ES2098031T3 - Nuevos analogos de vitamina d. - Google Patents
Nuevos analogos de vitamina d.Info
- Publication number
- ES2098031T3 ES2098031T3 ES93907825T ES93907825T ES2098031T3 ES 2098031 T3 ES2098031 T3 ES 2098031T3 ES 93907825 T ES93907825 T ES 93907825T ES 93907825 T ES93907825 T ES 93907825T ES 2098031 T3 ES2098031 T3 ES 2098031T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- hydrocarbile
- radical
- vitamin
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000004177 carbon cycle Methods 0.000 abstract 1
- 229910052805 deuterium Inorganic materials 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA (I) EN LA QUE X ES HIDROGENO O HIDROXIDO; R1 Y R2 SIGNIFICAN HIDROGENO O UN RADICAL DE HIDROCARBIL C1-C6; O TOMADAS JUNTO CON EL ATOMO DE CARBONO QUE SOPORTA EL GRUPO X, PUEDEN FORMAR UN ANILLO CARBOCICLICO C3-C8; R3 SIGNIFICA HIDROGENO O UN RADICAL DE HIDROCARBIL C1-C10 O YR4, EN DONDE Y SIGNIFICA LOS RADICALES -CO-, -CO-O-, -CO-S-, -CS-, -CS-O, CS-S-, -SOICA HIDROGENO O UN RADICAL DE HIDROCARBIL C1-C10; Q ES UN ENLACE SIMPLE O UN DIRADICAL DE HIDROCARBILENO C1-C8. R1, R2, R3 Y/P Q PUEDEN ESTAR OPCIONALMENTE SUSTITUIDAS CON UNO O MAS ATOMOS DE DEUTERIO O FLUOR. LOS COMPUESTOS MUESTRAN EFECTOS ANTIINFLAMATORIOS E INMUNOMODULADORES ASI COMO UNA FUERTE ACTIVIDAD EN LA INDUCCION DE LA DIFERENCIACION Y EN LA INHIBICION DE LA PROLIFERACION NO DESEADA DE CIERTAS CELULAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929206648A GB9206648D0 (en) | 1992-03-26 | 1992-03-26 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2098031T3 true ES2098031T3 (es) | 1997-04-16 |
Family
ID=10712921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93907825T Expired - Lifetime ES2098031T3 (es) | 1992-03-26 | 1993-03-23 | Nuevos analogos de vitamina d. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5446034A (es) |
| EP (1) | EP0633878B1 (es) |
| JP (1) | JP3553591B2 (es) |
| KR (1) | KR100268543B1 (es) |
| AT (1) | ATE148453T1 (es) |
| AU (1) | AU660795B2 (es) |
| CA (1) | CA2120703A1 (es) |
| DE (1) | DE69307871T2 (es) |
| DK (1) | DK0633878T3 (es) |
| ES (1) | ES2098031T3 (es) |
| FI (1) | FI106118B (es) |
| GB (1) | GB9206648D0 (es) |
| GR (1) | GR3022768T3 (es) |
| WO (1) | WO1993019044A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| GB9405715D0 (en) * | 1994-03-23 | 1994-05-11 | Res Inst Medicine Chem | Chemical compounds |
| GB9524812D0 (en) * | 1995-12-05 | 1996-02-07 | Leo Pharm Prod Ltd | Chemical compounds |
| US5939408A (en) * | 1996-05-23 | 1999-08-17 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
| NO971934L (no) * | 1996-05-23 | 1997-11-24 | Hoffmann La Roche | Flourinerte vitamin D3 -analoger |
| SG70009A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Vitamin d3 analogs |
| GB9611603D0 (en) | 1996-06-04 | 1996-08-07 | Leo Pharm Prod Ltd | Chemical compounds |
| US5891865A (en) * | 1996-10-04 | 1999-04-06 | Wisconsin Alumni Research Foundation | Treatment of arthritic disease induced by infectious agents |
| GB9622590D0 (en) * | 1996-10-30 | 1997-01-08 | Leo Pharm Prod Ltd | Chemical compounds |
| JP2002513416A (ja) | 1997-05-22 | 2002-05-08 | セファロン・インコーポレイテッド | ビタミンｄアナログおよびそれらのニューロン効果 |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| WO1999049870A1 (en) | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
| AU770771B2 (en) | 1999-08-04 | 2004-03-04 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Novel vitamin D analogues |
| DE60019947T2 (de) | 1999-09-29 | 2006-02-02 | Colotech A/S | Prävention von kolorektalem Krebs |
| US6703380B2 (en) | 1999-09-29 | 2004-03-09 | Colotech A/S | Prevention of cancer |
| WO2003033526A2 (en) | 2001-10-19 | 2003-04-24 | Isotechnika Inc. | Synthesis of cyclosporin analogs |
| US20030105027A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Nutritional supplements and methods for prevention, reduction and treatment of radiation injury |
| US7435725B2 (en) * | 2001-11-06 | 2008-10-14 | The Quigly Corporation | Oral compositions and methods for prevention, reduction and treatment of radiation injury |
| US20030118536A1 (en) * | 2001-11-06 | 2003-06-26 | Rosenbloom Richard A. | Topical compositions and methods for treatment of adverse effects of ionizing radiation |
| AU2006245283B2 (en) | 2005-05-10 | 2012-11-01 | Dermipsor Ltd. | Compositions and methods for treating hyperproliferative epidermal diseases |
| CA2608021A1 (en) * | 2005-05-10 | 2006-11-16 | Dermipsor Ltd. | Compositions and methods for skin care |
| AU2010208323B2 (en) | 2009-01-27 | 2016-03-10 | Berg Llc | Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy |
| EP2464357B1 (en) | 2009-08-14 | 2019-05-22 | Berg LLC | Vitamin d3 and analogs thereof for treating alopecia |
| SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| US20190183908A1 (en) | 2016-05-13 | 2019-06-20 | Case Western Reserve University | Autophagy activators for treating or preventing skin injury |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
-
1992
- 1992-03-26 GB GB929206648A patent/GB9206648D0/en active Pending
-
1993
- 1993-03-23 AT AT93907825T patent/ATE148453T1/de not_active IP Right Cessation
- 1993-03-23 ES ES93907825T patent/ES2098031T3/es not_active Expired - Lifetime
- 1993-03-23 DK DK93907825.9T patent/DK0633878T3/da active
- 1993-03-23 CA CA002120703A patent/CA2120703A1/en not_active Abandoned
- 1993-03-23 EP EP93907825A patent/EP0633878B1/en not_active Expired - Lifetime
- 1993-03-23 US US08/211,420 patent/US5446034A/en not_active Expired - Fee Related
- 1993-03-23 WO PCT/DK1993/000105 patent/WO1993019044A1/en not_active Ceased
- 1993-03-23 JP JP51618793A patent/JP3553591B2/ja not_active Expired - Fee Related
- 1993-03-23 DE DE69307871T patent/DE69307871T2/de not_active Expired - Fee Related
- 1993-03-23 AU AU38893/93A patent/AU660795B2/en not_active Ceased
-
1994
- 1994-05-12 KR KR1019940701590A patent/KR100268543B1/ko not_active Expired - Fee Related
- 1994-06-28 FI FI943099A patent/FI106118B/fi active
-
1997
- 1997-03-07 GR GR970400452T patent/GR3022768T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07504903A (ja) | 1995-06-01 |
| FI943099A7 (fi) | 1994-06-28 |
| EP0633878B1 (en) | 1997-01-29 |
| DE69307871T2 (de) | 1997-09-11 |
| DK0633878T3 (da) | 1997-04-21 |
| DE69307871D1 (de) | 1997-03-13 |
| US5446034A (en) | 1995-08-29 |
| GB9206648D0 (en) | 1992-05-06 |
| AU660795B2 (en) | 1995-07-06 |
| ATE148453T1 (de) | 1997-02-15 |
| AU3889393A (en) | 1993-10-21 |
| KR100268543B1 (en) | 2000-10-16 |
| JP3553591B2 (ja) | 2004-08-11 |
| WO1993019044A1 (en) | 1993-09-30 |
| EP0633878A1 (en) | 1995-01-18 |
| FI943099A0 (fi) | 1994-06-28 |
| GR3022768T3 (en) | 1997-06-30 |
| CA2120703A1 (en) | 1993-09-30 |
| FI106118B (fi) | 2000-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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