ES2109929T3 - Procedimiento para preparar un glucano de levadura - Google Patents

Procedimiento para preparar un glucano de levadura

Info

Publication number
ES2109929T3
ES2109929T3 ES91111143T ES91111143T ES2109929T3 ES 2109929 T3 ES2109929 T3 ES 2109929T3 ES 91111143 T ES91111143 T ES 91111143T ES 91111143 T ES91111143 T ES 91111143T ES 2109929 T3 ES2109929 T3 ES 2109929T3
Authority
ES
Spain
Prior art keywords
glucan
crustacea
stimulate
beta
subphylum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91111143T
Other languages
English (en)
Inventor
Gunnar Rorstad
Borre Robertson
Jan Raa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arcticzymes Technologies ASA
Original Assignee
Biotec Mackzymal ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotec Mackzymal ASA filed Critical Biotec Mackzymal ASA
Application granted granted Critical
Publication of ES2109929T3 publication Critical patent/ES2109929T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Catching Or Destruction (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA ESTIMULAR EL SISTEMA INMUNOLOGICO DE LOS ANIMALES ACUATICOS DE LA CLASE OSTEICHTIES Y CRUSTACEA SUBPHYLUM QUE COMPRENDEN LA ADMINISTRACION DE UNA CANTIDAD EFECTIVA DE UNA GLUCANO DE PARED DE CELULA DE LEVADURA COMPUESTO DE UNIDADES DE GLUCOPIRANOSA ENLAZADAS PREDOMINANTEMENTE POR ENLACES BETA-1,3 GLUCOSIDICO, QUE TIENE AL MENOS UNA RAMA DE ESTE COMPUESTO DE UNIDADES DE GLUCOPIRANOSA ENLAZADAS POR ENLACES BETA-1,6 GLICOSIDICOS. ADEMAS LA INVENCION SE REFIERE A UN PROCESO PARA MEJORAR EL EFECTO DE LAS VACUNAS ADMINISTRANDO UNA CANTIDAD EFECTIVA DEL GLUCANO DE PARED DE CELULA DE LEVADURA JUNTO CON LOS ANTIGENO DE VACUNA. ESTA INVENCION TAMBIEN SE REFIERE A UN PROCESO PARA OBTENER UN GLUCANO PARTICULARMENTE EFECTIVO PARA ESTIMULAR EL SISTEMA INMUNOLOGICO DE LOS ANIMALES ACUATICOS DE LA CLASE OSTEICHTHYES Y CRUSTACEA SUBPHYLUM.
ES91111143T 1990-07-06 1991-07-04 Procedimiento para preparar un glucano de levadura Expired - Lifetime ES2109929T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54957590A 1990-07-06 1990-07-06

Publications (1)

Publication Number Publication Date
ES2109929T3 true ES2109929T3 (es) 1998-02-01

Family

ID=24193557

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91111143T Expired - Lifetime ES2109929T3 (es) 1990-07-06 1991-07-04 Procedimiento para preparar un glucano de levadura

Country Status (12)

Country Link
US (1) US5401727A (es)
EP (1) EP0466037B1 (es)
JP (1) JP2828799B2 (es)
AT (1) ATE160787T1 (es)
AU (1) AU628752B2 (es)
CA (1) CA2040374C (es)
DE (1) DE69128308T2 (es)
DK (1) DK0466037T3 (es)
ES (1) ES2109929T3 (es)
FI (1) FI104537B (es)
GR (1) GR3026130T3 (es)
NO (1) NO305705B1 (es)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0665649B2 (ja) * 1991-02-01 1994-08-24 台糖株式会社 甲殻類の生体防御能増強剤、感染症予防ワクチン及び飼料
JP3522772B2 (ja) * 1991-05-21 2004-04-26 台糖株式会社 ワクチンの免疫効果増強剤
EP0640348A1 (en) * 1993-07-26 1995-03-01 Akzo Nobel N.V. Oil-based and water-based adjuvant mixture
PT664671E (pt) * 1993-08-06 2003-01-31 Biotec Pharmacon Asa Racoes para animais compreendendo glucano de levedura
JPH08113539A (ja) * 1993-09-22 1996-05-07 Nippon Paper Ind Co Ltd 免疫増強剤及びその製造方法、並びにそれを用いた甲殻類及び魚類の養殖用飼料
NO300692B1 (no) * 1994-04-29 1997-07-07 Biotec Mackzymal As Solubilisert forgrenet ß-1,3-glukan og anvendelse derav samt anvendelse av usolubilisert forgrenet ß-1,3-glukan
US5871751A (en) * 1994-10-12 1999-02-16 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Renibacterium salmoninarum vaccine and method for its preparation
JP3744020B2 (ja) * 1995-04-14 2006-02-08 日本製紙株式会社 免疫増強剤並びにそれを含有する甲殻類、魚類及び家畜用飼料
CA2231244C (en) 1995-09-05 2009-04-14 Tetra Werke Dr. Rer. Nat. Ulrich Baensch Gmbh Anti-stress agents for aquatic animals
US5722346A (en) * 1996-04-17 1998-03-03 The Board Of Governors For Higher Education Smolting feed
US5786343A (en) * 1997-03-05 1998-07-28 Immudyne, Inc. Phagocytosis activator compositions and their use
AU6691598A (en) * 1997-04-18 1998-11-13 Immudyne, Inc. Gel delivery system for animal nutrition and health
CA2344166C (en) * 1998-09-14 2008-11-18 Nabi Compositions of .beta.-glucans and specific igiv
US7030101B2 (en) 1998-09-14 2006-04-18 Nabi Biopharmaceuticals Compositions of β-glucans and specific antibodies
US20020009463A1 (en) * 2000-02-23 2002-01-24 Jan Raa Novel, non-antigenic, mucosal adjuvant formulation which enhances the effects of substances, including vaccine antigens, in contact with mucosal body surfaces
US20040127458A1 (en) * 2000-11-06 2004-07-01 Hunter Kenneth W. Beta-glucan containing compositions, methods for manufacturing beta-glucans, and for manufacturing and using beta-glucans and conjugates thereof as vaccine adjuvants
US7923437B2 (en) * 2001-02-16 2011-04-12 Cargill, Incorporated Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same
US8222232B2 (en) * 2001-02-16 2012-07-17 Cargill, Incorporated Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass
US7816514B2 (en) 2001-02-16 2010-10-19 Cargill, Incorporated Glucosamine and method of making glucosamine from microbial biomass
US7323140B2 (en) * 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6939864B1 (en) 2001-07-09 2005-09-06 Purdue Research Foundation Animal feed compositions and methods of using the same
KR20050043751A (ko) * 2001-11-06 2005-05-11 오리엔트 캔서 세라피 컴퍼니 리미티드 항암 조성물
DE10222358A1 (de) * 2002-05-21 2003-12-11 Nutrinova Gmbh ß-Glucanhaltiges Sorbinsäurepräparat als Futtermittelzusatz in der Nutztieraufzucht
US7018986B2 (en) * 2002-09-20 2006-03-28 Immudyne Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption
GB0225503D0 (en) * 2002-11-01 2002-12-11 Zoolife Internat Ltd Gel feed
GB0225502D0 (en) * 2002-11-01 2002-12-11 Zoolife Internat Ltd Therapeutic and prophylactic preparations
JP2004210895A (ja) * 2002-12-27 2004-07-29 Immudyne Japan:Kk 免疫機能を有する可能性β−グルカンの製造方法及び用途
JP2007524354A (ja) * 2003-01-29 2007-08-30 イミュダイン インコーポレーティッド 動物用の免疫増強剤
GB2399752A (en) * 2003-03-26 2004-09-29 Micap Plc Pharmaceutical composition comprising a fungal cell or cell fragment as adjuvant
PL1711058T3 (pl) 2004-01-23 2022-02-07 Eden Research Plc Sposoby zabijania nicieni obejmujące aplikację składnika terpenowego
DK1753529T3 (da) 2004-05-20 2013-11-11 Eden Research Plc Komposition indeholdende en hul glucan-partikel eller en hul cellevægspartikel, der indkapsler en terpenkomponent, fremgangsmåder til fremstilling og anvendelse af disse
US7740861B2 (en) * 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
CN101052383B (zh) * 2004-09-17 2013-01-30 马萨诸塞大学 用于溶酶体酶缺乏症的组合物和其用途
US7306818B2 (en) * 2005-01-03 2007-12-11 Promd Biotech Co., Ltd. Method for preventing and/or treating viral infection in aquatic animals
WO2006121803A1 (en) 2005-05-05 2006-11-16 Sensient Flavors Inc. Production of beta-glucans and mannans
JP5489462B2 (ja) * 2005-10-24 2014-05-14 ユニバーシティ オブ マサチューセッツ 骨病状の遺伝子治療のための組成物およびそれらの使用法
EP2982244B1 (en) 2005-11-30 2020-11-18 Eden Research Plc Insecticidal capsules containing thymol and methods of making and using them
EP1954130B1 (en) 2005-11-30 2018-06-13 Eden Research Plc Methods comprising terpene mixtures comprising thymol and citral
WO2008102151A1 (en) * 2007-02-21 2008-08-28 Biotec Pharmacon Asa Medical uses of glucans
JP5153188B2 (ja) * 2007-03-30 2013-02-27 小林製薬株式会社 Ｔｈ１／Ｔｈ２バランス改善剤
US20090061049A1 (en) * 2007-08-28 2009-03-05 Vadood Azarm Feed compositions for aquatic animals and methods of making the same
EP2222283A2 (en) * 2007-10-29 2010-09-01 University of Massachusetts Yeast cell wall protein (ycwp) encapsulated multilayered nanoparticles for nucleic acid delivery (sirna)
CA2705642A1 (en) * 2007-11-13 2009-05-22 Biotec Pharmacon Asa Methods of treating or preventing inflammatory diseases of the intestinal tract
CA2705544A1 (en) * 2007-11-19 2009-05-28 Calanus As Bioactive copepod-compositions, processes for the production thereof, and use thereof to prevent or treat hosts infested by phylogenetically similar ectoparasites
WO2010008582A2 (en) 2008-07-18 2010-01-21 Rxi Pharmaceuticals Corporation Phagocytic cell drug delivery system
WO2010078536A1 (en) 2009-01-05 2010-07-08 Rxi Pharmaceuticals Corporation Inhibition of pcsk9 through rnai
US20100267661A1 (en) * 2009-03-17 2010-10-21 Immudyne, Inc. Beta glucans and methods of use thereof
CN103200945B (zh) 2010-03-24 2016-07-06 雷克西制药公司 眼部症候中的rna干扰
KR101852210B1 (ko) 2010-03-24 2018-04-25 알엑스아이 파마슈티칼스 코포레이션 진피 및 섬유증성 적응증에서의 ｒｎａ 간섭
US9242857B2 (en) 2010-08-14 2016-01-26 University Of Massachusetts Yeast cell wall particles for receptor-targeted nanoparticle delivery
WO2012120290A2 (en) 2011-03-04 2012-09-13 Sana Pharma As Cosmetic formulations
GB201220940D0 (en) 2012-11-21 2013-01-02 Eden Research Plc Method P
US20160278367A1 (en) 2013-11-21 2016-09-29 Eden Research Plc Pesticidal Composition
CN105960265A (zh) 2013-12-04 2016-09-21 阿克赛医药公司 利用经化学修饰的寡核苷酸处理伤口愈合的方法
WO2015168108A2 (en) 2014-04-28 2015-11-05 Rxi Pharmaceuticals Corporation Methods for treating cancer using nucleic targeting mdm2 or mycn
US20170051290A1 (en) 2014-05-01 2017-02-23 Rxi Pharmaceuticals Corporation Methods for treatment of disorders in the front of the eye utilizing nucleic acid molecules
US10900039B2 (en) 2014-09-05 2021-01-26 Phio Pharmaceuticals Corp. Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
EP3234141A4 (en) 2014-12-18 2018-06-20 Alnylam Pharmaceuticals, Inc. Reversir tm compounds
GB201501793D0 (en) 2015-02-03 2015-03-18 Eden Research Plc Encapsulation of high potency active agents
KR20180026739A (ko) 2015-07-06 2018-03-13 알엑스아이 파마슈티칼스 코포레이션 슈퍼옥시드 디스뮤타제 1 (sod1)을 표적화하는 핵산 분자
US10808247B2 (en) 2015-07-06 2020-10-20 Phio Pharmaceuticals Corp. Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
EP3138573A1 (en) * 2015-07-09 2017-03-08 Danstar Ferment AG Compositions and methods for stimulating immune responses in human and/or animal
JP2018531037A (ja) 2015-10-19 2018-10-25 アールエックスアイ ファーマシューティカルズ コーポレーション 長い非コードｒｎａを標的とする減少したサイズの自己送達型核酸化合物
CN106719136A (zh) * 2016-11-30 2017-05-31 蚌埠市渔歌农业科技有限公司 一种防治鲶鱼病害的养殖方法
WO2018195355A1 (en) 2017-04-19 2018-10-25 Rxi Pharmaceuticals Corporation Topical delivery of nucleic acid compounds
JP6530846B1 (ja) * 2018-10-09 2019-06-12 アサヒグループホールディングス株式会社 免疫賦活剤及び感染予防方法
US20230002766A1 (en) 2019-11-08 2023-01-05 Phio Pharmaceuticals Corp. Chemically modified oligonucleotides targeting bromodomain containing protein 4 (brd4) for immunotherapy
JPWO2022244580A1 (es) * 2021-05-21 2022-11-24
TW202449152A (zh) 2023-02-09 2024-12-16 美商艾拉倫製藥股份有限公司 Ｒｅｖｅｒｓｉｒ分子及其使用方法
WO2025078537A1 (en) 2023-10-10 2025-04-17 Ab Mauri (Uk) Ltd Compositions comprising branched (1,3)(1,6)-beta-glucans for use in the treatment of cancer
WO2025078523A1 (en) 2023-10-10 2025-04-17 Ab Mauri (Uk) Ltd Compositions comprising a combination of (1,3)(1,6)-beta-glucans and uses thereof in therapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3301848A (en) * 1962-10-30 1967-01-31 Pillsbury Co Polysaccharides and methods for production thereof
GB2076418A (en) * 1980-05-22 1981-12-02 Sankyo Co Hydrolyzed polysaccharide
SE456911B (sv) * 1983-12-19 1988-11-14 Olle Larm Vattenloeslig, aminerad beta-1,3-bunden d-glukan och makrofagstimulerande komposition innehaallande densamma
JPS6120561A (ja) * 1984-07-09 1986-01-29 住友ベークライト株式会社 医療用吸着剤
US4810646A (en) * 1984-11-28 1989-03-07 Massachusetts Institute Of Technology Glucan compositions and process for preparation thereof
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
JPS6337801A (ja) * 1986-07-31 1988-02-18 Matsushita Electric Ind Co Ltd タ−ンテ−ブル
CA1330303C (en) * 1989-02-20 1994-06-21 Libor Henry Nikl Composition and process to enhance the efficacy of a fish vaccine

Also Published As

Publication number Publication date
CA2040374A1 (en) 1992-01-07
DE69128308D1 (de) 1998-01-15
JPH04253703A (ja) 1992-09-09
FI913275L (fi) 1992-01-07
US5401727A (en) 1995-03-28
DE69128308T2 (de) 1998-03-26
FI913275A0 (fi) 1991-07-05
EP0466037B1 (en) 1997-12-03
FI104537B (fi) 2000-02-29
EP0466037A2 (en) 1992-01-15
NO912645D0 (no) 1991-07-05
EP0466037A3 (en) 1992-10-28
JP2828799B2 (ja) 1998-11-25
AU628752B2 (en) 1992-09-17
NO305705B1 (no) 1999-07-12
NO912645L (no) 1992-01-07
CA2040374C (en) 1998-06-16
GR3026130T3 (en) 1998-05-29
DK0466037T3 (da) 1998-08-10
AU7933891A (en) 1992-01-23
ATE160787T1 (de) 1997-12-15

Similar Documents

Publication Publication Date Title
ES2109929T3 (es) Procedimiento para preparar un glucano de levadura
ES2155540T3 (es) Adyuvante para vacunas que comprende un polisacarido sulfolipidico hidrofobo.
ES2118109T3 (es) Antigenos polisacaridos de streptococcus pneumoniae.
ES2191016T3 (es) Anticuerpos monoclonales neutralizantes humanos para el virus respiratorio sincitial.
PT714444E (pt) Atenuacao de um epitopo imunodominante de um antigenio para utilizacao em vacinas e imunoterapias para plantas, animais e homens
ES2099744T3 (es) Sistema de localizacion.
ES2084827T3 (es) Composiciones de vacuna mejoradas.
AR002255A1 (es) Una composicion que comprende una formulacion de antigeno microfluidizada y usos de dicha formulacion.
ES2063033T3 (es) Empleo de igf-ii en el tratamiento de la enfermedades de los huesos.
ATE166530T1 (de) Vorrichtung zur frühembryonalen in ovo injektion
ES2134197T3 (es) Vacunas contra el virus del herpes simplex vp16.
ATE255419T1 (de) Für den vogelembryo geeignete multivalente impfstoffe
ES8900007A1 (es) Un metodo para producir normas orales frente a virus de hepatitis-b.
ES2194836T3 (es) Peptidos para su uso en vacunacion e induccion de anticuerpos neutralizantes contra el virus de la inmunodeficiencia humana.
GB1183506A (en) New vaccines for combating influenza and the preparation thereof
ES2160601T3 (es) Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina.
MX9301014A (es) Composiciones citoprotectora y metodos para preparar y usar las mismas.
NL165217C (nl) Werkwijze voor het bereiden van een vaccin voor het immuniseren van pluimvee tegen de ziekte van marek.
AR023536A1 (es) Vacunas
ATE211923T1 (de) Parenterale immunisierung gegen rotavirus
ES2055610T3 (es) Vacuna contra hrsv.
ES2055164T3 (es) Preparaciones efectivas contra infecciones por pseudomonas aeruginosa asi como preparaciones que contienen inmunoglobulina-g, efectivas contra la bacteria pseudomonas aeruginosa.
MX9401384A (es) Uso de vacunas anti-helminticas en el control de la enfermedad por parasitos asociada con la perdidade la inmunidad natural.
AR117783A1 (es) Tratamiento agudo y tratamiento rápido del dolor de cabeza utilizando anticuerpos anti-cgrp
Reynolds Method to provide artificial passive immunity in birds

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 466037

Country of ref document: ES