-06-27 富士フイルム株式会社 マイクロカプセル及びその製造方法
US20200001263A1 (en) * 2018-06-28 2020-01-02 Cornell University Encapsulation System and Method
CN116096905A (zh) 2020-02-21 2023-05-09 阿库斯股份有限公司 用于治疗人受试者的非年龄相关性听力损伤的组合物和方法

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FR2551072A1 (fr) * 1983-08-26 1985-03-01 Sandoz Sa Nouveaux esters de polyols, leur preparation et leur utilisation
FR2608988A1 (fr) * 1986-12-31 1988-07-01 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
WO1993025194A1 (fr) * 1992-06-16 1993-12-23 Centre National De La Recherche Scientifique (Cnrs) Preparation et application de nouveaux systemes colloidaux nanovesiculaires dispersibles a base de cyclodextrine, sous forme de nanocapsules

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FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5021248A (en) * 1988-09-19 1991-06-04 Enzytech, Inc. Hydrophobic protein microparticles and preparation thereof
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ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
AU651268B2 (en) * 1992-02-18 1994-07-14 Idemitsu Kosan Co. Ltd Mannich reaction product and process for producing the same and use of the product
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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
FR2551072A1 (fr) * 1983-08-26 1985-03-01 Sandoz Sa Nouveaux esters de polyols, leur preparation et leur utilisation
FR2608988A1 (fr) * 1986-12-31 1988-07-01 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
WO1993025194A1 (fr) * 1992-06-16 1993-12-23 Centre National De La Recherche Scientifique (Cnrs) Preparation et application de nouveaux systemes colloidaux nanovesiculaires dispersibles a base de cyclodextrine, sous forme de nanocapsules

Also Published As

Publication number Publication date
HU9600386D0 (en) 1996-04-29
AU696400B2 (en) 1998-09-10
EP0717989A1 (en) 1996-06-26
FI961348A0 (fi) 1996-03-25
PL312666A1 (en) 1996-04-29
ATE198548T1 (de) 2001-01-15
US5851452A (en) 1998-12-22
CA2167681A1 (en) 1995-11-30
GR3035655T3 (en) 2001-06-29
FI961348L (fi) 1996-03-25
NO960232D0 (no) 1996-01-19
DE69426568D1 (de) 2001-02-15
DE69426568T2 (de) 2001-08-23
EP0717989B1 (en) 2001-01-10
PT717989E (pt) 2001-06-29
HK1017807A1 (en) 1999-11-26
BG100372A (en) 1996-12-31
OA10257A (en) 1997-10-07
ES2078190B1 (es) 1996-08-01
NO960232L (no) 1996-03-19
WO1995031975A1 (es) 1995-11-30
AU7537994A (en) 1995-12-18
DK0717989T3 (da) 2001-05-21
JPH09501101A (ja) 1997-02-04
BR9407333A (pt) 1996-06-18
CN1130868A (zh) 1996-09-11
FI961348A7 (fi) 1996-03-25
KR960703577A (ko) 1996-08-31

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