ES2084335T3 - Union de sustancias de reconocimiento a liposomas. - Google Patents

Union de sustancias de reconocimiento a liposomas.

Info

Publication number
ES2084335T3
ES2084335T3 ES92900243T ES92900243T ES2084335T3 ES 2084335 T3 ES2084335 T3 ES 2084335T3 ES 92900243 T ES92900243 T ES 92900243T ES 92900243 T ES92900243 T ES 92900243T ES 2084335 T3 ES2084335 T3 ES 2084335T3
Authority
ES
Spain
Prior art keywords
liposomes
recognizing substances
crosslinking reagents
substances
methodologies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900243T
Other languages
English (en)
Inventor
Rimona Margalit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Application granted granted Critical
Publication of ES2084335T3 publication Critical patent/ES2084335T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE HAN DESARROLLADO METODOLOGIAS Y CIERTAS SUBSTANCIAS DE RECONOCIMIENTO Y SE HAN IDENTIFICADO REAGENTES ENLAZANTES PARA LIPOSOMAS DE MODIFICACION. LOS REAGENTES ENLAZANTES ENLAZAN LOS RESIDUOS SOBRE LA SUPERFICIE LIPOSOMAL A LOS RESIDUOS OFRECIDOS POR CIERTAS SUBSTANCIAS DE RECONOCIMIENTO. LOS REAGENTES ENLAZANTES INCLUYEN GLUTARALDEHIDO (GAD) Y UN CARBODIIMIDO SOLUBLE EN AGUA, PREFERIBLEMENTE, 1-ETIL-3-(3DIMETILAMINOPROPIL)CARBODIIMIDO (EDC). LAS SUBSTANCIAS DE RECONOCIMIENTO INCLUYEN GELATINA, COLAGENO Y ACIDO HIALURONICO (HA). COMO CONSECUENCIA DE ESTAS METODOLOGIAS, PUEDEN UTILIZARSE SUBSTANCIAS DE RECONOCIMIENTO COMO ADHESIVO O PEGAMENTO PARA SUJETAR LOS LIPOSOMAS EN UN AREA DESEADA. ESTOS LIPOSOMAS BIOADHESIVOS OFRECEN VENTAJAS POTENCIAS COMO SISTEMA MICROSCOPICO DE LIBERACION DE MEDICAMENTOS.
ES92900243T 1991-02-14 1991-10-30 Union de sustancias de reconocimiento a liposomas. Expired - Lifetime ES2084335T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65587891A 1991-02-14 1991-02-14

Publications (1)

Publication Number Publication Date
ES2084335T3 true ES2084335T3 (es) 1996-05-01

Family

ID=24630761

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900243T Expired - Lifetime ES2084335T3 (es) 1991-02-14 1991-10-30 Union de sustancias de reconocimiento a liposomas.

Country Status (10)

Country Link
US (1) US5401511A (es)
EP (1) EP0525132B1 (es)
JP (1) JP3407072B2 (es)
AT (1) ATE132367T1 (es)
AU (1) AU651414B2 (es)
CA (1) CA2079444C (es)
DE (1) DE69116144T2 (es)
DK (1) DK0525132T3 (es)
ES (1) ES2084335T3 (es)
WO (1) WO1992014447A1 (es)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603872A (en) * 1991-02-14 1997-02-18 Baxter International Inc. Method of binding recognizing substances to liposomes
GB9208339D0 (en) * 1992-04-15 1992-06-03 Unilever Plc Treatment composition
US5759566A (en) * 1992-07-28 1998-06-02 Poli Industria Chimica Spa Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
US5654000A (en) * 1992-07-28 1997-08-05 Poli Industria Chimica S.P.A. Pharmaceutical compositions for transmucosal delivery of peptides
CA2140053C (en) * 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5658588A (en) * 1995-03-31 1997-08-19 University Of Cincinnati Fibrinogen-coated liposomes
US6096863A (en) * 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
DE69732308T2 (de) * 1996-09-27 2005-06-02 Jagotec Ag Arzneistoffverabreichungssystem mit hyaluronsäure
DE19852928C1 (de) * 1998-11-17 2000-08-03 Steffen Panzner Strukturen in Form von Hohlkugeln
EP1754488A1 (en) 1999-05-24 2007-02-21 Introgen Therapeutics, Inc. Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
US8501701B2 (en) * 2000-01-10 2013-08-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Use of lipid conjugates in the treatment of disease
US8076312B2 (en) 2000-01-10 2011-12-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Use of lipid conjugates in the treatment of disease
US7393938B2 (en) * 2000-01-10 2008-07-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US8916539B2 (en) * 2000-01-10 2014-12-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of disease
US7893226B2 (en) 2004-09-29 2011-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
US7504384B2 (en) * 2000-01-10 2009-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of infection
US7811999B2 (en) 2000-01-10 2010-10-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
US7608598B2 (en) * 2000-01-10 2009-10-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of conjunctivitis
US20090325876A1 (en) * 2004-09-29 2009-12-31 Saul Yedgar Use of lipid conjugates in the treatment of diseases associated with vasculature
US9040078B2 (en) * 2000-01-10 2015-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases of the nervous system
US8304395B2 (en) * 2000-01-10 2012-11-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipid conjugates in the treatment of disease
US7772196B2 (en) * 2000-01-10 2010-08-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US10293056B1 (en) 2000-05-24 2019-05-21 Board Of Regents, The University Of Texas System Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
DE60142840D1 (de) 2000-09-08 2010-09-30 Univ Texas Durch phagendisplay identifizierte zielpeptide des menschen und der maus
US8883761B2 (en) * 2001-01-10 2014-11-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases associated with vasculature
DE60237696D1 (de) * 2001-08-01 2010-10-28 Univ Utah Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a
CN100542612C (zh) * 2001-08-14 2009-09-23 特拉维夫大学未来技术研发有限公司 类脂化糖胺聚糖颗粒及其在诊断和治疗用药物和基因传递中的应用
US7238477B2 (en) * 2001-09-24 2007-07-03 Intel Corporation Methods to increase nucleotide signals by Raman scattering
US6972173B2 (en) * 2002-03-14 2005-12-06 Intel Corporation Methods to increase nucleotide signals by raman scattering
FI115343B (fi) * 2001-10-22 2005-04-15 Filtronic Lk Oy Sisäinen monikaista-antenni
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US7381426B2 (en) * 2002-01-24 2008-06-03 Southwest Research Institute Targeted delivery of bioactive factors to the systemic skeleton
US8728510B1 (en) 2002-03-15 2014-05-20 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing a bioadhesive material
US20040110208A1 (en) * 2002-03-26 2004-06-10 Selena Chan Methods and device for DNA sequencing using surface enhanced Raman scattering (SERS)
US7476501B2 (en) * 2002-03-26 2009-01-13 Intel Corporation Methods and device for DNA sequencing using surface enhanced raman scattering (SERS)
US7361821B2 (en) * 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
JP4520857B2 (ja) * 2002-09-20 2010-08-11 インテル・コーポレーション 走査型プローブ顕微鏡検査（ｓｐｍ）読取用の特定の情報をエンコードするナノバーコードの制御された整列
US7270952B2 (en) * 2002-09-24 2007-09-18 Intel Corporation Detecting molecular binding by monitoring feedback controlled cantilever deflections
ATE346297T1 (de) * 2002-09-24 2006-12-15 Intel Corp Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungen
CA2509914A1 (en) 2002-12-11 2004-06-24 Ferrosan A/S Gelatine-based materials as swabs
US6861251B2 (en) 2003-02-24 2005-03-01 Pritest, Inc. Translucent solid matrix assay device for microarray analysis
US20050053668A1 (en) * 2003-08-21 2005-03-10 Southwest Research Institute Skeletally targeted nanoparticles
US20050064435A1 (en) * 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
US20050147976A1 (en) * 2003-12-29 2005-07-07 Xing Su Methods for determining nucleotide sequence information
US20050147979A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
US9062392B2 (en) 2003-12-30 2015-06-23 Intel Corporation Methods for isolating a peptide methods for identifying a peptide
US20050147980A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication
US20050147964A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Methods for identifying a peptide that binds a geometrical shape
AR054637A1 (es) * 2004-01-30 2007-07-11 Ferrosan As Aerosoles y composiciones hemostaticas
US20050221507A1 (en) * 2004-03-30 2005-10-06 Intel Corporation Method to detect molecular binding by surface-enhanced Raman spectroscopy
FR2870741B1 (fr) * 2004-05-25 2008-03-14 Coletica Sa Phase lamellaires hydratees ou liposomes, contenant une monoamine grasse ou un polymere cationique favorisant la penetration intercellulaire, et composition cosmetique ou pharmaceutique la contenant.
CN101001649B (zh) * 2004-07-09 2011-08-31 弗罗桑医疗设备公司 包括透明质酸的止血组合物及其制备方法
WO2006017195A1 (en) 2004-07-13 2006-02-16 Ramot At Tel-Aviv University Ltd. Lipidated glycoprotein particles and methods of use
US7709247B2 (en) * 2004-08-04 2010-05-04 Intel Corporation Methods and systems for detecting biomolecular binding using terahertz radiation
US20060210549A1 (en) * 2004-09-10 2006-09-21 Srivastava Devendra K Controlled release liposomes and methods of use
US8178129B2 (en) * 2004-11-02 2012-05-15 Tel-Aviv University Future Technology Development L.P. Formulations of water insoluble or poorly water soluble drugs in lipidated glycosaminoglycan particles and their use for diagnostic and therapy
KR20080065269A (ko) * 2005-08-03 2008-07-11 모리아 바이오파마슈티컬스 낭포성 섬유증에 대한 리피드 접합체의 용도 및 그의 적용
ES2747978T3 (es) 2005-10-03 2020-03-12 Mark A Pinsky Liposomas no fosfolipídicos que comprenden ácido hialurónico
WO2010132402A1 (en) 2009-05-11 2010-11-18 Morria Biopharmaceuticals, Inc Lipid-polymer conjugates, their preparation and uses thereof
US8859524B2 (en) 2005-11-17 2014-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of chronic rhinosinusitis
US8906882B2 (en) 2005-11-17 2014-12-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of allergic rhinitis
ES2798263T3 (es) 2005-12-08 2020-12-10 Insmed Inc Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares
WO2007092944A2 (en) * 2006-02-08 2007-08-16 Introgen Therapeutics, Inc. Compositions and methods involving gene therapy and proteasome modulation
US20080183282A1 (en) * 2006-03-09 2008-07-31 Saul Yedgar Use of lipid conjugates for the coating of stents and catheters
WO2007127272A2 (en) * 2006-04-24 2007-11-08 The Cbr Institute For Biomedical Research Method of producing immunoliposomes and compositions thereof
US7951776B2 (en) 2006-09-01 2011-05-31 American Type Culture Collection Methods for treatment of type 1 diabetes
US8119156B2 (en) 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8071127B2 (en) * 2006-10-24 2011-12-06 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
CA2705785A1 (en) * 2006-11-14 2008-05-22 Saul Yedgar Use of lipid conjugates in the treatment of diseases or disorders of the eye
AU2007320737B2 (en) * 2006-11-14 2014-04-03 Celsus Therapeutics Plc Contact lens compositions
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
JP5548616B2 (ja) 2007-08-08 2014-07-16 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ｖｅｇｆｒ−１／ｎｒｐ−１標的化ペプチド
WO2009108554A2 (en) 2008-02-27 2009-09-03 Ramot At Tel Aviv University Ltd. System for delivery of protein in insoluble fibrillar or aggregate form
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
WO2010107658A2 (en) 2009-03-16 2010-09-23 Vallera Daniel A Methods and compositions for bi-specific targeting of cd19/cd22
GB0913442D0 (en) 2009-07-31 2009-09-16 Univ Ramot Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
US20120269721A1 (en) * 2009-10-12 2012-10-25 The Regents Of The University Of California Targeted nanoclusters and methods of their use
AU2012254842A1 (en) * 2011-05-12 2013-05-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomes comprising polymer-conjugated lipids and related uses
WO2013131520A2 (en) 2012-03-06 2013-09-12 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
WO2013156989A1 (en) 2012-04-18 2013-10-24 Ramot At Tel-Aviv University Ltd. Lipidated glycosaminoglycan particles for the delivery of nucleic acids
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
CA2891487A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
EP3010419B1 (en) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
MX2016005232A (es) 2013-10-22 2017-01-19 Aradigm Corp Formulaciones liposomicas para inhalacion, modificadas con agente tensoactivo, que proveen un perfil de liberacion tanto inmediata como sostenida.
JP6489485B2 (ja) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ／エス 押し出し増強因子を含んでいる乾燥組成物
MX384843B (es) 2014-05-15 2025-03-14 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas.
JP2017520549A (ja) 2014-06-26 2017-07-27 ラモット アット テル アビブ ユニバーシティ， リミテッド 核酸の送達のためのリポソーム製剤
CA2960309A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
RU2705905C2 (ru) 2014-12-24 2019-11-12 Ферросан Медикал Дивайсиз А/С Шприц для удерживания и смешивания первого и второго веществ
AU2016290433B2 (en) 2015-07-03 2018-05-24 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
EP3773505B1 (en) 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
JP7197106B2 (ja) * 2018-04-27 2022-12-27 国立大学法人北海道大学 脂質ナノ粒子
EP3787602A4 (en) 2018-05-02 2022-03-23 Insmed Incorporated PROCESS FOR THE MANUFACTURE OF LIPOSOMAL DRUG FORMULATIONS
ES2968412T3 (es) 2018-05-09 2024-05-09 Ferrosan Medical Devices As Método para preparar una composición hemostática

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
JPS59210013A (ja) * 1983-05-04 1984-11-28 Ajinomoto Co Inc 活性物質含有リポソ−ム
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US4761288A (en) * 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
WO1986004232A1 (en) * 1985-01-18 1986-07-31 Cooper-Lipotech, Inc. Liposome composition and method
FR2597345B1 (fr) * 1986-04-22 1990-08-03 Oreal Composition cosmetique ou pharmaceutique a base d'une dispersion aqueuse de spherules lipidiques.
US4839175A (en) * 1986-07-28 1989-06-13 Liposome Technology, Inc. Liposomes with enhanced retention on mucosal tissue
EP0316345A1 (en) * 1986-07-28 1989-05-24 Liposome Technology, Inc. Liposomes with enhanced retention on mucosal tissue
US5000960A (en) * 1987-03-13 1991-03-19 Micro-Pak, Inc. Protein coupling to lipid vesicles
WO1989011270A1 (en) * 1988-05-16 1989-11-30 Sandoz Ag Liposomes coupled to hormones
ATE78156T1 (de) * 1988-12-02 1992-08-15 Coletica Stabilisierung von hydratierten lamellaren phasen.
FR2645741B1 (fr) * 1989-03-20 1995-06-23 Dior Christian Parfums Procede pour fixer un produit sur la membrane d'un keratinocyte au moyen d'une liaison ligand-recepteur, procede de preparation d'un tel produit, produit obtenu, composition cosmetique ou pharmaceutique le contenant et son procede de preparation
AU652778B2 (en) * 1990-10-15 1994-09-08 Quest International B.V. Treatment composition
PL296382A1 (en) * 1991-02-02 1993-11-02 Nika Health Products Ltd Li Li Artificial membrane beads containing functionally active peptides responsible for fusion as a drug administering system

Also Published As

Publication number Publication date
JPH05505827A (ja) 1993-08-26
DE69116144D1 (de) 1996-02-15
EP0525132A1 (en) 1993-02-03
ATE132367T1 (de) 1996-01-15
US5401511A (en) 1995-03-28
WO1992014447A1 (en) 1992-09-03
JP3407072B2 (ja) 2003-05-19
DE69116144T2 (de) 1996-05-09
AU651414B2 (en) 1994-07-21
AU9037091A (en) 1992-09-15
CA2079444A1 (en) 1992-08-15
DK0525132T3 (da) 1996-02-05
EP0525132B1 (en) 1996-01-03
CA2079444C (en) 2004-02-03

Similar Documents

Publication Publication Date Title
DE69116144D1 (de) Bindung substratspezifischer affinitätssubstanzen an liposomen
FR2730637B1 (fr) Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
ATE251895T1 (de) Hydrophobe arzneistoffabgabesysteme
FI945912A0 (fi) Proteinoidikantajat ja menetelmät niiden valmistamiseksi sekä niiden käyttö
DE69627769D1 (de) Funktionelle Faserprodukte
DK0636028T3 (da) Selvorganiserende polynucleotidleveringssystem omfattende et amfipatisk kationisk peptid
AU4094196A (en) Improvements in or relating to contrast agents
IL143063A0 (en) Cross-linked hyaluronic acids and medical uses thereof
DE59309257D1 (de) Verfahren zur herstellung von mikrokapseln
ATE186741T1 (de) Polyarylate, die derivate der natürlichen aminosäure l-tyrosin enthalten
EP0340741A3 (en) Polyethylene glycol derivatives, modified peptides and production thereof
AU8208291A (en) O-glycosylated alpha-2 interferon
IT7823679A0 (it) Processo enzimatico-microbiologico per la produzione di amminoacidi otticamente attivi a partire da idantoine e/o carbamil-derivati racemi.
ATE150319T1 (de) Behandlung von asthma
ATE158577T1 (de) Enzymatische auflösung von endo-bicyclo(2.2.1)- heptan-2-ol und pharmazeutische derivate
EP0224120A3 (en) Protein label and drug delivery system
AU1022588A (en) Ointment base and ointment
MX9801967A (es) Tetrahidroquinolinas como antagonistas de los aminoacidos excitadores (nmda).
AU1431188A (en) Dihydropyridine - pyridinium salt-type redox amino acids and peptides containing them
AU5816496A (en) Process for the depyrogenation of injectable pharmaceutical solutions
DE3676335D1 (de) Auf mercaptoethansulfonsaeuren basierende pharmazeutische zusammensetzungen, organische abkoemmlinge von mercaptoethansulfonsaeuren sowie verfahren zu deren herstellung.
HUT45058A (en) Process for producing 6-hydroxy-methyl-carbapenem derivatives and pharmaceuticals comprising the same as active ingredient
DE69607524D1 (de) Verfahren zur Herstellung von einem Bicyclohexanderivat
NZ229699A (en) Skin- or hair-care composition comprising silica and an ester of a di, tri or tetrabasic (hydroxy)carboxylic acid
TR199600583A2 (tr) Farmasötik aktiviteye sahip -amino asitlerin tolere edilebilirliginin arttirilmasi.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 525132

Country of ref document: ES