ES2148858T3 - (aminoalquil- y acilaminoalquil-oxi)benciloxiquinolinas, procedimiento para su preparacion y su empleo como antagonistas de receptores de bradiquinina. - Google Patents

(aminoalquil- y acilaminoalquil-oxi)benciloxiquinolinas, procedimiento para su preparacion y su empleo como antagonistas de receptores de bradiquinina.

Info

Publication number
ES2148858T3
ES2148858T3 ES97103163T ES97103163T ES2148858T3 ES 2148858 T3 ES2148858 T3 ES 2148858T3 ES 97103163 T ES97103163 T ES 97103163T ES 97103163 T ES97103163 T ES 97103163T ES 2148858 T3 ES2148858 T3 ES 2148858T3
Authority
ES
Spain
Prior art keywords
sup
alkyl
hydrogen
bradiquinine
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97103163T
Other languages
English (en)
Inventor
Holger Dr Heitsch
Adalbert Dr Wagner
Klaus Dr Wirth
Bernward Prof Dr Scholkens
Gerhard Dr Nolken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2148858T3 publication Critical patent/ES2148858T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBEN ETERES DE AMINOALQUILO Y ACILAMINOALQUILO CARACTERIZADOS POR UNA ELEVADA AFINIDAD AL RECEPTOR B{SUB,2} DE BRADIQUININA Y UNA MEJOR HIDROSOLUBILIDAD. ESTOS ETERES DE AMINOALQUILO Y ACILAMINOALQUILO PUEDEN REPRESENTARSE MEDIANTE LA FORMULA GENERAL (I) EN LA QUE R{SUP,1}, R{SUP,2} Y R{SUP,3} SIGNIFICAN ALQUILO, ARILO, ALQUILARILO, HALOGENO, HIDROGENO, CICLOALQUILOS, CHO, CO O - ALQUILO O COOH; R{SUP,4} Y R{SUP,5} SIGNIFICAN HIDROGENO, HALOGENO, ALCOXI, NITRO, CIANO O S - ALQUILO; N SIGNIFICA UN NUMERO DE 1 A 8; R{SUP,6} HIDROGENO, ALQUILO, ALQUILALQUENILO, ALQUILARILO Y R{SUP,7} HIDROGENO O UN RESTO ACILO SUSTITUTIDO O NO. ASIMISMO SE DESCRIBE UN METODO PARA LA PREPARACION DE COMPUESTOS CON LA FORMULA (I).
ES97103163T 1996-03-13 1997-02-27 (aminoalquil- y acilaminoalquil-oxi)benciloxiquinolinas, procedimiento para su preparacion y su empleo como antagonistas de receptores de bradiquinina. Expired - Lifetime ES2148858T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19609827A DE19609827A1 (de) 1996-03-13 1996-03-13 Aminoalkyl- und Acylaminoalkylether, Verfahren zu deren Herstellung und ihre Verwendung als Bradykinin-Rezeptorantagonisten

Publications (1)

Publication Number Publication Date
ES2148858T3 true ES2148858T3 (es) 2000-10-16

Family

ID=7788139

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97103163T Expired - Lifetime ES2148858T3 (es) 1996-03-13 1997-02-27 (aminoalquil- y acilaminoalquil-oxi)benciloxiquinolinas, procedimiento para su preparacion y su empleo como antagonistas de receptores de bradiquinina.

Country Status (26)

Country Link
US (1) US6140341A (es)
EP (1) EP0795547B1 (es)
JP (1) JP4317597B2 (es)
KR (1) KR970065521A (es)
AR (1) AR006189A1 (es)
AT (1) ATE192738T1 (es)
AU (1) AU1621797A (es)
BR (1) BR9701267A (es)
CA (1) CA2199771A1 (es)
CZ (1) CZ76697A3 (es)
DE (2) DE19609827A1 (es)
DK (1) DK0795547T3 (es)
ES (1) ES2148858T3 (es)
GR (1) GR3033415T3 (es)
HR (1) HRP970138A2 (es)
HU (1) HUP9700566A1 (es)
ID (1) ID16217A (es)
IL (1) IL120427A0 (es)
NO (1) NO971136L (es)
PL (1) PL318923A1 (es)
PT (1) PT795547E (es)
SI (1) SI0795547T1 (es)
SK (1) SK32097A3 (es)
TR (1) TR199700184A2 (es)
TW (1) TW363891B (es)
ZA (1) ZA972129B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
WO1998057931A2 (en) 1997-06-19 1998-12-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
ITMI20021247A1 (it) * 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
TWI407960B (zh) 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽ｂ２受體調節劑
CL2008003120A1 (es) * 2007-11-01 2009-10-09 Acucela Inc Compuestos derivados de fenilalquil-, fenilalquenil-, fenilalquinil- amina, feniltioalquilamina, fenilaminoalquilamina, fenilalcoxiamina y fenilalquilguanidina; composicion farmaceutica; y uso de los compuestos para tratar un trastorno o enfermedad oftalmologica tal como retinopatia, maculopatia, retinitis pigmentosa, uveitis, entre otras.
IL274883B2 (en) 2017-11-24 2023-11-01 Pharvaris Netherlands B V BRADYKININ B2 receptor antagonists
AR118982A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
UY38707A (es) 2019-05-23 2020-12-31 Pharvaris Gmbh Nuevos antagonistas cíclicos del receptor b2 de bradiquinina
BR112024002215A2 (pt) 2021-08-05 2024-04-30 Pharvaris Gmbh Composição à base de lipídios para administração oral de antagonistas do receptor b2 da bradicinina
EP4499100A1 (en) 2022-03-25 2025-02-05 Pharvaris GmbH Therapeutic uses of bradykinin b2-receptor antagonists
TW202345810A (zh) 2022-03-25 2023-12-01 瑞士商帕法瑞斯有限責任公司 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物
HRP20260166T1 (hr) 2022-03-25 2026-03-27 Pharvaris Gmbh Čvrsti sastav koji sadrži solubilizirane antagoniste bradikinin b2 receptora

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216165A (en) * 1990-10-03 1993-06-01 American Home Products Corporation N-substituted aminoquinolines as analgesic agents
US5288725A (en) * 1992-10-15 1994-02-22 Merck & Co., Inc. Pyrroloquinoline Bradykinin antagonist
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
WO1996013485A1 (en) * 1994-10-27 1996-05-09 Fujisawa Pharmaceutical Co., Ltd. Pyridopyrimidones, quinolines and fused n-heretocycles as bradykinin antagonists
FR2735128B1 (fr) * 1995-06-07 1997-07-25 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique.
FR2737892B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique

Also Published As

Publication number Publication date
CZ76697A3 (en) 1997-10-15
SK32097A3 (en) 1998-01-14
NO971136D0 (no) 1997-03-12
ZA972129B (en) 1997-09-15
MX9701857A (es) 1997-09-30
ID16217A (id) 1997-09-11
NO971136L (no) 1997-09-15
US6140341A (en) 2000-10-31
PT795547E (pt) 2000-10-31
EP0795547A1 (de) 1997-09-17
JPH101472A (ja) 1998-01-06
IL120427A0 (en) 1997-07-13
ATE192738T1 (de) 2000-05-15
HUP9700566A1 (hu) 2000-08-28
DE19609827A1 (de) 1997-09-18
TR199700184A2 (xx) 1997-10-21
HRP970138A2 (en) 1998-04-30
HU9700566D0 (en) 1997-04-28
PL318923A1 (en) 1997-09-15
DE59701617D1 (de) 2000-06-15
CA2199771A1 (en) 1997-09-13
EP0795547B1 (de) 2000-05-10
GR3033415T3 (en) 2000-09-29
KR970065521A (ko) 1997-10-13
AU1621797A (en) 1997-09-18
SI0795547T1 (en) 2000-10-31
AR006189A1 (es) 1999-08-11
TW363891B (en) 1999-07-11
BR9701267A (pt) 1999-01-12
DK0795547T3 (da) 2000-09-18
JP4317597B2 (ja) 2009-08-19

Similar Documents

Publication Publication Date Title
NO852558L (no) Fremgangsmaate ved fremstilling av benzodiazepinanaloger.
ES2055424T3 (es) Derivados de n-fenilbenzamida con actividad anti-ulcera y anti-alergia y un metodo para su preparacion.
ES2138691T3 (es) Procedimiento para la obtencion de derivados de n-acil-5-fluorocitidina.
PT1177176E (pt) Derivados de acidos triarilicos como ligandos de receptores ppar.
TR200000782T2 (tr) Resorsinol türevleri.
FI950192A0 (fi) Fluoresoiva merkkiaine, jota käytetään poistettaessa vettä lietteestä
ES2142123T3 (es) Derivados de organosiloxanilo de alcanodiol-monovinil-eteres, proceso para su preparacion, su modificacion y su empleo como aditivos para barnices.
TR200100426T2 (tr) Nematisit pirazoller
AR241531A1 (es) Un procedimiento para la preparacion derivados de 2-indolinona, y sus sales farmaceuticamente aceptables.
ES2061580T3 (es) Compuestos de 3,7-diazabiciclo(3,3,1)nonano, asi como procedimiento para su preparacion y medicamentos que contienen estos compuestos.
BR9709899A (pt) Dimercaptanos alcoxilados como aditivos de cobre.
GT199900011A (es) Nuevos derivados del acido dihidroxihexanoico
MX9304399A (es) Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
ATE297903T1 (de) Substituierte phenyluracile
AR006189A1 (es) Aminoalquil-eteres y acilaminoalquil-eteres, procedimiento para su preparacion y su utilizacion como antagonistas de receptores de bradiquinina
EA199901098A1 (ru) Новый способ
EA200100040A1 (ru) Химический синтез морфолиновых производных
BR9902084A (pt) Heterociclos.
ES2093286T3 (es) Bencimidazoles, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
ES8604520A1 (es) Procedimiento para preparar derivados de 2(1h)-piridona
ES8705421A1 (es) Un procedimiento para la preparacion de 4-amino-2-fenil-quinolinas
ES2181015T3 (es) P-trifluormetilfeniluracilos substituidos.
ES2145480T3 (es) Amidas de acido carbamoilcarboxilico.
ES544828A0 (es) Procedimiento para preparar nuevos compuestos de 3-(aminoal-quilaminocarbonilmetoxi)-5-fenilpirazol
ATE324366T1 (de) Verfahren zur herstellung von 3-pyrrolin-2- carbonsäure-derivaten

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 795547

Country of ref document: ES