ES2111615T3 - Imidazolidil macrolidos con actividad inmunosupresora. - Google Patents

Imidazolidil macrolidos con actividad inmunosupresora.

Info

Publication number
ES2111615T3
ES2111615T3 ES92308132T ES92308132T ES2111615T3 ES 2111615 T3 ES2111615 T3 ES 2111615T3 ES 92308132 T ES92308132 T ES 92308132T ES 92308132 T ES92308132 T ES 92308132T ES 2111615 T3 ES2111615 T3 ES 2111615T3
Authority
ES
Spain
Prior art keywords
imidazolidil
macrolides
immunosuppressive activity
diseases
immunosuppressive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92308132T
Other languages
English (en)
Inventor
Mark Goulet
Matthew J Wyvratt
Peter J Sinclair
Frederick Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2111615T3 publication Critical patent/ES2111615T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE PRESENTAN MACROLIDOS DE IMIDAZOLIDIL DE LA FORMULA ESTRUCTURAL GENERAL DE LA FORMULA (I): QUE HAN SIDO PREPARADOS A PARTIR DE PRECURSORES ADECUADOS MEDIANTE ALQUILATACION Y/O ARILACION EN C-3" Y/O C-4" DEL ANILLO CICLOEXIL. ESTOS MACROLIDOS INMUNOSUPRESANTES SON UTILES EN LOS MAMIFEROS PARA EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES, ENFERMEDADES INFECCIOSAS, LA PREVENCION DEL RECHAZO DE ORGANOS TRANSPLANTADOS Y PARA LAS AFECCIONES Y ENFERMEDADES RELACIONADAS.
ES92308132T 1991-09-09 1992-09-08 Imidazolidil macrolidos con actividad inmunosupresora. Expired - Lifetime ES2111615T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75663391A 1991-09-09 1991-09-09
US07/921,181 US5247076A (en) 1991-09-09 1992-08-04 Imidazolidyl macrolides having immunosuppressive activity
CA002116674A CA2116674C (en) 1991-09-09 1992-09-02 Imidazolidyl macrolides

Publications (1)

Publication Number Publication Date
ES2111615T3 true ES2111615T3 (es) 1998-03-16

Family

ID=27169717

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92308132T Expired - Lifetime ES2111615T3 (es) 1991-09-09 1992-09-08 Imidazolidil macrolidos con actividad inmunosupresora.

Country Status (23)

Country Link
US (2) US5247076A (es)
EP (1) EP0536896B1 (es)
JP (1) JP3098032B2 (es)
AT (1) ATE161266T1 (es)
AU (1) AU669672B2 (es)
BG (1) BG98640A (es)
CA (1) CA2116674C (es)
CZ (1) CZ47394A3 (es)
DE (1) DE69223583T2 (es)
DK (1) DK0536896T3 (es)
ES (1) ES2111615T3 (es)
FI (1) FI941084L (es)
GR (1) GR3025993T3 (es)
HU (1) HUT67267A (es)
IL (1) IL103011A (es)
NO (1) NO940804L (es)
NZ (1) NZ244154A (es)
PL (2) PL172789B1 (es)
RO (1) RO112620B1 (es)
RU (1) RU2108338C1 (es)
SK (1) SK28694A3 (es)
WO (1) WO1993005059A1 (es)
ZA (1) ZA926813B (es)

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US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
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WO1994021253A1 (en) * 1993-03-17 1994-09-29 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
WO1995020590A1 (en) * 1994-01-27 1995-08-03 The Trustees Of Columbia University In The City Of New York Enantioselective receptors for amino acid derivatives, and other compounds
US5496831A (en) * 1994-05-13 1996-03-05 The General Hospital Corporation Inhibition of insulin-induced adiposis
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5491159A (en) * 1994-08-30 1996-02-13 American Home Products Corporation 2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-oxazoles as anti-atherosclerotic agents
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
DK0786986T3 (da) 1994-10-26 2002-04-29 Novartis Ag Anvendelse af en umættet fedtalkohol
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
US6124453A (en) * 1995-07-04 2000-09-26 Novartis Ag Macrolides
CA2229718A1 (en) * 1995-08-24 1997-03-06 David J. Mathre Process for the preparation of imidazolyl macrolide immunosuppressants
US5777105A (en) * 1995-08-24 1998-07-07 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
US5877184A (en) * 1996-08-06 1999-03-02 Merck & Co., Inc. Macrolides having immunosuppressive activity
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
AU749623B2 (en) 1998-03-26 2002-06-27 Astellas Pharma Inc. Sustained release preparations
TR200003108T2 (tr) * 1998-04-27 2001-02-21 Fujisawa Pharmaceutical Co., Ltd. İlaç kompozisyonları
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
IL147803A0 (en) * 1999-08-24 2002-08-14 Ariad Gene Therapeutics Inc 28-epirapalogs
RU2189206C2 (ru) * 2000-02-04 2002-09-20 Ченцова Екатерина Валериановна Способ лечения дефектов роговицы
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
TWI324925B (en) * 2001-08-23 2010-05-21 Novartis Ag Ophthalmic composition
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
WO2005097766A1 (en) * 2004-03-31 2005-10-20 Lexicon Genetics, Inc. 2-aminomethylthiazole-5-carboxamides as protein kinase modulators
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
TW200637869A (en) * 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
US8859160B2 (en) * 2006-06-07 2014-10-14 Peugeot Citroen Automobiles Sa Monomers and polymers carrying imidazole and benzimidazole groupings, and proton exchange membrane containing the same for the production of a fuel cell
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
EP2245165A4 (en) * 2008-01-11 2011-06-01 Massachusetts Eye & Ear Infirm TRANSGENIC CONDITIONAL STOP DIMERICABLE CASPASE ANIMALS
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP3974831A1 (en) 2010-10-22 2022-03-30 T2 Biosystems, Inc. Methods for detecting the presence of a bacterium in a whole blood sample
WO2013158281A1 (en) 2012-04-20 2013-10-24 T2 Biosystems, Inc. Compositions and methods for detection of candida species
CN105283553B (zh) 2013-06-11 2021-06-25 克隆技术实验室有限公司 蛋白质富集的微泡及其制备和使用方法
US10143682B2 (en) 2014-10-28 2018-12-04 Koushi Yamaguchi Medicine for improving state of pregnancy, and use thereof
US10945997B2 (en) 2016-01-08 2021-03-16 Nippon Kayaku Kabushiki Kaisha Polymer derivative of macrolide immunosuppressant
US11519016B2 (en) 2016-01-21 2022-12-06 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
AU2019318035A1 (en) 2018-08-10 2021-03-04 Koushi Yamaguchi Therapeutic agent for humoral immunity-related diseases in materno-fetal relationship
CN113226331A (zh) 2018-12-18 2021-08-06 山口晃史 用于改善不孕不育症或妊娠状态的药物

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PH26083A (en) * 1987-11-09 1992-02-06 Sandoz Ltd 11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof
WO1990015805A1 (en) * 1989-06-14 1990-12-27 Sandoz Ltd Heteroatoms-containing tricyclic compounds
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US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
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CA2044846A1 (en) * 1990-06-25 1991-12-26 Thomas R. Beattie Antagonists of immunosuppressive macrolides
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
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US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
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US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity

Also Published As

Publication number Publication date
AU2660992A (en) 1993-04-05
HUT67267A (en) 1995-03-28
FI941084A7 (fi) 1994-03-08
DE69223583T2 (de) 1998-07-02
NO940804L (no) 1994-05-06
RU2108338C1 (ru) 1998-04-10
CA2116674C (en) 2002-09-17
NO940804D0 (no) 1994-03-08
RO112620B1 (ro) 1997-11-28
CZ47394A3 (en) 1994-10-19
JP3098032B2 (ja) 2000-10-10
ZA926813B (en) 1994-03-07
FI941084A0 (fi) 1994-03-08
AU669672B2 (en) 1996-06-20
JPH06510303A (ja) 1994-11-17
EP0536896B1 (en) 1997-12-17
SK28694A3 (en) 1994-08-10
NZ244154A (en) 1995-05-26
US5247076A (en) 1993-09-21
BG98640A (bg) 1995-05-31
DK0536896T3 (da) 1998-01-19
IL103011A0 (en) 1993-02-21
PL172789B1 (pl) 1997-11-28
ATE161266T1 (de) 1998-01-15
FI941084L (fi) 1994-03-08
DE69223583D1 (de) 1998-01-29
CA2116674A1 (en) 1993-03-18
EP0536896A1 (en) 1993-04-14
GR3025993T3 (en) 1998-04-30
PL172637B1 (pl) 1997-10-31
IL103011A (en) 1997-02-18
HU9400687D0 (en) 1994-06-28
US5344925A (en) 1994-09-06
WO1993005059A1 (en) 1993-03-18

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