ES2108497T3 - Compuestos de 3-benzoil-3,7-diazabiciclo(3,3,1)nonano con accion antiarritmica. - Google Patents

Compuestos de 3-benzoil-3,7-diazabiciclo(3,3,1)nonano con accion antiarritmica.

Info

Publication number
ES2108497T3
ES2108497T3 ES95100953T ES95100953T ES2108497T3 ES 2108497 T3 ES2108497 T3 ES 2108497T3 ES 95100953 T ES95100953 T ES 95100953T ES 95100953 T ES95100953 T ES 95100953T ES 2108497 T3 ES2108497 T3 ES 2108497T3
Authority
ES
Spain
Prior art keywords
pharmaceutical preparations
diazabiciclo
benzoil
compounds
treatments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95100953T
Other languages
English (en)
Inventor
Uwe Dr Schon
Reinhard Dr Bruckner
Jorg Dr Meil
Dirk Dr Thormahlen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Solvay Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals GmbH filed Critical Solvay Pharmaceuticals GmbH
Application granted granted Critical
Publication of ES2108497T3 publication Critical patent/ES2108497T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE LA UTILIZACION DE LOS COMPUESTOS 3 - BENZOIL - 3,7 - DIAZABICICLO[3,3,1]NONANOS DE LA FORMULA GENERAL I DONDE R1 SIGNIFICA UN GRUPO ALQUIL CON 1 - 6 ATOMOS DE CARBONO O UN GRUPO CICLOALQUIL ALQUIL CON 4 - 7 ATOMOS DE CARBONO, R2 SIGNIFICA ALQUIL INFERIOR Y R3 SIGNIFICA ALQUIL INFERIOR O R2 Y R3 DE FORMA CONJUNTA FORMAN UNA CADENA ALQUILENO CON 3 - 6 ATOMOS DE CARBONO, R4 ES HIDROGENO, HALOGENO, CIANO, NITRO, TRIFLUORMETIL O EL GRUPO R6 - SO2, DONDE R6 SIGNIFICA FLUOR O ALQUIL INFERIOR, Y R5 SIGNIFICA HIDROGENO, HALOGENO, TRIFLUOR METIL O NITRO, Y SUS SALES DE ADICION ACIDA TOLERABLES FISIOLOGICAMENTE PARA LA ELABORACION DE PREPARACIONES FARMACEUTICAS EN EL TRATAMIENTO DE PERTURBACIONES DEL RITMO CARDIACO EN MAMIFEROS GRANDES Y SERES HUMANOS.
ES95100953T 1994-02-01 1995-01-25 Compuestos de 3-benzoil-3,7-diazabiciclo(3,3,1)nonano con accion antiarritmica. Expired - Lifetime ES2108497T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4402933A DE4402933A1 (de) 1994-02-01 1994-02-01 Neue 3-Benzoyl-3,7-diazabicyclo[3,3,1] nonan-Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ES2108497T3 true ES2108497T3 (es) 1997-12-16

Family

ID=6509147

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95100953T Expired - Lifetime ES2108497T3 (es) 1994-02-01 1995-01-25 Compuestos de 3-benzoil-3,7-diazabiciclo(3,3,1)nonano con accion antiarritmica.

Country Status (21)

Country Link
US (1) US5532251A (es)
EP (1) EP0665014B1 (es)
JP (1) JP3762799B2 (es)
KR (1) KR100352898B1 (es)
CN (1) CN1110556A (es)
AT (1) ATE157539T1 (es)
AU (1) AU1146895A (es)
CA (1) CA2141367A1 (es)
CZ (1) CZ25295A3 (es)
DE (2) DE4402933A1 (es)
ES (1) ES2108497T3 (es)
FI (1) FI950423L (es)
HU (1) HUT70173A (es)
IL (1) IL112344A (es)
NO (1) NO950361L (es)
NZ (1) NZ270372A (es)
PL (1) PL184904B1 (es)
SK (1) SK11695A3 (es)
TW (1) TW284764B (es)
UA (1) UA39179C2 (es)
ZA (1) ZA95698B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030302A1 (es) * 2000-07-07 2003-08-20 Astrazeneca Ab Compuestos de bispidina, formulacion farmaceutica, uso para la fabricacion de medicamentos, proceso para la preparacion de estos compuestos y compuestos intermediarios
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
DE10131217A1 (de) 2001-06-28 2003-01-09 Solvay Pharm Gmbh 3-Phenyl-3,7-diazabicyclo 3,3,1 nonan-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
TW200418468A (en) * 2002-11-18 2004-10-01 Solvay Pharm Gmbh Liquid pharmaceutical formulations containing 3,7-diazabicyclo[3,3,1]nonane compounds and method of treatments relating to anti-arrhytmic events
GB201716871D0 (en) 2017-10-13 2017-11-29 Inst Of Cancer Research: Royal Cancer Hospital Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658558A1 (de) * 1976-12-23 1978-06-29 Bayer Ag Diazabicyclo(3,3,1)nonane, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
PT88381B (pt) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
DE4019080A1 (de) * 1990-06-15 1991-12-19 Kali Chemie Pharma Gmbh Neue 3,7-diazabicycolo (3,3,1)nonan-verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
IL112344A0 (en) 1995-03-30
PL184904B1 (pl) 2003-01-31
US5532251A (en) 1996-07-02
EP0665014A1 (de) 1995-08-02
JPH07252152A (ja) 1995-10-03
SK11695A3 (en) 1995-11-08
EP0665014B1 (de) 1997-09-03
NO950361L (no) 1995-08-02
CN1110556A (zh) 1995-10-25
JP3762799B2 (ja) 2006-04-05
CZ25295A3 (en) 1995-10-18
UA39179C2 (uk) 2001-06-15
PL307001A1 (en) 1995-08-07
KR950031072A (ko) 1995-12-18
DE59500575D1 (de) 1997-10-09
FI950423A7 (fi) 1995-08-02
FI950423L (fi) 1995-08-02
KR100352898B1 (ko) 2002-12-26
NO950361D0 (no) 1995-01-31
ZA95698B (en) 1996-02-07
IL112344A (en) 1997-06-10
ATE157539T1 (de) 1997-09-15
HUT70173A (en) 1995-09-28
TW284764B (es) 1996-09-01
CA2141367A1 (en) 1995-08-02
DE4402933A1 (de) 1995-08-03
NZ270372A (en) 1997-05-26
AU1146895A (en) 1995-08-10
FI950423A0 (fi) 1995-01-31

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