ES2091757T3 - Agonistas y agonistas parciales del neuropeptido y. - Google Patents

Agonistas y agonistas parciales del neuropeptido y.

Info

Publication number
ES2091757T3
ES2091757T3 ES89115469T ES89115469T ES2091757T3 ES 2091757 T3 ES2091757 T3 ES 2091757T3 ES 89115469 T ES89115469 T ES 89115469T ES 89115469 T ES89115469 T ES 89115469T ES 2091757 T3 ES2091757 T3 ES 2091757T3
Authority
ES
Spain
Prior art keywords
agonists
neuropeptide
partial
npy
antagonics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89115469T
Other languages
English (en)
Inventor
John L Krstenansky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2091757T3 publication Critical patent/ES2091757T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ANTAGONICOS DE NPY LOS CUALES SON DERIVADOS DE NPY NATURALES. EL ANTAGONISTA SE CONFIRMA USANDO LIGANTES COMPETITIVOS CONVENCIONALES Y MUESTRAS BIOQUIMICAS Y TAMBIEN SE DESCRIBE EL USO DE ESTOS DERIVADOS EN UNA VARIEDAD DE CONDICIONES EN LAS CUALES ESTA IMPLICADA LA NEUROPEPTIDA Y.
ES89115469T 1988-08-26 1989-08-22 Agonistas y agonistas parciales del neuropeptido y. Expired - Lifetime ES2091757T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23759188A 1988-08-26 1988-08-26

Publications (1)

Publication Number Publication Date
ES2091757T3 true ES2091757T3 (es) 1996-11-16

Family

ID=22894367

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89115469T Expired - Lifetime ES2091757T3 (es) 1988-08-26 1989-08-22 Agonistas y agonistas parciales del neuropeptido y.

Country Status (17)

Country Link
EP (1) EP0355793B1 (es)
JP (1) JP2791955B2 (es)
KR (1) KR0149160B1 (es)
CN (1) CN1042155A (es)
AT (1) ATE140235T1 (es)
AU (1) AU618118B2 (es)
CA (1) CA1341336C (es)
DE (1) DE68926804T2 (es)
DK (1) DK420789A (es)
ES (1) ES2091757T3 (es)
FI (1) FI894006A7 (es)
HU (1) HU204852B (es)
IL (1) IL91395A0 (es)
NO (1) NO893430L (es)
NZ (1) NZ230384A (es)
PT (1) PT91538B (es)
ZA (1) ZA896376B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3419454B2 (ja) * 1991-11-06 2003-06-23 ガーヴァン インスティチュート オブ メディカル リサーチ ヒト神経ペプチドｙ−ｙ１レセプター
WO1993012139A1 (en) * 1991-12-19 1993-06-24 Garvan Institute Of Medical Research A novel molecule which inhibits neuropeptide tyrosine biological function
AU662032B2 (en) * 1991-12-19 1995-08-17 Garvan Institute Of Medical Research A novel molecule which inhibits neuropeptide tyrosine biological function
GB9213215D0 (en) * 1992-06-20 1992-08-05 Wellcome Found Peptides
JPH11501281A (ja) * 1993-06-18 1999-02-02 ユニバーシティ オブ シンシナティ 神経ペプチドｙアンタゴニスト及びアゴニスト
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
US5545549A (en) * 1994-02-03 1996-08-13 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
US5602024A (en) 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5989920A (en) * 1994-12-02 1999-11-23 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
AUPN646795A0 (en) 1995-11-09 1995-11-30 Garvan Institute Of Medical Research Neuropeptide Y-Y5 receptor
DE19652033A1 (de) * 1996-12-13 1998-06-18 Irmgard Dr Med Guertner Neuropeptid (CGRP) als Modulator zur Zelldifferenzierung und Proliferation
US6713265B1 (en) 1997-06-04 2004-03-30 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
EP1620091B1 (en) 2003-05-05 2010-03-31 Probiodrug AG Inhibitors of glutaminyl cyclase
AU2004290499C1 (en) 2003-11-03 2011-02-24 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
WO2005075436A2 (en) 2004-02-05 2005-08-18 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CN111494606B (zh) * 2020-04-24 2021-12-14 广州医科大学 神经肽y的新应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3811193A1 (de) * 1988-04-01 1989-10-19 Boehringer Ingelheim Kg Neue peptide, verfahren zu ihrer herstellung und diese peptide enthaltende pharmazeutische zusammensetzungen

Also Published As

Publication number Publication date
KR900002799A (ko) 1990-03-23
ATE140235T1 (de) 1996-07-15
HUT50849A (en) 1990-03-28
DK420789D0 (da) 1989-08-25
EP0355793B1 (en) 1996-07-10
ZA896376B (en) 1990-05-30
NO893430D0 (no) 1989-08-25
IL91395A0 (en) 1990-04-29
NZ230384A (en) 1996-03-26
HU204852B (en) 1992-02-28
AU618118B2 (en) 1991-12-12
JP2791955B2 (ja) 1998-08-27
FI894006L (fi) 1990-02-27
FI894006A7 (fi) 1990-02-27
PT91538B (pt) 1995-05-04
EP0355793A3 (en) 1992-04-22
JPH02111794A (ja) 1990-04-24
CN1042155A (zh) 1990-05-16
FI894006A0 (fi) 1989-08-25
DK420789A (da) 1990-02-27
CA1341336C (en) 2002-01-29
DE68926804D1 (de) 1996-08-14
EP0355793A2 (en) 1990-02-28
KR0149160B1 (ko) 1998-10-15
DE68926804T2 (de) 1996-12-12
AU4082889A (en) 1990-03-01
PT91538A (pt) 1990-03-08
NO893430L (no) 1990-02-27

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