NO971136L - Aminoalkyl- og acylaminoalkyleter, fremgangsmåte for fremstilling derav og anvendelse som bradykinin-reseptor antagonister - Google Patents
Aminoalkyl- og acylaminoalkyleter, fremgangsmåte for fremstilling derav og anvendelse som bradykinin-reseptor antagonisterInfo
- Publication number
- NO971136L NO971136L NO971136A NO971136A NO971136L NO 971136 L NO971136 L NO 971136L NO 971136 A NO971136 A NO 971136A NO 971136 A NO971136 A NO 971136A NO 971136 L NO971136 L NO 971136L
- Authority
- NO
- Norway
- Prior art keywords
- aminoalkyl
- acylaminoalkyl
- ether
- preparation
- receptor antagonists
- Prior art date
Links
- -1 acylaminoalkyl ether Chemical compound 0.000 title abstract 3
- 125000004103 aminoalkyl group Chemical group 0.000 title abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title abstract 2
- 229940122155 Bradykinin receptor antagonist Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 101710085045 B2 bradykinin receptor Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005741 alkyl alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det er beskrevet aminoalkyl- og acylaminoalkyleter som utmerker seg ved en hoy affinitet for bradykinin-B2-reseptoren og forbedret vannopploselighet. Disse aminoalkyl- og acylaminoalkyleterene kan beskrives ved folgende generelle formel (1) O (CH2)fT N ^R^ (I) hvor R', r2, R^ alkyl, aryl, alkylaryl, halogen, hydrogen, cykloalkyl, CHO, CO-0- alkyl, COGH; R*^, R^, hydrogen, halogen, alkoksy, nitro, cyano, S-alkyl; n cr et tall fra 1 til 8; R° er hydrogen, alkyl, alkylalkenyl, a!kylar>l; R^ er hydrogen og en substituert eller usubstituert acylrest. Likeledes er det beskrevet en fremgangsmåte for fremstilling av forbindelsen med formel (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19609827A DE19609827A1 (de) | 1996-03-13 | 1996-03-13 | Aminoalkyl- und Acylaminoalkylether, Verfahren zu deren Herstellung und ihre Verwendung als Bradykinin-Rezeptorantagonisten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO971136D0 NO971136D0 (no) | 1997-03-12 |
| NO971136L true NO971136L (no) | 1997-09-15 |
Family
ID=7788139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO971136A NO971136L (no) | 1996-03-13 | 1997-03-12 | Aminoalkyl- og acylaminoalkyleter, fremgangsmåte for fremstilling derav og anvendelse som bradykinin-reseptor antagonister |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6140341A (no) |
| EP (1) | EP0795547B1 (no) |
| JP (1) | JP4317597B2 (no) |
| KR (1) | KR970065521A (no) |
| AR (1) | AR006189A1 (no) |
| AT (1) | ATE192738T1 (no) |
| AU (1) | AU1621797A (no) |
| BR (1) | BR9701267A (no) |
| CA (1) | CA2199771A1 (no) |
| CZ (1) | CZ76697A3 (no) |
| DE (2) | DE19609827A1 (no) |
| DK (1) | DK0795547T3 (no) |
| ES (1) | ES2148858T3 (no) |
| GR (1) | GR3033415T3 (no) |
| HR (1) | HRP970138A2 (no) |
| HU (1) | HUP9700566A1 (no) |
| ID (1) | ID16217A (no) |
| IL (1) | IL120427A0 (no) |
| NO (1) | NO971136L (no) |
| PL (1) | PL318923A1 (no) |
| PT (1) | PT795547E (no) |
| SI (1) | SI0795547T1 (no) |
| SK (1) | SK32097A3 (no) |
| TR (1) | TR199700184A2 (no) |
| TW (1) | TW363891B (no) |
| ZA (1) | ZA972129B (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6376670B1 (en) | 1997-06-19 | 2002-04-23 | Sepracor Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| WO1998057931A2 (en) | 1997-06-19 | 1998-12-23 | Sepracor Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| US6207679B1 (en) | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| EP1914236A1 (en) | 2002-04-10 | 2008-04-23 | Ortho-McNeil Pharmaceutical, Inc. | Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators |
| ITMI20021247A1 (it) * | 2002-06-07 | 2003-12-09 | Menarini Ricerche Spa | Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche |
| TWI407960B (zh) | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽ｂ２受體調節劑 |
| CL2008003120A1 (es) * | 2007-11-01 | 2009-10-09 | Acucela Inc | Compuestos derivados de fenilalquil-, fenilalquenil-, fenilalquinil- amina, feniltioalquilamina, fenilaminoalquilamina, fenilalcoxiamina y fenilalquilguanidina; composicion farmaceutica; y uso de los compuestos para tratar un trastorno o enfermedad oftalmologica tal como retinopatia, maculopatia, retinitis pigmentosa, uveitis, entre otras. |
| IL274883B2 (en) | 2017-11-24 | 2023-11-01 | Pharvaris Netherlands B V | BRADYKININ B2 receptor antagonists |
| AR118982A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| UY38707A (es) | 2019-05-23 | 2020-12-31 | Pharvaris Gmbh | Nuevos antagonistas cíclicos del receptor b2 de bradiquinina |
| BR112024002215A2 (pt) | 2021-08-05 | 2024-04-30 | Pharvaris Gmbh | Composição à base de lipídios para administração oral de antagonistas do receptor b2 da bradicinina |
| EP4499100A1 (en) | 2022-03-25 | 2025-02-05 | Pharvaris GmbH | Therapeutic uses of bradykinin b2-receptor antagonists |
| TW202345810A (zh) | 2022-03-25 | 2023-12-01 | 瑞士商帕法瑞斯有限責任公司 | 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物 |
| HRP20260166T1 (hr) | 2022-03-25 | 2026-03-27 | Pharvaris Gmbh | Čvrsti sastav koji sadrži solubilizirane antagoniste bradikinin b2 receptora |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216165A (en) * | 1990-10-03 | 1993-06-01 | American Home Products Corporation | N-substituted aminoquinolines as analgesic agents |
| US5288725A (en) * | 1992-10-15 | 1994-02-22 | Merck & Co., Inc. | Pyrroloquinoline Bradykinin antagonist |
| AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| WO1996013485A1 (en) * | 1994-10-27 | 1996-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Pyridopyrimidones, quinolines and fused n-heretocycles as bradykinin antagonists |
| FR2735128B1 (fr) * | 1995-06-07 | 1997-07-25 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique. |
| FR2737892B1 (fr) * | 1995-08-17 | 1997-10-24 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique |
-
1996
- 1996-03-13 DE DE19609827A patent/DE19609827A1/de not_active Withdrawn
-
1997
- 1997-02-27 SI SI9730063T patent/SI0795547T1/xx unknown
- 1997-02-27 EP EP97103163A patent/EP0795547B1/de not_active Expired - Lifetime
- 1997-02-27 DE DE59701617T patent/DE59701617D1/de not_active Expired - Lifetime
- 1997-02-27 ES ES97103163T patent/ES2148858T3/es not_active Expired - Lifetime
- 1997-02-27 PT PT97103163T patent/PT795547E/pt unknown
- 1997-02-27 AT AT97103163T patent/ATE192738T1/de not_active IP Right Cessation
- 1997-02-27 DK DK97103163T patent/DK0795547T3/da active
- 1997-03-10 ID IDP970758A patent/ID16217A/id unknown
- 1997-03-11 TR TR97/00184A patent/TR199700184A2/xx unknown
- 1997-03-11 HU HU9700566A patent/HUP9700566A1/hu unknown
- 1997-03-11 TW TW086102960A patent/TW363891B/zh active
- 1997-03-11 AU AU16217/97A patent/AU1621797A/en not_active Abandoned
- 1997-03-11 SK SK320-97A patent/SK32097A3/sk unknown
- 1997-03-11 AR ARP970100968A patent/AR006189A1/es unknown
- 1997-03-12 NO NO971136A patent/NO971136L/no unknown
- 1997-03-12 CZ CZ97766A patent/CZ76697A3/cs unknown
- 1997-03-12 KR KR1019970008175A patent/KR970065521A/ko not_active Withdrawn
- 1997-03-12 BR BR9701267A patent/BR9701267A/pt unknown
- 1997-03-12 ZA ZA9702129A patent/ZA972129B/xx unknown
- 1997-03-12 CA CA002199771A patent/CA2199771A1/en not_active Abandoned
- 1997-03-12 IL IL12042797A patent/IL120427A0/xx unknown
- 1997-03-12 HR HR19609827.0A patent/HRP970138A2/xx not_active Application Discontinuation
- 1997-03-12 JP JP05783497A patent/JP4317597B2/ja not_active Expired - Fee Related
- 1997-03-12 US US08/820,321 patent/US6140341A/en not_active Expired - Fee Related
- 1997-03-12 PL PL97318923A patent/PL318923A1/xx unknown
-
2000
- 2000-05-16 GR GR20000401105T patent/GR3033415T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ76697A3 (en) | 1997-10-15 |
| SK32097A3 (en) | 1998-01-14 |
| NO971136D0 (no) | 1997-03-12 |
| ZA972129B (en) | 1997-09-15 |
| ES2148858T3 (es) | 2000-10-16 |
| MX9701857A (es) | 1997-09-30 |
| ID16217A (id) | 1997-09-11 |
| US6140341A (en) | 2000-10-31 |
| PT795547E (pt) | 2000-10-31 |
| EP0795547A1 (de) | 1997-09-17 |
| JPH101472A (ja) | 1998-01-06 |
| IL120427A0 (en) | 1997-07-13 |
| ATE192738T1 (de) | 2000-05-15 |
| HUP9700566A1 (hu) | 2000-08-28 |
| DE19609827A1 (de) | 1997-09-18 |
| TR199700184A2 (xx) | 1997-10-21 |
| HRP970138A2 (en) | 1998-04-30 |
| HU9700566D0 (en) | 1997-04-28 |
| PL318923A1 (en) | 1997-09-15 |
| DE59701617D1 (de) | 2000-06-15 |
| CA2199771A1 (en) | 1997-09-13 |
| EP0795547B1 (de) | 2000-05-10 |
| GR3033415T3 (en) | 2000-09-29 |
| KR970065521A (ko) | 1997-10-13 |
| AU1621797A (en) | 1997-09-18 |
| SI0795547T1 (en) | 2000-10-31 |
| AR006189A1 (es) | 1999-08-11 |
| TW363891B (en) | 1999-07-11 |
| BR9701267A (pt) | 1999-01-12 |
| DK0795547T3 (da) | 2000-09-18 |
| JP4317597B2 (ja) | 2009-08-19 |
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