ES2114619T3 - Nuevos analogos de la vitamina d. - Google Patents

Nuevos analogos de la vitamina d.

Info

Publication number
ES2114619T3
ES2114619T3 ES93924535T ES93924535T ES2114619T3 ES 2114619 T3 ES2114619 T3 ES 2114619T3 ES 93924535 T ES93924535 T ES 93924535T ES 93924535 T ES93924535 T ES 93924535T ES 2114619 T3 ES2114619 T3 ES 2114619T3
Authority
ES
Spain
Prior art keywords
methylene
groups
vitamin
hidroxi
substitution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93924535T
Other languages
English (en)
Inventor
Martin John Calverley
Henrik Pedersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of ES2114619T3 publication Critical patent/ES2114619T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA (I) EN CUYA FORMULA EL SIGNO "O" INDICA QUE ESTE CARBONO PUEDE SER MODIFICADO, Y LA U MITAD, QUE SUSTITUYE EL METILENO 24 DE LA VITAMINA D3-EPI-20DIHIDROXI-25,1 , SIGNIFICA (CH2)N-Y-(CH2)M, DONDE N ES 0, 1 O 2 E Y ES OXIGENO O AZUFRE; Y DERIVADOS FORMADOS POR SUSTITUCION, O BIEN DEL METILENO 22 O DEL METILENO 23 POR UN OXIGENO O POR SUSTITUCION DEL METILENO 22 O DEL METILENO 23 POR -CH = CH-; R'' ES METILO O ETILO; Y EN LA CUAL UNO O MAS ATOMOS DE CARBONO UNIDOS DIRECTAMENTE A C-25 PUEDEN SER SUSTITUIDOS OPCIONALMENTE POR UNO O MAS ATOMOS DE FLUOR; Y DERIVADOS DE I EN LA CUAL UNO O MAS DE LOS GRUPOS HIDROXI ESTAN ENMASCARADOS COMO GRUPOS QUE PUEDEN SER RECONVERTIDOS A GRUPOS HIDROXI IN VIVO. LOS COMPUESTOS MUESTRAN EFECTOS ANTIINFLAMATORIOS E INMUNOMODULADORES, ASI COMO FUERTE ACTIVIDAD PARA INDUCIR LA DIFERENCIACION E INHIBIR LA PROLIFERACION INDESEABLE DE CIERTAS CELULAS.
ES93924535T 1992-11-04 1993-11-01 Nuevos analogos de la vitamina d. Expired - Lifetime ES2114619T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929223061A GB9223061D0 (en) 1992-11-04 1992-11-04 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2114619T3 true ES2114619T3 (es) 1998-06-01

Family

ID=10724491

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93924535T Expired - Lifetime ES2114619T3 (es) 1992-11-04 1993-11-01 Nuevos analogos de la vitamina d.

Country Status (16)

Country Link
US (1) US5710142A (es)
EP (1) EP0667856B1 (es)
JP (1) JPH08503700A (es)
KR (1) KR100301214B1 (es)
AT (1) ATE163007T1 (es)
AU (1) AU671326B2 (es)
CA (1) CA2144161A1 (es)
DE (1) DE69316910T2 (es)
DK (1) DK0667856T3 (es)
ES (1) ES2114619T3 (es)
FI (1) FI109687B (es)
GB (1) GB9223061D0 (es)
GR (1) GR3026647T3 (es)
NZ (1) NZ257533A (es)
RU (1) RU2128168C1 (es)
WO (1) WO1994010139A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
US6121469A (en) 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
GB9611603D0 (en) 1996-06-04 1996-08-07 Leo Pharm Prod Ltd Chemical compounds
GB9622590D0 (en) * 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US6358939B1 (en) * 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
ATE428692T1 (de) * 2001-08-22 2009-05-15 Univ Johns Hopkins 24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen
WO2003106411A1 (en) 2002-06-13 2003-12-24 Johns Hopkins University 24-sulfoximine vitamin d3 compounds
WO2004054968A2 (en) 2002-12-18 2004-07-01 Johns Hopkins University 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol)
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US8425784B2 (en) * 2007-11-05 2013-04-23 University Of Kansas Ozonolysis reactions in liquid CO2 and CO2-expanded solvents
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 and analogs thereof for treating alopecia
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4617297A (en) * 1982-02-12 1986-10-14 Hoffmann-La Roche Inc. Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
US4594432A (en) * 1983-01-28 1986-06-10 Hoffman-La Roche Inc. Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
ATE45347T1 (de) * 1985-05-30 1989-08-15 Taisho Pharmaceutical Co Ltd Vitamin d3-derivate.
WO1987003282A1 (fr) * 1985-11-21 1987-06-04 Taisho Pharmaceutical Co., Ltd. Derive de la vitamine d3
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
JPH05501718A (ja) * 1990-02-06 1993-04-02 シェーリング　アクチェンゲゼルシャフト 側鎖同族体ビタミン―ｄ―誘導体、その製造法ならびに該誘導体を含有する、過増殖を示す疾病を治療するための製薬学的調製剤
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
DE4011682A1 (de) * 1990-04-06 1991-10-10 Schering Ag 24-oxa-derivate in der vitamin d-reihe
US5486509A (en) * 1991-06-28 1996-01-23 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives

Also Published As

Publication number Publication date
JPH08503700A (ja) 1996-04-23
RU95113157A (ru) 1996-11-20
US5710142A (en) 1998-01-20
ATE163007T1 (de) 1998-02-15
FI951968A7 (fi) 1995-04-25
AU5418194A (en) 1994-05-24
AU671326B2 (en) 1996-08-22
DE69316910D1 (de) 1998-03-12
RU2128168C1 (ru) 1999-03-27
DE69316910T2 (de) 1998-10-01
GB9223061D0 (en) 1992-12-16
KR100301214B1 (ko) 2001-11-22
FI109687B (fi) 2002-09-30
FI951968A0 (fi) 1995-04-25
EP0667856B1 (en) 1998-02-04
DK0667856T3 (da) 1998-09-28
WO1994010139A1 (en) 1994-05-11
GR3026647T3 (en) 1998-07-31
NZ257533A (en) 1997-06-24
EP0667856A1 (en) 1995-08-23
CA2144161A1 (en) 1994-05-11

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