ES2179343T3 - Nuevos analogos de la vitamina d. - Google Patents

Nuevos analogos de la vitamina d.

Info

Publication number
ES2179343T3
ES2179343T3 ES97924929T ES97924929T ES2179343T3 ES 2179343 T3 ES2179343 T3 ES 2179343T3 ES 97924929 T ES97924929 T ES 97924929T ES 97924929 T ES97924929 T ES 97924929T ES 2179343 T3 ES2179343 T3 ES 2179343T3
Authority
ES
Spain
Prior art keywords
radical
arilo
rent
vitamin
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97924929T
Other languages
English (en)
Inventor
Claus Aage Svensgaard Bretting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of ES2179343T3 publication Critical patent/ES2179343T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), EN CUYA FORMULA X REPRESENTA HIDROGENO O HIDROXI; R 1 Y R 2 , QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN HIDROGENO O UN RADICAL ALQUILO C 1 - C 3 ; O R 1 Y R 2 , JUNTOS CON EL ATOMO DE CARBONO DEL GRUPO X, PUEDEN FORMAR UN ANILLO CARBOCICLICO C 3 - C 6 ; R 3 REPRESENTA UN RADICAL ALQUILO C 1 - C 3 , UN ARILO O UN RADICAL ARALQUILO, O YR 4 , REPRESENTANDO Y LOS RADICALES CO - S -, - CS - O - O - CS - S -, Y R 4 REPRESENTA UN RADICAL ALQUILO C 1 - C 3 O UN ARILO O UN RADICAL ARAL QUILO; Q ES (CH 2 ) N , SIENDO N DE 1 A 4; R 1 , R2 Y Q PUEDEN SER SUSTITUIDOS OPCIONALMENTE, INDEPENDIENT EMENTE, POR UNO O MAS ATOMOS DE FLUOR. LOS COMPUESTOS PRESENTAN UNA POTENTE ACTIVIDAD PARA INDUCIR UNA DIFERENCIACION E INHIBIR UNA PROLIFERACION NO DESEADA DE CIERTAS CELULAS ASI COMO EFECTOS INMUNOMODULADORES Y ANTIINFLAMATORIOS.
ES97924929T 1996-06-04 1997-05-15 Nuevos analogos de la vitamina d. Expired - Lifetime ES2179343T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9611603.3A GB9611603D0 (en) 1996-06-04 1996-06-04 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2179343T3 true ES2179343T3 (es) 2003-01-16

Family

ID=10794707

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97924929T Expired - Lifetime ES2179343T3 (es) 1996-06-04 1997-05-15 Nuevos analogos de la vitamina d.

Country Status (17)

Country Link
US (1) US6197982B1 (es)
EP (1) EP0906276B1 (es)
JP (1) JP2000511894A (es)
CN (1) CN1217926C (es)
AT (1) ATE221875T1 (es)
AU (1) AU714223B2 (es)
CZ (1) CZ296255B6 (es)
DE (1) DE69714590T2 (es)
DK (1) DK0906276T3 (es)
ES (1) ES2179343T3 (es)
GB (1) GB9611603D0 (es)
NZ (1) NZ332237A (es)
PL (1) PL186804B1 (es)
PT (1) PT906276E (es)
RO (1) RO120133B1 (es)
RU (1) RU2165413C2 (es)
WO (1) WO1997046522A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090098065A1 (en) * 2000-01-11 2009-04-16 Avikam Harel Composition and methods for the treatment of skin disorders
EP1458678A1 (en) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited A crystallization method for purification of calcipotriene
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
RU2452488C2 (ru) * 2006-08-29 2012-06-10 Тева Фармасьютикал Индастриес Лтд. Фармацевтические композиции, содержащие витамин группы d и кортикостероид
US8377913B2 (en) * 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
CN102655869B (zh) 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
NZ601001A (en) * 2009-12-22 2014-07-25 Leo Pharma As Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue
BR112012015433B8 (pt) * 2009-12-22 2020-03-03 Leo Pharma As composição farmacêutica substancialmente anidra para aplicação cutânea
ATE550318T1 (de) * 2010-01-26 2012-04-15 Hybrigenics Sa Neues verfahren zur isomerisierung kondensierter bicyclischer strukturen und herstellung von diese enthaltenden vitamin d analoga
RU2558362C2 (ru) 2010-10-25 2015-08-10 Тейдзин Фарма Лимитед Производное 23-ин-витамина d3
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
AU2016234990B2 (en) 2015-10-02 2018-12-06 Lg Electronics Inc. Washing machine and method for controlling the same
AU2016234988B2 (en) 2015-10-02 2018-08-02 Lg Electronics Inc. Washing machine
US20170096769A1 (en) 2015-10-02 2017-04-06 Lg Electronics Inc. Method for controlling washing machine
WO2021107646A1 (ko) * 2019-11-27 2021-06-03 연성정밀화학(주) 막사칼시톨의 제조방법 및 그를 위한 중간체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU688125A3 (ru) * 1974-12-09 1979-09-25 Тейдзин Лимитед (Фирма) Способ получени 1 , 24/ /диокси-холекальциферола или 1 , 24 / /-диоксихолекальциферола или их производных
DE3865544D1 (de) * 1987-06-23 1991-11-21 Yamanouchi Pharma Co Ltd Vitamin d3-derivate.
GB9206648D0 (en) 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds

Also Published As

Publication number Publication date
CZ397198A3 (cs) 1999-03-17
HK1019733A1 (en) 2000-02-25
US6197982B1 (en) 2001-03-06
EP0906276B1 (en) 2002-08-07
DK0906276T3 (da) 2002-12-02
RO120133B1 (ro) 2005-09-30
CN1217926C (zh) 2005-09-07
PT906276E (pt) 2002-12-31
GB9611603D0 (en) 1996-08-07
AU3025697A (en) 1998-01-05
AU714223B2 (en) 1999-12-23
DE69714590T2 (de) 2003-04-24
ATE221875T1 (de) 2002-08-15
EP0906276A1 (en) 1999-04-07
PL186804B1 (pl) 2004-02-27
DE69714590D1 (de) 2002-09-12
PL329941A1 (en) 1999-04-26
CN1219928A (zh) 1999-06-16
CZ296255B6 (cs) 2006-02-15
NZ332237A (en) 2000-07-28
JP2000511894A (ja) 2000-09-12
RU2165413C2 (ru) 2001-04-20
WO1997046522A1 (en) 1997-12-11

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