ES2078519T3 - Acidos hidroxamicos ciclicos y su uso. - Google Patents

Acidos hidroxamicos ciclicos y su uso.

Info

Publication number
ES2078519T3
ES2078519T3 ES91908579T ES91908579T ES2078519T3 ES 2078519 T3 ES2078519 T3 ES 2078519T3 ES 91908579 T ES91908579 T ES 91908579T ES 91908579 T ES91908579 T ES 91908579T ES 2078519 T3 ES2078519 T3 ES 2078519T3
Authority
ES
Spain
Prior art keywords
hydrogen
hydroxamic acids
lower alkyl
cyclic hydroxamic
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91908579T
Other languages
English (en)
Inventor
Reijo Backstrom
Erkki Honkanen
Atso Raasmaja
Inge-Britt Linden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Application granted granted Critical
Publication of ES2078519T3 publication Critical patent/ES2078519T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Earth Drilling (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

ACIDOS HIDROXAMICOS CICLICOS SUBSTITUIDOS CON LA FORMULA GENERAL (I) EN DONDE R1, R2 Y R3 SON, INDEPENDIENTEMENTE, HIDROGENO, HALOGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, CICLOALCOXI, ARILOXI QUE SE SUBSTITUYE OPCIONALMENTE POR 1 A 3 HALOGENO, O ARALQUILOXI, QUE SE SUBSTITUYE OPCIONALMENTE POR 1 A 3 HALOGENO, O R1 Y R2 JUNTOS FORMAN UN GRUPO -O-CH2-O-; CON LA CONDICION DE QUE R3 NO SEA HIDROGENO CUANDO R1 Y R2 SON AMBOS HIDROGENO; R4 Y R5 SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO INFERIOR, R6 ES HIDROGENO O ALQUILO INFERIOR Y SUS SALES Y ESTERES FISIOLOGICAMENTE ACEPTABLES SON INHIBIDORES SELECTIVOS DE ACTIVIDAD DE LA FOSFODIESTERASA IV Y DE LA SINTESIS DE LEUCOTRIENO B4 Y C4 SIN MOSTRAR EFECTO SIGNIFICATIVO ALGUNO EN LA ACTIVIDAD DE LA FOSFODIESTERASA III Y, POR LO TANTO, SON UTILES EN EL TRATAMIENTO DE LAS ENFERMEDADES DE HIPERSENSIBILIDAD E INFLAMATORIAS.
ES91908579T 1990-04-26 1991-04-26 Acidos hidroxamicos ciclicos y su uso. Expired - Lifetime ES2078519T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909009395A GB9009395D0 (en) 1990-04-26 1990-04-26 Cyclic hydroxamic acids and their use

Publications (1)

Publication Number Publication Date
ES2078519T3 true ES2078519T3 (es) 1995-12-16

Family

ID=10675035

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91908579T Expired - Lifetime ES2078519T3 (es) 1990-04-26 1991-04-26 Acidos hidroxamicos ciclicos y su uso.

Country Status (13)

Country Link
US (1) US5356923A (es)
EP (1) EP0526535B1 (es)
JP (1) JP3227155B2 (es)
AT (1) ATE128462T1 (es)
AU (1) AU7777491A (es)
DE (1) DE69113455T2 (es)
DK (1) DK0526535T3 (es)
ES (1) ES2078519T3 (es)
FI (1) FI100052B (es)
GB (1) GB9009395D0 (es)
GR (1) GR3017821T3 (es)
WO (1) WO1991016303A1 (es)
ZA (1) ZA912886B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234933A (en) * 1991-10-31 1993-08-10 Board Of Governors Of Wayne State University And Vanderbilt University Cyclic hydroxamic acids
JP3634861B2 (ja) * 1992-06-15 2005-03-30 セルテック リミテッド 選択的ホスホジエステラーゼｉｖ阻害剤としての三置換フェニル誘導体
CA2160928C (en) 1993-07-28 2005-07-05 Garry Fenton Compounds as pde iv and tnf inhibitors
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
US5502072A (en) * 1993-11-26 1996-03-26 Pfizer Inc. Substituted oxindoles
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
CN1604776A (zh) 2001-10-16 2005-04-06 记忆药物公司 作为用于治疗神经病综合症的pde－4抑制剂的4－(4－烷氧基－3－羟基苯基)－2－吡咯烷酮衍生物
EP1613590A2 (en) * 2003-04-16 2006-01-11 Memory Pharmaceutical Corporation 4-(3,4-disubstituted phenyl)-pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
EP1802615A1 (en) 2004-10-20 2007-07-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
CN102491929B (zh) * 2011-12-08 2014-04-30 贵州省中国科学院天然产物化学重点实验室 1-羟基-2-吡咯烷酮类化合物及其制备方法和应用
CN110407681B (zh) * 2019-08-12 2023-05-02 海南大学 一种脱氢姜酮衍生物、其制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
DE2413935A1 (de) * 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
LU85404A1 (fr) * 1984-06-06 1986-01-24 Continental Pharma Derives d'acides hydroxamiques cycliques,leur preparation et utilisation ainsi que les compositions contenant ces derives
PT82200B (pt) * 1985-03-16 1990-02-08 Wellcome Found Processo para a preparacao de novos derivados do acido hidroxamico e de composicoes farmaceuticas que os contem
GB8531839D0 (en) * 1985-12-30 1986-02-05 Wellcome Found Aryl derivatives
IE59397B1 (en) * 1985-03-16 1994-02-23 Wellcome Found New aryl derivatives

Also Published As

Publication number Publication date
FI100052B (fi) 1997-09-15
JP3227155B2 (ja) 2001-11-12
US5356923A (en) 1994-10-18
FI924839A0 (fi) 1992-10-23
DK0526535T3 (da) 1995-11-27
GR3017821T3 (en) 1996-01-31
DE69113455T2 (de) 1996-03-21
EP0526535B1 (en) 1995-09-27
FI924839A7 (fi) 1992-10-23
ATE128462T1 (de) 1995-10-15
ZA912886B (en) 1992-01-29
DE69113455D1 (de) 1995-11-02
JPH05506236A (ja) 1993-09-16
EP0526535A1 (en) 1993-02-10
AU7777491A (en) 1991-11-11
WO1991016303A1 (en) 1991-10-31
GB9009395D0 (en) 1990-06-20

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