ES2079697T3 - Procedimiento para la estabilizacion de 1-metil-hidantoinasa, utilizacion de una 1-metil-hidantoinasa estabilizada para la determinacion de un analito, correspondiente procedimiento de determinacion, asi como agentes apropiados para ello. - Google Patents

Procedimiento para la estabilizacion de 1-metil-hidantoinasa, utilizacion de una 1-metil-hidantoinasa estabilizada para la determinacion de un analito, correspondiente procedimiento de determinacion, asi como agentes apropiados para ello.

Info

Publication number
ES2079697T3
ES2079697T3 ES92101318T ES92101318T ES2079697T3 ES 2079697 T3 ES2079697 T3 ES 2079697T3 ES 92101318 T ES92101318 T ES 92101318T ES 92101318 T ES92101318 T ES 92101318T ES 2079697 T3 ES2079697 T3 ES 2079697T3
Authority
ES
Spain
Prior art keywords
determination
hydantoinase
methyl
procedure
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92101318T
Other languages
English (en)
Inventor
Rolf Nagel
Ulfert Dr Rer Nat Deneke
Jurgen Mistele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2079697T3 publication Critical patent/ES2079697T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G01N2333/986—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides (3.5.2), e.g. beta-lactamase (penicillinase, 3.5.2.6), creatinine amidohydrolase (creatininase, EC 3.5.2.10), N-methylhydantoinase (3.5.2.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA LA ESTABILIZACION DE LA ENZIMA 1-METILHIDANTOINASA (NMHASA), QUE ESTA CARACTERIZADA PORQUE, LA NMHASA SE TRATA CON IONES METALICOS BIVALENTES, UN MODELADOR COMPLEJO, QUE EFECTUA LA UTILIZACION DE ESTOS IONES METALES BIVALENTES, Y UN TRIFOSFATO NUCLEOXIDO. ADEMAS REFIERE LA INVENCION LA UTILIZACION DE UNA ENZIMA ESTABILIZADA EN UN PROCESO PARA LA DETERMINACION DE UN ANALITO, EN EL QUE REACCIONA O SE TRANSFORMA EL COMPUESTO 1-METILHADANTOINA, ASI COMO UN REACTIVO CORRESPONDIENTE.
ES92101318T 1991-02-02 1992-01-28 Procedimiento para la estabilizacion de 1-metil-hidantoinasa, utilizacion de una 1-metil-hidantoinasa estabilizada para la determinacion de un analito, correspondiente procedimiento de determinacion, asi como agentes apropiados para ello. Expired - Lifetime ES2079697T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4103220A DE4103220A1 (de) 1991-02-02 1991-02-02 Verfahren zur stabilisierung von 1-methylhydantoinase, verwendung einer stabilisierten 1-methylhydantoinase zur bestimmung eines analyten, entsprechendes bestimmungsverfahren sowie hierfuer geeignete mittel

Publications (1)

Publication Number Publication Date
ES2079697T3 true ES2079697T3 (es) 1996-01-16

Family

ID=6424290

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92101318T Expired - Lifetime ES2079697T3 (es) 1991-02-02 1992-01-28 Procedimiento para la estabilizacion de 1-metil-hidantoinasa, utilizacion de una 1-metil-hidantoinasa estabilizada para la determinacion de un analito, correspondiente procedimiento de determinacion, asi como agentes apropiados para ello.

Country Status (6)

Country Link
US (1) US5374546A (es)
EP (1) EP0498260B1 (es)
JP (1) JPH0736756B2 (es)
AT (1) ATE127852T1 (es)
DE (2) DE4103220A1 (es)
ES (1) ES2079697T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19531173A1 (de) * 1995-08-24 1997-02-27 Boehringer Mannheim Gmbh Verfahren zum Stabilisieren des Gehalts glykierten Proteins einer Probe auf einem Matrixmaterial
JP3039854U (ja) * 1997-01-22 1997-07-31 株式会社ピーエスピー トイレ清掃用具
US7083939B2 (en) * 2002-05-01 2006-08-01 Polymer Technology Systems, Inc. Method for determining concentration of creatinine in a bodily fluid
CN101238374B (zh) 2005-06-13 2012-08-29 日本化药株式会社 使用全血的血液成分测定方法及测定试剂盒
US8465940B2 (en) * 2006-12-14 2013-06-18 Nippon Kayaku Kabushiki Kaisha Method for electrochemically measuring 1,5-anhydroglucitol in whole blood
DE102018200518B4 (de) * 2018-01-15 2023-09-14 Robert Bosch Gmbh Mikrofluidischen Vorrichtung und Verfahren zu dessen Betrieb
CN116735857A (zh) * 2023-03-08 2023-09-12 宁波海尔施智造有限公司 一种碱性磷酸酶酶标缓冲液和碱性磷酸酶酶标试剂

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133001A (en) * 1959-11-26 1964-05-12 Muset Pedro Puig Stabilization of enzymes
US3325364A (en) * 1966-04-18 1967-06-13 Us Vitamin Pharm Corp Process for stabilizing enzyme compositions
US3413198A (en) * 1966-06-30 1968-11-26 Calbiochem Reagents and method for assaying biological samples
US3539450A (en) * 1966-06-30 1970-11-10 Calbiochem Stabilization of enzymes
NL7610608A (nl) * 1976-09-24 1978-03-29 Akzo Nv Werkwijze voor het stabiliseren van peroxidase- -bevattende composities.
US4230664A (en) * 1979-01-23 1980-10-28 Technion Research & Development Foundation Ltd. Test pack kit for immunoassay
US4465770A (en) * 1979-09-11 1984-08-14 Modrovich Ivan Endre Stabilized enzymic solutions for determining urea
DE3023485A1 (de) * 1980-06-24 1982-01-07 Merck Patent Gmbh, 6100 Darmstadt Verfahren und mittel sowie deren verwendung zur stabilisierung der alkalischen phosphatase
DE3248145A1 (de) * 1982-12-27 1984-06-28 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagenz zur bestimmung von n-carbamoylsarcosin und hierfuer geeignetes neues enzym
DE3406770A1 (de) * 1984-02-24 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Nucleosidtriphosphat-abhaengige 1-methylhydantoinase und ihre verwendung
JPS62104598A (ja) * 1985-11-01 1987-05-15 Yatoron:Kk クレアチンキナ−ゼ測定用試薬
DE3630999A1 (de) * 1986-09-12 1988-03-17 Boehringer Mannheim Gmbh Mehrschichtiger testtraeger
FR2605330B1 (fr) * 1986-10-20 1989-01-20 Millipore Sa Recipient destine a recevoir un ou plusieurs milieux de culture pour microorganismes.
JPH0698032B2 (ja) * 1987-01-23 1994-12-07 財団法人野田産業科学研究所 クレアチンもしくはクレアチニンの測定法及びこれらの測定用試薬

Also Published As

Publication number Publication date
US5374546A (en) 1994-12-20
JPH0736756B2 (ja) 1995-04-26
EP0498260B1 (de) 1995-09-13
EP0498260A1 (de) 1992-08-12
DE4103220A1 (de) 1992-08-06
DE59203614D1 (de) 1995-10-19
JPH0614778A (ja) 1994-01-25
ATE127852T1 (de) 1995-09-15

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