ES2147754T3 - Inactivacion selectiva de celulas en sangre. - Google Patents

Inactivacion selectiva de celulas en sangre.

Info

Publication number
ES2147754T3
ES2147754T3 ES93909729T ES93909729T ES2147754T3 ES 2147754 T3 ES2147754 T3 ES 2147754T3 ES 93909729 T ES93909729 T ES 93909729T ES 93909729 T ES93909729 T ES 93909729T ES 2147754 T3 ES2147754 T3 ES 2147754T3
Authority
ES
Spain
Prior art keywords
blood
cells
treatment
high levels
selective inactivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93909729T
Other languages
English (en)
Inventor
Janice North
Julia Levy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Novelion Therapeutics Inc
Original Assignee
University of British Columbia
QLT Phototherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia, QLT Phototherapeutics Inc filed Critical University of British Columbia
Application granted granted Critical
Publication of ES2147754T3 publication Critical patent/ES2147754T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EL TRATAMIENTO CON UN CONJUNTO DE COMPUESTOS DE PORFIRINA, USANDO PROCEDIMIENTO DE TERAPIA FOTODINAMICA, ES CAPAS DE, SELECTIVAMENTE, REDUCIR NIVELES ELEVADOS DE LEUCOCITOS ACTIVADOS EN UNA POBLACION DE LEUCOCITOS. MEDIANTE EL USO DE TALES COMPUESTOS, CON ABSORCION MAXIMA DE 670 NM O SUPERIOR, LAS LONGITUDES DE ONDA DE IRRADIACION PUEDEN SELECCIONARSE, PARA PERMITIR EL TRATAMIENTO DE TEJIDOS COMPLEJOS, TALES COMO LA SANGRE TOTAL. ESTO RESULTA ESPECIALMENTE UTIL EN PERSONAS QUE CONTIENEN TALES NIVELES ELEVADOS DE SUBCONJUNTOS DE CELULAS T, TALES COMO PERSONAS INFECTADAS DE HIV.
ES93909729T 1992-05-27 1993-05-27 Inactivacion selectiva de celulas en sangre. Expired - Lifetime ES2147754T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/889,707 US5776966A (en) 1992-05-27 1992-05-27 Selective cell inactivation in blood

Publications (1)

Publication Number Publication Date
ES2147754T3 true ES2147754T3 (es) 2000-10-01

Family

ID=25395640

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93909729T Expired - Lifetime ES2147754T3 (es) 1992-05-27 1993-05-27 Inactivacion selectiva de celulas en sangre.

Country Status (23)

Country Link
US (1) US5776966A (es)
EP (1) EP0642342B1 (es)
JP (1) JP3174821B2 (es)
KR (1) KR950701522A (es)
AT (1) ATE194491T1 (es)
AU (1) AU687734B2 (es)
CA (1) CA2136447C (es)
CZ (1) CZ283846B6 (es)
DE (1) DE69329026T2 (es)
DK (1) DK0642342T3 (es)
ES (1) ES2147754T3 (es)
FI (1) FI945586L (es)
GR (1) GR3034529T3 (es)
HU (1) HUT78021A (es)
IL (1) IL105815A (es)
MX (1) MX9303127A (es)
NO (1) NO308506B1 (es)
NZ (1) NZ252085A (es)
PT (1) PT642342E (es)
SK (1) SK143994A3 (es)
TW (1) TW257674B (es)
WO (1) WO1993024127A1 (es)
ZA (1) ZA933723B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807881A (en) * 1992-05-27 1998-09-15 Quadra Logic Technologies, Inc. Method for selectively reducing activated leukocyte cell population
US5756541A (en) 1996-03-11 1998-05-26 Qlt Phototherapeutics Inc Vision through photodynamic therapy of the eye
CA2221912A1 (en) * 1997-11-21 1999-05-21 David Dolphin Photosensitizers with improved biodistribution and light-absorbing properties
US6117862A (en) * 1998-10-09 2000-09-12 Qlt, Inc. Model and method for angiogenesis inhibition
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
JP2002534218A (ja) 1999-01-15 2002-10-15 ライト サイエンシーズ コーポレイション 非侵襲性の脈管療法
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
US7022843B1 (en) 1999-04-14 2006-04-04 The University Of British Columbia β,β′-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
US6734192B1 (en) * 1999-08-23 2004-05-11 Mp-1 Inc. Treatment of viral infections
US7541184B2 (en) 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
WO2002064163A2 (en) 2001-02-15 2002-08-22 Qlt Inc. Reduction or prevention of pdt related inflammation
WO2002100326A2 (en) 2001-05-01 2002-12-19 The General Hospital Corporation Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies
EP1401479B1 (en) * 2001-06-04 2007-04-18 The General Hospital Corporation Detection and therapy of vulnerable plaque with photodynamic compounds
AU2003253684A1 (en) * 2002-06-28 2004-01-19 Xcyte Therapies, Inc. Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US20050084967A1 (en) * 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US20040175373A1 (en) * 2002-06-28 2004-09-09 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US7659301B2 (en) * 2003-04-15 2010-02-09 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
KR100604350B1 (ko) 2004-07-15 2006-07-25 학교법인 인제학원 광역학 치료용 광민감성 물질로 유용한 사이클릭테트라피롤 고분자와 이의 제조방법
WO2009003173A1 (en) 2007-06-27 2008-12-31 The General Hospital Corporation Method and apparatus for optical inhibition of photodymanic therapy
PL233504B1 (pl) 2014-05-09 2019-10-31 Univ Jagiellonski Protoporfiryna IX kobaltu do stosowania w leczeniu neutropenii i białaczek
US10328085B2 (en) 2014-05-09 2019-06-25 Uniwersytet Jagiellonski Cobalt porphyrins for the treatment of blood-related disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610241A (en) * 1984-07-03 1986-09-09 Gordon Robert T Atherosclerosis treatment method
US5011684A (en) 1985-09-05 1991-04-30 Beth Israel Hospital Association Lysing or blocking unwanted cells with IL-2 receptor-specific binding substance
US5171749A (en) * 1987-01-20 1992-12-15 University Of British Columbia Wavelength-specific cytotoxic agents
US5095030A (en) * 1987-01-20 1992-03-10 University Of British Columbia Wavelength-specific cytotoxic agents
DE3821254A1 (de) 1988-06-23 1990-01-04 Hoffmann Elektrokohle Schleifstueck fuer stromabnehmer sowie verfahren zu seiner herstellung
US5190966A (en) * 1988-07-06 1993-03-02 Health Research, Inc. Purified hematoporphyrin dimers and trimers useful in photodynamic therapy
US5028594A (en) * 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US4960408A (en) * 1989-01-10 1990-10-02 Klainer Albert S Treatment methods and vaccines for stimulating an immunological response against retroviruses
US5149708A (en) * 1989-06-07 1992-09-22 University Of British Columbia Photosensitizing Diels-Alder porphyrin derivatives
US5087636A (en) * 1990-02-20 1992-02-11 University Of British Columbia Method to destroy malignant cells in mononuclear cell populations
US5214036A (en) * 1990-03-08 1993-05-25 University Of British Columbia Benzoporphyrin derivatives for photodynamic therapy

Also Published As

Publication number Publication date
HUT78021A (hu) 1999-05-28
ATE194491T1 (de) 2000-07-15
CZ291894A3 (en) 1995-09-13
CZ283846B6 (cs) 1998-06-17
WO1993024127A1 (en) 1993-12-09
DK0642342T3 (da) 2000-10-09
CA2136447A1 (en) 1993-12-09
FI945586A7 (fi) 1995-01-27
AU687734B2 (en) 1998-03-05
EP0642342A1 (en) 1995-03-15
NO308506B1 (no) 2000-09-25
IL105815A0 (en) 1993-09-22
ZA933723B (en) 1993-12-15
AU4057193A (en) 1993-12-30
PT642342E (pt) 2000-11-30
US5776966A (en) 1998-07-07
EP0642342B1 (en) 2000-07-12
DE69329026T2 (de) 2001-03-22
GR3034529T3 (en) 2000-12-29
NZ252085A (en) 1998-02-26
DE69329026D1 (de) 2000-08-17
KR950701522A (ko) 1995-04-28
SK143994A3 (en) 1996-07-03
NO944537D0 (no) 1994-11-25
MX9303127A (es) 1994-06-30
FI945586A0 (fi) 1994-11-28
CA2136447C (en) 2001-06-19
JPH08501278A (ja) 1996-02-13
JP3174821B2 (ja) 2001-06-11
HU9403385D0 (en) 1995-02-28
IL105815A (en) 2000-01-31
TW257674B (es) 1995-09-21
FI945586L (fi) 1995-01-27
NO944537L (no) 1995-01-20

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